CN107927790A - A kind of composition and its application - Google Patents

A kind of composition and its application Download PDF

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Publication number
CN107927790A
CN107927790A CN201711293480.5A CN201711293480A CN107927790A CN 107927790 A CN107927790 A CN 107927790A CN 201711293480 A CN201711293480 A CN 201711293480A CN 107927790 A CN107927790 A CN 107927790A
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composition
vitamin
trehalose
food
female
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冯纪敏
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Individual
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention relates to ordinary food field, more particularly to a kind of composition and its application.Trehalose provided by the invention, composition ordinary food can adjust female endocrinic disorders, improve ovarian function, improve oocyte quality, promote the combination of sperm and ovum, improve female fertility.

Description

A kind of composition and its application
Technical field
The present invention relates to field of food, more particularly to a kind of composition and its application.
Background technology
Infertility is known as female sterility caused by female factors, female sterility be a kind of incidence compared with High and more refractory illness more.Research data shows at present both at home and abroad：Incidence of the infertility in child-bearing period Mr. and Mrs is about For 15%-20%, root is according to the statistics of the World Health Organization：The whole world about 600-8000 ten thousand suffers from different degrees of infertility to Mr. and Mrs Disease, wherein infertility accounts for the 50% of all infertile couples as caused by female factors.Female fertility is in the increase at age Downward trend, the probability being pregnant in 1 year can reach 90% at 20 years old, and be only 36.4% at 40 years old or so.Chinese population base Number is big, and the opening of two child's policies in recent years, there is that the advanced age Mr. and Mrs of fertility demand are more and more, and the incidence of sterility is in recent years Also it is in rising trend.Sterility often results in goodwill as between spouses discord, and marriage and family rupture, destabilizing factor is brought to society.Female Property infertility the cause of disease it is varied, most directly show as endocrine disturbance, premature ovarian failure, oocyte quality decline.
China's pharmaceutical technology field have accumulated more rich experience in terms of female sterility is treated at present, have doctor trained in Western medicine to control Treat, such as using medicine, operation, also there are many effective Chinese patent drugs, although these treatment methods are each in terms of sterility is treated There is its advantage, but every kind of method all has some limitations.And the drug therapy duration is grown, and with numerous secondary works With operative treatment wound is big.And due to the tradition of the Chinese nation, people are more willing to prioritizing selection tonic.A kind of therefore it provides effect Fruit is notable, without side-effects, can adjust female endocrinic disorders, improves ovarian function, improves oocyte quality, improves female fertility The health food of ability has important practical significance.
The content of the invention
In view of this, the present invention provides a kind of composition and its application, said composition is scientific and effective, without side-effects, energy Female endocrinic disorders are adjusted, improve ovarian function, improve oocyte quality, improve the ordinary food of female fertility.
In order to realize foregoing invention purpose, the present invention provides following technical scheme：
The present invention provides trehalose to prepare adjusting female endocrinic disorders, improve ovarian function, raising ooplasm Application in the food of the combination of amount or promotion sperm and ovum.
Present invention also offers application of the trehalose in the food for improving female fertility is prepared.
In addition, present invention also offers a kind of composition, including trehalose, l-cn.
The present invention some specific embodiments in, the trehalose, the l-cn mass ratio for (500~ 1200):(100~500).
The present invention some specific embodiments in, said composition further include vitamin, antioxidant, mineral matter or Mixture more than one or both of amino acid.
In some specific embodiments of the present invention, the vitamin includes vitamine D3, folic acid, vitamin C, dimension life Plain B5, vitamin B6 or vitamin B12；The antioxidant includes lycopene, haematococcus pluvialis or bata-carotene；The ore deposit Material includes iron, zinc or calcium；The amino acid must amino acid, preferably arginine for reproduction.
In some specific embodiments of the present invention, in parts by weight, the composition includes following component：
In some specific embodiments of the present invention, in parts by weight, the composition includes following component：
Present invention also offers the composition to prepare adjusting female endocrinic disorders, improve ovarian function, raising Application in the food of the combination of oocyte quality or promotion sperm and ovum.
Present invention also offers application of the composition in the food for improving female fertility is prepared.
