CN107929334A - A kind of preparation method of micro-capsule antiacid - Google Patents
A kind of preparation method of micro-capsule antiacid Download PDFInfo
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- CN107929334A CN107929334A CN201711114681.4A CN201711114681A CN107929334A CN 107929334 A CN107929334 A CN 107929334A CN 201711114681 A CN201711114681 A CN 201711114681A CN 107929334 A CN107929334 A CN 107929334A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
Abstract
The invention discloses a kind of preparation method of micro-capsule antiacid, belong to pharmaceutical technology field.Spinach is mixed with water, crushing, stirring, obtains spinach juice；Cod-liver oil is mixed with spinach juice, and sequentially adds soy lecithin powder, alkaloid, gastric mucin and emulsifying agent after being stirred, obtain preconditioned mixture；Wall material and water are stirred, obtain wall material solution, wall material solution is mixed with preconditioned mixture, and sequentially add emulsifying agent and chitosan, after being stirred, blank is obtained, blank is moved into emulsifying agitator, emulsification pretreatment, homogeneous, obtains emulsion, and emulsion is moved into spray drying tower, spray drying, obtains micro-capsule antiacid.Micro-capsule antiacid prepared by the present invention has excellent Antacid effectiveness, while film forming is preferable under one's belt.
Description
Technical field
The invention discloses a kind of preparation method of micro-capsule antiacid, belong to pharmaceutical technology field.
Background technology
Gastritis and gastric ulcer are common disease of digestive systems, and incidence is 10%~20% in crowd, and gastritis is as not in time
Treatment, can also develop into gastric ulcer, attack factor（Hydrochloric acid in gastric juice and pepsin etc.）Unbalance with the mucosal defense factor is current medicine
The pathogenesis that boundary generally acknowledges.In daily life, alcohol and maror can directly injure stomach lining, non-steroidal anti-inflammatory drugs for example Ah
Woods etc. is taken charge of, suppresses internal peroxidase activity, prostaglandin synthesis in mucous membrane is reduced, causes the defencive function of stomach lining
It is weakened, therefore antiacid and protection stomach lining no less important in peptic digest systemic disease is treated.Another effect of antiacid is,
After neutralizing hydrochloric acid in gastric juice, the secretory volume of duodenum pancreatic juice can be reduced, blood pH is increased, is conducive to the discharge of uric acid.
At present, proton pump inhibitor is with gradual substitution traditional antiacid the advantages of its fast and effective gastric acid secretion inhibiting, and
Proton pump inhibitor is considered Small side effects always, therefore is widely applied clinically and has the trend of abuse.Many is ground
Study carefully discovery, the adverse reaction that abuse proton pump inhibitor triggers is more and more, as hypergastrinemia, hypomagnesemia, sclerotin are dredged
Loose disease and katz syndrome disease etc., this makes traditional antiacid retrieve concern, and exploitation has gastric mucosal protection work(
Can, Small side effects can long-time service antiacid be tool it is vital.Montmorillonite is safe and free of toxic and side effects, in field of medicaments
Application receive much concern, being used as alimentary canal mucous membrane protective agent, research prepares antiacid with modification of sodium carbonate montmorillonite, though
So there is the protective effects on gastric mucosa, but neutralize hydrochloric acid in gastric juice process generation carbon dioxide to cause gaseous distention, thus it is unsatisfactory.Tradition is anti-
Sour agent still there are it is antiacid ineffective the problem of, therefore also need to study it.
The content of the invention
The present invention solves the technical problem of：For traditional antiacid Antacid effectiveness it is bad the problem of, there is provided one
The preparation method of kind micro-capsule antiacid.
In order to solve the above-mentioned technical problem, the technical solution adopted in the present invention is：
（1）By spinach and water in mass ratio 1：2~1：3 mixing, crushing, stirring, obtains spinach juice；
（2）By cod-liver oil and spinach juice in mass ratio 1：1~1：2 mixing, obtain mixed liquor, mixed liquor are sequentially added into mixed liquor
The soy lecithin powder that 0.1~0.3 times of quality, the alkaloid that 0.08~0.15 times of mixed liquor quality, mixed liquor quality 0.12
~0.20 times 0.12~0.15 times of emulsifying agent of gastric mucin and mixed liquor quality, after being stirred, obtains preconditioned mixture；
（3）By wall material and water in mass ratio 1：3~1：5 are stirred, and obtain wall material solution, by wall material solution and preconditioned mixture
In mass ratio 3：2~5：2 mixing, and sequentially add emulsifying agent and the pretreatment mixing of preconditioned mixture quality 0.08~0.12
The chitosan that 0.08~0.18 times of amount of substance, after being stirred, obtains blank, and blank moved into emulsifying agitator, emulsification pretreatment,
Matter, obtains emulsion, and emulsion is moved into spray drying tower, and spray drying, obtains micro-capsule antiacid.
Step（2）The alkaloid is hygrine, any one in atropine or leonurine.
Step（3）The preparation method of the wall material is by soybean protein isolate and maltodextrin in mass ratio 1：4~1：6 stir
Mixing is mixed, obtains wall material.
The emulsifying agent is glycerine monofatty ester, any one in sucrose ester or lauric monoglyceride.
Step（3）The condition of the spray drying is that centrifugal turntable spraying rotating speed is 15000~22000r/min, air inlet
Temperature is 150~170 DEG C, and air outlet temperature is 65~75 DEG C.
The beneficial effects of the invention are as follows：
（1）The present invention adds spinach juice when preparing micro-capsule antiacid, firstly, since spinach juice neutral and alkali nutritional ingredient is more,
After taking in stomach, hydrochloric acid in gastric juice excessive in stomach can be neutralized, so that the Antacid effectiveness of product is improved；Secondly it is rich in spinach juice
Containing vitamin C, antiinflammation can be played to damaged tissues in stomach, promote the recovery of gastric tissue, so that protection of the product to stomach
Performance improves, furthermore the addition of spinach juice can provide abundant dietary fiber, on the one hand dietary fiber can improve the mechanics of wall material
Performance, and dietary fiber has excellent viscosity, can be adhered to mucosa surface after organic compound in combination product, play
Protective effect；
（2）The addition soy lecithin powder when preparing micro-capsule antiacid and soybean protein isolate and maltodextrin of the invention mix
Compound, on the one hand, the soybean phosphorus ovum cosmetics end of addition can be adsorbed on stomach lining, protect stomach lining, make product under one's belt into
Film improves, and on the other hand, soybean lecithin can issue unboiled water solution by sour environment under one's belt, consume hydrogen ion in hydrochloric acid in gastric juice, so that
The antiacid effect of product is further improved, and soybean protein isolate and maltodextrin can be under dietary fiber effects, in stomach lining table
Face forms a film, and reduces the secretion of hydrochloric acid in gastric juice, so that the Antacid effectiveness of product improves；
（3）The present invention adds cod-liver oil when preparing micro-capsule antiacid, and cod-liver oil contains abundant fat, after entering in stomach,
Can inhibit the secretion of hydrochloric acid in gastric juice, and one layer of fatty protective layer can be formed in mucosa surface so that the Antacid effectiveness of product and
Filming performance is improved.
Embodiment
By spinach and water in mass ratio 1：2~1：3 mixing are added in pulverizer, are crushed 15~25min, are obtained spinach juice；Will
Cod-liver oil and spinach juice in mass ratio 1：1~1：2 are mixed in beaker, and beaker immigration digital display is tested the speed temperature constant magnetic stirring
Device, is 55~65 DEG C in temperature, under conditions of rotating speed is 250~280r/min, is stirred 30~50min, obtains mixed liquor, then
The soy lecithin powder of 0.1~0.3 times of mixed liquor quality, 0.08~0.15 times of mixed liquor quality are added into mixed liquor successively
Alkaloid, 0.12~0.15 times of emulsifying agent of gastric mucin and mixed liquor quality that 0.12~0.20 times of mixed liquor quality, in temperature
For 45~60 DEG C, under conditions of rotating speed is 280~350r/min, 60~80min is stirred, obtains preconditioned mixture；By wall
Material and water in mass ratio 1：3~1：5 mixing, are 80~90 DEG C in temperature, under conditions of rotating speed is 320~380r/min, stir
Dissolving, obtains wall material solution, by wall material solution and preconditioned mixture in mass ratio 3：2~5：2 mixing, and successively to wall material solution
Emulsifying agent and preconditioned mixture with adding preconditioned mixture quality 0.08~0.12 in the mixed liquor of preconditioned mixture
The chitosan that 0.08~0.18 times of quality, is 75~90 DEG C in temperature, under conditions of rotating speed is 320~380r/min, stirring is mixed
1~2h is closed, blank is obtained, blank is moved into emulsifying agitator, is 50~65 DEG C in temperature, shearing rotating speed is 1800~2200r/
Under conditions of min, after shearing 15~25min, high pressure homogenizer is moved into, under conditions of pressure is 15~22MPa, homogeneous 2~3
It is secondary, emulsion is obtained, emulsion is moved into spray drying tower, is spray-dried, obtains micro-capsule antiacid.The alkaloid is hygrine,
Any one in atropine or leonurine.The preparation method of the wall material is that soybean protein isolate and maltodextrin are pressed quality
Than 1：4~1：6 are stirred, and obtain wall material.The emulsifying agent is glycerine monofatty ester, in sucrose ester or lauric monoglyceride
Any one.The condition of the spray drying is that centrifugal turntable spraying rotating speed is 15000~22000r/min, and intake air temperature is
150~170 DEG C, air outlet temperature is 65~75 DEG C.
Example 1
By spinach and water in mass ratio 1：3 mixing are added in pulverizer, are crushed 25min, are obtained spinach juice；By cod-liver oil and spinach juice
In mass ratio 1：2 are mixed in beaker, and beaker immigration digital display is tested the speed constant temperature blender with magnetic force, in temperature be 65 DEG C, rotating speed
Under conditions of 280r/min, 50min is stirred, obtains mixed liquor, then add 0.3 times of mixed liquor quality into mixed liquor successively
Soy lecithin powder, the alkaloid that 0.15 times of mixed liquor quality, the gastric mucin and mixed liquor matter that 0.20 times of mixed liquor quality
0.15 times of emulsifying agent is measured, is 60 DEG C in temperature, under conditions of rotating speed is 350r/min, is stirred 80min, mixing must be pre-processed
Thing；By wall material and water in mass ratio 1：5 mixing, are 90 DEG C in temperature, under conditions of rotating speed is 380r/min, stirring and dissolving, obtains
Wall material solution, by wall material solution and preconditioned mixture in mass ratio 5：2 mixing, and mixed successively to wall material solution with pretreatment
The emulsifying agent of preconditioned mixture quality 0.12 and the chitosan of 0.18 times of preconditioned mixture quality are added in the mixed liquor of thing,
It is 90 DEG C in temperature, under conditions of rotating speed is 380r/min, is stirred 2h, obtains blank, blank is moved into emulsifying agitator, in
Temperature is 65 DEG C, under conditions of shearing rotating speed is 2200r/min, after shearing 25min, moves into high pressure homogenizer, is in pressure
Under conditions of 22MPa, homogeneous 3 times obtains emulsion, and emulsion is moved into spray drying tower, and spray drying, obtains micro-capsule antiacid.
The alkaloid is hygrine.The preparation method of the wall material is by soybean protein isolate and maltodextrin in mass ratio 1：6 stir
Mixing is mixed, obtains wall material.The emulsifying agent is glycerine monofatty ester.The condition of the spray drying is centrifugal turntable spraying rotating speed
For 22000r/min, intake air temperature is 170 DEG C, and air outlet temperature is 75 DEG C.
