CN107854597A - Combined application for acute mastitis and preparation method thereof - Google Patents

Combined application for acute mastitis and preparation method thereof Download PDF

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Publication number
CN107854597A
CN107854597A CN201711214281.0A CN201711214281A CN107854597A CN 107854597 A CN107854597 A CN 107854597A CN 201711214281 A CN201711214281 A CN 201711214281A CN 107854597 A CN107854597 A CN 107854597A
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parts
pawpaw
acute mastitis
folium artemisiae
artemisiae argyi
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CN107854597B (en
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陈飞宇
张克兢
罗娜
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Xiangya Hospital of Central South University
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Xiangya Hospital of Central South University
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/33Cactaceae (Cactus family), e.g. pricklypear or Cereus
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
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    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
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    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/732Chaenomeles, e.g. flowering quince
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms

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Abstract

The invention discloses a combined application for acute mastitis, which comprises precoating liquid and an application plaster, wherein the application plaster comprises the following raw materials in parts by weight, namely pawpaw, dandelion, rheum officinale, towel gourd, madder, folium artemisiae argyi, rhizoma cyperi, fistular onion stalk, silkworm excrement and honey. Aiming at the first stage or the second stage of acute mastitis, the combined application for treating acute mastitis is provided, which has high cure rate, convenient preparation and small side effect. Meanwhile, the invention also discloses a preparation method of the combined plaster for treating acute mastitis, which comprises the steps of pre-coating liquid preparation and plaster preparation, wherein the plaster preparation comprises pretreatment, mixing, heating and cooling; the preparation of the pre-coating liquid comprises preheating and mixing. The process is unique, fully exerts the efficacy and the coordination effect of the components, is simple and easy to obtain, and is suitable for large-scale production.

