CN107929632A - A kind of Chinese medicine composition for treating infantile enuresis and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating infantile enuresis and preparation method thereof Download PDFInfo
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- CN107929632A CN107929632A CN201711225926.0A CN201711225926A CN107929632A CN 107929632 A CN107929632 A CN 107929632A CN 201711225926 A CN201711225926 A CN 201711225926A CN 107929632 A CN107929632 A CN 107929632A
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- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 208000008967 Enuresis Diseases 0.000 title claims abstract description 26
- 239000003814 drug Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 244000001632 Acorus gramineus Species 0.000 claims abstract description 13
- 235000013073 Acorus gramineus Nutrition 0.000 claims abstract description 13
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 13
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 13
- 241000756943 Codonopsis Species 0.000 claims abstract description 13
- 241000287828 Gallus gallus Species 0.000 claims abstract description 13
- 244000241872 Lycium chinense Species 0.000 claims abstract description 13
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 13
- 240000003152 Rhus chinensis Species 0.000 claims abstract description 13
- 235000014220 Rhus chinensis Nutrition 0.000 claims abstract description 13
- 235000011034 Rubus glaucus Nutrition 0.000 claims abstract description 13
- 244000235659 Rubus idaeus Species 0.000 claims abstract description 13
- 235000009122 Rubus idaeus Nutrition 0.000 claims abstract description 13
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 13
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 13
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 12
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 12
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 12
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 12
- 210000000582 semen Anatomy 0.000 claims abstract description 12
- 210000004317 gizzard Anatomy 0.000 claims abstract description 11
- 239000012528 membrane Substances 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000000706 filtrate Substances 0.000 claims description 13
- 239000012141 concentrate Substances 0.000 claims description 10
- 235000008504 concentrate Nutrition 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 7
- 230000008901 benefit Effects 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 210000003734 kidney Anatomy 0.000 abstract description 2
- 230000000144 pharmacologic effect Effects 0.000 abstract description 2
- 210000000952 spleen Anatomy 0.000 abstract description 2
- 230000007812 deficiency Effects 0.000 description 6
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 206010057315 Daydreaming Diseases 0.000 description 1
- 241001459693 Dipterocarpus zeylanicus Species 0.000 description 1
- 206010021925 Inferiority complex Diseases 0.000 description 1
- XLBIBBZXLMYSFF-UHFFFAOYSA-M Propantheline bromide Chemical compound [Br-].C1=CC=C2C(C(=O)OCC[N+](C)(C(C)C)C(C)C)C3=CC=CC=C3OC2=C1 XLBIBBZXLMYSFF-UHFFFAOYSA-M 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 229960000836 amitriptyline Drugs 0.000 description 1
- KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229960004801 imipramine Drugs 0.000 description 1
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 208000005346 nocturnal enuresis Diseases 0.000 description 1
- 230000001734 parasympathetic effect Effects 0.000 description 1
- 230000004793 poor memory Effects 0.000 description 1
- 229940099209 probanthine Drugs 0.000 description 1
- 239000003340 retarding agent Substances 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of Chinese medicine composition for treating infantile enuresis, it is made of following raw material：10 15 parts of the fruit of Chinese wolfberry, 10 15 parts of the membrane of a chicken's gizzard, 10 15 parts of fructus alpiniae oxyphyllae, 10 15 parts of Rhizoma Atractylodis Macrocephalae, 30 40 parts of raspberry, 30 40 parts of calcined Dragon's bone, 20 30 parts of Semen Cuscutae, 20 30 parts of cassia twig, 20 30 parts of Chinese yam, 15 20 parts of grass-leaved sweetflag, 15 20 parts of Radix Codonopsis, 15 20 parts of Chinese gall.The Chinese medicine composition of the present invention can warm kidney benefit spleen, astringent method only lose, can effectively treat infantile enuresis, and of low cost, preparation process is simple, quick, curative for effect, and pharmacological property is gentle, without any side effects, is very suitable for child administration.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating infantile enuresis and its preparation
Method.
