CN107941784A - A kind of protein Raman microscratch detector of wirelessly transmitting data - Google Patents
A kind of protein Raman microscratch detector of wirelessly transmitting data Download PDFInfo
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- CN107941784A CN107941784A CN201711430913.7A CN201711430913A CN107941784A CN 107941784 A CN107941784 A CN 107941784A CN 201711430913 A CN201711430913 A CN 201711430913A CN 107941784 A CN107941784 A CN 107941784A
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- raman
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- raman spectrum
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
-
- G—PHYSICS
- G08—SIGNALLING
- G08C—TRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
- G08C17/00—Arrangements for transmitting signals characterised by the use of a wireless electrical link
- G08C17/02—Arrangements for transmitting signals characterised by the use of a wireless electrical link using a radio link
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- General Physics & Mathematics (AREA)
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Computer Networks & Wireless Communication (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The present invention relates to a kind of protein Raman microscratch detector of wirelessly transmitting data, including wireless transmission unit, analysis shows that six module, laser module, lens module, Raman lens and detection probe parts, wherein, laser module, for generating laser；Raman lens, beat in surface enhanced probe for laser is converged to；Raman spectrum display module is ccd detector, for showing the next Raman spectral information of collection；Wireless transmission unit, be for being connected with external equipment or printer communication, realize Raman spectrum data be wirelessly transferred or wireless printing.The directly contact with micro article of surface enhanced probe detects, its main body is optical fiber, and the collection of the Raman spectrum to trace level sample to be tested is can reach formed with nano metal silver coating by surface diposition in optical fiber surface.
Description
Technical field
The invention belongs to the fast inspection technical field of microscratch sample.
Background technology
Daily life, production activity and the scientific experiment of the mankind all be unable to do without test and information gathering.Information gathering is exactly
Information is obtained, is to the parameter of physics, chemistry, engineering technology etc. and numerical information are extracted in real work mistake
Journey.Since information does not possess the function of processing, transmission in itself, can only be translated the information into by certain means and method
Signal, and be transmitted.
With the progress of the communication technology, embedding assembly technology and sensor technology, including microelectromechanical systems
The rapid development of existing technology at (Micro-Electro-Mechanical Systems, MEMS) and relevant interface, signal
With it is increasingly mature, the microsensor network with perception, computing capability and communication capacity causes the very big pass of people
Note.Wireless sensor network combines the wonderful reason technology of sensor technology, embedding assembly technology, distributed information and communication skill
Art, collaboratively can monitor, perceives and gather the information of the various environment or monitoring object in network distribution region in real time, and right
These information are handled；Detailed and accurate information is obtained, is transmitted to the user for needing these information.
But in biology, medical research, traditional biology sensor volume is larger, is simply possible to use in tissue, cell hangs
The measurement of liquid etc., it is real when such as detecting living cells or other subcellular components when detecting the size reduction of sample to micron order
When, chemistry and natural component become extremely difficult in accurate, interference-free measurement sample.And traditional Raman spectrometer one
As include extremely complex structure, but since its internal structure is extremely complex so that signal acquisition efficiency and coupling efficiency are low
Under, cause that accuracy in detection is high, bulky, of high cost, application range is limited.
The content of the invention
Present invention aims at a kind of protein Raman microscratch detector of wirelessly transmitting data is provided, probe manufacturing is improved
Technique, and wireless data transmission technology and Raman detector body are combined, is detected to be measured micro- by detection probe
Trace sample, laser send laser, obtain Raman signal, and then the Raman spectrum display module being transferred in detector body,
Again by wireless transmission unit realize to Raman spectrum data be wirelessly transferred and wireless printing.Technical solution is as follows：
A kind of protein Raman microscratch detector of wirelessly transmitting data, including wireless transmission unit, analysis shows that module,
Six laser module, lens module, Raman lens and detection probe parts, wherein,
Laser module, for generating laser；
Raman lens, beat in surface enhanced probe for laser is converged to；
Raman spectrum display module is ccd detector, for showing the next Raman spectral information of collection；
Wireless transmission unit, is for being connected with external equipment or printer communication, realizing the nothing of Raman spectrum data
Line transmits or wireless printing.
