CN107854644A - Utilize the method for Chinese yew production antibiotic and sterilizing hemostasis class product - Google Patents
Utilize the method for Chinese yew production antibiotic and sterilizing hemostasis class product Download PDFInfo
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- CN107854644A CN107854644A CN201711057861.3A CN201711057861A CN107854644A CN 107854644 A CN107854644 A CN 107854644A CN 201711057861 A CN201711057861 A CN 201711057861A CN 107854644 A CN107854644 A CN 107854644A
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- chinese yew
- raw material
- antibiotic
- sterilizing
- chinese
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- 241001149649 Taxus wallichiana var. chinensis Species 0.000 title claims abstract description 169
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 52
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 43
- 230000023597 hemostasis Effects 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 25
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- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 6
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 6
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- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 11
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The method that Chinese yew is raw material production antibiotic and sterilizing hemostasia products is utilized the present invention relates to a kind of.The stem of Chinese yew, branch, leaf, root are crushed, after mixing to the water for adding 20 60% in the raw material of crushing, carries out fermenting for 36 48 hours under conditions of 20 50 DEG C, is then dried, crushes again, obtain 150 200 mesh Chinese yew fine powders.Then extraction with aqueous solution method and organic solvent extraction are used, obtains Chinese yew water logging extracting method through drying the powder raw material obtained and Chinese yew organic solvent leach extraction method through drying the powder raw material obtained.The Chinese yew raw material that two kinds of methods are obtained carries out scientific matching, according to the production method of washing lotion, gel, spray and hemostasia products, production Chinese yew antibiotic and sterilizing hemostasis series of products.The present invention is primary raw material using Chinese yew, produces the wide variety of antibiotic and sterilizing hemostasia products of the mankind, and a new way is opened up for Chinese yew development and application.New resources are developed for antibiotic and sterilizing hemostasis industry.
Description
Technical field
It is more particularly to a kind of to be prepared using Chinese yew for raw material the invention belongs to the preparation method technical field of biochemical article
The method of antibiotic and sterilizing hemostasis class product.
Background technology
Chinese yew, it is the common name of the plant of Taxus.About 11 kinds of the category, is distributed in the Northern Hemisphere.There is 4 kind of 1 mutation in China.
For Taxus in shallow rooted plant, its main root unobvious, lateral root are flourishing, are that generally acknowledged endangered natural rare anticancer is planted in the world
Thing, it is that have passed through the ancient few survivors seeds that quaternary glacier carries over, the existing history of 2,500,000 years on earth.Due to
Growth of taxol speed is slow under natural conditions, and power of regeneration is poor, so since some time, has not been formed also in world wide
The Chinese yew raw material forestbase touched is advised greatly.
Chinese yew is used as medicine with stem, branch, leaf, root.Main component is containing taxol, taxine, diterpenoids compound.There is anticancer work(
Can, and have and suppress diabetes and the cardiopathic effectiveness for the treatment of.The taxol pair being extract from the bark and leaf of Chinese yew
Several late cancers curative effect protrudes, and is referred to as " last line of defense for the treatment of cancer ".But growth of taxol is slow, naturally more
New ability, 10 mu of artificial growth are only capable of refining the taxol of 1 kilogram of 1% purity.High-purity taxol is expensive, per kilogram
2000000 yuans or so.So extracting drug taxol active ingredient using Chinese yew, cost is too high.In order to obtain effectively
Medicine, artificial propagation of the scientific circles to Chinese yew have carried out substantial amounts of research work, in the late two decades, the artificial growth of Chinese yew
Rapid development is had occurred that, for cultivated area from 140,000 mu of 2005, development increases to 300,000 mu, thoroughly solves Chinese yew
Main points of cultivation, but from Chinese yew extraction taxol production technology do not developed accordingly really, carried using Chinese yew
Take taxol drug cost too high, restricted by economic condition, without the development prospect of large-scale production, cause innumerable trials and tribulations to plant
Chinese yew do not sell outlet, its main cause is:The complex manufacturing of taxol, factor of influence are extracted from Chinese yew
More, working condition is difficult control, and batch production difficulty is big, and no scale standard practices so far.
