CN107890105A - Application of the papaya extractives in Medicament for Alcoholism is prepared - Google Patents
Application of the papaya extractives in Medicament for Alcoholism is prepared Download PDFInfo
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- CN107890105A CN107890105A CN201710971218.5A CN201710971218A CN107890105A CN 107890105 A CN107890105 A CN 107890105A CN 201710971218 A CN201710971218 A CN 201710971218A CN 107890105 A CN107890105 A CN 107890105A
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- papaya
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- 235000009467 Carica papaya Nutrition 0.000 title claims abstract description 54
- 241000219173 Carica Species 0.000 title claims abstract description 44
- 239000003814 drug Substances 0.000 title claims abstract description 14
- 208000007848 Alcoholism Diseases 0.000 title claims abstract description 7
- 201000007930 alcohol dependence Diseases 0.000 title claims abstract description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000000706 filtrate Substances 0.000 claims abstract description 24
- 238000000034 method Methods 0.000 claims abstract description 11
- 239000007864 aqueous solution Substances 0.000 claims abstract description 10
- 238000005119 centrifugation Methods 0.000 claims abstract description 10
- 238000002137 ultrasound extraction Methods 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000012153 distilled water Substances 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 238000004108 freeze drying Methods 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 3
- 238000002604 ultrasonography Methods 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 35
- 102000007698 Alcohol dehydrogenase Human genes 0.000 abstract description 21
- 108010021809 Alcohol dehydrogenase Proteins 0.000 abstract description 21
- 230000004060 metabolic process Effects 0.000 abstract description 6
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 241000219172 Caricaceae Species 0.000 abstract description 4
- 230000004913 activation Effects 0.000 abstract description 4
- 230000003213 activating effect Effects 0.000 abstract description 3
- 239000000284 extract Substances 0.000 abstract description 3
- 238000002474 experimental method Methods 0.000 abstract description 2
- 235000019441 ethanol Nutrition 0.000 description 25
- 230000000694 effects Effects 0.000 description 12
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 235000006264 Asimina triloba Nutrition 0.000 description 6
- 240000006432 Carica papaya Species 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000007853 buffer solution Substances 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 2
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 230000003228 microsomal effect Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 2
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 2
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 229940100228 acetyl coenzyme a Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- 230000009483 enzymatic pathway Effects 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 125000005909 ethyl alcohol group Chemical group 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Botany (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses application of the papaya extractives in Medicament for Alcoholism is prepared, papaya extractives are made of following methods：(1) wrinkled papaya is crushed；(2) mixed with methanol aqueous solution, ultrasonic extraction, centrifuge, obtain filter residue and filtrate；(3) methanol aqueous solution is added into filter residue, ultrasonic extraction, centrifugation, obtains filter residue and filtrate；(4) filtrate that combining step (2) and step (3) obtain；Evaporated under reduced pressure obtains residue；(5) distilled water is added into residue to redissolve；Filtering, filtrate freeze-drying, obtains papaya extractives.50g wrinkled papayas can obtain 30g dried extracts.Experiment proves that papaya extractives have activation to alcohol dehydrogenase (ADH), by activating ADH, accelerates metabolism of the ethanol in human body, blood alcohol concentration is reduced, so as to play sober-up function.
Description
Technical field
The present invention relates to the application of papaya extractives, belong to technical field of traditional Chinese medicines.
Background technology
Wine, it is a kind of common drink in people's daily life.Modern study finds that heavy drinking can be to each internal organs of body
Very big damage, and trigger a variety of diseases.Liver is the main place of alcohol metabolism in human body, therefore heavy drinking can give liver
Eubolism bring very big burden, or even trigger hepatic disease.
After alcohol enters human body, the organ such as direct oral cavity, esophagus, stomach, intestines directly enters blood circulation by biomembrane quickly,
And promptly transported to each histoorgan of whole body.About 10~20% alcohol absorbs under one's belt, and 70%~80% alcohol exists
Absorbed in intestines, the alcohol of stomach and intestinal absorption enters liver by blood circulation, has about 90% alcohol in liver metabolism.Alcohol
Metabolism in liver can be carried out by following three approach：1. the alcohol dehydrogenase of cytoplasm or intracellular soluble area
(ADH) approach；2. the microsomal ethanol oxidase approach of endoplasmic reticulum；3. the hydrogen peroxide enzymatic pathway of catalase system.When
When ethanol in blood concentration is not high, under ADH catalysis, ethanol is oxidized into acetaldehyde；When concentration of alcohol is too high, ethanol is main
Aoxidized, while also needed to by means of hydrogen peroxide oxidation enzyme system, microsomal ethanol oxidation system by ADH metabolic systems
It is metabolized with film combination ion conveyer system etc., and then forms acetaldehyde.In mitochondria, acetaldehyde passes through acetaldehyde dehydrogenase
(ALDH) acetic acid is converted into, acetic acid is entered tricarboxylic acid cycle in the form of acetyl coenzyme A, is oxidized to H2O and CO2, discharge simultaneously
A large amount of ATP.Therefore, ADH is that the Major Enzymes that ethanol is metabolized in vivo are participated in liver, has in alcohol metabolism and accelerates ethanol generation
Thank, reduce blood alcohol concentration, mitigate the important function such as its injury to body.
