CN1078901A - Lactaggue oral administration liquid medicine and production method thereof - Google Patents
Lactaggue oral administration liquid medicine and production method thereof Download PDFInfo
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- CN1078901A CN1078901A CN 93103015 CN93103015A CN1078901A CN 1078901 A CN1078901 A CN 1078901A CN 93103015 CN93103015 CN 93103015 CN 93103015 A CN93103015 A CN 93103015A CN 1078901 A CN1078901 A CN 1078901A
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Abstract
The present invention relates to a kind of puerpera to promote lactation and strengthen oral liquid and production method thereof.
The Lactaggue oral administration liquid medicine that the invention provided is to be boiled through decocting by Polyhachis vicina Roger, Radix Angelicae Sinensis, Radix Glycyrrhizae Preparata, Semen Vaccariae, Medulla Tetrapanacis, Mel and yellow wine, and alcohol extraction makes oral liquid.Through pharmacology and clinical trial, the lactogenic effect is obvious, has no side effect taking convenience, but industrialized mass production.
Description
The invention relates to a kind of Lactaggue oral administration liquid medicine and production method thereof.
Common puerpera to promote lactation and strengthen, biography side among the people is a lot of, but seldom standardization, effect differs, and uses inconvenience, no specially good effect lactagogue.
The purpose of the invention is to provide a kind of Lactaggue oral administration liquid medicine and production method thereof, the oral liquid taking convenience, and effect is obvious, but the production method industrialized mass production.
The Lactaggue oral administration liquid medicine that the invention provided is made up of the extract of Polyhachis vicina Roger, Radix Angelicae Sinensis, Radix Glycyrrhizae Preparata, Semen Vaccariae, Medulla Tetrapanacis, Mel and yellow wine.
The Lactaggue oral administration liquid medicine that the invention provided makes by following step successively:
A) get Polyhachis vicina Roger 3000g,, in 350 high speed disintegrators, break into coarse powder 40-45 order, under vacuum 380mmHg post, be heated to 67 ± 3 ℃, kept 0.25 hour through roguing.Adding moisture by 2: 1: 1 of Polyhachis vicina Roger weight then decocts for three times, 3 hours time, 3 hours, 2 hours, three decocting liquids are merged, under vacuum 380mmHg post, 67 ± 3 ℃ of temperature are condensed into 1: 1 rare cream, add 95% ethanol again and transfer to the alcohol amount 50% that contains, left standstill 48 hours, get supernatant again under the 380mmHg post temperature be concentrated into 1: 0.5 rare cream for 67 ± 3 ℃.
B) get Radix Angelicae Sinensis 1800g, Radix Glycyrrhizae Preparata 500g, Semen Vaccariae 1800g, Medulla Tetrapanacis 700g, add water by 2: 1: 1 of Radix Angelicae Sinensis weight, respectively by 3 hours, 3 hours, decocted in 2 hours three times, three decocting liquids are merged, add 95% ethanol and transfer to and contain alcohol 50%, left standstill 48 hours, and got supernatant concentration to 1: 0.5 rare cream.
C) got Mel 2500g heated and boiled 0.5 hour, filter, add by a, the spissated rare cream of b two procedures while hot and add 3000g yellow wine mixing, again through the middling speed filter paper filtering, the 10000ml Lactaggue oral administration liquid medicine.
The Lactaggue oral administration liquid medicine that makes as stated above is a dark-brown liquid, and sweet in the mouth, pH value are 4-5, and proportion is 1.01-1.05, and 1 milliliter of this product oral liquid is used spectrophotometry in acetic acid-sodium-acetate buffer, and there is absorption maximum at the wavelength place at 228 ± 2mm.
This Lactaggue oral administration liquid medicine is regulated drug toxicology inspection center through China's fertility, use Lactaggue oral administration liquid medicine female Mus of feeding to do the lactogenic test and show: it is active that Lactaggue oral administration liquid medicine has the mammary glandular cell of making, galactopoiesis increases, the pharmacological action that the filial mice growth is accelerated.The result shows to female mice per os toxicity test, and maximum tolerated dose is 60g/kg, belongs to non-toxic type in accordance with regulations.To the observation of rat growthing development and histopathology, through surpassing 25 times of clinical dosages, test in continuous 30 days shows, does not see change.Thereby infer that it is safe using human body at clinical dosage.But the content of visible hemoglobin rises and the hemocyte sum raises, and all is rich in aminoacid with oral liquid, vitamin, and trace element or other bioactive substance are relevant, and the effect that strengthens the human body resistance is arranged.
The Lactaggue oral administration liquid medicine that the invention provides, is taken the Lactaggue oral administration liquid medicine clinical observation and is shown 50 routine puerperal hypogalactia puerperas through the Chinese People's Liberation Army's 208 obstetrics and gynecology hospitals, and treatment back milk production all obviously increases, and total effective rate is 100%.Begin to take medicine second day puerperal, each 20ml, and 3 times/day, to take half an hour after meal, clothes back average 120-150ml/ day of day next day galactopoiesis, the 3rd day average 450-600ml/ day of galactopoiesis, milk concentration more not pill taker obviously changes, and does not have other pair effect.
