CN107865932B - Traditional Chinese medicine composition with weight losing effect - Google Patents
Traditional Chinese medicine composition with weight losing effect Download PDFInfo
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- CN107865932B CN107865932B CN201610849575.XA CN201610849575A CN107865932B CN 107865932 B CN107865932 B CN 107865932B CN 201610849575 A CN201610849575 A CN 201610849575A CN 107865932 B CN107865932 B CN 107865932B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
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Abstract
The invention provides a traditional Chinese medicine composition with a weight-losing effect, and raw material medicines of the traditional Chinese medicine composition comprise rhizoma alismatis, poria cocos and dogwood. The traditional Chinese medicine composition can obviously inhibit the weight increase of high-fat mice, but does not influence the food intake of the mice.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition with a weight-losing effect, and belongs to the field of medicine and health care.
Background
The rapid development of modern urban life also brings a series of rich diseases. Among them, three highs and obesity are the first enemies bothering people. "hypertension, hyperglycemia and hyperlipidemia" refer to hypertension, hyperglycemia (diabetes) and hyperlipidemia. Often accompanied by obesity. They are "rich diseases" derived from modern society, and may exist alone or be related to each other. Such as: diabetes patients are easy to suffer from hypertension or hyperlipidemia at the same time, the hyperlipidemia is also a main factor for the formation and development of arteriosclerosis, and the blood vessel elasticity of arteriosclerosis patients is poor to aggravate the increase of blood pressure, so that the three-high disease is formed in the later period. The world health organization has clearly proposed that the first line of defense in preventing cardiovascular disease is to reduce "three highs" and control "three highs". Therefore, the weight loss becomes a fashion of modern people.
The methods for losing weight and reducing fat are various, and comprise dietotherapy, exercise therapy, pharmacotherapy, clinical treatment and the like, and the methods have more or less defects and are easy to cause side effects such as diarrhea, anorexia and the like. The traditional Chinese medicine for losing weight has the characteristics of convenient use, no toxic or side effect, remarkable efficacy and the like, and is favored by consumers.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition with a weight-losing effect, and raw material medicines of the traditional Chinese medicine composition comprise rhizoma alismatis, poria cocos and dogwood.
Preferably, the traditional Chinese medicine composition comprises the following raw medicines: 30-60 parts of rhizoma alismatis, 1-5 parts of poria cocos and 40-70 parts of dogwood;
further preferably, the traditional Chinese medicine composition comprises the following raw medicines: 30-40 parts of rhizoma alismatis, 3-5 parts of poria cocos and 50-70 parts of dogwood; or 40-60 parts of rhizoma alismatis, 1-3 parts of poria cocos and 40-50 parts of dogwood;
further preferably, the Chinese medicinal composition comprises the following raw material medicaments: 33-38 parts of rhizoma alismatis, 3.5-4.5 parts of poria cocos and 55-65 parts of dogwood; or rhizoma alismatis 45-58 parts by weight, poria cocos wolf 1.5-2.5 parts by weight and cornus officinalis 42-46 parts by weight;
most preferably, the traditional Chinese medicine composition comprises the following raw medicines: 36 parts of rhizoma alismatis, 4 parts of poria cocos and 60 parts of dogwood; or 54 parts of rhizoma alismatis, 2 parts of poria cocos and 44 parts of dogwood.
In some embodiments, the composition is a composition prepared by pulverizing rhizoma alismatis, poria cocos and dogwood and then combining the pulverized rhizoma alismatis, poria cocos and dogwood, or an extract prepared by combining the rhizoma alismatis, the poria cocos and the dogwood or respectively extracting the rhizoma alismatis, the poria cocos and the dogwood by any conventional method, and the extraction method comprises soaking extraction, decoction extraction, percolation extraction, reflux extraction, ultrasonic extraction and the like; the extraction solvent comprises water and 20-95% ethanol solution.
In some embodiments, the composition can be processed into conventional dosage forms for convenient administration, such as powders, oral liquids, capsules, tablets, pills, granules, and the like.