Background technology
Enruesis is commonly called as wetting the bed, and is often referred to more than the 3 years old especially children of more than 5 years old and is unable to automatic micturition when sleeping soundly, and one
As 3-4 Sui when have 20% children have an enruesis, 10 years old when, has 5% children to have enruesis, there is small number of patients enuresis symptoms last
To the manhood.The characteristics of primary enuresis symptoms of children is：There is no obvious urinary tract neurological organic disease.Primary is small
Youngster's enruesis number of the infected is higher, accounts for the 70-80% of enruesis total number of persons.Infantile enuresis makes child as treated not in time
Introversive, sensitive, timid, inferiority complex is formed, causes Character Limitation, and child's growth can be influenced, is occurred partially short, partially thin or empty
Fat type stature.Enuresis time length is also possible to cause child's poor memory, and absent minded, school grade is poor, and then influences child
Interpersonal relationships after son adult, career development and family harmony.The clinical symptoms of infantile enuresis are：Patient is sunk into sleep difficulty before wetting the bed
Wake, haled after leaving the bed, his (she) often walks around here, walks around there, grabs body and scratch one's head, vague mind, is at a loss, after bed-wetting
Infant is waken up by wet freeze.Activity on daytime fatiguability, coldness of extremities, deficiency of QI with disinclination to talk, spiritlessness and weakness, deficiency of food receive difference.Doctor trained in Western medicine thinks：The disease
The cause of disease is patient due to cerebral cortex hypoevolutism, it is impossible to suppresses vertebra micturition centre, unrestraint occurs in detrusor after sleep
Property shrink, urine is discharged.At present, specific treatment method is there is no, commonly uses central nervous excitation agent：Such as imipramine；Parasympathetic god
Through retarding agent：Such as pro-banthine or amitriptyline, enter per os hora somni, detrusor can be made to relax, and suppress bladder contraction, and control is lost
Urine.But these medicine side effects are big, and effect is only 30-40%, is easily recurred after drug withdrawal.The traditional Chinese medical science thinks that children are because of native endowment deficiency
Or ferritic weakness causes deficiency of kidney-QI, below element deficiency and cold, it is impossible to which the foster bladder of temperature, functioning of bladder functional disturbance, closes Tibetan dereliction of duty, it is impossible to about
Water channel processed, and it is the enuresis.During asthenia of pulmonosplenic qi, during dampness-heat of liver channel, deficiency of the upper portion of the body resulting in inability to control the lower portion, lower void cannot on hold, cause to have no right to constrain
Water channel, then incontinence of urine, or sleep middle urine and go out certainly, can also cause the enuresis.
The content of the invention
For above-mentioned, the object of the present invention is to provide a kind of Chinese medicine composition for treating infantile enuresis and its preparation side
Method.
The present invention adopts the technical scheme that：
A kind of Chinese medicine composition for treating infantile enuresis, is made of following raw material：10-15 parts of the fruit of Chinese wolfberry, chicken
Interior 10-15 parts of gold, 10-15 parts of fructus alpiniae oxyphyllae, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 30-40 parts of raspberry, 30-40 parts of calcined Dragon's bone, Semen Cuscutae 20-30
Part, 20-30 parts of cassia twig, 20-30 parts of Chinese yam, 15-20 parts of grass-leaved sweetflag, 15-20 parts of Radix Codonopsis, 15-20 parts of Chinese gall.
Preferably, the Chinese medicine composition of the treatment infantile enuresis, is made of following raw material：The fruit of Chinese wolfberry
12.5 parts, 12.5 parts of the membrane of a chicken's gizzard, 12.5 parts of fructus alpiniae oxyphyllae, 12.5 parts of Rhizoma Atractylodis Macrocephalae, 35 parts of raspberry, 35 parts of calcined Dragon's bone, 25 parts of Semen Cuscutae,
25 parts of cassia twig, 25 parts of Chinese yam, 17.5 parts of grass-leaved sweetflag, 17.5 parts of Radix Codonopsis, 17.5 parts of Chinese gall.
Correspondingly, present invention also offers above-mentioned treatment infantile enuresis Chinese medicine composition preparation method, including with
Lower step：
(1) by the fruit of Chinese wolfberry, the membrane of a chicken's gizzard, fructus alpiniae oxyphyllae, Rhizoma Atractylodis Macrocephalae, raspberry, calcined Dragon's bone, Semen Cuscutae, cassia twig, Chinese yam, grass-leaved sweetflag,
Radix Codonopsis and Chinese gall crush, and obtain mixing medicinal powder, soak 1.5-2.5h with the water of 10-16 times of medicinal powder gross weight of mixing；
(2) after soaking, it is heated to seething with excitement, is filtered after being cooked by slow fire 2-3h, collect first time filtrate, the dregs of a decoction is spare；
(3) water of 8-12 times of weight is added into the dregs of a decoction, is heated to seething with excitement, is filtered after being cooked by slow fire 2-3h, collects second
Secondary filtrate；
(4) merge first and second filtrate, be concentrated into the concentrate that relative density is 1.05-1.10；
(5) above-mentioned concentrate is taken, routinely preparation process adds proper auxiliary materials, is processed into corresponding formulation.
