CN107929275A - A kind of children's iron supplementary - Google Patents
A kind of children's iron supplementary Download PDFInfo
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- CN107929275A CN107929275A CN201711045938.5A CN201711045938A CN107929275A CN 107929275 A CN107929275 A CN 107929275A CN 201711045938 A CN201711045938 A CN 201711045938A CN 107929275 A CN107929275 A CN 107929275A
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- children
- iron
- strawberry
- iron supplementary
- ferrous gluconate
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 136
- 229910052742 iron Inorganic materials 0.000 title claims abstract description 68
- 150000004676 glycans Chemical class 0.000 claims abstract description 36
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 35
- 239000005017 polysaccharide Substances 0.000 claims abstract description 35
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 34
- 235000016623 Fragaria vesca Nutrition 0.000 claims abstract description 23
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims abstract description 23
- 241000220223 Fragaria Species 0.000 claims abstract description 22
- 229920002472 Starch Polymers 0.000 claims abstract description 22
- 235000019698 starch Nutrition 0.000 claims abstract description 22
- 239000008107 starch Substances 0.000 claims abstract description 22
- 239000004222 ferrous gluconate Substances 0.000 claims abstract description 19
- 229960001645 ferrous gluconate Drugs 0.000 claims abstract description 19
- 235000013924 ferrous gluconate Nutrition 0.000 claims abstract description 19
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 claims abstract description 19
- 238000000855 fermentation Methods 0.000 claims abstract description 18
- 230000004151 fermentation Effects 0.000 claims abstract description 18
- 241000894006 Bacteria Species 0.000 claims abstract description 17
- 239000004310 lactic acid Substances 0.000 claims abstract description 17
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 17
- 240000004922 Vigna radiata Species 0.000 claims abstract description 14
- 235000010721 Vigna radiata var radiata Nutrition 0.000 claims abstract description 14
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 4
- 230000035622 drinking Effects 0.000 claims description 18
- 241001474374 Blennius Species 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 239000002002 slurry Substances 0.000 claims description 10
- 241000195493 Cryptophyta Species 0.000 claims description 9
- 238000004806 packaging method and process Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 241000186000 Bifidobacterium Species 0.000 claims description 5
- 244000199885 Lactobacillus bulgaricus Species 0.000 claims description 5
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 claims description 5
- 241000186673 Lactobacillus delbrueckii Species 0.000 claims description 5
- 240000004713 Pisum sativum Species 0.000 claims description 5
- 235000010582 Pisum sativum Nutrition 0.000 claims description 5
- 238000003306 harvesting Methods 0.000 claims description 5
- 238000007654 immersion Methods 0.000 claims description 5
- 229940004208 lactobacillus bulgaricus Drugs 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000010304 firing Methods 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 235000021028 berry Nutrition 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 241000192700 Cyanobacteria Species 0.000 claims 1
- 244000307700 Fragaria vesca Species 0.000 claims 1
- 240000001046 Lactobacillus acidophilus Species 0.000 claims 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 230000000291 postprandial effect Effects 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 abstract description 11
- 238000010521 absorption reaction Methods 0.000 abstract description 8
- 239000004615 ingredient Substances 0.000 abstract description 7
- 206010012735 Diarrhoea Diseases 0.000 abstract description 6
- 208000024891 symptom Diseases 0.000 abstract description 6
- 206010010774 Constipation Diseases 0.000 abstract description 5
- 206010028813 Nausea Diseases 0.000 abstract description 5
- 208000002193 Pain Diseases 0.000 abstract description 5
- 210000001015 abdomen Anatomy 0.000 abstract description 5
- 230000007661 gastrointestinal function Effects 0.000 abstract description 5
- 230000008693 nausea Effects 0.000 abstract description 5
- 235000009508 confectionery Nutrition 0.000 abstract description 4
- 230000035764 nutrition Effects 0.000 abstract description 4
- 150000003384 small molecules Chemical class 0.000 abstract description 4
- 235000012976 tarts Nutrition 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 3
- 230000002496 gastric effect Effects 0.000 abstract description 3
- 238000007876 drug discovery Methods 0.000 abstract description 2
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 abstract description 2
- 238000010438 heat treatment Methods 0.000 abstract description 2
- 239000002547 new drug Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 26
- 230000002159 abnormal effect Effects 0.000 description 12
- 210000003743 erythrocyte Anatomy 0.000 description 8
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 102000001554 Hemoglobins Human genes 0.000 description 5