In some embodiments, the composition is prepared by mixing the extracts of the rhizoma alismatis, the poria cocos and the dogwood according to the proportion, the extracts are obtained by extracting the rhizoma alismatis, the poria cocos and the dogwood by any conventional method, and the extraction method comprises soaking extraction, decoction extraction, percolation extraction, reflux extraction, ultrasonic extraction and the like; the extraction solvent comprises water and 20-95% ethanol solution.
The invention also provides application of the traditional Chinese medicine composition in preparation of a medicine or health-care product with the weight-losing effect.
The auxiliary materials are substances except the main medicine which are necessary in the preparation or blending process of the medicine preparation, generally have no physiological activity, and do not influence the curative effect, content measurement and stability of the medicine in the medicine preparation. Comprises bulking agent, disintegrating agent, lubricant, suspending agent, binder, sweetener, correctant, antiseptic, matrix, etc. The filler comprises: starch, pregelatinized starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose, etc.; the disintegrating agent comprises: starch, pregelatinized starch, microcrystalline cellulose, sodium carboxymethyl starch, crospolyvinylpyrrolidone, low-substituted hydroxypropylcellulose, croscarmellose sodium, etc.; the lubricant comprises: magnesium stearate, sodium lauryl sulfate, talc, silica, and the like; the suspending agent comprises: polyvinylpyrrolidone, microcrystalline cellulose, sucrose, agar, hydroxypropyl methylcellulose, and the like; the binder includes starch slurry, polyvinylpyrrolidone, hydroxypropyl methylcellulose, etc.
The research of the invention shows that the traditional Chinese medicine composition can obviously inhibit the weight increase of a high-fat mouse, but does not influence the food intake of the mouse, and the effect of inhibiting the weight increase of the composition of the invention is unrelated to the food intake inhibition.
Detailed Description
Example 1 powder preparation
36g of rhizoma alismatis, 4g of poria cocos and 60g of dogwood;
the raw materials are taken according to the proportion and are crushed into fine powder to obtain the traditional Chinese medicine.
EXAMPLE 2 tablets
33g of rhizoma alismatis, 4.5g of poria cocos and 55g of dogwood;
taking the raw materials according to the proportion, adding water, decocting for 2 times, each time for 1 hour, filtering, combining filtrates, concentrating, adding appropriate amount of adjuvants, mixing, granulating, tabletting, and coating with film to obtain tablet.
EXAMPLE 3 capsules
38g of rhizoma alismatis, 3.5g of poria cocos and 65g of dogwood;
taking the raw materials according to the proportion, adding water, decocting for 2 times, each time for 1 hour, filtering, combining filtrates, concentrating, adding an appropriate amount of auxiliary materials, mixing uniformly, granulating in one step, and encapsulating to obtain the capsule.
EXAMPLE 4 oral liquid
30g of rhizoma alismatis, 5g of poria cocos and 50g of dogwood;
taking the raw materials according to the proportion, adding ethanol, extracting under reflux for 2 times, each time for 1 hour, filtering, mixing filtrates, recovering ethanol, adding adjuvants, and making into oral liquid.
Example 5 granules
40g of rhizoma alismatis, 3g of poria cocos and 70g of dogwood;
taking the raw materials according to the proportion, adding ethanol, performing ultrasonic extraction for 2 times, each time for 30min, filtering, combining filtrates, recovering ethanol, and performing dry granulation to obtain the granule.
EXAMPLE 6 powder preparation
54g of rhizoma alismatis, 2g of poria cocos and 44g of dogwood;
the raw materials are taken according to the proportion and are crushed into fine powder to obtain the traditional Chinese medicine.
EXAMPLE 7 tablets
45g of rhizoma alismatis, 2.5g of poria cocos and 42g of dogwood;
taking the raw materials according to the proportion, adding water, decocting for 2 times, each time for 1 hour, filtering, combining filtrates, concentrating, adding appropriate amount of adjuvants, mixing, granulating, tabletting, and coating with film to obtain tablet.
EXAMPLE 8 capsules
58g of rhizoma alismatis, 1.5g of poria cocos and 46g of dogwood;
taking the raw materials according to the proportion, adding water, decocting for 2 times, each time for 1 hour, filtering, combining filtrates, concentrating, adding an appropriate amount of auxiliary materials, mixing uniformly, granulating in one step, and encapsulating to obtain the capsule.
Example 9 oral liquid
40g of rhizoma alismatis, 3g of poria cocos and 40g of dogwood;
taking the raw materials according to the proportion, adding ethanol, extracting under reflux for 2 times, each time for 1 hour, filtering, mixing filtrates, recovering ethanol, adding adjuvants, and making into oral liquid.
Example 10 granules
60g of rhizoma alismatis, 1g of poria cocos and 50g of dogwood;
taking the raw materials according to the proportion, adding ethanol, performing ultrasonic extraction for 2 times, each time for 30min, filtering, combining filtrates, recovering ethanol, and performing dry granulation to obtain the granule.
Example 11
36g of rhizoma alismatis extract, 4g of poria cocos extract and 60g of dogwood extract.
The extracts are respectively obtained by decocting the raw material medicines with water.
Example 12
54g of rhizoma alismatis extract, 2g of poria cocos extract and 44g of dogwood.
The extracts are respectively obtained by decocting the raw material medicines with water.
Example 13
1. Experimental Material
1.1 Experimental animals:
SPF grade 10 week old C57BL/6 male mouse (Beijing Wittingli experiment animal technology Co., Ltd., animal qualification No.: SCXK (Jing) 2012-0001)
1.2 drugs and reagents:
the feed includes low-fat feed (D12450B), high-fat feed (D12451) and Research Diets.
The medicine is LIUWEIDIHUANG pill (big honeyed pill), and is prepared by pharmaceutical factory of Tongrentang scientific and technological development GmbH.
The medicinal materials are as follows: poria, Alismatis rhizoma, and Corni fructus, which are purchased from Peking Hojingtang drugstore, by pulverizing and sieving with 100 mesh sieve.
Preparation: all the medicines and the medicinal powder are prepared into a suspension solution by using purified water for gastric lavage.
1.3 Instrument:
electronic balance (model YP 2001N), upper marine flat instruments ltd; precision balance (model JA 1103N), shanghai national bridge precision scientific instruments ltd.
2. Experimental methods
2.1 animal grouping and administration
Animal grouping: the group was randomly divided into control (low fat, LFD), High Fat (HFD), high fat + group formula 1 (Alisma orientale 0.22g/kg/d + Cornus officinalis 0.7g/kg/d + Poria cocos 0.08g/kg/d), high fat + group formula 2 (Alisma orientale 0.36g/kg/d + Poria cocos 0.04g/kg/d + Cornus officinalis 0.6g/kg/d), high fat + group formula 3 (Cornus officinalis 0.44g/kg/d + Poria cocos 0.02g/kg/d + Alisma orientale 0.54g/kg/d), high fat + Liuwei Dihuang pill group, and 12 patients in each group.
Animal administration: the administration route is intragastric administration, the administration volume is 0.1ml/10g, once a day, wherein the mice in a control group (low fat, LFD) and High Fat (HFD) group are intragastric with purified water with the same volume, the formula of the group is 1.0g/kg/d for 1-3, and the aqueous solution of the six-ingredient pill of rehmannia is 1.5g/kg/d for six-ingredient group.
2.2 measurement of mouse body weight and food intake
Initial body weights were recorded before the start of the experiment and mouse body weights and food intake were measured weekly after the start of the experiment.
2.3 statistical analysis
Data of the experiment are expressed as mean values
Standard Deviation (SD) expressed as SPSS17.0 statistical analysis, as determined by Oneway-ANOVA, and as compared two-by-two by post hoc Bonferroni/Tukey test, P<0.05 was statistically significant.
3. Results of the experiment
3.1 Effect of drugs on mouse body weight
The results are shown in table 1, where the mice in the high-fat group gained significantly more body weight than the control group at the end of the first week compared to the low-fat diet group; at the end of the second week, the average body weight of mice in the high fat group was significantly higher than that in the control group.