Composition or food provided by the invention can adjust female endocrinic disorders, improve ovarian function, and it is thin to improve ovum Kytoplasm amount, promotes the combination of sperm and ovum, improves female fertility.
Embodiment
The invention discloses a kind of composition and its application, those skilled in the art can use for reference present disclosure, suitably change Realized into technological parameter.In particular, all similar substitutions and modifications are for a person skilled in the art aobvious And be clear to, they are considered as being included in the present invention.The method of the present invention and application are carried out by preferred embodiment Description, related personnel can substantially not depart from present invention, method described herein and application carried out in spirit and scope Change is suitably changed with combining, to realize and using the technology of the present invention.
The present invention provides trehalose to prepare adjusting female endocrinic disorders, improve ovarian function, raising ooplasm Application in the ordinary food of the combination of amount, promotion sperm and ovum.
Present invention also offers application of the trehalose in the ordinary food for improving female fertility is prepared.
Present invention also offers a kind of composition, including trehalose and l-cn.
The present invention some specific embodiments in, the trehalose, the l-cn mass ratio for (500~ 1200):(100~500).
The present invention some specific embodiments in, the composition further include vitamine D3, lycopene, folic acid, One in haematococcus pluvialis, vitamin C, iron, vitamin B5, zinc, bata-carotene, vitamin B6, vitamin B12, arginine, calcium Mixture more than kind or both.
In some specific embodiments of the present invention, by weight, the composition includes following component：
In some specific embodiments of the present invention, by weight, the composition includes following component：
In ordinary food of the present invention：
Trehalose：Trehalose has organism magical protective effect, can keep cytoactive.It is because trehalose exists The protective film of uniqueness can be formed under the severe environmental conditions such as high temperature, high and cold, hyperosmosis and dry dehydration in cell surface, effectively Ground protected protein matter molecule consistency inactivation, so that the life process and biological characteristic of the body that sustains life.
L-cn：The material is the required component for maintaining human normal physiological activity.It has extremely important and various Effect.L-cn is the important carrier of transhipment Energy supply material in human body.The material also has stronger reproducibility, can drop Response to oxidative stress in low ovum is horizontal, protects the structure of ovum.
Vitamine D3：Vitamin D adjusts development and the function of placenta, this shows that pregnant woman maintains preferable vitamin D level It can prevent such as to miscarry, pre-eclampsia, and the generation of the complications of pregnancy such as premature labor.In utero and infant obtains enough vitamin Ds Type 1 diabetes, asthma and schizoid incidence can be reduced.
Lycopene：It is most one of the powerful antioxidant being found at present in the plant of nature.Can effectively it protect Egg cell 26S Proteasome Structure and Function, moreover it is possible to which slow down aging process.
Folic acid：Folic acid is a kind of water soluble vitamin, is played an important role to protein synthesis and the metabolism of various amino acid, And purine and pyrimidine synthesis are participated in, play a role in cell DNA synthesis.It can prevent fetus under-weight, harelip, heart Defect and nerve channel developmental defect etc. are lopsided.Folic acid can be synthesized by anti-oxidant, rush nucleic acid and the approach such as rush methylate promote Oocyte maturation, influences female fertility.
Haematococcus pluvialis：With the ability in terms of anti-oxidant, elimination free radical, the generation of antibody, enhancing can be promoted dynamic The immune function of thing.
Vitamin B5：Contribute to the secretion of internal compressive resistance hormone.The formation of cell is helped, maintains normal development and maincenter The development of nervous system；For maintaining adrenal normal function extremely important；It is that fat and sugar class can not when being transformed into energy The material lacked.
Zinc：Zinc plays very important effect in the Physiological effect of various mammal brains, in a variety of enzymes and acceptor work( It is indispensable and closely related with the biosynthesis of DNA and RNA, protein in adjusting, the formation of reproduction cell can be influenced.
Bata-carotene：Beta carotene is a kind of antioxidant, has detoxication, is to safeguard that health is indispensable Nutrient, and most generally existing is also most stable of natural pigment in nature.
Vitamin B6：Vitamin b6 is the necessary material of body fat and glycometabolism, and the estrogen metabolism of women is also required to Vitamin B6.
