CN107854644A - Utilize the method for Chinese yew production antibiotic and sterilizing hemostasis class product - Google Patents

Utilize the method for Chinese yew production antibiotic and sterilizing hemostasis class product Download PDF

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CN107854644A
CN107854644A CN201711057861.3A CN201711057861A CN107854644A CN 107854644 A CN107854644 A CN 107854644A CN 201711057861 A CN201711057861 A CN 201711057861A CN 107854644 A CN107854644 A CN 107854644A
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chinese yew
raw material
antibiotic
sterilizing
chinese
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孙悦迎
闫高峰
张鑫
阎菲
种红敏
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The method that Chinese yew is raw material production antibiotic and sterilizing hemostasia products is utilized the present invention relates to a kind of.The stem of Chinese yew, branch, leaf, root are crushed, after mixing to the water for adding 20 60% in the raw material of crushing, carries out fermenting for 36 48 hours under conditions of 20 50 DEG C, is then dried, crushes again, obtain 150 200 mesh Chinese yew fine powders.Then extraction with aqueous solution method and organic solvent extraction are used, obtains Chinese yew water logging extracting method through drying the powder raw material obtained and Chinese yew organic solvent leach extraction method through drying the powder raw material obtained.The Chinese yew raw material that two kinds of methods are obtained carries out scientific matching, according to the production method of washing lotion, gel, spray and hemostasia products, production Chinese yew antibiotic and sterilizing hemostasis series of products.The present invention is primary raw material using Chinese yew, produces the wide variety of antibiotic and sterilizing hemostasia products of the mankind, and a new way is opened up for Chinese yew development and application.New resources are developed for antibiotic and sterilizing hemostasis industry.

Description

Utilize the method for Chinese yew production antibiotic and sterilizing hemostasis class product
Technical field
It is more particularly to a kind of to be prepared using Chinese yew for raw material the invention belongs to the preparation method technical field of biochemical article The method of antibiotic and sterilizing hemostasis class product.
Background technology
Chinese yew, it is the common name of the plant of Taxus.About 11 kinds of the category, is distributed in the Northern Hemisphere.There is 4 kind of 1 mutation in China. For Taxus in shallow rooted plant, its main root unobvious, lateral root are flourishing, are that generally acknowledged endangered natural rare anticancer is planted in the world Thing, it is that have passed through the ancient few survivors seeds that quaternary glacier carries over, the existing history of 2,500,000 years on earth.Due to Growth of taxol speed is slow under natural conditions, and power of regeneration is poor, so since some time, has not been formed also in world wide The Chinese yew raw material forestbase touched is advised greatly.
Chinese yew is used as medicine with stem, branch, leaf, root.Main component is containing taxol, taxine, diterpenoids compound.There is anticancer work( Can, and have and suppress diabetes and the cardiopathic effectiveness for the treatment of.The taxol pair being extract from the bark and leaf of Chinese yew Several late cancers curative effect protrudes, and is referred to as " last line of defense for the treatment of cancer ".But growth of taxol is slow, naturally more New ability, 10 mu of artificial growth are only capable of refining the taxol of 1 kilogram of 1% purity.High-purity taxol is expensive, per kilogram 2000000 yuans or so.So extracting drug taxol active ingredient using Chinese yew, cost is too high.In order to obtain effectively Medicine, artificial propagation of the scientific circles to Chinese yew have carried out substantial amounts of research work, in the late two decades, the artificial growth of Chinese yew Rapid development is had occurred that, for cultivated area from 140,000 mu of 2005, development increases to 300,000 mu, thoroughly solves Chinese yew Main points of cultivation, but from Chinese yew extraction taxol production technology do not developed accordingly really, carried using Chinese yew Take taxol drug cost too high, restricted by economic condition, without the development prospect of large-scale production, cause innumerable trials and tribulations to plant Chinese yew do not sell outlet, its main cause is:The complex manufacturing of taxol, factor of influence are extracted from Chinese yew More, working condition is difficult control, and batch production difficulty is big, and no scale standard practices so far.