At present, there has been no using report of the papaya extractives as Medicament for Alcoholism.
The content of the invention
The purpose of the present invention is overcome the deficiencies in the prior art, there is provided a kind of papaya extractives answering in Medicament for Alcoholism is prepared
With.
Technical scheme is summarized as follows：
Application of the papaya extractives in Medicament for Alcoholism is prepared.
Preferably, papaya extractives are made of following methods：
(1) wrinkled papaya is crushed；
(2) it is 50% by the volumetric concentration of 10~15 times of the wrinkled papaya powder that step (1) obtains and wrinkled papaya silty amount
~70% methanol aqueous solution mixing, ultrasonic extraction 30~60 minutes, centrifugation, obtains filter residue and filtrate；
(3) volumetric concentration that 8~10 times of filter residue quality is added into the filter residue is 50%~70% methanol aqueous solution, is surpassed
Sound extracts 30~60 minutes, centrifugation, obtains filter residue and filtrate；
(4) filtrate that combining step (2) and step (3) obtain；Evaporated under reduced pressure obtains residue；
(5) distilled water that 5~8 times of mass of residue is added into residue redissolves；Filtering, filtrate freeze-drying, obtains pawpaw and carries
Take thing.
Experiment proves that papaya extractives have activation to alcohol dehydrogenase (ADH), by activating ADH, accelerates ethanol and exists
Metabolism in human body, blood alcohol concentration is reduced, so as to play sober-up function.
Embodiment
With reference to specific embodiment, the present invention is further illustrated.
Following examples are served only for explaining the present invention, are not intended to limit the scope of the present invention.
Embodiment 1
Papaya extractives are made of following methods：
(1) wrinkled papaya is crushed；
(2) first for being 60% by the volumetric concentration of 13 times of the wrinkled papaya powder that step (1) obtains and wrinkled papaya silty amount
Alcohol solution mixes, ultrasonic extraction 45 minutes, centrifugation, obtains filter residue and filtrate；
(3) volumetric concentration that 9 times of filter residue quality is added into the filter residue is 60% methanol aqueous solution, and ultrasonic extraction 45 is divided
Clock, centrifugation, obtains filter residue and filtrate；
(4) filtrate that combining step (2) and step (3) obtain；Evaporated under reduced pressure obtains residue；
(5) distilled water that 6 times of mass of residue is added into residue redissolves；Filtering, filtrate freeze-drying, obtain pawpaw extraction
Thing.
50g wrinkled papayas obtain 30g papaya extractives.
Embodiment 2
Papaya extractives are made of following methods：
(1) wrinkled papaya is crushed；
(2) first for being 50% by the volumetric concentration of 10 times of the wrinkled papaya powder that step (1) obtains and wrinkled papaya silty amount
Alcohol solution mixes, ultrasonic extraction 60 minutes, centrifugation, obtains filter residue and filtrate；
(3) volumetric concentration that 10 times of filter residue quality is added into the filter residue is 50% methanol aqueous solution, ultrasonic extraction 60
Minute, centrifugation, obtain filter residue and filtrate；
(4) filtrate that combining step (2) and step (3) obtain；Evaporated under reduced pressure obtains residue；
(5) distilled water that 8 times of mass of residue is added into residue redissolves；Filtering, filtrate freeze-drying, obtain pawpaw extraction
Thing.
50g wrinkled papayas obtain 31g papaya extractives.
Embodiment 3
Papaya extractives are made of following methods：
(1) wrinkled papaya is crushed；
(2) first for being 70% by the volumetric concentration of 15 times of the wrinkled papaya powder that step (1) obtains and wrinkled papaya silty amount
Alcohol solution mixes, ultrasonic extraction 30 minutes, centrifugation, obtains filter residue and filtrate；
(3) volumetric concentration that 8 times of filter residue quality is added into the filter residue is 70% methanol aqueous solution, and ultrasonic extraction 30 is divided
Clock, centrifugation, obtains filter residue and filtrate；
(4) filtrate that combining step (2) and step (3) obtain；Evaporated under reduced pressure obtains residue；
(5) distilled water that 5 times of mass of residue is added into residue redissolves；Filtering, filtrate freeze-drying, obtain pawpaw extraction
Thing.
50g wrinkled papayas obtain 29g papaya extractives.
