CN107961002A - One kind is based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method - Google Patents
One kind is based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method Download PDFInfo
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- CN107961002A CN107961002A CN201711108746.4A CN201711108746A CN107961002A CN 107961002 A CN107961002 A CN 107961002A CN 201711108746 A CN201711108746 A CN 201711108746A CN 107961002 A CN107961002 A CN 107961002A
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- 230000004089 microcirculation Effects 0.000 title claims abstract description 28
- 230000017531 blood circulation Effects 0.000 title claims abstract description 26
- 238000005259 measurement Methods 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title claims abstract description 18
- 238000007493 shaping process Methods 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 239000000284 extract Substances 0.000 claims description 2
- 230000010287 polarization Effects 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 abstract description 2
- 239000008280 blood Substances 0.000 abstract description 2
- 230000003287 optical effect Effects 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- 241000406668 Loxodonta cyclotis Species 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 210000002565 arteriole Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- 238000000701 chemical imaging Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000005388 cross polarization Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000002356 laser light scattering Methods 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000012014 optical coherence tomography Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000000264 venule Anatomy 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
The invention discloses one kind based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method.What the device mainly utilized is laser-Doppler dual-beam double scattering principle.Device is mainly by the most of composition of laser beam emitting device, laser beam splitter and focusing arrangement, detector reception device, and scanning means four.Wherein, laser beam emitting device is mainly made of laser, collimating mirror and optoisolator.And laser beam splitter and focusing arrangement are then by Amici prism, shaping lens and convex lens group into detector reception device is mainly by polarizer, aperture, and detector composition, scanning means is mainly three-dimensional mobile platform；Collimating mirror and shaping lens are formed by convex lens and concavees lens；Three-dimensional mobile platform, detector are respectively controlled and are shown by computer.By the simple and effective optical system of the device, microcirculation of nail rugae blood circumstance can be accurately measured, and microcirculation of nail rugae blood flow is imaged.
Description
Technical field
The invention belongs to Laser Measuring blood flow field, and in particular to laser Doppler apparatus measurement microcirculation of nail rugae blood flow side
Method.
Background technology
Microcirculation refers to the blood circulation between arteriole and venule.First folds in a garment is the skin wrinkle for being covered in nail root
Folding.The important circulatory system of the microcirculation of nail rugae system as human body, directly participates in cell and organizes self-energy, information, material
Transmit, pass through grinding for the forms such as the aggregation of Bai Weishuan, red blood cell to microcirculations such as first folds in a garments, cryptomere expansion and capilary stream
Study carefully, the disease symptoms such as cerebral thrombus, hypertension, coronary heart disease, diabetes can be diagnosed, for understanding, diagnosis and treatment, the mechanism of study of disease
There is highly important effect with drug therapy.
At present, although capillary microscopy can observe blood vessel, limited by instrument itself, picture quality is to measurement pair
The Influence of Displacement of elephant is larger, is easily influenced be subject to dermal melanin, and need inject fluorescer lifting image contrast degree and it is unfavorable
In health.Means of optical coherence tomography, though more clear image can be obtained, imaging depth is shallow, is unfavorable for
It was observed that the blood vessel of first folds in a garment depths.Cross-polarization spectral imaging technology, is deep to be implemented as picture by varying the polarization state of flashlight
The selection of degree, passes through multiple reflections, intensity is weaker, and detection is more difficult, and image contrast degree is not high, can not obtain due to becoming inclined flashlight
Accurate velocity of blood flow information.
To solve the above-mentioned problems, the present invention proposes one kind using laser Doppler apparatus measurement microcirculation of nail rugae blood flow side
Method, what which mainly utilized is laser-Doppler dual-beam double scattering principle.By measuring the movement velocity of red blood cell, carry out table
Levy the velocity of blood flow of microcirculation of nail rugae.This method is a kind of contactless, horizontal scanning device, has precision height, spatial discrimination
The advantages that rate is good, and dynamic response is fast, and measurement range is big.
The content of the invention
The purpose of the present invention is using laser Doppler apparatus measurement microcirculation of nail rugae blood flow method, this method by using
Two beam laser focus at first folds in a garment, the blood vessel being irradiated under first folds in a garment, the difference on the frequency produced using red blood cell movement to laser light scattering,
Flashlight is received by detector reception device, and is converted to electric signal, the processing such as filtered, amplification and digital-to-analogue conversion, comes
Microcirculation of nail rugae velocity of blood flow is measured, and microcirculation of nail rugae rheography is obtained by scanning.