Secondly, the technology that taxol is produced using synthetic method has been mature on the whole, and the simple production cost of technique is low, and implementing should With conveniently.Therefore, the Chinese yew by research plantation in arduous how many years can not obtain effective utilization, not have following process product, It can only be appreciated as potted landscape, or the scattered pearl of people's wearing be processed into using it.Cause the great wasting of resources.
The content of the invention
The present invention provides a kind of method for producing antibiotic and sterilizing hemostasis class product for resource using Chinese yew, solves Chinese yew Resource utilization issue, an effective way is provided for the development of Chinese yew.Meanwhile provided for antibiotic and sterilizing hemostasis industry development New resources.
The technical scheme is that producing the method for antibiotic and sterilizing class product using Chinese yew, comprise the steps:
Step 1, Feedstock treating:
The growth selection Chinese yew stem of more than 3 years, branch, leaf, root are dried;Then with pulverizer by dried stem, Branch, leaf, root are crushed to the coarse powder of 60-100 mesh, to addition water 20-60% mixing, stirring in raw material, under conditions of 20-50 DEG C Spontaneous fermentation 36-48 hours are carried out, are dried, then crush the Chinese yew fine powder raw material for obtaining 150-200 mesh, Chinese yew crushed Environment temperature is less than 80 DEG C in journey;
The extraction of step 2, active ingredient:
Extraction with aqueous solution method:In 25 DEG C~60 DEG C temperature ranges, Chinese yew fine powder 30-50 unit of weight of raw material is added Enter into the aqueous solution of 100 unit of weights, filtered after soaking 4-10 hours, obtain Chinese yew water immersion extracting liq;Then It is spray-dried, drying condition is 40 DEG C~60 DEG C of normal temperature, and spray drying material liquid pressure is 2020-20200kpa, 20- 200atm;
Organic solvent extraction:In 25 DEG C~40 DEG C temperature ranges, by Chinese yew fine powder 30-50 unit of weight of raw material It is added in the ethanol solution of 100 unit of weights, is filtered after soaking 4-6 hours, obtains Chinese yew organic solvent soak extraction Liquid;Then it is dried, drying condition is 40 DEG C~60 DEG C of normal temperature, and spray drying material liquid pressure is 2020-20200kpa, 20-200atm;
Step 3, mixing obtain the raw materials for production of different proportion:
The Chinese yew water immersion extracting liq that said extracted is obtained is organic through drying the powder raw material obtained and Chinese yew Solvent soaking extract solution dries the powder raw material obtained according to 1:1~1.5,1:1.5~2,1:2~2.5 ratio mixing, is obtained The mixed material of three kinds of heterogeneity contents, and it is named as Chinese yew No.1 raw material;No. two raw materials of Chinese yew;Chinese yew No. three raw materials;
Step 4, production antibiotic and sterilizing hemostasis class product:
A, antibacterial disinfecting lotion product is prepared:By Chinese yew No.1 raw material according to antibacterial disinfecting lotion preparation method, production Antibiotic and sterilizing product, specific product production method are as follows:Each raw material weight proportioning of soup processed is as follows:Chinese yew No.1 raw material 50-80%, hundred Portion 3--15%, frutus cnidii 5-15%, kuh-seng 5-15%, Radix Angelicae Sinensis 3-6%, borneol 2-6%, poly hexamethylene biguanide 0.002- 0.003%;The tuber of stemona, frutus cnidii, kuh-seng, Radix Angelicae Sinensis are weighed according to formula, add water 1000ml to decoct 60-80 minutes;Filtering, heating 500-600ml is concentrated to, Chinese yew No.1 raw material is then added and borneol, poly hexamethylene biguanide is mixed, concentrates, divided Dress, manufactured Chinese yew bacteriostatic water solution;The density of Chinese yew bacteriostatic water solution is not less than 1.300kg/L;Its antibacterial prepared Disinfectant lotion product reaches national sterile products requirement standard;