Example 2
By spinach and water in mass ratio 1：3 mixing are added in pulverizer, are crushed 25min, are obtained spinach juice；By cod-liver oil and spinach juice
In mass ratio 1：2 are mixed in beaker, and beaker immigration digital display is tested the speed constant temperature blender with magnetic force, in temperature be 65 DEG C, rotating speed
Under conditions of 280r/min, 50min is stirred, obtains mixed liquor, then add 0.3 times of mixed liquor quality into mixed liquor successively
Soy lecithin powder, the alkaloid that 0.15 times of mixed liquor quality, the gastric mucin and mixed liquor matter that 0.20 times of mixed liquor quality
0.15 times of emulsifying agent is measured, is 60 DEG C in temperature, under conditions of rotating speed is 350r/min, is stirred 80min, mixing must be pre-processed
Thing；By wall material and water in mass ratio 1：5 mixing, are 90 DEG C in temperature, under conditions of rotating speed is 380r/min, stirring and dissolving, obtains
Wall material solution, by wall material solution and preconditioned mixture in mass ratio 5：2 mixing, and mixed successively to wall material solution with pretreatment
The emulsifying agent of preconditioned mixture quality 0.12 is added in the mixed liquor of thing, is 90 DEG C in temperature, rotating speed is the bar of 380r/min
Under part, be stirred 2h, obtain blank, blank is moved into emulsifying agitator, in temperature be 65 DEG C, shearing rotating speed 2200r/min
Under conditions of, after shearing 25min, high pressure homogenizer is moved into, under conditions of pressure is 22MPa, homogeneous 3 times, obtains emulsion, will
Emulsion moves into spray drying tower, and spray drying, obtains micro-capsule antiacid.The alkaloid is hygrine.The preparation of the wall material
Method is by soybean protein isolate and maltodextrin in mass ratio 1：6 are stirred, and obtain wall material.The emulsifying agent is aliphatic acid list
Glyceride.The condition of the spray drying is that centrifugal turntable spraying rotating speed is 22000r/min, and intake air temperature is 170 DEG C, is gone out
Draught temperature is 75 DEG C.
Example 3
By spinach and water in mass ratio 1：3 mixing are added in pulverizer, are crushed 25min, are obtained spinach juice；By cod-liver oil and spinach juice
In mass ratio 1：2 are mixed in beaker, and beaker immigration digital display is tested the speed constant temperature blender with magnetic force, in temperature be 65 DEG C, rotating speed
Under conditions of 280r/min, 50min is stirred, obtains mixed liquor, then add mixed liquor quality 0.15 into mixed liquor successively
Times alkaloid, 0.15 times of emulsifying agent of gastric mucin and mixed liquor quality that 0.20 times of mixed liquor quality, in temperature be 60 DEG C, rotating speed
Under conditions of 350r/min, 80min is stirred, obtains preconditioned mixture；By wall material and water in mass ratio 1：5 mixing, in
Temperature is 90 DEG C, and under conditions of rotating speed is 380r/min, stirring and dissolving, obtains wall material solution, and wall material solution is mixed with pretreatment
Thing in mass ratio 5：2 mixing, and preconditioned mixture matter is added into the mixed liquor of wall material solution and preconditioned mixture successively
The emulsifying agent of amount 0.12 and the chitosan of 0.18 times of preconditioned mixture quality, are 90 DEG C in temperature, rotating speed is 380r/min's
Under the conditions of, be stirred 2h, obtain blank, blank is moved into emulsifying agitator, in temperature be 65 DEG C, shearing rotating speed 2200r/
Under conditions of min, after shearing 25min, high pressure homogenizer is moved into, under conditions of pressure is 22MPa, homogeneous 3 times, must emulsify
Liquid, spray drying tower is moved into by emulsion, and spray drying, obtains micro-capsule antiacid.The alkaloid is hygrine.The wall material
Preparation method is by soybean protein isolate and maltodextrin in mass ratio 1：6 are stirred, and obtain wall material.The emulsifying agent is fat
Sour monoglyceride.The condition of the spray drying is that centrifugal turntable spraying rotating speed is 22000r/min, intake air temperature 170
DEG C, air outlet temperature is 75 DEG C.