- 108010054147 Hemoglobins Proteins 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000013642 negative control Substances 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 231100000460 acute oral toxicity Toxicity 0.000 description 3
- 238000011047 acute toxicity test Methods 0.000 description 3
- 208000007502 anemia Diseases 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000000840 anti-viral effect Effects 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 2
- 230000003766 combability Effects 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical group [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
- 206010022971 Iron Deficiencies Diseases 0.000 description 1
- 241001147746 Lactobacillus delbrueckii subsp. lactis Species 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 241000385540 bacterium 10 Species 0.000 description 1
- 241000933856 bacterium 8 Species 0.000 description 1
- 241000753821 bacterium 9 Species 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 244000013123 dwarf bean Species 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 235000021331 green beans Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 229960004857 mitomycin Drugs 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 235000020995 raw meat Nutrition 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
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- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
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- Molecular Biology (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
The invention mainly relates to New drug discovery formulation technologies field, discloses a kind of children's iron supplementary, is made of following raw material：Ferrous gluconate, strawberry, green starch, algal polysaccharides, lactic acid bacteria；Sweet mouthfeel, the smell of fruits is very sweet, fine and smooth smooth, is adapted to children's mouthfeel, easy to drink and digest and assimilate, absorptivity reaches 86.7%；Add strawberry and green starch; tart up and nutrition; promote the absorption of iron; strawberry and mung bean produce substantial amounts of small molecule nutritional ingredient after lactobacillus-fermented; desalinate iron taste; gastrointestinal function is protected, avoids producing the ill symptoms such as upset,gastro-intestinal, nausea, upper abdomen pain, diarrhea, constipation during iron is mended；Ferrous gluconate is added after fermentation, and after slow heating, the extracellular products for making to produce after lactic fermentation is fully combined with ferrous gluconate, is eliminated iron taste, is increased agreeable to the taste sense.
Description
Technical field
The invention mainly relates to New drug discovery formulation technologies field, more particularly to a kind of children's iron supplementary.
Background technology
Iron is a kind of indispensable element for human body composition, and iron is the important component of hemoglobin, is mended
Suitable iron is filled, anaemia can be prevented, enhancing development, toxin-expelling and face nourishing, resistance building, resisting pathogenic microbes is anti-oxidant,
It is antifatigue, build up health, strengthen notice, anaemia can cause to have a dizzy spell, palpitation and insomnia, spiritlessness and weakness, the lazy speech of shortness of breath, limbs
Numb or pupil moves, and pale white complexion or sallow, lip and nail color is light, spiritlessness and weakness, sallow complexion, and deficiency of food abdominal distension, loose stool is dizzy,
Woman in menstrual period amount is few, pale tongue, and tongue is thin white, and weak pulse, certain injury is caused to body.
Children are one of main populations of iron deficiency, but the gastrointestinal function of children is weaker, and conventional iron supplementary has
Denseer iron taste, children's eating difficulties, can cause upset,gastro-intestinal, and nausea, upper abdomen pain, diarrhea, constipation etc. can be caused bad
Symptom, benefit iron effect is poor, and therefore, it is necessary to the high children's iron supplementary of a kind of suitable children's mouthfeel, absorption rate.
The content of the invention
The defects of in order to make up prior art, the object of the present invention is to provide a kind of children's iron supplementary.
A kind of children's iron supplementary, is made of the raw material of following parts by weight：It is ferrous gluconate 93 ~ 95, strawberry 16 ~ 18, green
Beans starch 10 ~ 12, algal polysaccharides 7 ~ 9, lactic acid bacteria 3 ~ 5.
The green starch, the green starch prepared for the fresh mung bean that harvests then, during immersion, GREEN PEAS and mung bean
The weight ratio of grain is 1:11~13.
The algal polysaccharides, are made of red seaweed polysaccharide and blue algae polysaccharide, and the weight ratio of red seaweed polysaccharide and blue algae polysaccharide is 4
~6:1。
The lactic acid bacteria, is made of the raw material of following parts by weight：It is Lactobacillus delbrueckii 14 ~ 16, Bifidobacterium 11 ~ 13, thermophilic
Lactobacillus lactis 8 ~ 10, lactobacillus bulgaricus 7 ~ 9.