Embodiment 4
Using effect of watt Le-Huo He (Valle＆Hoch) the improved method papaya extractives to ADH activity, specific side
Method is as follows：
1.5mL 20mmol/L sodium pyrophosphate buffer solutions (pH=8.8), 1.0mL 27mmol/L are added in test tube with ground stopper
DPN (NAD+) and 0.5mL absolute ethyl alcohols, be separately added into 0.2mL various concentrations the papaya extractives aqueous solution (25mg crude drugs/
ML, 10mg crude drug/mL), rapid mixing, capping incubation 5 minutes at 37 DEG C.Added immediately in test tube with ground stopper after incubation
0.1mLADH solution (adds the dissolving of 1.5mL sodium pyrophosphate buffer solutions and is prepared into ADH solution) in 5mgADH, with burnt phosphorus in control tube
Sour sodium buffer solution replaces ADH, shakes up, and 37 DEG C incubate 3 minutes, with its absorbance at 340nm of 722 type spectrophotometric determinations
Value, later reading every 30s once, METHOD FOR CONTINUOUS DETERMINATION 5min.Zero point is set up with control tube, the reaction group for being not added with medicine is blank
Group, calculate average absorbance value Δ A/min per minute.(papaya extractives are prepared by embodiment 1)
ADH activity calculating methods：
ADH activity (U/mL)=Δ A/min × 4900
Activity ratio calculates：
Activity ratio (%)=(enzymatic activity is without medicine control group-enzymatic activity dosing measure group)/enzymatic activity is without medicine × 100%
1 is the results are shown in Table, shows that papaya extractives have activation to ADH, and high and low dose group is without significant difference (P<
0.05).Papaya extractives can be accelerated metabolism of the ethanol in human body, reduce blood alcohol concentration, so as to play solution by activating ADH
Wine effect.
Activation of the papaya extractives of table 1 to ADH
| Group | ADH activity (U) | ADH activity ratios (%) |
| Blank group | 36.75±3.46a | --- |
| Pawpaw high dose group (25mg crude drugs/mL) | 42.47±2.83b | 15.56 |
| Pawpaw low dose group (10mg crude drugs/mL) | 45.73±2.83b | 24.44 |
Note：Alphabetical a, b represent two groups of data in P<0.05 level is upper, and there were significant differences.
It is demonstrated experimentally that the extract of embodiment 2 and embodiment 3 is similar to Example 1 to the effect of ADH activity influences.
Papaya extractives prepared by the present invention process piece agent, capsule, particle, oral liquid, effervescent tablet etc. as needed.
Claims (2)
1. application of the papaya extractives in Medicament for Alcoholism is prepared.
2. the application according to claim 1, it is characterized in that the papaya extractives are made of following methods：
(1) wrinkled papaya is crushed；
(2) volumetric concentration for 10~15 times of wrinkled papaya powder and wrinkled papaya silty amount for obtaining step (1) for 50%~
70% methanol aqueous solution mixing, ultrasonic extraction 30~60 minutes, centrifugation, obtains filter residue and filtrate；
(3) volumetric concentration that 8~10 times of filter residue quality is added into the filter residue is 50%~70% methanol aqueous solution, and ultrasound carries
Take 30~60 minutes, centrifuge, obtain filter residue and filtrate；
(4) filtrate that combining step (2) and step (3) obtain；Evaporated under reduced pressure obtains residue；
(5) distilled water that 5~8 times of mass of residue is added into residue redissolves；Filtering, filtrate freeze-drying, obtains papaya extractives.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710971218.5A CN107890105A (en) | 2017-10-18 | 2017-10-18 | Application of the papaya extractives in Medicament for Alcoholism is prepared |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710971218.5A CN107890105A (en) | 2017-10-18 | 2017-10-18 | Application of the papaya extractives in Medicament for Alcoholism is prepared |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107890105A true CN107890105A (en) | 2018-04-10 |
Family
ID=61803569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710971218.5A Pending CN107890105A (en) | 2017-10-18 | 2017-10-18 | Application of the papaya extractives in Medicament for Alcoholism is prepared |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107890105A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1443543A (en) * | 2002-03-07 | 2003-09-24 | 程彦杰 | Medicine composition with the action of relieving alcoholism and protecting liver and its application |
| CN105456819A (en) * | 2015-12-25 | 2016-04-06 | 东平县第二苗圃 | Pawpaw anti-alcohol liquid and preparation process thereof |
-
2017
- 2017-10-18 CN CN201710971218.5A patent/CN107890105A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1443543A (en) * | 2002-03-07 | 2003-09-24 | 程彦杰 | Medicine composition with the action of relieving alcoholism and protecting liver and its application |
| CN105456819A (en) * | 2015-12-25 | 2016-04-06 | 东平县第二苗圃 | Pawpaw anti-alcohol liquid and preparation process thereof |
Non-Patent Citations (4)
| Title |
|---|
| 《中医堂》编委会: "《食物功效与食疗全典》", 30 April 2015 * |
| 《健康大讲堂》编委会: "《不吃药治百病 男人食疗秘方大全书》", 28 February 2014 * |
| 赵余庆等: "《食疗与保健食品原料功能因子手册》", 1 March 2013 * |
| 马汴梁等: "《饮酒与解酒的学问》", 31 December 2015 * |
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