Description

A kind of combination application of acute mastitis and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicine, the combination application of specially a kind of acute mastitis and its preparation side Method.
Background technology
Mastitis is the common disease of women, can be divided into acute purulent mammitis, by mammary areola according to the difference of the cause of disease Fistula, plasma cell mastitis etc.;Most common acute purulent mammitis, it is called acute nursing period or puerperium suppurative breast Adenositis, the traditional Chinese medical science are referred to as " acute mastitis ".The clinical manifestation of acute mastitis, three phases or three phases can be divided into.
One phase, stasis of blood milk lump phase or red and swollen phase.Main performance is certain a part of, typically outside upper or inner upper quadrant of breast The swollen hard distending pain of burst, obscure boundary, there is obvious tenderness more.The inflammation of this phase internal mammary is in cellulitis stage, not yet shape Into abscess.The color of skin of breast is normal or micro- red or low-grade fever.Unexpected high fever shiver with cold, pain and swelling, part are scarlet, change quickly Purulence ulceration, more with headache uncomfortable in chest, poor appetite etc..If there is cracked nipple, during lactation can sensory papillae pain as being pricked pin, The breach of visible small one or two pus point in nipple surface or very little.
Second phase, abscess form the phase.The cellulitis stage fails to dissipate in time, and inflammation continues to develop, necrosis, abscess shape Into unavoidable.Gradually increase is hardened lump, and pain aggravates, and mostly pulsation jumps pain, or even continuation severe pain, breast office It is portion's rubefaction, scorching hot.Whole body high fever does not move back, thirsty to think drink, nauseous apocleisis, ipsilateral axillary enlargement of lymph nodes etc..Red and swollen heat pain 2 After~3 days, lump center softens gradually, there is fluctuation, and center redness is shinny, thinning of skin, and surrounding skin sheet is scarlet.Puncture Have fester sucking-off.This phase abscess is into guarding the opportunity mistake cured.
Three phases, abscess are burst the later stage.Can voluntarily ulceration, or surgical incision apocenosis during abscess maturation.If drainage is unobstructed, office The swollen pain that disappears in portion subtracts, and body temperature is normal, and by dressing, wound gradually heals in about one month.If purulence goes out not smooth after bursting, the gesture that swells is not Disappear, pain does not subtract, and body heat is not moved back, that is, inadequate drainage, do not recover for a long time and change into chronic mastitis, can also form newborn fistula, that is, have Milk is with fester mixing outflow.
After morbidity, not only puerpera has huge physiology pain, and is generally adopted by the injection treatment of doctor trained in Western medicine, notes Enter the anti-inflammatory agents such as cephalo, it is impossible to continue lactation, influence the health of baby, and then there may be psychological burden;And therapeutic effect Typically.
The content of the invention
The purpose of the present invention is to be directed to problem above, there is provided a kind of combination application of acute mastitis, for acute mammary gland Scorching stage phase or the second stage of initial stage, cure rate is high, preparation is convenient, the combination of Small side effects treatment acute mastitis is applied Patch.
Meanwhile the invention also discloses a kind of preparation method of the combination application of acute mastitis, technique is unique, fully hair The efficacy of a drug and trade-off effect of component are waved, it is simple and easy to get, it is applicable large-scale production.
To realize object above, the technical solution adopted by the present invention is:A kind of combination application of acute mastitis, including it is pre- Masking liquid and application plaster, the application plaster include the raw material of following parts by weight:Pawpaw 20-25 parts, dandelion 10-14 parts, rheum officinale 18-22 parts, sponge gourd 8-12 parts, madder 5-7 parts, folium artemisiae argyi 10-16 parts, rhizoma cyperi 5-8 parts, Bulbus Allii Fistulosi 5-8 parts, silkworm excrement 10-15 parts, honey 30-50 parts.
Preferably, the pre-coating solution includes white wine 50-80 parts, cactus mud 12-18 parts, peppermint oil 6-9 parts.
Preferably, each raw material weight number is in the application plaster:24 parts of pawpaw, 12 parts of dandelion, 20 parts of rheum officinale, sponge gourd 9 parts, 7 parts of madder, 15 parts of folium artemisiae argyi, 6 parts of rhizoma cyperi, 7 parts of Bulbus Allii Fistulosi, 12 parts of silkworm excrement, 45 parts of honey.
Preferably, folium artemisiae argyi, rhizoma cyperi, Bulbus Allii Fistulosi usage ratio are 2:1:1.
Preferably, folium artemisiae argyi is fresh folium artemisiae argyi, and rhizoma cyperi is prepared RHIZOMA CYPERI with vinegar.
A kind of preparation method of the combination application of acute mastitis, including pre-coating solution prepares and prepared by application plaster, application plaster Preparation comprises the following steps:
A, pre-process, take pawpaw one, along away from being cut at the 1/4-1/3 of top, after steaming 3-5 minutes, after remove seed, pawpaw meat is scraped In pawpaw shell, the parts by weight of pawpaw meat are 20-25 parts;It is 2 in proportion by folium artemisiae argyi, rhizoma cyperi, Bulbus Allii Fistulosi:1:1 mixing, crush, Grinding;Dandelion, rheum officinale, madder are pulverized, and sponge gourd is smashed;