A kind of preparation method of children's iron supplementary, comprises the following steps：
（1）Strawberry is cleaned, is beaten, adds the pure water of 5 ~ 6 times of amounts of strawberry weight, it is 180 ~ 200 mesh to be ground to particle diameter, is obtained careless
The certain kind of berries is starched；
（2）Green starch is added in strawberry slurry, tarts up and nutrition, promotes the absorption of iron, strawberry and mung bean are through lactic acid bacteria
Substantial amounts of small molecule nutritional ingredient is produced after fermentation, desalinates iron taste, gastrointestinal function is protected, avoids producing stomach during iron is mended
The ill symptoms such as intestines discomfort, nausea, upper abdomen pain, diarrhea, constipation, are uniformly mixed, and access lactic acid bacteria, are placed in 41 ~ 43 DEG C of perseverances
Temperature fermentation 6 ~ 7 it is small when, be cooled to 23 ~ 25 DEG C, be uniformly mixed, continue fermentation 8 ~ 10 it is small when, obtain fermentation slurry；
（3）Ferrous gluconate is added into fermentation slurry, the water of 2.2 ~ 2.4 times of amounts of ferrous gluconate weight is added, stirs to complete
Fully dissolved, is gradually heated to 78 ~ 80 DEG C, and the extracellular products for making to produce after lactic fermentation is fully combined with ferrous gluconate, is disappeared
Except iron taste, increase agreeable to the taste sense, add algal polysaccharides, increase the smooth mouthfeel of solution, increase the interest of drinking of children, while energy
Enough promote the overall absorption of nutritional ingredient, antibacterial anti-inflammatory is antiviral, strengthens immunization programs for children power, promotes upgrowth and development of children, mixing
Uniformly, 121 DEG C are placed in sterilize 20 ~ 25 minutes, obtains children's iron supplementary；
（4）Packaging, examines, obtains finished product.
The step（3）Be gradually heated up, firing rate be 0.7 ~ 0.9 DEG C/min.
The step（4）Packaging, be filled with nitrogen after packaging, capacity is 5ml/ branch.
The drinking method of children's iron supplementary, drinks during dining or in dining half an hour after, drinks 1 daily, continuously
Ganderwa when continuously drinking 30 days, should at least stop drinking 5 days no more than 30 days.
It is an advantage of the invention that：A kind of children's iron supplementary provided by the invention, sweet mouthfeel, the smell of fruits is very sweet, fine and smooth smooth,
It is adapted to children's mouthfeel, easy to drink and digest and assimilate, absorptivity reaches 86.7%；Add strawberry and green starch, tart up and
Nutrition, promotes the absorption of iron, and strawberry and mung bean produce substantial amounts of small molecule nutritional ingredient after lactobacillus-fermented, desalinate iron raw meat
Taste, protects gastrointestinal function, avoids generation upset,gastro-intestinal, nausea, upper abdomen pain, diarrhea, constipation etc. during iron is mended bad
Symptom；Ferrous gluconate is added after fermentation, and after slow heating, makes the extracellular products and gluconic acid produced after lactic fermentation
It is ferrous fully to combine, iron taste is eliminated, increases agreeable to the taste sense；The algal polysaccharides of addition can increase the smooth mouthfeel of solution, increase
Children's drinks interest, while can promote the overall absorption of nutritional ingredient, and antibacterial anti-inflammatory is antiviral, strengthens immunization programs for children power,
Promote upgrowth and development of children.
Embodiment
Illustrate the present invention with specific embodiment below.
Embodiment 1
A kind of children's iron supplementary, is made of the raw material of following parts by weight：Ferrous gluconate 93, strawberry 16, green starch 10, sea
Polysaccharides 7, lactic acid bacteria 3.
The green starch, the green starch prepared for the fresh mung bean that harvests then, during immersion, GREEN PEAS and mung bean
The weight ratio of grain is 1:11.
The algal polysaccharides, are made of red seaweed polysaccharide and blue algae polysaccharide, and the weight ratio of red seaweed polysaccharide and blue algae polysaccharide is
4:1。
The lactic acid bacteria, is made of the raw material of following parts by weight：Lactobacillus delbrueckii 14, Bifidobacterium 11, acidophilus breast bar
Bacterium 8, lactobacillus bulgaricus 7.
