CN107921102B - 组合疗法 - Google Patents

组合疗法 Download PDF

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Publication number
CN107921102B
CN107921102B CN201680042973.9A CN201680042973A CN107921102B CN 107921102 B CN107921102 B CN 107921102B CN 201680042973 A CN201680042973 A CN 201680042973A CN 107921102 B CN107921102 B CN 107921102B
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biofilm
polypeptide
trypsin
serine protease
protease activity
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Chinese (zh)
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CN107921102A (zh
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阿古斯塔·格维兹门斯多蒂尔
雷尼尔·谢温
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Mei Gongsi
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Mei Gongsi
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Otolaryngology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
CN201680042973.9A 2015-07-24 2016-07-22 组合疗法 Active CN107921102B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15178209.1A EP3120866A1 (en) 2015-07-24 2015-07-24 Use of marine serine proteases for removal, prevention and inhibition of formation and growth of biofilms
EP15178209.1 2015-07-24
PCT/EP2016/067570 WO2017017027A1 (en) 2015-07-24 2016-07-22 Combination therapies

Publications (2)

Publication Number Publication Date
CN107921102A CN107921102A (zh) 2018-04-17
CN107921102B true CN107921102B (zh) 2022-09-09

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ID=53785469

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680042973.9A Active CN107921102B (zh) 2015-07-24 2016-07-22 组合疗法

Country Status (12)

Country Link
US (1) US11338021B2 (https=)
EP (2) EP3120866A1 (https=)
JP (1) JP2018521143A (https=)
KR (1) KR20180031704A (https=)
CN (1) CN107921102B (https=)
AU (1) AU2016301021B2 (https=)
CA (1) CA2992677A1 (https=)
DK (1) DK180380B1 (https=)
ES (1) ES2989635T3 (https=)
MX (1) MX2018000984A (https=)
RU (1) RU2725800C2 (https=)
WO (1) WO2017017027A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201701315D0 (en) 2017-01-26 2017-03-15 Enzymatica Ab Novel treatments
WO2020229521A1 (en) * 2019-05-14 2020-11-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for inhibiting or reducing bacterial biofilms on a surface
CN115666512A (zh) * 2020-05-13 2023-01-31 智密科技公司 用于治疗微生物感染的蛋白酶制剂
CN119499437A (zh) * 2024-11-27 2025-02-25 武汉大学中南医院 一种负载胰蛋白酶抗细菌生物膜的温敏性水凝胶敷料及其制备方法与应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078332A2 (en) * 1999-06-18 2000-12-28 Jon Bragi Bjarnason Fish serine proteinases and their pharmaceutical and cosmetic use
CN100496514C (zh) * 2002-03-09 2009-06-10 英国国防部 细菌聚集表面的处理
CN103191491A (zh) * 2012-01-10 2013-07-10 查红梅 一种包装物及其用途和制法
CN203090136U (zh) * 2013-02-02 2013-07-31 成都玺汇科技有限公司 一种口鼻两用喷雾器
CN104602700A (zh) * 2012-05-11 2015-05-06 史密夫和内修公司 蜂蜜曲霉蛋白酶在用于去除细菌生物膜的用途

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US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
SE459005B (sv) 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
US20020037260A1 (en) * 1997-10-16 2002-03-28 Budny John A. Compositions for treating biofilm
EP2504025A4 (en) 2009-11-23 2013-05-01 Stephen F Olmstead COMPOSITIONS AND METHODS USING SERRATIA PEPTIDASE FOR INHIBITING AND TREATING BIOFILMS ASSOCIATED WITH PARTICULAR SUFFERING
EP2714719B1 (en) 2011-05-31 2018-12-12 Hutchison Biofilm Medical Solutions Limited Dispersion and detachment of cell aggregates
CN103007258A (zh) 2011-09-22 2013-04-03 安淇生物控释技术(苏州)有限公司 含鱼丝氨酸蛋白酶和抗菌化合物的医用组合物及其用途
MX349991B (es) * 2011-12-21 2017-08-22 Colgate Palmolive Co Composiciones de cuidado oral.
BR112014027818B1 (pt) 2012-05-09 2023-03-28 Contrafect Corporation Usos de composições compreendendo polipeptídeo de lisina para prevenção, ruptura ou tratamento de um biofilme bacteriano
ES2890555T3 (es) * 2014-01-29 2022-01-20 Enzymatica Ab Tripsina de bacalao para uso en el tratamiento de infecciones microbianas en un sujeto con inmunodeficiencia
GB201405784D0 (en) * 2014-03-31 2014-05-14 Enzymatica Ab Novel methods, polypeptides and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078332A2 (en) * 1999-06-18 2000-12-28 Jon Bragi Bjarnason Fish serine proteinases and their pharmaceutical and cosmetic use
CN100496514C (zh) * 2002-03-09 2009-06-10 英国国防部 细菌聚集表面的处理
CN103191491A (zh) * 2012-01-10 2013-07-10 查红梅 一种包装物及其用途和制法
CN104602700A (zh) * 2012-05-11 2015-05-06 史密夫和内修公司 蜂蜜曲霉蛋白酶在用于去除细菌生物膜的用途
CN203090136U (zh) * 2013-02-02 2013-07-31 成都玺汇科技有限公司 一种口鼻两用喷雾器

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Assessment of enzymatic cleaning agents and disinfectants against bacterial biofilms;M. Augustin等;《J Pharm Pharmaceut Sci》;20040218;第7卷(第1期);摘要，第57页左栏第3段，表2 *
Potential Use of Atlantic Cod Trypsin in Biomedicine;Agusta Gudmundsdottir等;《BioMed Research International》;20130101;第54卷(第8期);第1-11页 *
SspA对生物材料细菌黏附及生物膜;林兴等;《国外医学生物医学工程分册》;20051028;第28卷(第5期);第290-294页 *
trypsinogenⅠ[Gadus morhua];A. Gudmundsdottir等;《GenBank，Accession：CAA54214.1》;20050418;Features and Origin *
丝氨酸蛋白酶对心血管涤纶生物材料上;林兴等;《生物医学工程学杂志》;20090825;第26卷(第4期);第787-791页 *

Also Published As

Publication number Publication date
RU2018106490A (ru) 2019-08-26
EP3325002B1 (en) 2024-09-04
US20200085921A1 (en) 2020-03-19
DK201870043A1 (en) 2018-02-05
US11338021B2 (en) 2022-05-24
WO2017017027A1 (en) 2017-02-02
AU2016301021B2 (en) 2022-11-10
EP3325002C0 (en) 2024-09-04
CN107921102A (zh) 2018-04-17
EP3120866A1 (en) 2017-01-25
KR20180031704A (ko) 2018-03-28
EP3325002A1 (en) 2018-05-30
BR112018001391A2 (en) 2018-09-11
RU2725800C2 (ru) 2020-07-06
MX2018000984A (es) 2018-08-09
RU2018106490A3 (https=) 2020-01-24
ES2989635T3 (es) 2024-11-27
CA2992677A1 (en) 2017-02-02
DK180380B1 (en) 2021-03-17
AU2016301021A1 (en) 2018-02-01
JP2018521143A (ja) 2018-08-02

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