Example 4
By spinach and water in mass ratio 1：3 mixing are added in pulverizer, are crushed 25min, are obtained spinach juice；By cod-liver oil and spinach juice
In mass ratio 1：2 are mixed in beaker, and beaker immigration digital display is tested the speed constant temperature blender with magnetic force, in temperature be 65 DEG C, rotating speed
Under conditions of 280r/min, 50min is stirred, obtains mixed liquor, then add 0.3 times of mixed liquor quality into mixed liquor successively
Soy lecithin powder, the alkaloid that 0.15 times of mixed liquor quality, the gastric mucin and mixed liquor matter that 0.20 times of mixed liquor quality
0.15 times of emulsifying agent is measured, is 60 DEG C in temperature, under conditions of rotating speed is 350r/min, is stirred 80min, mixing must be pre-processed
Thing；By wall material and water in mass ratio 1：5 mixing, are 90 DEG C in temperature, under conditions of rotating speed is 380r/min, stirring and dissolving, obtains
Wall material solution, by wall material solution and preconditioned mixture in mass ratio 5：2 mixing, and mixed successively to wall material solution with pretreatment
The emulsifying agent of preconditioned mixture quality 0.12 and the chitosan of 0.18 times of preconditioned mixture quality are added in the mixed liquor of thing,
It is 90 DEG C in temperature, under conditions of rotating speed is 380r/min, is stirred 2h, obtains blank, blank is moved into emulsifying agitator, in
Temperature is 65 DEG C, under conditions of shearing rotating speed is 2200r/min, after shearing 25min, moves into high pressure homogenizer, is in pressure
Under conditions of 22MPa, homogeneous 3 times obtains emulsion, and emulsion is moved into spray drying tower, and spray drying, obtains micro-capsule antiacid.
The alkaloid is hygrine.The wall material is maltodextrin.The emulsifying agent is glycerine monofatty ester.The spray drying
Condition be that centrifugal turntable spraying rotating speed is 22000r/min, intake air temperature is 170 DEG C, and air outlet temperature is 75 DEG C.
Example 5
By spinach and water in mass ratio 1：3 mixing are added in pulverizer, are crushed 25min, are obtained spinach juice；Add successively into spinach juice
Enter the soy lecithin powder of 0.3 times of spinach juice quality, the alkaloid that 0.15 times of spinach juice quality, 0.20 times of spinach juice quality
0.15 times of emulsifying agent of gastric mucin and spinach juice quality, is 60 DEG C in temperature, under conditions of rotating speed is 350r/min, is stirred
80min, obtains preconditioned mixture；By wall material and water in mass ratio 1：5 mixing, are 90 DEG C in temperature, rotating speed is 380r/min's
Under the conditions of, stirring and dissolving, obtains wall material solution, by wall material solution and preconditioned mixture in mass ratio 5：2 mixing, and successively to wall
The emulsifying agent and preconditioned mixture of preconditioned mixture quality 0.12 are added in the mixed liquor of material solution and preconditioned mixture
The chitosan that 0.18 times of quality, is 90 DEG C in temperature, under conditions of rotating speed is 380r/min, is stirred 2h, obtains blank, by base
Material moves into emulsifying agitator, is 65 DEG C in temperature, under conditions of shearing rotating speed is 2200r/min, after shearing 25min, moves into high
Homogenizer is pressed, under conditions of pressure is 22MPa, homogeneous 3 times, obtains emulsion, emulsion is moved into spray drying tower, spraying is dry
It is dry, obtain micro-capsule antiacid.The alkaloid is hygrine.The preparation method of the wall material is to paste soybean protein isolate and malt
Essence in mass ratio 1：6 are stirred, and obtain wall material.The emulsifying agent is glycerine monofatty ester.The condition of the spray drying is
Centrifugal turntable spraying rotating speed is 22000r/min, and intake air temperature is 170 DEG C, and air outlet temperature is 75 DEG C.