Secondly, the technology that taxol is produced using synthetic method has been mature on the whole, and the simple production cost of technique is low, and implementing should
With conveniently.Therefore, the Chinese yew by research plantation in arduous how many years can not obtain effective utilization, not have following process product,
It can only be appreciated as potted landscape, or the scattered pearl of people's wearing be processed into using it.Cause the great wasting of resources.
The content of the invention
The present invention provides a kind of method for producing antibiotic and sterilizing hemostasis class product for resource using Chinese yew, solves Chinese yew
Resource utilization issue, an effective way is provided for the development of Chinese yew.Meanwhile provided for antibiotic and sterilizing hemostasis industry development
New resources.
The technical scheme is that producing the method for antibiotic and sterilizing class product using Chinese yew, comprise the steps:
Step 1, Feedstock treating:
The growth selection Chinese yew stem of more than 3 years, branch, leaf, root are dried;Then with pulverizer by dried stem,
Branch, leaf, root are crushed to the coarse powder of 60-100 mesh, to addition water 20-60% mixing, stirring in raw material, under conditions of 20-50 DEG C
Spontaneous fermentation 36-48 hours are carried out, are dried, then crush the Chinese yew fine powder raw material for obtaining 150-200 mesh, Chinese yew crushed
Environment temperature is less than 80 DEG C in journey;
The extraction of step 2, active ingredient:
Extraction with aqueous solution method:In 25 DEG C~60 DEG C temperature ranges, Chinese yew fine powder 30-50 unit of weight of raw material is added
Enter into the aqueous solution of 100 unit of weights, filtered after soaking 4-10 hours, obtain Chinese yew water immersion extracting liq;Then
It is spray-dried, drying condition is 40 DEG C~60 DEG C of normal temperature, and spray drying material liquid pressure is 2020-20200kpa, 20-
200atm;
Organic solvent extraction:In 25 DEG C~40 DEG C temperature ranges, by Chinese yew fine powder 30-50 unit of weight of raw material
It is added in the ethanol solution of 100 unit of weights, is filtered after soaking 4-6 hours, obtains Chinese yew organic solvent soak extraction
Liquid;Then it is dried, drying condition is 40 DEG C~60 DEG C of normal temperature, and spray drying material liquid pressure is 2020-20200kpa,
20-200atm;
Step 3, mixing obtain the raw materials for production of different proportion:
The Chinese yew water immersion extracting liq that said extracted is obtained is organic through drying the powder raw material obtained and Chinese yew
Solvent soaking extract solution dries the powder raw material obtained according to 1:1~1.5,1:1.5~2,1:2~2.5 ratio mixing, is obtained
The mixed material of three kinds of heterogeneity contents, and it is named as Chinese yew No.1 raw material;No. two raw materials of Chinese yew;Chinese yew
No. three raw materials;
Step 4, production antibiotic and sterilizing hemostasis class product:
A, antibacterial disinfecting lotion product is prepared:By Chinese yew No.1 raw material according to antibacterial disinfecting lotion preparation method, production
Antibiotic and sterilizing product, specific product production method are as follows:Each raw material weight proportioning of soup processed is as follows:Chinese yew No.1 raw material 50-80%, hundred
Portion 3--15%, frutus cnidii 5-15%, kuh-seng 5-15%, Radix Angelicae Sinensis 3-6%, borneol 2-6%, poly hexamethylene biguanide 0.002-
0.003%;The tuber of stemona, frutus cnidii, kuh-seng, Radix Angelicae Sinensis are weighed according to formula, add water 1000ml to decoct 60-80 minutes;Filtering, heating
500-600ml is concentrated to, Chinese yew No.1 raw material is then added and borneol, poly hexamethylene biguanide is mixed, concentrates, divided
Dress, manufactured Chinese yew bacteriostatic water solution;The density of Chinese yew bacteriostatic water solution is not less than 1.300kg/L;Its antibacterial prepared
Disinfectant lotion product reaches national sterile products requirement standard;