B, mix, add silkworm excrement to the pawpaw shell for having pawpaw meat, after stirring, cover the upper part of incision, continue to steam 1-2 minutes; The folium artemisiae argyi pre-processed, rhizoma cyperi, Bulbus Allii Fistulosi, dandelion, rheum officinale, madder, sponge gourd are added in pawpaw shell again, stirred;
C, heat, the pawpaw shell after step B processing is heated into 1-2h;
D, after step C heating, after pawpaw shell surface covering honey, natural cooling, stirring, it is sealed.
In addition, pre-coating solution preparation process includes:
A, preheat, after cactus mud is mixed with peppermint oil, be heated to 50-60 DEG C;
B, mix, by the mixture after being preheated in step a, add in the white wine of normal temperature and be uniformly mixed, be sealed;Peppermint Oil can promote the osmosis of application plaster and cactus mud, and not only there is cactus the promoting flow of qi and blood circulation, heat clearing and inflammation relieving to detoxify, row The effect of pus and growing muscle, coordinate peppermint oil it can be promoted to be dissolved in wine.
Preferably, folium artemisiae argyi in the step A, rhizoma cyperi, Bulbus Allii Fistulosi mixing concretely comprise the following steps, by folium artemisiae argyi, Bulbus Allii Fistulosi mixed grinding After juice, Nutgrass Galingale Rhizome is added, is stirred.
Preferably, the temperature heated in the step C is 60-80 DEG C.
Beneficial effects of the present invention:
1st, for stage phase of acute mastitis or the second stage of initial stage, cure rate is high, prepare convenience, Small side effects, quick, Do not influence to continue lactation, and then avoid psychological burden;
2nd, Bulbus Allii Fistulosi external application has the function that to treat sore carbuncle serious case of furuncle, coordinates folium artemisiae argyi, rhizoma cyperi;In early stage patient skin can be avoided thinning Or chap, thinning skin or chap skin be not suitable for this product, therefore, Bulbus Allii Fistulosi, folium artemisiae argyi, rhizoma cyperi its act synergistically into one Step improves the applicability of this medicine;
3rd, pawpaw and silkworm excrement compatibility, there is the good Repercusion analgesia that stimulates the menstrual flow, expelling wind and clearing away cold;And then alleviate and eliminate illness;
4th, applied using combination, first precoat emplastrum again, in order, promote drug effect absorption and pharmacology synergy successively, it is quick, treat Imitate;
5th, the invention also discloses a kind of preparation method of the combination application of acute mastitis, technique is unique, gives full play to component The efficacy of a drug and trade-off effect, it is simple and easy to get, be applicable large-scale production;Meanwhile the processing of pawpaw and silkworm excrement, promote drug effect mutual Fusion;After the heating, after pawpaw shell surface covering honey, natural cooling, drug effect is avoided to volatilize, while from depositing into honey and be used as medicine.
Embodiment
In order that those skilled in the art more fully understand technical scheme, the present invention is retouched in detail below State, the description of this part is only exemplary and explanatory, there should not be any restriction effect to protection scope of the present invention.
Embodiment 1
A kind of combination application of acute mastitis, including pre-coating solution and application plaster, the application plaster include following parts by weight Raw material:20 parts of pawpaw, 10 parts of dandelion, 18 parts of rheum officinale, 8 parts of sponge gourd, 5 parts of madder, 10 parts of folium artemisiae argyi, 5 parts of rhizoma cyperi, 5 parts of Bulbus Allii Fistulosi, silkworm It is husky 10 parts, 30 parts of honey.
Pre-coating solution includes 50 parts of white wine, 12 parts of cactus mud, 6 parts of peppermint oil.
In the present embodiment, folium artemisiae argyi, rhizoma cyperi, Bulbus Allii Fistulosi usage ratio are 2:1:1.
In the preferred case, folium artemisiae argyi is fresh folium artemisiae argyi, and rhizoma cyperi is prepared RHIZOMA CYPERI with vinegar.
Embodiment 2
A kind of combination of acute mastitis applies, including pre-coating solution and application plaster, and each raw material weight number is in application plaster:Pawpaw 24 parts, 12 parts of dandelion, 20 parts of rheum officinale, 9 parts of sponge gourd, 7 parts of madder, 15 parts of folium artemisiae argyi, 6 parts of rhizoma cyperi, 7 parts of Bulbus Allii Fistulosi, 12 parts of silkworm excrement, honeybee 45 parts of honey.
The pre-coating solution includes 70 parts of white wine, 14 parts of cactus mud, 7 parts of peppermint oil.
Embodiment 3
A kind of combination application of acute mastitis, including pre-coating solution and application plaster, the application plaster include following parts by weight Raw material:25 parts of pawpaw, 14 parts of dandelion, 22 parts of rheum officinale, 12 parts of sponge gourd, 7 parts of madder, 16 parts of folium artemisiae argyi, 8 parts of rhizoma cyperi, 8 parts of Bulbus Allii Fistulosi, 15 parts of silkworm excrement, 50 parts of honey.
The pre-coating solution includes 80 parts of white wine, 18 parts of cactus mud, 9 parts of peppermint oil.
The invention also discloses the preparation method of the combination application of above acute mastitis:
A kind of preparation method of the combination application of acute mastitis, including pre-coating solution prepares and prepared by application plaster, it is prepared by application plaster Comprise the following steps:
A, pre-process, take pawpaw one, along away from being cut the 1/4-1/3 of top at, after steaming 3-5 minutes, after remove seed, pawpaw meat is scraped Fall in pawpaw shell, the parts by weight of the pawpaw meat in pawpaw shell are 20-25 parts;It is 2 in proportion by folium artemisiae argyi, rhizoma cyperi, Bulbus Allii Fistulosi:1: 1 mixing, crush, grinding;Dandelion, rheum officinale, madder are pulverized, and sponge gourd is smashed;