A kind of preparation method of children's iron supplementary, comprises the following steps：
（1）Strawberry is cleaned, is beaten, adds the pure water of 6 times of amounts of strawberry weight, it is 200 mesh to be ground to particle diameter, obtains strawberry slurry；
（2）Green starch is added in strawberry slurry, tarts up and nutrition, promotes the absorption of iron, strawberry and mung bean are through lactic acid bacteria
Substantial amounts of small molecule nutritional ingredient is produced after fermentation, desalinates iron taste, gastrointestinal function is protected, avoids producing stomach during iron is mended
The ill symptoms such as intestines discomfort, nausea, upper abdomen pain, diarrhea, constipation, are uniformly mixed, and access lactic acid bacteria, are placed in 41 DEG C of constant temperature hairs
When ferment 7 is small, be cooled to 24 DEG C, be uniformly mixed, continue fermentation 10 it is small when, obtain fermentation slurry；
（3）Ferrous gluconate is added into fermentation slurry, adds the water of 2.4 times of amounts of ferrous gluconate weight, is stirred to completely molten
Solution, is gradually heated to 78 ~ 80 DEG C, and the extracellular products for making to produce after lactic fermentation is fully combined with ferrous gluconate, eliminates iron
Fishy smell, increases agreeable to the taste sense, adds algal polysaccharides, increases the smooth mouthfeel of solution, increase the interest of drinking of children, while can promote
Into the overall absorption of nutritional ingredient, antibacterial anti-inflammatory is antiviral, strengthens immunization programs for children power, promotes upgrowth and development of children, and mixing is equal
It is even, it is placed in 121 DEG C and sterilizes 25 minutes, obtains children's iron supplementary；
（4）Packaging, examines, obtains finished product.
The step（3）Be gradually heated up, firing rate be 0.8 DEG C/min.
The step（4）Packaging, be filled with nitrogen after packaging, capacity is 5ml/ branch.
The drinking method of children's iron supplementary, drinks during dining or in dining half an hour after, drinks 1 daily, continuously
Ganderwa when continuously drinking 30 days, should at least stop drinking 5 days no more than 30 days.
Embodiment 2
A kind of children's iron supplementary, is made of the raw material of following parts by weight：Ferrous gluconate 94, strawberry 17, green starch 11, sea
Polysaccharides 8, lactic acid bacteria 4.
The green starch, the green starch prepared for the fresh mung bean that harvests then, during immersion, GREEN PEAS and mung bean
The weight ratio of grain is 1:12.
The algal polysaccharides, are made of red seaweed polysaccharide and blue algae polysaccharide, and the weight ratio of red seaweed polysaccharide and blue algae polysaccharide is
5:1。
The lactic acid bacteria, is made of the raw material of following parts by weight：Lactobacillus delbrueckii 15, Bifidobacterium 12, acidophilus breast bar
Bacterium 9, lactobacillus bulgaricus 8.
Prepare and drinking method is the same as embodiment 1.
Embodiment 3
A kind of children's iron supplementary, is made of the raw material of following parts by weight：Ferrous gluconate 95, strawberry 18, green starch 12, sea
Polysaccharides 9, lactic acid bacteria 5.
The green starch, the green starch prepared for the fresh mung bean that harvests then, during immersion, GREEN PEAS and mung bean
The weight ratio of grain is 1:13.
The algal polysaccharides, are made of red seaweed polysaccharide and blue algae polysaccharide, and the weight ratio of red seaweed polysaccharide and blue algae polysaccharide is
6:1。
The lactic acid bacteria, is made of the raw material of following parts by weight：Lactobacillus delbrueckii 16, Bifidobacterium 13, acidophilus breast bar
Bacterium 10, lactobacillus bulgaricus 9.
Prepare and drinking method is the same as embodiment 1.
Comparative example 1
Strawberry is removed, remaining is prepared and drinking method, with embodiment 1.
Comparative example 2
Green starch is removed, remaining is prepared and drinking method, with embodiment 1.
Comparative example 3
Algal polysaccharides are removed, remaining is prepared and drinking method, with embodiment 1.
Comparative example 4
Lactic acid bacteria is removed, remaining is prepared and drinking method, with embodiment 1.
Comparative example 5
Removal step（3）In be gradually heated up, remaining prepare and drinking method, with embodiment 1.