B. antibiotic and sterilizing gel products are prepared:By No. two raw materials of Chinese yew according to antibiotic and sterilizing gel process for preparing, production
Antibiotic and sterilizing gel products, specific product production method are as follows:Each raw material weight proportioning of soup processed is as follows:No. two raw material 50- of Chinese yew
80%th, tuber of stemona 3--10%, frutus cnidii 5-15%, kuh-seng 5-15%, golden cypress 3-10%, borneol 2-6%, the pyridine of acetic acid chlorine
0.002-0.005%, auxiliary material card pool nurse 2-5%, glycerine 4-8%, triethanolamine 2-5%, ethylparaben 2-4%;By the tuber of stemona,
Frutus cnidii, kuh-seng, golden cypress weigh according to formula, add water 1000ml to decoct 60-80 minutes;Filtering, then add Chinese yew No. two
Raw material and borneol, the pyridine of acetic acid chlorine mix, add card pool nurse, glycerine, triethanolamine, ethylparaben mixing,
Concentration, packing, the manufactured antibacterial hydrogel of Chinese yew;The addition of auxiliary material is control production in the antibacterial hydrogel of Chinese yew of preparation
The key factor of product concentration and viscosity;Its antibiotic and sterilizing gel products prepared reaches national sterile products requirement standard;
C. antibiotic and sterilizing spray product is prepared:By the extraction raw material of three kinds of different proportions of Chinese yew according to antibiotic and sterilizing spray
Preparation method, produce antibiotic and sterilizing spray product, specific product production method is as follows:Each raw material weight proportioning of soup processed is as follows:Red bean
China fir No.1 raw material 20-50%;, No. two raw material 20-50% of Chinese yew, Chinese yew No. three raw material 40-60%, auxiliary material borneol 1-8%,
Peppermint 2-6%, purified water 300-1000ml;No. three Chinese yew No.1 raw material, No. two raw materials of Chinese yew and Chinese yew raw materials are pressed
Weighed according to formula, add water to mix;Filtering, it is concentrated to 500-800ml and then adds borneol, peppermint auxiliary material mixes dissolving, divides
Dress, manufactured Chinese yew stoste wound aqueous solution spray;The antibiotic and sterilizing spray product of preparation reaches national sterile products will
Seek standard.
D, antibiotic and sterilizing hemostasia products are prepared:By the extraction raw material of three kinds of different proportions of Chinese yew according to antibiotic and sterilizing spray
Preparation method, produce antibiotic and sterilizing hemostasia products, specific product production method is as follows:Each raw material weight proportioning of soup processed is as follows:Red bean
China fir No.1 raw material 30-50%;, No. two raw material 30-50% of Chinese yew, Chinese yew No. three raw material 20-60%, auxiliary material borneol 1-4%,
Peppermint 2-5%, purified water 100-300ml;By Chinese yew No.1 raw material, No. three raw materials of No. two raw materials of Chinese yew and Chinese yew according to
Formula weighs, and adds water to mix;Borneol, peppermint auxiliary material mixing dissolving, packing are added under the conditions of 40 DEG C~60 DEG C, it is manufactured
The Chinese yew stoste trauma hemostasis aqueous solution, the hemostasis sterile products that can be prepared using the solution, and reach national disinfecting hemostasis
Product requirement standard.
The Chinese yew production antibiotic and sterilizing hemostasis class product obtained according to the above method, including antibiotic and sterilizing hemostasis etc.
Extensive pharmacological action, its main function active component is taxol, taxine, the effect of diterpenoids compound and Chinese yew
Tannin, the combined reaction of phenols component, that is to say, that it is by activating phagocytic cells and stimulates generation antibody to improve people to reach
The physiological action of body immunocompetence, after antibody produces, it will appear as strong antibacterial activity and very strong to cell on epidermis
Restraint, along with the effect of diterpenoids compound and organic matter, its drug effect is relatively extensively and practical, thus it may be said that it is pre-
Functionalized substrate that is anti-and treating many diseases.
The preparation technology of product of the present invention carries out biotechnology production completely, does not use any chemical substance, applies
Raw material also all from plant, do not produce any pollution sources, that obtains that product accessory has a high added value treasures Chinese medicine
Raw material and domestic and international advanced rare biochemical special effect medicine raw material, with high content of technology, competitiveness is strong, and market prospects are good, its technology
Scheme practices the contradiction that can effectively alleviate Chinese yew production and mankind's application demand, and is realized for China and treasure wild medicine
Material domestication and factorial praluction substitute have founded precedent.
It using the Chinese yew largely planted be raw material that the technology of invention, which is, and the processing mankind are wide variety of to be resisted
Bacterium bactericidal haemostatic product, a new way is opened up for the development and application of Chinese yew, is the various diseases of human social development prophylactic treatment
Disease provides new resources.Meanwhile during popularization and application, the obvious special efficacy of antibiotic and sterilizing anastalsis of Chinese yew, at 2 minutes
Time in, to golden yellow grape bacillus, Escherichia coli, Candida albicans, the sterilization rate of copper chlorine pseudomonad reach 95% with
On, it was demonstrated that Chinese yew has been examined in prophylactic treatment skin disease;Gynaecological disease, the effective efficiency of stop blooding etc..With prior art phase
Than main innovation of the invention point is:
1st, it is applied to production antibiotic and sterilizing hemostasia products industry using Chinese yew as raw material first.
2nd, extracts active ingredients are carried out to Chinese yew using two kinds of extracting methods, not only obtains the water solubility of Chinese yew effectively
Composition also obtains the fat-soluble active ingredient of Chinese yew.
3rd, research obtains the aqueous soluble active constituent of Chinese yew and the fat-soluble active ingredient of Chinese yew in different ratio.
His effective efficiency is different.
4th, in terms of the antibiotic and sterilizing hemostatic function of Chinese yew can be only applied to mucocutaneous wound, and positive effect.
5th, water-soluble material and the fat-soluble substances collective effect of Chinese yew, can be only achieved antibiotic and sterilizing anastalsis.
Embodiment
It is that resource produces antibiotic and sterilizing hemostasis class product using Chinese yew, is obtained by following preparation technology, the preparation
Technique comprises the steps:
Step 1, Feedstock treating:The growth selection Chinese yew stem of more than 3 years, branch, leaf, root are dried;Then with crushing
Machine crushes dried stem, branch, leaf, root for the coarse powder of 80 mesh or so, and the water for adding 20% mixes static fermentation 36
Hour, dry, then the Chinese yew fine powder raw material for obtaining 200 mesh is crushed, Chinese yew environment temperature in crushing process is less than 80 DEG C.
The extraction of step 2, active ingredient:
The present invention uses second extraction method:First method is extraction with aqueous solution method.
Its extracting method is:Under 50-80 DEG C of temperature conditionss, by Chinese yew raw material, 500 grams are added to the water-soluble of 1000ml
In liquid, immersion is filtered after 40 hours, obtains Chinese yew water immersion extracting liq.Then it is spray-dried, drying condition is temperature
60-80 DEG C of degree, spray drying material liquid pressure is 50atm, and acquisition main component is polysaccharide, tannin, phenols, amino acid, inorganic member
The materials such as element.
Second method is organic solvent method:
Its extracting method is:Under 40 DEG C of temperature conditionss, by 500 grams of ethanol solutions for being added to 1000ml of Chinese yew raw material
In, immersion precipitates filtering after 24 hours, obtains Chinese yew organic solvent soak extraction liquid.Then it is spray-dried, is dried
Condition is temperature 60 C, and spray drying material liquid pressure is 50atm, and acquisition main component is taxol, taxanes, lignin etc.
Material.
Step 3, mixing obtain the raw materials for production of different proportion:
By the powder raw material and Chinese yew organic solvent that obtain Chinese yew water immersion extracting liq and dry acquisition of said extracted
Soaked extracting solution dries the powder raw material obtained according to 1:1、1:1.5、1:2 ratio mixing, obtains three kinds of heterogeneity contents
Mixed material.And it is named as Chinese yew No.1 raw material;No. two raw materials of Chinese yew;No. three raw materials of Chinese yew.
Step 4, prepare antibacterial disinfecting lotion product
By Chinese yew No.1 raw material according to antibacterial disinfecting lotion preparation method, antibiotic and sterilizing product, specific product life are produced
Production method is shown in embodiment one.
Step 5, prepare antibiotic and sterilizing gel products
By No. two raw materials of Chinese yew according to antibiotic and sterilizing gel process for preparing, antibiotic and sterilizing gel products, specific production are produced
Product production method is shown in embodiment two.
Step 6, prepare antibiotic and sterilizing spray product
Preparation method by Chinese yew No.1, No. two and No. three raw materials according to antibiotic and sterilizing spray, production antibiotic and sterilizing spray
Agent product.
Step 7, prepare disinfecting hemostasis product
Preparation method by Chinese yew No.1, No. two and No. three raw materials according to disinfecting hemostasis product, production disinfecting hemostasis production
Product.
Specific product production method is shown in following four example.
Example one:Chinese yew bacteriostatic lotion
【Name of product】Chinese yew antibacterial liquid
【Factory formula】Chinese yew (Taxus chinensis (Pilger) No.1s raw material 60%, the tuber of stemona (Stemonae
Radix) 8%, frutus cnidii (Cnidii Fructus) 10%, kuh-seng (Sophorae Flavescentis Radix) 10%, when
Return (Angelicae Sinensis Radix) 6%, borneol (Borneolim Syntbeticum5-10%) 6%, poly- six methylene
Base biguanides 0.003%.
【Ingredient requirement】
Chinese yew should meet《Northeast medicine plants will》Pertinent regulations under;The tuber of stemona, frutus cnidii, kuh-seng, Radix Angelicae Sinensis, borneol should meet
《Chinese Pharmacopoeia》Pertinent regulations under each name of an article item;Poly hexamethylene biguanide should meet pertinent regulations in GB 26367.
【Auxiliary material requirement】:Purified water should meet《Chinese Pharmacopoeia》Regulation under every.
【Production technology】
The tuber of stemona, frutus cnidii, kuh-seng, Radix Angelicae Sinensis are weighed according to formula, add 1000ml decoctings to boil 60 minutes;Filtering, is concentrated to
500ml.Then add Chinese yew No.1 raw material and borneol, poly hexamethylene biguanide are mixed, concentrate, dispensed, it is manufactured red
Beans China fir antibacterial liquid.The relative density of Chinese yew antibacterial liquid should be not less than 1.300kg/L.
【Suppress microbe sort】There is antibacterial and bacteriostasis to staphylococcus aureus, Escherichia coli, Candida albicans etc..
Main function effect is:
At 2 minutes, to the killing rate average out to 98.999% of Escherichia coli (8099),
To the killing rate average out to 96.999% of golden yellow grape bacillus (6538),
To the killing rate average out to 99.999% of Candida albicans (ATCC10231),
【Use range】For skin and bacterio static itching-relieving, the cleaning-nursing of private parts discomfort.
【Application method】External application, this product is taken to be used in right amount at skin and private parts discomfort, it is daily 1-2 times.
Example two:Chinese yew antibacterial bacteriostatic hydrogel
【Name of product】The antibacterial hydrogel of Chinese yew
【Factory formula】Chinese yew (No. two raw materials 50% of Taxus chinensis (Pilger), the tuber of stemona (Stemonae
Radix) 8%, frutus cnidii (Cnidii Fructus) 8%, kuh-seng (Sophorae Flavescentis Radix) 8%, golden cypress
10%th, borneol (Borneolim Syntbeticu) 6%, pyridine 0.004%, auxiliary material card moor nurse 2%, glycerine 4%, three to acetic acid chlorine
Monoethanolamine 2%, ethylparaben 2%.
【Ingredient requirement】
Chinese yew should meet《Northeast medicine plants will》Pertinent regulations under;The tuber of stemona, frutus cnidii, kuh-seng, golden cypress, borneol should meet
《Chinese Pharmacopoeia》Pertinent regulations under each name of an article item;The pyridine of acetic acid chlorine should meet pertinent regulations in GB 26367.
【Auxiliary material requirement】:Card pool nurse, glycerine, triethanolamine, ethylparaben, purified water should meet《Chinese Pharmacopoeia》It is every
Under regulation.
【Production technology】
By the tuber of stemona, frutus cnidii, kuh-seng, golden cypress, according to formula weigh, add water 1000ml decoct 60 minutes;Filtering, Ran Houjia
Enter No. two raw materials of Chinese yew and borneol, the pyridine of acetic acid chlorine mix, add card pool nurse, glycerine, triethanolamine, nipalgin second
Ester is mixed, concentrated, packing, the manufactured antibacterial hydrogel of Chinese yew.
【Suppress microbe sort】There is antibacterial and bacteriostasis to staphylococcus aureus, Escherichia coli, Candida albicans.
Main function effect is:At 2 minutes,
To the killing rate average out to 99.999% of Escherichia coli (8099),
To the killing rate average out to 98.999% of golden yellow grape bacillus (6538),
To the killing rate average out to 97.999% of Candida albicans (ATCC10231),
【Use range】Antibacterial, the antipruritic, dispelling abnormal flavor of cleaning for female private part.
After cleaning vulva, this product one is taken, first removes the protecgulum of gel boost motor, and taken protecgulum is inserted into boost motor
Rear end uses as push rod;Borrow gel boost motor that gel is pushed at vagina discomfort after lying low, it is quiet to lie.One time a day.
Example three:Chinese yew stoste wound spray:
【Name of product】Chinese yew stoste wound spray:
【Factory formula】Chinese yew No.1 raw material 30%;No. two raw materials 30% of Chinese yew
No. three raw materials 40% of Chinese yew
【Ingredient requirement】Chinese yew should meet《Northeast medicine plants will》Pertinent regulations under.
【Auxiliary material requirement】:Borneol 1%, peppermint 2%, purified water 1000ml etc. should meet《Chinese Pharmacopoeia》Rule under every
It is fixed.
【Production technology】
By No. two Chinese yew No.1 raw material, Chinese yew raw materials, No. three raw materials of Chinese yew, weighed according to formula, add water to mix,
Filtering, it is concentrated to 500ml and then adds the auxiliary materials such as borneol, peppermint and mix and dissolve, dispense, outside manufactured Chinese yew stoste
Hinder spray:
【Suppress microbe sort】To skins such as staphylococcus aureus, Escherichia coli, Candida albicans, pseudomonas aeruginosas
Skin is infected with good antibacterial and bacteriostasis;There is unique curative effect to skin disease.
Main function effect be at 2 minutes,
To the killing rate average out to 99.999% of Escherichia coli (8099),
To the killing rate average out to 97.999% of Candida albicans (ATCC10231),
To the killing rate average out to 98.999% of pseudomonas aeruginosa (ATCC15442)
【Use range】For skin;Mucous membrane etc. has antibacterial, sterilization, cleans antipruritic, dispelling abnormal flavor, externally recovers from injury and closes, skin
The skin effect such as fester is obvious.
Example four:Chinese yew stoste trauma hemostasis spray:
【Name of product】Chinese yew stoste trauma hemostasis spray:
【Factory formula】Chinese yew No.1 raw material 40%;No. two raw materials 40% of Chinese yew
No. three raw materials 20% of Chinese yew
【Ingredient requirement】Chinese yew should meet《Northeast medicine plants will》Pertinent regulations under.
【Auxiliary material requirement】:Borneol 1%, peppermint 2%, purified water 200ml etc. should meet《Chinese Pharmacopoeia》Regulation under every.
【Production technology】
By No. two Chinese yew No.1 raw material, Chinese yew raw materials, No. three raw materials of Chinese yew, weighed according to formula, add water to mix,
The auxiliary materials such as borneol, peppermint are added when being then heated to 50 DEG C and mix dissolving, packing, manufactured Chinese yew stoste trauma hemostasis
Spray:
【Suppress microbe sort】To skins such as staphylococcus aureus, Escherichia coli, Candida albicans, pseudomonas aeruginosas
Skin is infected with good antibacterial and bacteriostasis;There is unique curative effect to various trauma hemostasis.
Main function effect be at 2 minutes,
To the killing rate average out to 99.988% of Escherichia coli (8099),
To the killing rate average out to 98.999% of Candida albicans (ATCC10231),
To the killing rate average out to 98.999% of pseudomonas aeruginosa (ATCC15442)
【Use range】For skin;Mucous membrane etc. has antibacterial, sterilization, antipruritic, dispelling abnormal flavor is cleaned, to various trauma hemostasis
The effects such as healing are obvious.
Claims (1)
1. utilize the method for Chinese yew production antibiotic and sterilizing hemostasis class product, it is characterised in that:Comprise the steps:
Step 1, Feedstock treating:
The growth selection Chinese yew stem of more than 3 years, branch, leaf, root are dried;Then with pulverizer by dried stem, branch,
Leaf, root are crushed to the coarse powder of 60-100 mesh, to water 20-60% mixing, stirring is added in raw material, enter under conditions of 20-50 DEG C
Row spontaneous fermentation 36-48 hours, dry, then crush the Chinese yew fine powder raw material for obtaining 150-200 mesh, Chinese yew is in crushing process
Middle environment temperature is less than 80 DEG C;
The extraction of step 2, active ingredient:
Extraction with aqueous solution method:In 25 DEG C~60 DEG C temperature ranges, Chinese yew fine powder 30-50 unit of weight of raw material is added to
In the aqueous solution of 100 unit of weights, filtered after soaking 4-10 hours, obtain Chinese yew water immersion extracting liq;Then carry out
Spray drying, drying condition is 40 DEG C~60 DEG C of normal temperature, and spray drying material liquid pressure is 2020-20200kpa, 20-200atm;
Organic solvent extraction:In 25 DEG C~40 DEG C temperature ranges, 30-50 unit of weight of Chinese yew fine powder raw material is added
Into the ethanol solution of 100 unit of weights, filtered after soaking 4-6 hours, obtain Chinese yew organic solvent soak extraction liquid;
Then it is dried, drying condition is 40 DEG C~60 DEG C of normal temperature, and spray drying material liquid pressure is 2020-20200kpa, 20-
200atm;
Step 3, mixing obtain the raw materials for production of different proportion:
The Chinese yew water immersion extracting liq that said extracted is obtained is through drying the powder raw material and Chinese yew organic solvent that obtain
Soaked extracting solution dries the powder raw material obtained according to 1:1~1.5,1:1.5~2,1:2~2.5 ratio mixing, obtains three kinds
The mixed material of heterogeneity content, and it is named as Chinese yew No.1 raw material;No. two raw materials of Chinese yew;Chinese yew No. three
Raw material;
Step 4, production antibiotic and sterilizing hemostasis class product:
A, antibacterial disinfecting lotion product is prepared:By Chinese yew No.1 raw material according to antibacterial disinfecting lotion preparation method, antibacterial is produced
Sterile products, specific product production method are as follows:Each raw material weight proportioning of soup processed is as follows:Chinese yew No.1 raw material 50-80%, the tuber of stemona
3--15%, frutus cnidii 5-15%, kuh-seng 5-15%, Radix Angelicae Sinensis 3-6%, borneol 2-6%, poly hexamethylene biguanide 0.002-
0.003%;The tuber of stemona, frutus cnidii, kuh-seng, Radix Angelicae Sinensis are weighed according to formula, add water 1000ml to decoct 60-80 minutes;Filtering, heating
500-600ml is concentrated to, Chinese yew No.1 raw material is then added and borneol, poly hexamethylene biguanide is mixed, concentrates, divided
Dress, manufactured Chinese yew bacteriostatic water solution;The density of Chinese yew bacteriostatic water solution is not less than 1.300kg/L;Its antibacterial prepared
Disinfectant lotion product reaches national sterile products requirement standard;
B. antibiotic and sterilizing gel products are prepared:By No. two raw materials of Chinese yew according to antibiotic and sterilizing gel process for preparing, antibacterial is produced