B. antibiotic and sterilizing gel products are prepared:By No. two raw materials of Chinese yew according to antibiotic and sterilizing gel process for preparing, production Antibiotic and sterilizing gel products, specific product production method are as follows:Each raw material weight proportioning of soup processed is as follows:No. two raw material 50- of Chinese yew 80%th, tuber of stemona 3--10%, frutus cnidii 5-15%, kuh-seng 5-15%, golden cypress 3-10%, borneol 2-6%, the pyridine of acetic acid chlorine 0.002-0.005%, auxiliary material card pool nurse 2-5%, glycerine 4-8%, triethanolamine 2-5%, ethylparaben 2-4%;By the tuber of stemona, Frutus cnidii, kuh-seng, golden cypress weigh according to formula, add water 1000ml to decoct 60-80 minutes;Filtering, then add Chinese yew No. two Raw material and borneol, the pyridine of acetic acid chlorine mix, add card pool nurse, glycerine, triethanolamine, ethylparaben mixing, Concentration, packing, the manufactured antibacterial hydrogel of Chinese yew;The addition of auxiliary material is control production in the antibacterial hydrogel of Chinese yew of preparation The key factor of product concentration and viscosity;Its antibiotic and sterilizing gel products prepared reaches national sterile products requirement standard;
C. antibiotic and sterilizing spray product is prepared:By the extraction raw material of three kinds of different proportions of Chinese yew according to antibiotic and sterilizing spray Preparation method, produce antibiotic and sterilizing spray product, specific product production method is as follows:Each raw material weight proportioning of soup processed is as follows:Red bean China fir No.1 raw material 20-50%;, No. two raw material 20-50% of Chinese yew, Chinese yew No. three raw material 40-60%, auxiliary material borneol 1-8%, Peppermint 2-6%, purified water 300-1000ml;No. three Chinese yew No.1 raw material, No. two raw materials of Chinese yew and Chinese yew raw materials are pressed Weighed according to formula, add water to mix;Filtering, it is concentrated to 500-800ml and then adds borneol, peppermint auxiliary material mixes dissolving, divides Dress, manufactured Chinese yew stoste wound aqueous solution spray;The antibiotic and sterilizing spray product of preparation reaches national sterile products will Seek standard.
D, antibiotic and sterilizing hemostasia products are prepared:By the extraction raw material of three kinds of different proportions of Chinese yew according to antibiotic and sterilizing spray Preparation method, produce antibiotic and sterilizing hemostasia products, specific product production method is as follows:Each raw material weight proportioning of soup processed is as follows:Red bean China fir No.1 raw material 30-50%;, No. two raw material 30-50% of Chinese yew, Chinese yew No. three raw material 20-60%, auxiliary material borneol 1-4%, Peppermint 2-5%, purified water 100-300ml;By Chinese yew No.1 raw material, No. three raw materials of No. two raw materials of Chinese yew and Chinese yew according to Formula weighs, and adds water to mix;Borneol, peppermint auxiliary material mixing dissolving, packing are added under the conditions of 40 DEG C~60 DEG C, it is manufactured The Chinese yew stoste trauma hemostasis aqueous solution, the hemostasis sterile products that can be prepared using the solution, and reach national disinfecting hemostasis Product requirement standard.
The Chinese yew production antibiotic and sterilizing hemostasis class product obtained according to the above method, including antibiotic and sterilizing hemostasis etc. Extensive pharmacological action, its main function active component is taxol, taxine, the effect of diterpenoids compound and Chinese yew Tannin, the combined reaction of phenols component, that is to say, that it is by activating phagocytic cells and stimulates generation antibody to improve people to reach The physiological action of body immunocompetence, after antibody produces, it will appear as strong antibacterial activity and very strong to cell on epidermis Restraint, along with the effect of diterpenoids compound and organic matter, its drug effect is relatively extensively and practical, thus it may be said that it is pre- Functionalized substrate that is anti-and treating many diseases.
The preparation technology of product of the present invention carries out biotechnology production completely, does not use any chemical substance, applies Raw material also all from plant, do not produce any pollution sources, that obtains that product accessory has a high added value treasures Chinese medicine Raw material and domestic and international advanced rare biochemical special effect medicine raw material, with high content of technology, competitiveness is strong, and market prospects are good, its technology Scheme practices the contradiction that can effectively alleviate Chinese yew production and mankind's application demand, and is realized for China and treasure wild medicine Material domestication and factorial praluction substitute have founded precedent.
It using the Chinese yew largely planted be raw material that the technology of invention, which is, and the processing mankind are wide variety of to be resisted Bacterium bactericidal haemostatic product, a new way is opened up for the development and application of Chinese yew, is the various diseases of human social development prophylactic treatment Disease provides new resources.Meanwhile during popularization and application, the obvious special efficacy of antibiotic and sterilizing anastalsis of Chinese yew, at 2 minutes Time in, to golden yellow grape bacillus, Escherichia coli, Candida albicans, the sterilization rate of copper chlorine pseudomonad reach 95% with On, it was demonstrated that Chinese yew has been examined in prophylactic treatment skin disease;Gynaecological disease, the effective efficiency of stop blooding etc..With prior art phase Than main innovation of the invention point is:
1st, it is applied to production antibiotic and sterilizing hemostasia products industry using Chinese yew as raw material first.
2nd, extracts active ingredients are carried out to Chinese yew using two kinds of extracting methods, not only obtains the water solubility of Chinese yew effectively Composition also obtains the fat-soluble active ingredient of Chinese yew.
3rd, research obtains the aqueous soluble active constituent of Chinese yew and the fat-soluble active ingredient of Chinese yew in different ratio. His effective efficiency is different.
4th, in terms of the antibiotic and sterilizing hemostatic function of Chinese yew can be only applied to mucocutaneous wound, and positive effect.
5th, water-soluble material and the fat-soluble substances collective effect of Chinese yew, can be only achieved antibiotic and sterilizing anastalsis.
Embodiment
It is that resource produces antibiotic and sterilizing hemostasis class product using Chinese yew, is obtained by following preparation technology, the preparation Technique comprises the steps:
Step 1, Feedstock treating:The growth selection Chinese yew stem of more than 3 years, branch, leaf, root are dried;Then with crushing Machine crushes dried stem, branch, leaf, root for the coarse powder of 80 mesh or so, and the water for adding 20% mixes static fermentation 36 Hour, dry, then the Chinese yew fine powder raw material for obtaining 200 mesh is crushed, Chinese yew environment temperature in crushing process is less than 80 DEG C.
The extraction of step 2, active ingredient:
The present invention uses second extraction method:First method is extraction with aqueous solution method.
Its extracting method is:Under 50-80 DEG C of temperature conditionss, by Chinese yew raw material, 500 grams are added to the water-soluble of 1000ml In liquid, immersion is filtered after 40 hours, obtains Chinese yew water immersion extracting liq.Then it is spray-dried, drying condition is temperature 60-80 DEG C of degree, spray drying material liquid pressure is 50atm, and acquisition main component is polysaccharide, tannin, phenols, amino acid, inorganic member The materials such as element.
Second method is organic solvent method:
Its extracting method is:Under 40 DEG C of temperature conditionss, by 500 grams of ethanol solutions for being added to 1000ml of Chinese yew raw material In, immersion precipitates filtering after 24 hours, obtains Chinese yew organic solvent soak extraction liquid.Then it is spray-dried, is dried Condition is temperature 60 C, and spray drying material liquid pressure is 50atm, and acquisition main component is taxol, taxanes, lignin etc. Material.
Step 3, mixing obtain the raw materials for production of different proportion:
By the powder raw material and Chinese yew organic solvent that obtain Chinese yew water immersion extracting liq and dry acquisition of said extracted Soaked extracting solution dries the powder raw material obtained according to 1:1、1:1.5、1:2 ratio mixing, obtains three kinds of heterogeneity contents Mixed material.And it is named as Chinese yew No.1 raw material;No. two raw materials of Chinese yew;No. three raw materials of Chinese yew.
Step 4, prepare antibacterial disinfecting lotion product
By Chinese yew No.1 raw material according to antibacterial disinfecting lotion preparation method, antibiotic and sterilizing product, specific product life are produced Production method is shown in embodiment one.
Step 5, prepare antibiotic and sterilizing gel products
By No. two raw materials of Chinese yew according to antibiotic and sterilizing gel process for preparing, antibiotic and sterilizing gel products, specific production are produced Product production method is shown in embodiment two.
Step 6, prepare antibiotic and sterilizing spray product
Preparation method by Chinese yew No.1, No. two and No. three raw materials according to antibiotic and sterilizing spray, production antibiotic and sterilizing spray Agent product.
Step 7, prepare disinfecting hemostasis product
Preparation method by Chinese yew No.1, No. two and No. three raw materials according to disinfecting hemostasis product, production disinfecting hemostasis production Product.
Specific product production method is shown in following four example.
Example one:Chinese yew bacteriostatic lotion
【Name of product】Chinese yew antibacterial liquid
【Factory formula】Chinese yew (Taxus chinensis (Pilger) No.1s raw material 60%, the tuber of stemona (Stemonae Radix) 8%, frutus cnidii (Cnidii Fructus) 10%, kuh-seng (Sophorae Flavescentis Radix) 10%, when Return (Angelicae Sinensis Radix) 6%, borneol (Borneolim Syntbeticum5-10%) 6%, poly- six methylene Base biguanides 0.003%.
【Ingredient requirement】
Chinese yew should meet《Northeast medicine plants will》Pertinent regulations under;The tuber of stemona, frutus cnidii, kuh-seng, Radix Angelicae Sinensis, borneol should meet 《Chinese Pharmacopoeia》Pertinent regulations under each name of an article item;Poly hexamethylene biguanide should meet pertinent regulations in GB 26367.
【Auxiliary material requirement】:Purified water should meet《Chinese Pharmacopoeia》Regulation under every.
【Production technology】
The tuber of stemona, frutus cnidii, kuh-seng, Radix Angelicae Sinensis are weighed according to formula, add 1000ml decoctings to boil 60 minutes;Filtering, is concentrated to 500ml.Then add Chinese yew No.1 raw material and borneol, poly hexamethylene biguanide are mixed, concentrate, dispensed, it is manufactured red Beans China fir antibacterial liquid.The relative density of Chinese yew antibacterial liquid should be not less than 1.300kg/L.
【Suppress microbe sort】There is antibacterial and bacteriostasis to staphylococcus aureus, Escherichia coli, Candida albicans etc.. Main function effect is:
At 2 minutes, to the killing rate average out to 98.999% of Escherichia coli (8099),
To the killing rate average out to 96.999% of golden yellow grape bacillus (6538),
To the killing rate average out to 99.999% of Candida albicans (ATCC10231),
【Use range】For skin and bacterio static itching-relieving, the cleaning-nursing of private parts discomfort.
【Application method】External application, this product is taken to be used in right amount at skin and private parts discomfort, it is daily 1-2 times.
Example two:Chinese yew antibacterial bacteriostatic hydrogel
【Name of product】The antibacterial hydrogel of Chinese yew
【Factory formula】Chinese yew (No. two raw materials 50% of Taxus chinensis (Pilger), the tuber of stemona (Stemonae Radix) 8%, frutus cnidii (Cnidii Fructus) 8%, kuh-seng (Sophorae Flavescentis Radix) 8%, golden cypress 10%th, borneol (Borneolim Syntbeticu) 6%, pyridine 0.004%, auxiliary material card moor nurse 2%, glycerine 4%, three to acetic acid chlorine Monoethanolamine 2%, ethylparaben 2%.
【Ingredient requirement】
Chinese yew should meet《Northeast medicine plants will》Pertinent regulations under;The tuber of stemona, frutus cnidii, kuh-seng, golden cypress, borneol should meet 《Chinese Pharmacopoeia》Pertinent regulations under each name of an article item;The pyridine of acetic acid chlorine should meet pertinent regulations in GB 26367.
【Auxiliary material requirement】:Card pool nurse, glycerine, triethanolamine, ethylparaben, purified water should meet《Chinese Pharmacopoeia》It is every Under regulation.
【Production technology】
By the tuber of stemona, frutus cnidii, kuh-seng, golden cypress, according to formula weigh, add water 1000ml decoct 60 minutes;Filtering, Ran Houjia Enter No. two raw materials of Chinese yew and borneol, the pyridine of acetic acid chlorine mix, add card pool nurse, glycerine, triethanolamine, nipalgin second Ester is mixed, concentrated, packing, the manufactured antibacterial hydrogel of Chinese yew.
【Suppress microbe sort】There is antibacterial and bacteriostasis to staphylococcus aureus, Escherichia coli, Candida albicans.
Main function effect is:At 2 minutes,
To the killing rate average out to 99.999% of Escherichia coli (8099),
To the killing rate average out to 98.999% of golden yellow grape bacillus (6538),
To the killing rate average out to 97.999% of Candida albicans (ATCC10231),
【Use range】Antibacterial, the antipruritic, dispelling abnormal flavor of cleaning for female private part.
After cleaning vulva, this product one is taken, first removes the protecgulum of gel boost motor, and taken protecgulum is inserted into boost motor Rear end uses as push rod;Borrow gel boost motor that gel is pushed at vagina discomfort after lying low, it is quiet to lie.One time a day.
Example three:Chinese yew stoste wound spray:
【Name of product】Chinese yew stoste wound spray:
【Factory formula】Chinese yew No.1 raw material 30%;No. two raw materials 30% of Chinese yew
No. three raw materials 40% of Chinese yew
【Ingredient requirement】Chinese yew should meet《Northeast medicine plants will》Pertinent regulations under.
【Auxiliary material requirement】:Borneol 1%, peppermint 2%, purified water 1000ml etc. should meet《Chinese Pharmacopoeia》Rule under every It is fixed.
【Production technology】
By No. two Chinese yew No.1 raw material, Chinese yew raw materials, No. three raw materials of Chinese yew, weighed according to formula, add water to mix, Filtering, it is concentrated to 500ml and then adds the auxiliary materials such as borneol, peppermint and mix and dissolve, dispense, outside manufactured Chinese yew stoste Hinder spray:
【Suppress microbe sort】To skins such as staphylococcus aureus, Escherichia coli, Candida albicans, pseudomonas aeruginosas Skin is infected with good antibacterial and bacteriostasis;There is unique curative effect to skin disease.
Main function effect be at 2 minutes,
To the killing rate average out to 99.999% of Escherichia coli (8099),
To the killing rate average out to 97.999% of Candida albicans (ATCC10231),
To the killing rate average out to 98.999% of pseudomonas aeruginosa (ATCC15442)
【Use range】For skin;Mucous membrane etc. has antibacterial, sterilization, cleans antipruritic, dispelling abnormal flavor, externally recovers from injury and closes, skin The skin effect such as fester is obvious.
Example four:Chinese yew stoste trauma hemostasis spray:
【Name of product】Chinese yew stoste trauma hemostasis spray:
【Factory formula】Chinese yew No.1 raw material 40%;No. two raw materials 40% of Chinese yew
No. three raw materials 20% of Chinese yew
【Ingredient requirement】Chinese yew should meet《Northeast medicine plants will》Pertinent regulations under.
【Auxiliary material requirement】:Borneol 1%, peppermint 2%, purified water 200ml etc. should meet《Chinese Pharmacopoeia》Regulation under every.
【Production technology】
By No. two Chinese yew No.1 raw material, Chinese yew raw materials, No. three raw materials of Chinese yew, weighed according to formula, add water to mix, The auxiliary materials such as borneol, peppermint are added when being then heated to 50 DEG C and mix dissolving, packing, manufactured Chinese yew stoste trauma hemostasis Spray:
【Suppress microbe sort】To skins such as staphylococcus aureus, Escherichia coli, Candida albicans, pseudomonas aeruginosas Skin is infected with good antibacterial and bacteriostasis;There is unique curative effect to various trauma hemostasis.
Main function effect be at 2 minutes,
To the killing rate average out to 99.988% of Escherichia coli (8099),
To the killing rate average out to 98.999% of Candida albicans (ATCC10231),
To the killing rate average out to 98.999% of pseudomonas aeruginosa (ATCC15442)
【Use range】For skin;Mucous membrane etc. has antibacterial, sterilization, antipruritic, dispelling abnormal flavor is cleaned, to various trauma hemostasis The effects such as healing are obvious.

Claims (1)

1. utilize the method for Chinese yew production antibiotic and sterilizing hemostasis class product, it is characterised in that:Comprise the steps:
Step 1, Feedstock treating:
The growth selection Chinese yew stem of more than 3 years, branch, leaf, root are dried;Then with pulverizer by dried stem, branch, Leaf, root are crushed to the coarse powder of 60-100 mesh, to water 20-60% mixing, stirring is added in raw material, enter under conditions of 20-50 DEG C Row spontaneous fermentation 36-48 hours, dry, then crush the Chinese yew fine powder raw material for obtaining 150-200 mesh, Chinese yew is in crushing process Middle environment temperature is less than 80 DEG C;
The extraction of step 2, active ingredient:
Extraction with aqueous solution method:In 25 DEG C~60 DEG C temperature ranges, Chinese yew fine powder 30-50 unit of weight of raw material is added to In the aqueous solution of 100 unit of weights, filtered after soaking 4-10 hours, obtain Chinese yew water immersion extracting liq;Then carry out Spray drying, drying condition is 40 DEG C~60 DEG C of normal temperature, and spray drying material liquid pressure is 2020-20200kpa, 20-200atm;
Organic solvent extraction:In 25 DEG C~40 DEG C temperature ranges, 30-50 unit of weight of Chinese yew fine powder raw material is added Into the ethanol solution of 100 unit of weights, filtered after soaking 4-6 hours, obtain Chinese yew organic solvent soak extraction liquid; Then it is dried, drying condition is 40 DEG C~60 DEG C of normal temperature, and spray drying material liquid pressure is 2020-20200kpa, 20- 200atm;
Step 3, mixing obtain the raw materials for production of different proportion:
The Chinese yew water immersion extracting liq that said extracted is obtained is through drying the powder raw material and Chinese yew organic solvent that obtain Soaked extracting solution dries the powder raw material obtained according to 1:1~1.5,1:1.5~2,1:2~2.5 ratio mixing, obtains three kinds The mixed material of heterogeneity content, and it is named as Chinese yew No.1 raw material;No. two raw materials of Chinese yew;Chinese yew No. three Raw material;
Step 4, production antibiotic and sterilizing hemostasis class product:
A, antibacterial disinfecting lotion product is prepared:By Chinese yew No.1 raw material according to antibacterial disinfecting lotion preparation method, antibacterial is produced Sterile products, specific product production method are as follows:Each raw material weight proportioning of soup processed is as follows:Chinese yew No.1 raw material 50-80%, the tuber of stemona 3--15%, frutus cnidii 5-15%, kuh-seng 5-15%, Radix Angelicae Sinensis 3-6%, borneol 2-6%, poly hexamethylene biguanide 0.002- 0.003%;The tuber of stemona, frutus cnidii, kuh-seng, Radix Angelicae Sinensis are weighed according to formula, add water 1000ml to decoct 60-80 minutes;Filtering, heating 500-600ml is concentrated to, Chinese yew No.1 raw material is then added and borneol, poly hexamethylene biguanide is mixed, concentrates, divided Dress, manufactured Chinese yew bacteriostatic water solution;The density of Chinese yew bacteriostatic water solution is not less than 1.300kg/L;Its antibacterial prepared Disinfectant lotion product reaches national sterile products requirement standard;