Comparative example 6
The ferrous gluconate in ferrous gluconate tablets of existing commercially available Kaifeng Kang Nuo medicine companies.
The benefit iron blood-nourishing effect of embodiment and comparative example iron supplementary：
900 children of patient of selection tool Anemia, the age is 2 ~ 7 years old, is randomly divided into 9 groups, and every group of 100 people, men and women is fifty-fifty,
Everyone does not take the medicine and food for mending iron blood-nourishing deliberately in tested period, illustratively carries out the edible of iron supplementary for each person every day,
The tested time is 30 days, tested front and rear respectively in examination in hospital erythrocyte number（RBC）, hemoglobin（HGB）, red blood cell ratio
Product (HCT), mean cell hemoglobin concentration（MCHC）With average erythrocyte volume distribution width（RDW）, embodiment and contrast
The benefit iron blood-nourishing effect of example iron supplementary is shown in Table 1.
Table 1：The benefit iron blood-nourishing effect of embodiment and comparative example iron supplementary
| Project | RBC/(1012/L) | HGB/(g/L) | HCT | MCHC/(g/L) | RDW/(%) |
| Embodiment 1 | 4.3 | 134 | 0.44 | 341 | 13 |
| Embodiment 2 | 4.2 | 138 | 0.41 | 344 | 13 |
| Embodiment 3 | 4.5 | 135 | 0.42 | 343 | 14 |
| Comparative example 1 | 3.9 | 118 | 0.35 | 327 | 8 |
| Comparative example 2 | 3.6 | 112 | 0.38 | 326 | 10 |
| Comparative example 3 | 3.5 | 109 | 0.37 | 325 | 9 |
| Comparative example 4 | 3.7 | 111 | 0.36 | 324 | 8 |
| Comparative example 5 | 4.0 | 127 | 0.39 | 336 | 11 |
| Comparative example 6 | 3.3 | 106 | 0.34 | 321 | 7 |
From table 1 the result shows that, children's iron supplementary of embodiment, eat 30 days after, erythrocyte number, hemoglobin, red blood cell
Specific volume, mean cell hemoglobin concentration and average erythrocyte volume distribution width data are substantially better than comparative example, illustrate this hair
Children's iron supplementary of bright offer has mends iron blood-nourishing effect well.
The malicious combability measurements of embodiment and comparative example children's iron supplementary：
Children's iron supplementary of appropriate embodiment and comparative example is taken respectively, it is spare.
（1）Rat oral acute toxicity test：
Experimental group：Big white mouse 100, is randomly divided into 10 groups, every group 10, half male and half female, respectively by embodiment and comparative example
Children's iron supplementary gives experiment rat by the oral gavage of 1ml/kgbw amounts, is given once per 4h, observes 7d after four times, see whether there is
Any poisoning symptom is seen；Negative control group：Experimental animal 10, half male and half female, does not give children's iron supplementary, with test group at the same time
Controlled observation, the results are shown in Table 2；
（2）Mouse inbred strain：
Experimental group：Male mice 110, is randomly divided into 11 groups, every group 10, the children of embodiment and comparative example is mended iron respectively
The amount of 1ml/kgbw, the male mice of the continuous 5d difference gavages group are pressed in agent；Positive controls：Easily mouse sperm will be caused abnormal
The mitomycin C of change presses the male mice of the 1ml/kgbw dosage continuous 5d gavages group；Negative control group：It will be not easy to cause small
The distilled water of mouse sperm distortion the results are shown in Table 2 by the male mice of the 1ml/kgbw dosage continuous 5d gavages group；
Table 2：The malicious combability measurements of embodiment and comparative example children's iron supplementary
| Project | Rat oral acute toxicity test | Micronucleus number/(‰) |
| Embodiment 1 | None is abnormal or dead | 1.72 |
| Embodiment 2 | None is abnormal or dead | 1.74 |
| Embodiment 3 | None is abnormal or dead | 1.73 |
| Comparative example 1 | None is abnormal or dead | 1.72 |
| Comparative example 2 | None is abnormal or dead | 1.73 |
| Comparative example 3 | None is abnormal or dead | 1.71 |
| Comparative example 4 | None is abnormal or dead | 1.73 |
| Comparative example 5 | None is abnormal or dead | 1.72 |
| Comparative example 6 | None is abnormal or dead | 1.72 |
| Positive controls | — | 18.46 |
| Negative control group | None is abnormal or dead | 1.72 |
Note："-" indicate without.