The directly contact with micro article of surface enhanced probe detects, its main body is optical fiber, passes through surface in optical fiber surface
Deposition technique can reach the collection of the Raman spectrum to trace level sample to be tested formed with nano metal silver coating；Surface enhanced
The production method of probe is as follows：
1) solid core fibres are chosen；
2) solid core fibres surface is roughened by electrochemical method；
3) so that Ag is coated in the solid core fibres surface by roughening processing, nano level projection is formed.
The present invention can realize the function of the wireless data transmission and wireless printing to Raman spectrum, suitable for human body protein
Quality detection, have trace detection, detection speed fast, wireless printing, wireless data transmission, accuracy height, compact structure, it is quick gently
Just the advantages of.
Brief description of the drawings
Fig. 1 is testing result schematic diagram of the present invention；
Fig. 2 is the portable Raman microscratch detector structure diagram of the present invention；
Fig. 3 is the portable Raman microscratch detector testing process schematic diagram of the present invention.
Embodiment
Below according to Figure of description, technical scheme is introduced in detail.
Heretofore described detection probe is to use fiber optic materials, which formed by surface diposition
Nano metal silver coating, strengthen its Raman detection signal；And it is that activity is strengthened by the Raman of Electrochemical roughening processing
Surface, the increase of the surface-enhanced Raman factor.Raman spectrum display module is equipped with detector body at the same time, what display was collected
Raman spectral information (as shown in Figure 1), realizes the quick detection to microscratch sample.
The present invention makes to be equipped with wireless transmission unit in detector body, when upper Raman molecular and and albumen are modified in metal surface
The ligand such as antibody that matter molecule combines, can obtain Raman signal after protein molecule is recognized, and Raman is gathered to micro-example
Spectrum, carries out communication with external equipment by wireless transmission unit and is connected, and realizes being wirelessly transferred and wirelessly for Raman spectrum data
Printing.
The protein Raman microscratch detector structure of wirelessly transmitting data of the present invention was as shown in Fig. 2, as can be seen should
Portable Raman microscratch detector be by wireless transmission unit (1), Raman spectrum display module (2), laser module (3), thoroughly
(6) six mirror module (4), Raman lens (5), detection probe major parts form.Wherein wireless transmission unit be for
External equipment or printer communication connection, realize Raman spectrum data be wirelessly transferred or wireless printing.Raman spectrum is shown
Module is ccd detector, for showing the next Raman spectral information of collection.Laser module specifically uses 785nm laser dies
Block.Raman lens are to be beaten after laser to be converged to a dot in detection probe.Detection probe directly with micro article
Contact detection, its material is use fiber optic materials, surface be by surface diposition formation nano metal silver coating, and
And it is that active surface is strengthened by the Raman of Electrochemical roughening processing；When upper Raman molecular and and protein are modified in metal surface
The ligand such as antibody that molecule combines, can obtain Raman signal after protein molecule is recognized, and will gather Raman to micro-example
Spectrum, realizes the quick detection of microscratch sample
In order to illustrate more clearly of the operation principle of the present invention, the detection probe of front end is first introduced.Detection probe is used
Material be solid core fibres material, be first roughened by electrochemical method with solid core fibres probe, put after having handled
In the glass tubule for entering to fill Ag colloidal sols, solid core fibres probe is at the uniform velocity lifted upwards, so that Ag is coated in optical fiber probe table
Face, forms nano level projection, improves the surface-enhanced Raman factor, strengthens the Raman signal detected, realize portable Raman
The quick detection of detector.
The protein Raman microscratch detector testing process schematic diagram of wirelessly transmitting data of the present invention is as shown in Figure 3.Work as inspection
When probing pin is contacted with microscratch sample, laser is sent from 785nm laser modules to lens module, by Raman lens, will be swashed
Light is beaten in detection probe after converging to a dot.The detecting probe surface coated with nano Ag metal layers, when in the modification of metal surface
Raman molecular and the ligand such as antibody combined with target molecule, can obtain Raman signal after target molecule is recognized；Detected sample
Product are produced Raman signal after laser excitation, and are collected by Raman lens, and the Raman signal after collection is imaged by lens module
On Raman spectrum display module, it is stored in internal storage unit.And the wireless transmission unit in detector body can be with
External storage equipment, the Raman spectral information tested is exported, easy to the analysis and management in later stage；At the same time can with it is outer
Portion's equipment or printer communication connection, the gathered Raman spectrum data of realization is wirelessly transferred and wireless printing.