Further, the formulation is granule, capsule, honeyed bolus, oral liquid or syrup.
It is an advantage of the invention that：The present invention Chinese medicine composition can warm kidney benefit spleen, astringent method only lose, can effectively treat small
Youngster's enruesis, and it is of low cost, preparation process is simple, quick, curative for effect, and pharmacological property is gentle, without any side effects, non-
Often suitable child administration.
Embodiment
Presently preferred embodiments of the present invention is described in detail below so that advantages and features of the invention can be easier to by
It will be appreciated by those skilled in the art that so as to make a clearer definition of the protection scope of the present invention.
Embodiment 1
A kind of Chinese medicine composition for treating infantile enuresis, is made of following raw material：10 parts of the fruit of Chinese wolfberry, the membrane of a chicken's gizzard
10 parts, 10 parts of fructus alpiniae oxyphyllae, 10 parts of Rhizoma Atractylodis Macrocephalae, 30 parts of raspberry, 30 parts of calcined Dragon's bone, 20 parts of Semen Cuscutae, 20 parts of cassia twig, 20 parts of Chinese yam,
15 parts of grass-leaved sweetflag, 15 parts of Radix Codonopsis, 15 parts of Chinese gall.
The preparation method of the Chinese medicine composition of above-mentioned treatment infantile enuresis, comprises the following steps：
(1) by the fruit of Chinese wolfberry, the membrane of a chicken's gizzard, fructus alpiniae oxyphyllae, Rhizoma Atractylodis Macrocephalae, raspberry, calcined Dragon's bone, Semen Cuscutae, cassia twig, Chinese yam, grass-leaved sweetflag,
Radix Codonopsis and Chinese gall crush, and obtain mixing medicinal powder, soak 1.5h with the water of 10 times of medicinal powder gross weight of mixing；
(2) after soaking, it is heated to seething with excitement, is filtered after being cooked by slow fire 2h, collect first time filtrate, the dregs of a decoction is spare；
(3) water of 8 times of weight is added into the dregs of a decoction, is heated to seething with excitement, is filtered after being cooked by slow fire 2h, second is collected and filters
Liquid；
(4) merge first and second filtrate, be concentrated into the concentrate that relative density is 1.05；
(5) above-mentioned concentrate is taken, routinely preparation process adds proper auxiliary materials, is processed into corresponding formulation.
Embodiment 2
A kind of Chinese medicine composition for treating infantile enuresis, is made of following raw material：In 12.5 parts of the fruit of Chinese wolfberry, chicken
12.5 parts of gold, 12.5 parts of fructus alpiniae oxyphyllae, 12.5 parts of Rhizoma Atractylodis Macrocephalae, 35 parts of raspberry, 35 parts of calcined Dragon's bone, 25 parts of Semen Cuscutae, 25 parts of cassia twig, mountain
25 parts of medicine, 17.5 parts of grass-leaved sweetflag, 17.5 parts of Radix Codonopsis, 17.5 parts of Chinese gall.
The preparation method of the Chinese medicine composition of above-mentioned treatment infantile enuresis, comprises the following steps：
(1) by the fruit of Chinese wolfberry, the membrane of a chicken's gizzard, fructus alpiniae oxyphyllae, Rhizoma Atractylodis Macrocephalae, raspberry, calcined Dragon's bone, Semen Cuscutae, cassia twig, Chinese yam, grass-leaved sweetflag,
Radix Codonopsis and Chinese gall crush, and obtain mixing medicinal powder, soak 2h with the water of 13 times of medicinal powder gross weight of mixing；
(2) after soaking, it is heated to seething with excitement, is filtered after being cooked by slow fire 2.5h, collect first time filtrate, the dregs of a decoction is spare；
(3) water of 10 times of weight is added into the dregs of a decoction, is heated to seething with excitement, is filtered after being cooked by slow fire 2.5h, is collected second
Filtrate；
(4) merge first and second filtrate, be concentrated into the concentrate that relative density is 1.10；
(5) above-mentioned concentrate is taken, routinely preparation process adds proper auxiliary materials, is processed into corresponding formulation.
Embodiment 3
A kind of Chinese medicine composition for treating infantile enuresis, is made of following raw material：15 parts of the fruit of Chinese wolfberry, the membrane of a chicken's gizzard
15 parts, 15 parts of fructus alpiniae oxyphyllae, 15 parts of Rhizoma Atractylodis Macrocephalae, 40 parts of raspberry, 40 parts of calcined Dragon's bone, 30 parts of Semen Cuscutae, 30 parts of cassia twig, 30 parts of Chinese yam,
20 parts of grass-leaved sweetflag, 20 parts of Radix Codonopsis, 20 parts of Chinese gall.