From table 2 the result shows that, children's iron supplementary of the invention, after rat oral acute toxicity test, with negative control group
Identical, none is abnormal or dead, shows that children's iron supplementary provided by the invention is safe and non-toxic, after mouse inbred strain,
The mouse sperm deformity rate of embodiment is suitable with negative control group, hence it is evident that less than positive controls, shows youngster provided by the invention
Virgin iron supplementary will not produce detrimental effect to the reproduction cell of mouse.
Claims (8)
1. a kind of children's iron supplementary, it is characterised in that be made of the raw material of following parts by weight：Ferrous gluconate 93 ~ 95, strawberry
16 ~ 18, green starch 10 ~ 12, algal polysaccharides 7 ~ 9, lactic acid bacteria 3 ~ 5.
2. children's iron supplementary according to claim 1, it is characterised in that the green starch is fresh to harvest then
Green starch prepared by mung bean, during immersion, the weight ratio of GREEN PEAS and mung bean grain is 1:11~13.
3. children's iron supplementary according to claim 1, it is characterised in that the algal polysaccharides, by red seaweed polysaccharide and cyanobacteria
Polysaccharide forms, and the weight ratio of red seaweed polysaccharide and blue algae polysaccharide is 4 ~ 6:1.
4. children's iron supplementary according to claim 1, it is characterised in that the lactic acid bacteria, by the raw material of following parts by weight
Composition：Lactobacillus delbrueckii 14 ~ 16, Bifidobacterium 11 ~ 13, lactobacillus acidophilus 8 ~ 10, lactobacillus bulgaricus 7 ~ 9.
5. a kind of preparation method of the iron supplementary of children according to claim 1, it is characterised in that comprise the following steps：
（1）Strawberry is cleaned, is beaten, adds the pure water of 5 ~ 6 times of amounts of strawberry weight, it is 180 ~ 200 mesh to be ground to particle diameter, is obtained careless
The certain kind of berries is starched；
（2）By green starch add strawberry slurry in, be uniformly mixed, access lactic acid bacteria, be placed in 41 ~ 43 DEG C of ferment at constant temperature 6 ~ 7 it is small when,
Be cooled to 23 ~ 25 DEG C, be uniformly mixed, continue fermentation 8 ~ 10 it is small when, obtain fermentation slurry；
（3）Ferrous gluconate is added into fermentation slurry, the water of 2.2 ~ 2.4 times of amounts of ferrous gluconate weight is added, stirs to complete
Fully dissolved, is gradually heated to 78 ~ 80 DEG C, adds algal polysaccharides, is uniformly mixed, and is placed in 121 DEG C and sterilizes 20 ~ 25 minutes, obtains children
Iron supplementary；
（4）Packaging, examines, obtains finished product.
6. the preparation method of children's iron supplementary according to claim 5, it is characterised in that the step（3）Be gradually heated up,
Firing rate is 0.7 ~ 0.9 DEG C/min.
7. the preparation method of children's iron supplementary according to claim 5, it is characterised in that the step（4）Packaging, packaging
After be filled with nitrogen, capacity is 5ml/ branch.
8. according to the drinking method of any one of claim 1 ~ 7 children's iron supplementary, it is characterised in that during dining or into postprandial
Drunk in half an hour, drink 1 daily, continuous Ganderwa when continuously drinking 30 days, should at least stop drinking no more than 30 days
With 5 days.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109123654A (en) * | 2018-07-11 | 2019-01-04 | 广州富诺营养科技有限公司 | A kind of suitable probiotic for children dietary supplements and preparation method thereof |
-
2017
- 2017-10-31 CN CN201711045938.5A patent/CN107929275A/en not_active Withdrawn
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| Title |
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| 张志琴: "葡萄糖酸亚铁治疗儿童缺铁性贫血疗效观察", 《基层医学论坛》 * |
| 郑鹏然等: "《食品卫生全书》", 31 July 1996, 红旗出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109123654A (en) * | 2018-07-11 | 2019-01-04 | 广州富诺营养科技有限公司 | A kind of suitable probiotic for children dietary supplements and preparation method thereof |
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