The Lactaggue oral administration liquid medicine that the invention provides, from 429 puerperas of sum that give a birth, select person 80 people that do not have milk puerperal on July 31, March 10 to the same year in 1991 through Wusong Central Hospital, Baoshan District, Shanghai again, through using Lactaggue oral administration liquid medicine, taking medicine one day after, the responder is 67 people, it is 14 people that the 2-3 days interior milk amounts in back of taking medicine can increase 80-100ml, increasing to 50-60ml is 55 people, increase 50ml with interior be 11 people, total effective rate is 100%.
It is short that the production method that the invention provided has flow process, and the batching of selecting for use is easy to get, but industrialized mass production, and the product effect is obvious.
Claims (2)
1, our puerpera to promote lactation and strengthen oral liquid is characterized in that it is made up of the extract of following composition:
Polyhachis vicina Roger 3000g Radix Angelicae Sinensis 1800g
Radix Glycyrrhizae Preparata 500g Semen Vaccariae 1800g
Medulla Tetrapanacis 700g Mel 2500g
Yellow wine 3000g
2, a kind of puerpera to promote lactation and strengthen production method of oral liquid is characterized in that making by following step successively:
A) get Polyhachis vicina Roger 3000g through roguing, in 350 high speed disintegrators, break into coarse powder 40-45 order, under vacuum 380mmHg post, heat 67 ± 3 ℃, kept 0.25 hour, by Polyhachis vicina Roger weight 2: 1: 1 add water then, divide three decoctions, and the time is 3 hours, 3 hours, 2 hours, three decocting liquids are merged, under vacuum 380mmHg post, temperature is condensed into 1: 1 rare cream for 67 ± 3 ℃, adds 95% ethanol again and transfers to the alcohol amount 50% that contains, left standstill 48 hours, get supernatant, under the 380mmHg post, temperature is concentrated into 1: 0.5 rare cream for 67 ± 3 ℃ again;
B) get Radix Angelicae Sinensis 1800g, Radix Glycyrrhizae Preparata 500g, Semen Vaccariae 1800g, Medulla Tetrapanacis 700g, add water by 2: 1: 1 of Radix Angelicae Sinensis weight, respectively by 3 hours, 3 hours, 2 hours, decoct three times, three decoction liquor are merged, add 95% ethanol transfer to contain alcohol 50%, left standstill 48 hours, get supernatant concentration to 1: 0.5 rare cream;
C) got Mel 2500g heated and boiled 0.5 hour, filter, add while hot, add 3000g yellow wine mixing again,, get the 10000ml Lactaggue oral administration liquid medicine again through the middling speed filter paper filtering by a, the spissated rare cream of b two procedures.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93103015 CN1078901A (en) | 1993-03-23 | 1993-03-23 | Lactaggue oral administration liquid medicine and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93103015 CN1078901A (en) | 1993-03-23 | 1993-03-23 | Lactaggue oral administration liquid medicine and production method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1078901A true CN1078901A (en) | 1993-12-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93103015 Pending CN1078901A (en) | 1993-03-23 | 1993-03-23 | Lactaggue oral administration liquid medicine and production method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN1078901A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1076612C (en) * | 1998-12-01 | 2001-12-26 | 王福臣 | Chinese-medicinal instant particles for promoting milk secretion and recovery of puerperant |
| CN101391059B (en) * | 2008-11-03 | 2011-10-26 | 吴旭东 | Oral liquid capable of stimulating milk secretion and restoring normal menstruation and preparation method thereof |
| CN102559453A (en) * | 2011-11-15 | 2012-07-11 | 黎秋萍 | Sweet wine with function of promoting lactation |
| CN104013041A (en) * | 2014-05-10 | 2014-09-03 | 安徽林苑农副食品有限公司 | Chicken soup for postnatal woman and making method of chicken soup |
-
1993
- 1993-03-23 CN CN 93103015 patent/CN1078901A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1076612C (en) * | 1998-12-01 | 2001-12-26 | 王福臣 | Chinese-medicinal instant particles for promoting milk secretion and recovery of puerperant |
| CN101391059B (en) * | 2008-11-03 | 2011-10-26 | 吴旭东 | Oral liquid capable of stimulating milk secretion and restoring normal menstruation and preparation method thereof |
| CN102559453A (en) * | 2011-11-15 | 2012-07-11 | 黎秋萍 | Sweet wine with function of promoting lactation |
| CN104013041A (en) * | 2014-05-10 | 2014-09-03 | 安徽林苑农副食品有限公司 | Chicken soup for postnatal woman and making method of chicken soup |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |