CN107875078A - A kind of anti-inflammatory oral cavity nursing agent - Google Patents
A kind of anti-inflammatory oral cavity nursing agent Download PDFInfo
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- CN107875078A CN107875078A CN201711435540.2A CN201711435540A CN107875078A CN 107875078 A CN107875078 A CN 107875078A CN 201711435540 A CN201711435540 A CN 201711435540A CN 107875078 A CN107875078 A CN 107875078A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
A kind of anti-inflammatory oral cavity nursing agent, it includes following components in parts by weight：3.0~4.5 parts of acrylic acid polymer；1.5~4.5 parts of sodium lauroyl sarcosine；1.0~3.0 parts of lauryl sodium sulfate；28~40 parts of NMF；0.2~0.5 part of sweetener；0.3~0.7 part of thickener；30~50 parts of rubbing agent；10~25 parts of deionized water；7~10 parts of marigold；The rubbing agent is longan seed powder and the compounding of wolf's milk powder.By the present invention in that the rubbing agent in being compounded by the use of longan seed powder and wolf's milk powder as oral cavity nursing agent both effectively drives away tooth stain, and can avoids therefore rubbed to cause the phenomenon of bleeding gums, and new hemostatic compositions need not be added, so as to reduce the production cost of oral cavity nursing agent.
Description
Technical field
The present invention relates to a kind of commodity technical field, more particularly to a kind of anti-inflammatory oral cavity nursing agent.
Background technology
Periodontal disease is common mouth disease, and its symptom mainly has bleeding gums, swelling, pain.There is statistics to show, tooth
The main reason for all diseases are more than 35 years old crowd's absence of tooth, it is seen that the seriousness of periodontal disease.But because patient is not easy to examine
Feel, most people is not aware that oneself is suffered from this disease.Think that people can just suffer from periodontal disease to old many human factor errors, it is actual
Upper 5 year old, children's can suffered from gingivitis.
Periodontosis is not only to influence the health of tooth, can also systemic health.Periodontosis is to whole body health in recent years
Influence caused the concern of people.Bacterial component and bacterial product are easy to be diffused into by oral pocket ulcer surface nearby or remote
Every organ, cause or aggravate some general diseases, such as coronary heart disease, low birth weight infant, diabetes, the hair of pulmonary infection disease
Hair tonic exhibition, seriously endanger health.It is that can not meet that people improve oral health water to depend merely on stomatological hospital and drug therapy
Flat needs, with the use of the oral cavity nursing health products with preventing and treating periodontal disease, periodontal disease is that progressively to be had
Imitate what is prevented and control.
In order to preferably prevent and treat periodontal disease, many people's selections are added into rubbing agent in oral cavity nursing agent, but add
After entering rubbing agent, people have found the easy bleeding of gum when carrying out oral care using the oral cavity nursing agent with rubbing agent, from
And infection is easily caused, and in order to stop blooding, also also need to be added into hemostatic compositions in oral cavity nursing agent, be able to must so increase
The production cost of oral cavity nursing agent.
The content of the invention
It is an object of the invention to overcome the shortcomings of that the above and defect propose a kind of anti-inflammatory oral cavity nursing agent.
To use following technical scheme up to this purpose, the present invention：
A kind of anti-inflammatory oral cavity nursing agent, it includes following components in parts by weight：
3.0~4.5 parts of acrylic acid polymer；
1.5~4.5 parts of sodium lauroyl sarcosine；
1.0~3.0 parts of lauryl sodium sulfate；
28~40 parts of NMF；
0.2~0.5 part of sweetener；
0.3~0.7 part of thickener；
15~30 parts of rubbing agent；
10~25 parts of deionized water；
7~10 parts of marigold；
The rubbing agent is longan seed powder and the compounding of wolf's milk powder.
Preferably, it also includes 0.02-0.06 part preservatives.
Preferably, the preservative is more than one or both of OIT, nipagin esters, potassium sorbate mixed
Compound.
Preferably, the NMF compounds for the one or more of which of propane diols, butanediol or glycine betaine.
Preferably, the sweetener is the one or two of saccharin sodium or xylitol.
Preferably, the thickener is that sodium carboxymethylcellulose, hydroxyethyl cellulose, the one or more of carbomer are answered
Match somebody with somebody.
Preferably, longan seed powder, the size of wolf's milk powder are 500-1000 mesh.If the powder used is crossed conference and made
Into laborious when brushing teeth, the inconvenience brushed teeth is caused；If too small, easily remain in the space of tooth, reduce in friction process
Friction, so as to reduce the ability of tooth stain expeling.And longan seed powder, wolf's milk floury texture be not hard, will not cause tooth
Tooth damages.
The present invention is used as rubbing agent by adding longan seed powder and wolf's milk powder compounding in oral cavity nursing agent, makes
The oral cavity nursing agent of acquisition can quickly remove the dirt for being attached to dental surface, avoid tooth jaundice or long decayed tooth, simultaneously because
The effect of friction, the easy bleeding of gum, and longan seed powder, humid euphorbia grass meal have the effect of cooling blood and hemostasis in itself, therefore use
Oral cavity nursing agent in longan seed powder, wolf's milk powder as rubbing agent both effectively drives away tooth stain, and can enough avoid because
This, which rubs, causes the phenomenon of bleeding gums, and need not add new hemostatic compositions, so as to reduce the production of oral cavity nursing agent
Cost.
Embodiment
Technical scheme is further illustrated below by embodiment.
Embodiment 1
A kind of anti-inflammatory oral cavity nursing agent, it includes following components in parts by weight：
3.0 parts of acrylic acid polymer；
1.5 parts of sodium lauroyl sarcosine；
1.0 parts of lauryl sodium sulfate；
28 parts of glycine betaine；
0.2 part of saccharin sodium；
0.3 part of sodium carboxymethylcellulose；
Longan seed powder, wolf's milk powder：Addition is added by table 1；
0.02 part of nipagin esters；
10 parts of deionized water；
7 parts of marigold.
Table 1 is influence of the addition of rubbing agent to expeling tooth stain ability
It can be obtained by table 1, after having used the rubbing agent of longan seed powder and wolf's milk powder as compounding, drive away tooth stain
Ability enhance, and either can reach 91 for the expeling dirt ability of the tooth stain that has been aged 15 days or 30 days
More than, and the compounding proportioning that optimal expeling soils are the longan seed powder and wolf's milk powder used is 2:1.
In order to test the effect of the present embodiment 1-1 to embodiment 1-3 obtains the hemostasis aspect of oral cavity nursing agent, mouse is carried out
Clinical hemostasis experiment mice clinical hemostasis experiment.
Clinical trial of stopping blooding uses blank lotion, Colgate-Palmolive toothpaste, Crest toothpaste, embodiment 1-1 into embodiment 1-3
Oral cavity nursing agent as examination thing sample.
Carried out using hemostasis observational technique is damaged to mouse liver local woanded surface.Take the kunming mice 108 of health, body weight
18~22g, male and female dual-purpose.After anesthetized mice, cut liver in left lobe of liver with operating scissors and be about 0.5cm, wide about 0.5cm, it is high about
0.5cm, after the blood for wiping ejection, immediately in situation portion spreading thing sample 0.5g to be tried, 1min is oppressed with 200g counterweights, after 1min
Counterweight is removed, haemostatic effect is observed, untill not bleeding.Such as still bleeding, add to apply and pressurizeed after thing sample is tried, observed every 30s
Once, bleeding stopping period is recorded, is such as no more than 3min, is then designated as stopping blooding；Such as fail to stop blooding more than 3min, be then designated as failing to stop
Blood, experimental result are shown in Table 2.
The clinical blood coagulation hemostasis experimental result of the mouse of table 2
| Try thing sample | Experiment number | Bleeding stopping period |
| Blank lotion | 18 | ＞ 3 |
| Colgate-Palmolive toothpaste | 18 | 2.65±0.22 |
| Crest toothpaste | 18 | 2.51±0.18 |
| Embodiment 1-1 oral cavity nursing agent | 18 | 2.17±0.15 |
| Embodiment 1-2 oral cavity nursing agent | 18 | 2.11±0.13 |
| Embodiment 1-3 oral cavity nursing agent | 18 | 2.06±0.12 |
As shown in Table 2, embodiment 1-1 to embodiment 1-3 oral cavity nursing agent is to mouse liver local woanded surface bleeding due to trauma
There is obvious blood coagulation haemostatic effect.
Embodiment 2
A kind of anti-inflammatory oral cavity nursing agent, it includes following components in parts by weight：
4.5 parts of acrylic acid polymer；
3.5 parts of sodium lauroyl sarcosine；
3.0 parts of lauryl sodium sulfate；
30 parts of butanediol；
0.3 part of saccharin sodium；
0.7 part of hydroxyethyl cellulose；
17 parts of longan seed powder, 8 parts of wolf's milk powder；
0.06 part of potassium sorbate；
20 parts of deionized water；
7.5 parts of marigold.
The oral cavity nursing agent of the present embodiment is 97/8 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of the tooth stain of 30 days is 91/12 day.
Embodiment 3
A kind of anti-inflammatory oral cavity nursing agent, it includes following components in parts by weight：
3.5 parts of acrylic acid polymer；
4.5 parts of sodium lauroyl sarcosine；
2.0 parts of lauryl sodium sulfate；
32 parts of propane diols；
0.5 part of xylitol；
0.6 part of carbomer；
13.5 parts of longan seed powder, wolf's milk powder 11.5；
0.04 part of OIT；
15 parts of deionized water；
10 parts of marigold.
The oral cavity nursing agent of the present embodiment is 97/8 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of the tooth stain of 30 days is 92/11 day.
Embodiment 4
A kind of anti-inflammatory oral cavity nursing agent, it includes following components in parts by weight：
4 parts of acrylic acid polymer；
3 parts of sodium lauroyl sarcosine；
1.5 parts of lauryl sodium sulfate；
35 parts of glycine betaine；
0.3 part of saccharin sodium；
0.2 part of sodium carboxymethylcellulose, 0.2 part of hydroxyethyl cellulose, 0.3 part of carbomer；
8 parts of longan seed powder 11, wolf's milk powder；
Nipagin esters 0.25,0.15 part of potassium sorbate；
22 parts of deionized water；
9 parts of marigold.
The oral cavity nursing agent of the present embodiment is 96/8 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of the tooth stain of 30 days is 92/19 day.
Embodiment 5
A kind of anti-inflammatory oral cavity nursing agent, it includes following components in parts by weight：
4.5 parts of acrylic acid polymer；
2.5 parts of sodium lauroyl sarcosine；
2.5 parts of lauryl sodium sulfate；
30 parts of butanediol；
0.4 part of xylitol；
0.4 part of sodium carboxymethylcellulose, 0.2 part of hydroxyethyl cellulose；
9 parts of longan seed powder, 7 parts of wolf's milk powder；
0.02 part of OIT, 0.03 part of nipagin esters；
14 parts of deionized water；
9.5 parts of marigold.
The oral cavity nursing agent of the present embodiment is 96/9 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of the tooth stain of 30 days is 91/18 day.
Embodiment 6
A kind of anti-inflammatory oral cavity nursing agent, it includes following components in parts by weight：
3.5 parts of acrylic acid polymer；
4 parts of sodium lauroyl sarcosine；
2 parts of lauryl sodium sulfate；
38 parts of propane diols；
0.3 part of xylitol, 0.2 part of saccharin sodium；
0.1 part of sodium carboxymethylcellulose, 0.3 part of carbomer；
10 parts of longan seed powder, 11.5 parts of wolf's milk powder；
0.05 part of OIT；
17.5 parts of deionized water；
8.5 parts of marigold.
The oral cavity nursing agent of the present embodiment is 97/9 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of the tooth stain of 30 days is 91/13 day.
Embodiment 7
A kind of anti-inflammatory oral cavity nursing agent, it includes following components in parts by weight：
4.1 parts of acrylic acid polymer；
4.5 parts of sodium lauroyl sarcosine；
2.7 parts of lauryl sodium sulfate；
10 parts of propane diols, 21 parts of glycine betaine；
0.3 part of saccharin sodium；
0.25 part of hydroxyethyl cellulose, 0.35 part of carbomer；
11 parts of longan seed powder, 11 parts of wolf's milk powder；
0.01 part of OIT, 0.01 part of potassium sorbate；
14.5 parts of deionized water；
8.5 parts of marigold.
The oral cavity nursing agent of the present embodiment is 97/7 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of the tooth stain of 30 days is 92/12 day.
Embodiment 8
A kind of anti-inflammatory oral cavity nursing agent, it includes following components in parts by weight：
3.8 parts of acrylic acid polymer；
4.2 parts of sodium lauroyl sarcosine；
2.5 parts of lauryl sodium sulfate；
24 parts of butanediol, 10 parts of glycine betaine；
0.3 part of xylitol, 0.1 part of saccharin sodium；
0.55 part of hydroxyethyl cellulose；
9 parts of longan seed powder, 15 parts of wolf's milk powder；
0.01 part of OIT, 0.02 part of nipagin esters；
20.5 parts of deionized water；
9.5 parts of marigold.
The oral cavity nursing agent of the present embodiment is 97/10 day for the expeling ability of the tooth stain of ageing 15 days；For old
The expeling ability for changing the tooth stain of 30 days is 91/17 day.
Embodiment 9
A kind of anti-inflammatory oral cavity nursing agent, it includes following components in parts by weight：
3.2 parts of acrylic acid polymer；
1.8 parts of sodium lauroyl sarcosine；
1.0 parts of lauryl sodium sulfate；
28 parts of propane diols, butanediol or glycine betaine；
0.25 part of xylitol；
0.35 part of sodium carboxymethylcellulose；
8 parts of longan seed powder, 10 parts of wolf's milk powder；
0.02 part of OIT, 0.01 part of nipagin esters, 0.03 part of potassium sorbate；
15 parts of deionized water；
7 parts of marigold.
The oral cavity nursing agent of the present embodiment is 97/9 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of the tooth stain of 30 days is 91/15 day.
Embodiment 10
A kind of anti-inflammatory oral cavity nursing agent, it includes following components in parts by weight：
3.2 parts of acrylic acid polymer；
2.1 parts of sodium lauroyl sarcosine；
1.8 parts of lauryl sodium sulfate；
14 parts of propane diols, 23 parts of butanediol；
0.2 part of xylitol, 0.25 part of saccharin sodium；
0.5 part of carbomer；
12 parts of longan seed powder, 8 parts of wolf's milk powder；
0.01 part of potassium sorbate, 0.02 part of OIT；
25 parts of deionized water；
10 parts of marigold.
The oral cavity nursing agent of the present embodiment is 98/8 day for the expeling ability of the tooth stain of ageing 15 days；For ageing
The expeling ability of the tooth stain of 30 days is 92/12 day.
The technical principle of the present invention is described above in association with specific embodiment.These descriptions are intended merely to explain the present invention's
Principle, and limiting the scope of the invention can not be construed in any way.Based on explanation herein, the technology of this area
Personnel would not require any inventive effort the other embodiments that can associate the present invention, and these modes are fallen within
Within protection scope of the present invention.
Claims (7)
1. a kind of anti-inflammatory oral cavity nursing agent, it is characterised in that it includes following components in parts by weight：
3.0~4.5 parts of acrylic acid polymer；
1.5~4.5 parts of sodium lauroyl sarcosine；
1.0~3.0 parts of lauryl sodium sulfate；
28~40 parts of NMF；
0.2~0.5 part of sweetener；
0.3~0.7 part of thickener；
30~50 parts of rubbing agent；
10~25 parts of deionized water；
7~10 parts of marigold；
The rubbing agent is longan seed powder and the compounding of wolf's milk powder.
A kind of 2. anti-inflammatory oral cavity nursing agent according to claim 1, it is characterised in that：It also prevents including 0.02-0.06 parts
Rotten agent.
A kind of 3. anti-inflammatory oral cavity nursing agent according to claim 2, it is characterised in that：The preservative is isothiazoline
Mixture more than one or both of ketone, nipagin esters, potassium sorbate.
A kind of 4. anti-inflammatory oral cavity nursing agent according to claim 1, it is characterised in that：The NMF is propane diols, fourth
The one or more of which of glycol or glycine betaine compounds.
A kind of 5. anti-inflammatory oral cavity nursing agent according to claim 1, it is characterised in that：The sweetener is saccharin sodium or wood
The one or two of sugar alcohol.
A kind of 6. anti-inflammatory oral cavity nursing agent according to claim 1, it is characterised in that：The thickener is carboxymethyl cellulose
Plain sodium, hydroxyethyl cellulose, one or more compoundings of carbomer.
A kind of 7. anti-inflammatory oral cavity nursing agent according to claim 1, it is characterised in that：The longan seed powder, wolf's milk
The size of powder is 500-1000 mesh.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711435540.2A CN107875078A (en) | 2017-12-26 | 2017-12-26 | A kind of anti-inflammatory oral cavity nursing agent |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711435540.2A CN107875078A (en) | 2017-12-26 | 2017-12-26 | A kind of anti-inflammatory oral cavity nursing agent |
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| CN107875078A true CN107875078A (en) | 2018-04-06 |
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| CN201711435540.2A Withdrawn CN107875078A (en) | 2017-12-26 | 2017-12-26 | A kind of anti-inflammatory oral cavity nursing agent |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020118603A1 (en) * | 2018-12-13 | 2020-06-18 | Colgate-Palmolive Company | Oral care compositions including botanicals and methods for the same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104248571A (en) * | 2014-09-19 | 2014-12-31 | 云南七丹药业股份有限公司 | Purely natural plant-containing abradant toothpaste and preparation method thereof |
-
2017
- 2017-12-26 CN CN201711435540.2A patent/CN107875078A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104248571A (en) * | 2014-09-19 | 2014-12-31 | 云南七丹药业股份有限公司 | Purely natural plant-containing abradant toothpaste and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 熊辅信，等: "《中药现代研究荟萃》", 31 May 2002, 云南科技出版社 * |
| 老中医养生堂: "《本草纲目中药草使用图鉴》", 30 April 2016, 福建科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020118603A1 (en) * | 2018-12-13 | 2020-06-18 | Colgate-Palmolive Company | Oral care compositions including botanicals and methods for the same |
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Application publication date: 20180406 |