Claims (1)
1. a kind of protein Raman microscratch detector of wirelessly transmitting data, including wireless transmission unit, analysis shows that module, swashing
Six light device module, lens module, Raman lens and detection probe parts, wherein,
Laser module, for generating laser；
Raman lens, beat in surface enhanced probe for laser is converged to；
Raman spectrum display module is ccd detector, for showing the next Raman spectral information of collection；
Wireless transmission unit, is for being connected with external equipment or printer communication, realizing the wireless biography of Raman spectrum data
Defeated or wireless printing.
The directly contact with micro article of surface enhanced probe detects, its main body is optical fiber, is deposited in optical fiber surface by surface
Technology can reach the collection of the Raman spectrum to trace level sample to be tested formed with nano metal silver coating；Surface enhanced probe
Production method it is as follows：
1) solid core fibres are chosen；
2) solid core fibres surface is roughened by electrochemical method；
3) so that Ag is coated in the solid core fibres surface by roughening processing, nano level projection is formed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711430913.7A CN107941784A (en) | 2017-12-26 | 2017-12-26 | A kind of protein Raman microscratch detector of wirelessly transmitting data |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711430913.7A CN107941784A (en) | 2017-12-26 | 2017-12-26 | A kind of protein Raman microscratch detector of wirelessly transmitting data |
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| CN107941784A true CN107941784A (en) | 2018-04-20 |
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| CN201711430913.7A Pending CN107941784A (en) | 2017-12-26 | 2017-12-26 | A kind of protein Raman microscratch detector of wirelessly transmitting data |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112840386A (en) * | 2018-10-18 | 2021-05-25 | 日东电工株式会社 | Data acquisition method and signal measurement system |
Citations (5)
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|---|---|---|---|---|
| CN103048306A (en) * | 2012-12-18 | 2013-04-17 | 上海纳米技术及应用国家工程研究中心有限公司 | Core-shell nanogold biological probe with high SERS (surface enhanced Raman scattering) effect and preparation and application thereof |
| CN104568905A (en) * | 2015-01-19 | 2015-04-29 | 东南大学 | Three-dimensional code biological detection chip based on surface-enhanced Raman scattering (SERS) microflow platform as well as preparation method and detection method of biological detection chip |
| CN106596509A (en) * | 2016-12-29 | 2017-04-26 | 天津大学 | Portable raman-microscratch rapid detector integrated with wireless data transmission function |
| CN106770170A (en) * | 2016-12-29 | 2017-05-31 | 天津大学 | Can modularization apolegamy assembling Raman microscratch fast detector |
| CN107703114A (en) * | 2016-08-09 | 2018-02-16 | 新疆维吾尔自治区纤维检验局 | The enhanced portable Raman microscratch fast detector of novel surface |
-
2017
- 2017-12-26 CN CN201711430913.7A patent/CN107941784A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103048306A (en) * | 2012-12-18 | 2013-04-17 | 上海纳米技术及应用国家工程研究中心有限公司 | Core-shell nanogold biological probe with high SERS (surface enhanced Raman scattering) effect and preparation and application thereof |
| CN104568905A (en) * | 2015-01-19 | 2015-04-29 | 东南大学 | Three-dimensional code biological detection chip based on surface-enhanced Raman scattering (SERS) microflow platform as well as preparation method and detection method of biological detection chip |
| CN107703114A (en) * | 2016-08-09 | 2018-02-16 | 新疆维吾尔自治区纤维检验局 | The enhanced portable Raman microscratch fast detector of novel surface |
| CN106596509A (en) * | 2016-12-29 | 2017-04-26 | 天津大学 | Portable raman-microscratch rapid detector integrated with wireless data transmission function |
| CN106770170A (en) * | 2016-12-29 | 2017-05-31 | 天津大学 | Can modularization apolegamy assembling Raman microscratch fast detector |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112840386A (en) * | 2018-10-18 | 2021-05-25 | 日东电工株式会社 | Data acquisition method and signal measurement system |
| CN112840386B (en) * | 2018-10-18 | 2023-10-24 | 日东电工株式会社 | Data acquisition method and signal measurement system |
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Application publication date: 20180420 |