Comparative example：The antiacid of Zhengzhou bio tech ltd production.
The gained of example 1 to 5 antiacid and comparative example product are subjected to performance detection, specific detection method is as follows：
The external Antacid effectiveness of antiacid is evaluated according to improved Beekman methods, and method is as follows：Will
300mL0.025mol·L-1HCl solution be added in 500mL three-necked flasks, be placed in exact constant temperature bath, 37.0 DEG C
Constant temperature stirs, after the solution temperature stabilization in three-necked flask after 37.0 DEG C, according to Ca (OH)2Assay is as a result, to flask
Middle addition antiacid, while with 1.0mLmin-1Speed supplement HCl solution, with 1.0mLmin-1Speed take out flask
Interior solution, records the pH value change of solution in 1h, so that obtaining pH reaches delaying between time, the maximum of pH, pH3~5 used in 3
Rush time and the time of more than pH5.Specific testing result is as shown in table 1：
Table 1
From 1 testing result of table, micro-capsule antiacid prepared by the present invention has excellent Antacid effectiveness, while forms a film under one's belt
Property is preferable.
Claims (5)
1. a kind of preparation method of micro-capsule antiacid, it is characterised in that specifically preparation process is：
（1）By spinach and water in mass ratio 1：2~1：3 mixing, crushing, stirring, obtains spinach juice；
（2）By cod-liver oil and spinach juice in mass ratio 1：1~1：2 mixing, obtain mixed liquor, mixed liquor are sequentially added into mixed liquor
The soy lecithin powder that 0.1~0.3 times of quality, the alkaloid that 0.08~0.15 times of mixed liquor quality, mixed liquor quality 0.12
~0.20 times 0.12~0.15 times of emulsifying agent of gastric mucin and mixed liquor quality, after being stirred, obtains preconditioned mixture；
（3）By wall material and water in mass ratio 1：3~1：5 are stirred, and obtain wall material solution, by wall material solution and preconditioned mixture
In mass ratio 3：2~5：2 mixing, and sequentially add emulsifying agent and the pretreatment mixing of preconditioned mixture quality 0.08~0.12
The chitosan that 0.08~0.18 times of amount of substance, after being stirred, obtains blank, and blank moved into emulsifying agitator, emulsification pretreatment,
Matter, obtains emulsion, and emulsion is moved into spray drying tower, and spray drying, obtains micro-capsule antiacid.
A kind of 2. preparation method of antiacid according to power requires 1, it is characterised in that：Step（2）The alkaloid is Gu
Any one in beans alkali, atropine or leonurine.
A kind of 3. preparation method of antiacid according to power requires 1, it is characterised in that：Step（3）The preparation of the wall material
Method is by soybean protein isolate and maltodextrin in mass ratio 1：4~1：6 are stirred, and obtain wall material.
A kind of 4. preparation method of antiacid according to power requires 1, it is characterised in that：The emulsifying agent is sweet for aliphatic acid list
Any one in grease, sucrose ester or lauric monoglyceride.
A kind of 5. preparation method of antiacid according to power requires 1, it is characterised in that：Step（3）The spray drying
Condition is that centrifugal turntable spraying rotating speed is 15000~22000r/min, and intake air temperature is 150~170 DEG C, and air outlet temperature is
65~75 DEG C.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023094817A1 (en) * | 2021-11-25 | 2023-06-01 | Orexo Ab | Pharmaceutical composition comprising atropine |
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| CN101444495A (en) * | 2008-12-31 | 2009-06-03 | 江南大学 | Vitamin E microcapsule preparation method |
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| 崔炳群等: ""鱼肝油微胶囊化研究"", 《食品工业科技》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023094817A1 (en) * | 2021-11-25 | 2023-06-01 | Orexo Ab | Pharmaceutical composition comprising atropine |
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