Vitamin B12：Exist in the form of coenzyme, the utilization rate of folic acid can be increased, promote carbohydrate, fat and The metabolism of protein.
Arginine：Arginine is the nitric oxide production precursor substance of synthesis in human body, and supplement arginine contributes to increase internal Nitric oxide production synthesis, and the increase of nitric oxide synthesis in vivo, for improving genitals official rank blood supply significant effect.In addition, Arginine can effectively improve immunity, promote immune system secretion natural killer cells, phagocyte, in white blood cell in alkene element etc. Natural disposition material, has anti-inflammatory effect.
Present invention also offers the composition to prepare adjusting female endocrinic disorders, improve ovarian function, raising Application in the ordinary food of the combination of oocyte quality, promotion sperm and ovum.
Present invention also offers application of the composition in the ordinary food for improving female fertility is prepared.
Tablet is made after auxiliary material is added for the composition of the present invention or ordinary food is made in capsule, and instructions of taking is：It is oral, One at a time, 1 times a day, a clothes (or following the doctor's advice) from morning.Each course for the treatment of 30 days.The lighter takes the 1-2 course for the treatment of, and severe one takes 3-4 treatment Journey.
Raw materials used and reagent can be bought by market in a kind of composition provided by the invention and its application.
With reference to embodiment, the present invention is further explained：
Embodiment 1
Each component presses following dosimetric system into capsule：
Daily 1, a clothes from morning, 30 days as one therapeutic course, takes 3 courses for the treatment of altogether.
Embodiment 2
Each component presses following dosimetric system into capsule：
Daily 1, a clothes from morning, 30 days as one therapeutic course, takes 2 courses for the treatment of altogether.
Embodiment 3
Each component presses following dosimetric system into capsule：
Daily 1, a clothes from morning, 30 days as one therapeutic course, takes 4 courses for the treatment of altogether.
Embodiment 4
Each component presses following dosimetric system into capsule：
Daily 1, a clothes from morning, 30 days as one therapeutic course, takes 4 courses for the treatment of altogether.
Embodiment 5
Each component presses following dosimetric system into capsule：
Daily 1, a clothes from morning, 30 days as one therapeutic course, takes 4 courses for the treatment of altogether.
Embodiment 6
Using the female CD-1 mouse of 8 weeks after 80 births, 8 groups are randomly divided into, every group 10, be respectively control group, a left side Revolving carnitine group, trehalose group and ovum again can 1-5 group.Control group is only left by weight feeding distilled water, l-cn group feeding 0.4mg Carnitine is revolved, trehalose group feeds 25 μ g/kg trehaloses by weight, and ovum again can 1 group of group as made from mouse weight feeding embodiment 1 Compound 10mg/kg, ovum again can 2 groups as mouse weight feeding embodiment 2 made from composition 10mg/kg, ovum again can 3 groups press mouse Composition 10mg/kg made from weight feeding embodiment 3, ovum again can 4 groups of compositions as made from mouse weight feeding embodiment 4 10mg/kg, ovum again can 5 groups of composition 10mg/kg as made from mouse weight feeding embodiment 5.The super row of rush is used after feeding 3 weeks Medicine promotees super row, and egg cell is collected after mouse is euthanized, and assesses the quality and quantity of egg cell, and use experiment in vitro fertilization Assess it and form the ability of blastaea.
Experimental result is shown in Table 1.
Table 1
aShow has significant difference (P ＜ 0.05) compared with control group,bShow has significant difference (P compared with l-cn group ＜ 0.05)
By 1 result of table as it can be seen that in terms of egg cell degradation ratio, compared with control group, there is notable (P in l-cn group ＜ 0.05) decline, trehalose group and ovum again can 1~5 group of declines for notable (P ＜ 0.05) equally occur.Ovum again can 1~5 Group is compared with trehalose group compared with l-cn group, and egg cell degradation ratio is there are downward trend, and ovum again can 1~5 group of more left-handed meat Alkali group declines obvious (P<0.05).Illustrate that trehalose and composition provided by the invention can significantly improve high-quality egg cell Ratio, compared with l-cn, significant difference, more alone trehalose also carries the raising effect of composition provided by the invention It is high.