The preparation method of the Chinese medicine composition of above-mentioned treatment infantile enuresis, comprises the following steps：
(1) by the fruit of Chinese wolfberry, the membrane of a chicken's gizzard, fructus alpiniae oxyphyllae, Rhizoma Atractylodis Macrocephalae, raspberry, calcined Dragon's bone, Semen Cuscutae, cassia twig, Chinese yam, grass-leaved sweetflag,
Radix Codonopsis and Chinese gall crush, and obtain mixing medicinal powder, soak 2.5h with the water of 16 times of medicinal powder gross weight of mixing；
(2) after soaking, it is heated to seething with excitement, is filtered after being cooked by slow fire 3h, collect first time filtrate, the dregs of a decoction is spare；
(3) water of 12 times of weight is added into the dregs of a decoction, is heated to seething with excitement, is filtered after being cooked by slow fire 2-3h, is collected second
Filtrate；
(4) merge first and second filtrate, be concentrated into the concentrate that relative density is 1.10；
(5) above-mentioned concentrate is taken, routinely preparation process adds proper auxiliary materials, is processed into corresponding formulation.
From 2014-2017, Chinese medicine composition using the present invention treats infantile enuresis patient 79 altogether, through 1-2
The course for the treatment of, cures 72, improves 7, and effective percentage is 100%.
Claims (4)
1. a kind of Chinese medicine composition for treating infantile enuresis, it is characterised in that be made of following raw material：Fruit of Chinese wolfberry 10-
15 parts, 10-15 parts of the membrane of a chicken's gizzard, 10-15 parts of fructus alpiniae oxyphyllae, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 30-40 parts of raspberry, 30-40 parts, Tu of calcined Dragon's bone
20-30 parts sub-, 20-30 parts of cassia twig, 20-30 parts of Chinese yam, 15-20 parts of grass-leaved sweetflag, 15-20 parts of Radix Codonopsis, 15-20 parts of Chinese gall.
2. the Chinese medicine composition for the treatment of infantile enuresis according to claim 1, it is characterised in that former by following parts by weight
Material is made：12.5 parts of the fruit of Chinese wolfberry, 12.5 parts of the membrane of a chicken's gizzard, 12.5 parts of fructus alpiniae oxyphyllae, 12.5 parts of Rhizoma Atractylodis Macrocephalae, 35 parts of raspberry, calcined Dragon's bone 35
Part, 25 parts of Semen Cuscutae, 25 parts of cassia twig, 25 parts of Chinese yam, 17.5 parts of grass-leaved sweetflag, 17.5 parts of Radix Codonopsis, 17.5 parts of Chinese gall.
3. the preparation method of the Chinese medicine composition for the treatment of infantile enuresis according to claim 1 or 2, it is characterised in that bag
Include following steps：
(1) by the fruit of Chinese wolfberry, the membrane of a chicken's gizzard, fructus alpiniae oxyphyllae, Rhizoma Atractylodis Macrocephalae, raspberry, calcined Dragon's bone, Semen Cuscutae, cassia twig, Chinese yam, grass-leaved sweetflag, Radix Codonopsis
Crushed with Chinese gall, obtain mixing medicinal powder, soak 1.5-2.5h with the water of 10-16 times of medicinal powder gross weight of mixing；
(2) after soaking, it is heated to seething with excitement, is filtered after being cooked by slow fire 2-3h, collect first time filtrate, the dregs of a decoction is spare；
(3) water of 8-12 times of weight is added into the dregs of a decoction, is heated to seething with excitement, is filtered after being cooked by slow fire 2-3h, second is collected and filters
Liquid；
(4) merge first and second filtrate, be concentrated into the concentrate that relative density is 1.05-1.10；
(5) above-mentioned concentrate is taken, routinely preparation process adds proper auxiliary materials, is processed into corresponding formulation.
4. preparation method according to claim 3, it is characterised in that the formulation for granule, capsule, honeyed bolus,
Oral liquid or syrup.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115364188A (en) * | 2022-08-31 | 2022-11-22 | 成都中医药大学附属医院 | Pharmaceutical composition for treating primary enuresis of children |
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2017
- 2017-11-29 CN CN201711225926.0A patent/CN107929632A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115364188A (en) * | 2022-08-31 | 2022-11-22 | 成都中医药大学附属医院 | Pharmaceutical composition for treating primary enuresis of children |
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Application publication date: 20180420 |