Disinfecting gel product, specific product production method are as follows:Each raw material weight proportioning of soup processed is as follows:Chinese yew No. two raw material 50-80%, hundred
Portion 3--10%, frutus cnidii 5-15%, kuh-seng 5-15%, golden cypress 3-10%, borneol 2-6%, acetic acid chlorine pyridine 0.002-
0.005%, auxiliary material card pool nurse 2-5%, glycerine 4-8%, triethanolamine 2-5%, ethylparaben 2-4%;By the tuber of stemona, cnidium monnieri
Son, kuh-seng, golden cypress weigh according to formula, add water 1000ml to decoct 60-80 minutes;Filtering, then add No. two raw materials of Chinese yew
With borneol, the pyridine of acetic acid chlorine mix, add card pool nurse, glycerine, triethanolamine, ethylparaben mix, concentrate,
Packing, the manufactured antibacterial hydrogel of Chinese yew;The addition of auxiliary material is that control product is dense in the antibacterial hydrogel of Chinese yew of preparation
The key factor of degree and viscosity;Its antibiotic and sterilizing gel products prepared reaches national sterile products requirement standard;
C. antibiotic and sterilizing spray product is prepared:System by the extraction raw material of three kinds of different proportions of Chinese yew according to antibiotic and sterilizing spray
Preparation Method, produces antibiotic and sterilizing spray product, and specific product production method is as follows:Each raw material weight proportioning of soup processed is as follows:Chinese yew one
Number raw material 20-50%;, No. two raw material 20-50% of Chinese yew, Chinese yew No. three raw material 40-60%, auxiliary material borneol 1-8%, peppermint
2-6%, purified water 300-1000ml;By Chinese yew No.1 raw material, No. three raw materials of No. two raw materials of Chinese yew and Chinese yew according to
Side weighs, and adds water to mix;Filtering, it is concentrated to 500-800ml and then adds borneol, peppermint auxiliary material mixing dissolving, packing,
Manufactured Chinese yew stoste wound aqueous solution spray;The antibiotic and sterilizing spray product of preparation reaches national sterile products requirement mark
It is accurate.
D, antibiotic and sterilizing hemostasia products are prepared:System by the extraction raw material of three kinds of different proportions of Chinese yew according to antibiotic and sterilizing spray
Preparation Method, produces antibiotic and sterilizing hemostasia products, and specific product production method is as follows:Each raw material weight proportioning of soup processed is as follows:Chinese yew one
Number raw material 30-50%;, No. two raw material 30-50% of Chinese yew, Chinese yew No. three raw material 20-60%, auxiliary material borneol 1-4%, peppermint
2-5%, purified water 100-300ml;By No. three Chinese yew No.1 raw material, No. two raw materials of Chinese yew and Chinese yew raw materials according to formula
Weigh, add water to mix;Borneol is added under the conditions of 40 DEG C~60 DEG C, peppermint auxiliary material mixes dissolving, packing, manufactured red bean
The China fir stoste trauma hemostasis aqueous solution, the hemostasis sterile products that can be prepared using the solution, and reach national disinfecting hemostasis product
It is required that standard.
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104706831A (en) * | 2015-03-11 | 2015-06-17 | 黄仁爱 | Taxus chinensis antibacterial lotion and production technologic method thereof |
-
2017
- 2017-10-24 CN CN201711057861.3A patent/CN107854644A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104706831A (en) * | 2015-03-11 | 2015-06-17 | 黄仁爱 | Taxus chinensis antibacterial lotion and production technologic method thereof |
Non-Patent Citations (2)
Title |
---|
卫强等: "红豆杉枝叶中化学成分及含量研究进展", 《广州化工》 * |
潘明等: "利用微生物转化技术改良中药材品质", 《安微农业科学》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112190605A (en) * | 2020-09-11 | 2021-01-08 | 江西中医药大学 | Antibacterial and anti-inflammatory composition and preparation method thereof |
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