In terms of blastocyst rate, compared with control group, there is the rising of notable (P ＜ 0.05), trehalose in l-cn group Group and ovum again can 1~5 group of risings for notable (P ＜ 0.05) equally occur.Ovum again can 1~5 group and the more left-handed meat of trehalose group Alkali group is compared, and egg cell forms the ratio of blastaea there are ascendant trend, and ovum again can 1~5 group rise compared with l-cn group it is obvious (P<0.05).Illustrate that trehalose and composition provided by the invention can significantly improve egg cell development to the ratio of blastula stage Rate, compared with l-cn, significant difference, more alone trehalose is also improved the raising effect of composition provided by the invention.
In order to prove the effect of composition provided by the invention, 2015-2016, applicant is carried out using this ordinary food Clinical test, treats sterile female patient 80 after marriage, evident in efficacy, particulars are as follows.
80 are atocia special outpatient clinic patient, and diagnosis meets following standard:The couple at child-bearing age, there is normal sexuality, Do not take contraceptives not educate within more than 2 years and (exclude bridegroom's or husband's side factor), exclude obstruction of fallopian tube, other endocrine system diseases, serious life Grow the organic diseases such as deformity.At 22~44 years old age, average age 32.5 years old, the course of disease was at 2 years~15 years.
Diagnostic criteria
With reference to the female infertility diagnosis of ASRM committees issue in 2015 and the guide of assessment.
Treatment method
The composition provided using the embodiment of the present invention 1~5, instructions of taking are：It is oral, once a grain, once a day, Clothes.Each course for the treatment of 30 days.The lighter takes the 1-2 course for the treatment of, and severe one takes the 3-4 course for the treatment of and judges curative effect.
Curative effect determinate standard
Recovery from illness:Symptom disappears, wife's side pregnancy.
It is effective:Wife's side unpregnancy, endocrine disturbance symptom are clearly better.
Effectively:Endocrine disturbance symptom improves earlier above.
It is invalid:Clinical symptoms are without significant change, unpregnancy.
As a result
Fully recover 38 (47.5%), effective 26 (32.5%), effective 10 (12.5%), invalid 6 (7.5%), always Effective percentage 92.5%.
As it can be seen that composition effect provided by the invention is notable, has the following advantages：(1) curative effect is preferable, and female is adjusted after taking Property endocrine disturbance, improve ovarian function, improve oocyte quality, promote the combination of sperm and ovum, improve female fertility. 2) it is applied widely, suitable for various age groups, especially to having good therapeutic effect because age increase causes fecundity to decline, And non-evident effect.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (10)

1. trehalose prepare adjust female endocrinic disorders, improve ovarian function, improve oocyte quality or promote sperm with Application in the food of the combination of ovum.
2. application of the trehalose in the food for improving female fertility is prepared.
3. a kind of composition, it is characterised in that including trehalose, l-cn.
4. composition according to claim 3, it is characterised in that the trehalose, the mass ratio of the l-cn are (500~1200):(100~500).
5. the composition according to claim 3 or 4, it is characterised in that further include vitamin, antioxidant, mineral matter or Mixture more than one or both of amino acid.
6. composition according to claim 5, it is characterised in that the vitamin includes vitamine D3, folic acid, vitamin C, vitamin B5, vitamin B6 or vitamin B12；The antioxidant includes lycopene, haematococcus pluvialis or bata-carotene； The mineral matter includes iron, zinc or calcium；The amino acid must amino acid for reproduction.
7. composition according to claim 6, it is characterised in that in parts by weight, including following component：
8. composition according to claim 6, it is characterised in that in parts by weight, including following component：
9. preparing adjusting female endocrinic disorders according to claim 3 to 8 any one of them composition, improving ovary work( Application in the food that, oocyte quality can be improved or promote the combination of sperm and ovum.
10. according to claim 3 to 8 any one of them composition answering in the food for improving female fertility is prepared With.
CN201711293480.5A 2017-12-08 2017-12-08 A kind of composition and its application Pending CN107927790A (en)

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