B. antibiotic and sterilizing gel products are prepared:By No. two raw materials of Chinese yew according to antibiotic and sterilizing gel process for preparing, antibacterial is produced Disinfecting gel product, specific product production method are as follows:Each raw material weight proportioning of soup processed is as follows:Chinese yew No. two raw material 50-80%, hundred Portion 3--10%, frutus cnidii 5-15%, kuh-seng 5-15%, golden cypress 3-10%, borneol 2-6%, acetic acid chlorine pyridine 0.002- 0.005%, auxiliary material card pool nurse 2-5%, glycerine 4-8%, triethanolamine 2-5%, ethylparaben 2-4%;By the tuber of stemona, cnidium monnieri Son, kuh-seng, golden cypress weigh according to formula, add water 1000ml to decoct 60-80 minutes;Filtering, then add No. two raw materials of Chinese yew With borneol, the pyridine of acetic acid chlorine mix, add card pool nurse, glycerine, triethanolamine, ethylparaben mix, concentrate, Packing, the manufactured antibacterial hydrogel of Chinese yew;The addition of auxiliary material is that control product is dense in the antibacterial hydrogel of Chinese yew of preparation The key factor of degree and viscosity;Its antibiotic and sterilizing gel products prepared reaches national sterile products requirement standard;
C. antibiotic and sterilizing spray product is prepared:System by the extraction raw material of three kinds of different proportions of Chinese yew according to antibiotic and sterilizing spray Preparation Method, produces antibiotic and sterilizing spray product, and specific product production method is as follows:Each raw material weight proportioning of soup processed is as follows:Chinese yew one Number raw material 20-50%;, No. two raw material 20-50% of Chinese yew, Chinese yew No. three raw material 40-60%, auxiliary material borneol 1-8%, peppermint 2-6%, purified water 300-1000ml;By Chinese yew No.1 raw material, No. three raw materials of No. two raw materials of Chinese yew and Chinese yew according to Side weighs, and adds water to mix;Filtering, it is concentrated to 500-800ml and then adds borneol, peppermint auxiliary material mixing dissolving, packing, Manufactured Chinese yew stoste wound aqueous solution spray;The antibiotic and sterilizing spray product of preparation reaches national sterile products requirement mark It is accurate.
D, antibiotic and sterilizing hemostasia products are prepared:System by the extraction raw material of three kinds of different proportions of Chinese yew according to antibiotic and sterilizing spray Preparation Method, produces antibiotic and sterilizing hemostasia products, and specific product production method is as follows:Each raw material weight proportioning of soup processed is as follows:Chinese yew one Number raw material 30-50%;, No. two raw material 30-50% of Chinese yew, Chinese yew No. three raw material 20-60%, auxiliary material borneol 1-4%, peppermint 2-5%, purified water 100-300ml;By No. three Chinese yew No.1 raw material, No. two raw materials of Chinese yew and Chinese yew raw materials according to formula Weigh, add water to mix;Borneol is added under the conditions of 40 DEG C~60 DEG C, peppermint auxiliary material mixes dissolving, packing, manufactured red bean The China fir stoste trauma hemostasis aqueous solution, the hemostasis sterile products that can be prepared using the solution, and reach national disinfecting hemostasis product It is required that standard.
CN201711057861.3A 2017-10-24 2017-10-24 Utilize the method for Chinese yew production antibiotic and sterilizing hemostasis class product Pending CN107854644A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112190605A (en) * 2020-09-11 2021-01-08 江西中医药大学 Antibacterial and anti-inflammatory composition and preparation method thereof

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CN104706831A (en) * 2015-03-11 2015-06-17 黄仁爱 Taxus chinensis antibacterial lotion and production technologic method thereof

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