The purpose of the present invention is what is be achieved through the following technical solutions：
One kind is based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method；What the device mainly utilized is laser-Doppler
Dual-beam double scattering principle；Device is mainly by laser beam emitting device, laser beam splitter and focusing arrangement, detector reception device, with
And the most of composition of scanning means four；Wherein, laser beam emitting device is mainly made of laser, collimating mirror and optoisolator, and
Laser beam splitter and focusing arrangement are then by Amici prism, shaping lens and convex lens group into detector reception device is mainly by inclined
Shake piece, aperture, and detector composition, scanning means is mainly three-dimensional mobile platform；Collimating mirror and shaping lens are by convex lens
Mirror and concavees lens composition；Three-dimensional mobile platform, detector are respectively controlled and are shown by computer.
The optoisolator is mainly used for avoiding generation back reflected laser in light path to be had an impact to light source.
The shaping lens are mainly used for being compressed two light beams, increase the length of the overlapping region of the light velocity, expand
Larger Dynamic measurement range.
The condenser lens is mainly focused two-beam.
The polarizer is mainly the polarised light obtained after beam divergence.
The detector is mainly used for collection and carries the polarised light of information, and extracts blood flow information.
One kind is comprised the following steps based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method：
(1) laser emitting device is opened, adjusts the convex lens of collimation lens and the position of concavees lens, the laser sent is carried out
Collimation；
(2) position of three-dimensional mobile platform and convex lens is adjusted, laser is focused on first folds in a garment；
(3) position of polarizer and the size of aperture are adjusted, the scattering light of proper strength is selected, is detected；
(4) in the vertical direction is controlled three-dimensional mobile platform using computer control, is allowed to right successively in the horizontal direction
First folds in a garment carries out two-dimensional scan.
Compared with prior art, the caused beneficial effect of technical scheme is：
1. apparatus of the present invention are simple in structure, of less demanding to the collimation property of whole experiment light path, compact-sized, operability
Height, it is highly practical；
2. the present invention can be quickly accurate using laser-Doppler and continuously monitors, accurate to measure microcirculation of nail rugae blood
Flow velocity, and imaging is scanned to whole microcirculation of nail rugae blood circumstance.
Brief description of the drawings
Fig. 1 is laser Doppler apparatus measurement microcirculation of nail rugae structure diagram；
Fig. 2 is laser focusing illumination first folds in a garment schematic diagram；
Reference numeral：1- lasers, 2- collimating mirrors, 3- optoisolators, 4- Amici prisms, 5- shaping lens, 6- convex lenses, 7- first
Folds in a garment marker bit, 8- detector reception devices, 9- three-dimensional mobile platforms, 10- computers.
Embodiment
The present invention is further illustrated below in conjunction with the accompanying drawings：
As shown in Figure 1, the present invention, which provides a kind of laser Doppler apparatus that is based on, measures microcirculation of nail rugae blood flow method, device master
What is utilized is laser-Doppler dual-beam double scattering principle.Beam of laser is produced including laser 1, collimation lens 2 is to producing
Light beam collimated, afterwards by optoisolator 3 come avoid in light path produce back reflected laser light source is had an impact, then
Two beam laser are obtained using Amici prism 4, and is realized by shaping lens 5 and two light beams is compressed, it is real using convex lens 6
The focusing of existing two light beams, three-dimensional mobile platform 9 and convex lens 6 are adjusted by the vertical direction, find with first folds in a garment marker bit 7
The light beam focal length that first folds in a garment is most suitable for, and polarizer and aperture in rotation detector reception device 8, are controlled using computer 10
Three-dimensional mobile platform 9 is scanned in the horizontal direction, and observes microcirculation of nail rugae blood flow effect using computer 10.
Claims (7)
1. one kind is based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method；What the device mainly utilized is that how general laser is
Strangle dual-beam double scattering principle；Device is mainly by laser beam emitting device, laser beam splitter and focusing arrangement, detector reception device,
And the most of composition of scanning means four；Wherein, laser beam emitting device is mainly made of laser, collimating mirror and optoisolator,
And laser beam splitter and focusing arrangement then by Amici prism, shaping lens and convex lens group into, detector reception device mainly by
Polarizer, aperture, detector composition, scanning means is mainly three-dimensional mobile platform；Collimating mirror and shaping lens are by convex
Lens and concavees lens composition；Three-dimensional mobile platform, detector are respectively controlled and are shown by computer.