And the administration of the formula or LIUWEIDIHUANG pill has an inhibitory effect on the weight gain of the mice compared with the high-fat group, wherein at the end of the second week, the average weight of the mice of the two groups of formula 2 and formula 3 is significantly lower than that of the high-fat group (P < 0.05; P < 0.01); mice in the LIUWEIDIHUANG pill group were slightly lower in body weight than the high fat group, but there was no statistical difference.
Table 1 effect of drugs on high fat diet induced obesity in mice (g) (n-12)
In contrast to the low-fat group,##P<0.01, to high fat group,. P<0.05
3.2 Effect of drugs on mouse food intake
Through observation of 2 weeks, the food intake of mice in the high-fat feed and each drug group is not obviously changed, which indicates that the effect of the drug on inhibiting the weight increase of the mice has no direct relation with the food intake.
Table 2 effect of drugs on high fat diet induced feed intake (grams) in obese mice (n ═ 12)
| Group/time | 1 week | 2 weeks |
| Low fat group | 2.32±0.28 | 2.33±0.08 |
| High fat group | 2.18±0.28 | 2.13±0.14 |
| Six-ingredient group | 2.52±0.77 | 2.47±0.05 |
| Composition 1 group | 2.18±0.39 | 2.23±0.24 |
| Composition 2 groups | 2.14±0.10 | 2.13±0.15 |
| Composition 3 groups | 2.20±0.14 | 2.14±0.28 |
The following conclusions were drawn from the analysis of the experimental results: the medicine has effect in reducing body weight of mice induced obesity by high fat diet without affecting food intake. Wherein, the effects of the compositions 2 and 3 are more obvious and rapid.
Claims (4)
1. A traditional Chinese medicine composition with a weight-losing effect is characterized by comprising the following raw material medicines: 33-38 parts of rhizoma alismatis, 3.5-4.5 parts of poria cocos and 55-65 parts of dogwood; or rhizoma alismatis 45-58 parts by weight, poria cocos wolf 1.5-2.5 parts by weight and dogwood 42-46 parts by weight.
2. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition comprises the following raw medicines: 36 parts of rhizoma alismatis, 4 parts of poria cocos and 60 parts of dogwood; or 54 parts of rhizoma alismatis, 2 parts of poria cocos and 44 parts of dogwood.
3. The Chinese medicinal composition according to claim 1 or 2, wherein the composition is prepared by pulverizing Alismatis rhizoma, Poria and Corni fructus and mixing, or by mixing Alismatis rhizoma, Poria and Corni fructus or extracting respectively by conventional method, wherein the extraction method is selected from one of soaking extraction, decocting extraction, percolating extraction, reflux extraction and ultrasonic extraction; the extraction solvent is selected from water or 20-95% ethanol solution.
4. Use of the Chinese medicinal composition of claim 1 or 2 in the preparation of a medicament or health product with weight-reducing effect.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102688366A (en) * | 2012-06-20 | 2012-09-26 | 高娟 | Medicine for treating senile adiposity |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102688366A (en) * | 2012-06-20 | 2012-09-26 | 高娟 | Medicine for treating senile adiposity |
Non-Patent Citations (3)
| Title |
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| 《中药泽泻对小鼠前体脂肪细胞3T3-L1细胞增殖及凋亡的影响》;潘开瑞等;《生物技术世界》;20130915(第9期);第2段 * |
| 《山茱萸糖蛋白的纯化及部分理化性质研究》;唐成康等;《天然产物研究与开发》;20050228;第17卷(第2期);摘要 * |
| 《药食两用中药茯苓的研究进展》;邵岩岩等;《中华中医药学会中药化学分会第九届学术年会论文集》;20140719;第一卷(第一期);摘要 * |
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Inventor after: Tang Minke Inventor after: Qiao Yuan Inventor after: Ma Qing Inventor after: Fan Yue Inventor after: Li Ya Inventor after: Fan Chunlan Inventor after: Yang Fei Inventor after: Gao Wenhui Inventor before: Tang Minke Inventor before: Qiao Yuan Inventor before: Fan Yue Inventor before: Li Ya Inventor before: Ma Qing Inventor before: Fan Chunlan Inventor before: Yang Fei Inventor before: Gao Wenhui |
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