It is 2. according to claim 1 a kind of based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method, its feature
It is, the laser beam emitting device collimate and avoid generation back reflected laser in light path to have an impact light source.
It is 3. according to claim 1 a kind of based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method, its feature
It is, the shaping lens can be compressed two light beams, the length of increase light beam overlapping region, expand dynamic measurement model
Enclose.
It is 4. according to claim 1 a kind of based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method, its feature
It is, the condenser lens can be focused two-beam.
It is 5. according to claim 1 a kind of based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method, its feature
It is, the polarizer can obtain the polarised light after beam divergence.
It is 6. according to claim 1 a kind of based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method, its feature
It is, the detector is mainly used for collection and carries the polarised light of information, and extracts blood flow information.
It is 7. according to claim 1 a kind of based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method, its feature
It is, comprises the following steps：
(1) laser emitting device is opened, adjusts the convex lens of collimation lens and the position of concavees lens, the laser sent is carried out
Collimation；
(2) position of three-dimensional mobile platform and convex lens is adjusted, laser is focused on first folds in a garment；
(3) size of the position of adjustment polarization and aperture, selects the scattering light of proper strength, is detected；
(4) in the vertical direction is controlled three-dimensional mobile platform using computer, is allowed in the horizontal direction successively to first folds in a garment
It is scanned.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711108746.4A CN107961002A (en) | 2017-11-11 | 2017-11-11 | One kind is based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711108746.4A CN107961002A (en) | 2017-11-11 | 2017-11-11 | One kind is based on laser Doppler apparatus measurement microcirculation of nail rugae blood flow method |
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| CN107961002A true CN107961002A (en) | 2018-04-27 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113116303A (en) * | 2021-04-16 | 2021-07-16 | 佛山科学技术学院 | Three-dimensional scan analysis system and method for microcirculation blood vessels of nail folds |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2421145C1 (en) * | 2009-12-10 | 2011-06-20 | Государственное учреждение Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского (ГУ МОНИКИ им. М.Ф. Владимирского) | Method of predicting risk of development of digestive tract bleeding in case of polypectomy with application of high-frequency current |
| CN202631566U (en) * | 2012-03-07 | 2012-12-26 | 中国计量学院 | Double-beam laser Doppler tachymeter |
| CN107115099A (en) * | 2017-03-29 | 2017-09-01 | 广州医软智能科技有限公司 | A kind of microcirculation of nail rugae imaging device |
| CN107320112A (en) * | 2017-07-07 | 2017-11-07 | 广州医软智能科技有限公司 | The multi-parameter imaging detection method and device of microcirculation |
-
2017
- 2017-11-11 CN CN201711108746.4A patent/CN107961002A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2421145C1 (en) * | 2009-12-10 | 2011-06-20 | Государственное учреждение Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского (ГУ МОНИКИ им. М.Ф. Владимирского) | Method of predicting risk of development of digestive tract bleeding in case of polypectomy with application of high-frequency current |
| CN202631566U (en) * | 2012-03-07 | 2012-12-26 | 中国计量学院 | Double-beam laser Doppler tachymeter |
| CN107115099A (en) * | 2017-03-29 | 2017-09-01 | 广州医软智能科技有限公司 | A kind of microcirculation of nail rugae imaging device |
| CN107320112A (en) * | 2017-07-07 | 2017-11-07 | 广州医软智能科技有限公司 | The multi-parameter imaging detection method and device of microcirculation |
Non-Patent Citations (8)
| Title |
|---|
| 夏雪湔: "《工程分离流动力学》", 31 May 1991 * |
| 工业自动化仪表手册 编辑委员会: "《工业自动化仪表手册》", 30 October 1987 * |
| 张庆富: "局部温度变化对人体足甲襞微循环的影响", 《中国微循环》 * |
| 张荷叶 等: "《冷刺激对青年人甲襞微循环及微区血流量的影响》", 《微循环学杂志》 * |
| 田牛: "《微循环的临床与基础》", 30 April 1996 * |
| 胡琅琳、嵇波: "《甲襞微循环检查和激光多普勒技术对针灸效应的评价作用》", 《微循环学》 * |
| 董惠 等: "《建筑环境测试技术》", 31 March 2017, 哈尔滨工程大学出版社 * |
| 迟泽英: "《纤维光学与光纤应用技术》", 30 April 2009 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113116303A (en) * | 2021-04-16 | 2021-07-16 | 佛山科学技术学院 | Three-dimensional scan analysis system and method for microcirculation blood vessels of nail folds |
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