B, mix, add silkworm excrement to the pawpaw shell for having pawpaw meat, after stirring, cover the upper part of incision, continue to steam 1-2 minutes; The folium artemisiae argyi pre-processed, rhizoma cyperi, Bulbus Allii Fistulosi, dandelion, rheum officinale, madder, sponge gourd are added in pawpaw shell again, stirred;
C, heat, the pawpaw shell after step B processing is heated into 1-2h;
D, after step C heating, after pawpaw shell surface covering honey, natural cooling, stirring, it is sealed.
In addition, pre-coating solution preparation process includes:
A, preheat, after cactus mud is mixed with peppermint oil, be heated to 50-60 DEG C;
B, mix, by the mixture after being preheated in step a, add in the white wine of normal temperature and be uniformly mixed, be sealed;Peppermint Oil can promote the osmosis of application plaster and cactus mud, and not only there is cactus the promoting flow of qi and blood circulation, heat clearing and inflammation relieving to detoxify, row The effect of pus and growing muscle, coordinate peppermint oil it can be promoted to be dissolved in wine.
Preferably, folium artemisiae argyi in the step A, rhizoma cyperi, Bulbus Allii Fistulosi mixing concretely comprise the following steps, by folium artemisiae argyi, Bulbus Allii Fistulosi mixed grinding After juice, Nutgrass Galingale Rhizome is added, is stirred.
Preferably, the temperature heated in the step C is 60-80 DEG C.
When specifically used, pre-coating solution is first used in affected part, pre-coating solution first shakes up sediment using preceding, in need to be preheated to 40 DEG C or so uses, after waiting pre-coating solution slightly dry after use, smear application plaster and uniformly coated in affected part and with gauze, such as to the cold In season, warmer can be affixed on gauze, it is better.
Analysis of cases:
Case 1
Mrs Li, Changsha Wangcheng County resident, 26 years old, first time acute mastitis was or when baby is 5 months big.Burst Acute mastitis, the place that left chest rises have changed into the stone for being covered with blue veins.Hot compress+rub lump always, firmly rubs, also along The past extrapolation in nipple direction;Child sucks the breast while rubbing that lump, and lump fades away.Second, recurred after two weeks, Same position blocks, same method, effectively.For the third time, recurred after a week, be same position again, at once obvious sense Feel stifled milk, it is general red that high fever starts stifled milk position skin(Seem that internal injury is the same);Specifically lump is flung with awfully hot water shower one Position, ache very much, oneself all be unable to start and rub, the sensation of pain will swoon, and see a doctor.
After being treated using this product, the same day brings down a fever, and pain reduces, and skin recovers the colour of skin, and symptom is clearly better;Continuous one After the individual course for the treatment of, symptom disappears, and adds with after a course for the treatment of, is not recurred to baby's wean.
Case 2
Mrs Fang, Zhuzhou Youxian County loess ridge resident, 29 years old, nursing period, breast had distending pain sense suddenly, inside there is lump, and face is yellow, breast Room skin is micro- red, and acute mastitis is diagnosed as in institute of traditional Chinese medicine of Youxian County.Inventive formulation is used afterwards, by 5 days control of course for the treatment of Treat, fully recovered, for recurrence.
In June, 2016 in June, 2017, treated for 78 volunteers, primary treatment data are as follows:
It should be noted that herein, term " comprising ", "comprising" or its any other variant are intended to nonexcludability Include so that process, method, article or equipment including a series of elements not only include those key elements, but also Including the other element being not expressly set out, or also include for this process, method, article or equipment intrinsic want Element.
Specific case used herein is set forth to the principle and embodiment of the present invention, the explanation of above example It is only intended to help the method and its core concept for understanding the present invention.Described above is only the preferred embodiment of the present invention, should When pointing out due to the finiteness of literal expression, and unlimited concrete structure objectively be present, for the common skill of the art For art personnel, under the premise without departing from the principles of the invention, some improvement, retouching or change can also be made, can also incited somebody to action Above-mentioned technical characteristic is combined by rights;These improve retouching, change or combination, or the not improved structure by invention Think and technical scheme directly applies to other occasions, be regarded as protection scope of the present invention.

Claims (9)

1. a kind of acute mastitis combination application, it is characterised in that including pre-coating solution and application plaster, the application plaster include with The raw material of lower parts by weight:Pawpaw 20-25 parts, dandelion 10-14 parts, rheum officinale 18-22 parts, sponge gourd 8-12 parts, madder 5-7 parts, Folium artemisiae argyi 10-16 parts, rhizoma cyperi 5-8 parts, Bulbus Allii Fistulosi 5-8 parts, silkworm excrement 10-15 parts, honey 30-50 parts.
2. the combination application of a kind of acute mastitis according to claim 1, it is characterised in that the pre-coating solution includes white Wine 50-80 parts, cactus mud 12-18 parts, peppermint oil 6-9 parts.
A kind of 3. combination application of acute mastitis according to claim 1, it is characterised in that each original in the application plaster Expect that parts by weight are:24 parts of pawpaw, 12 parts of dandelion, 20 parts of rheum officinale, 9 parts of sponge gourd, 7 parts of madder, 15 parts of folium artemisiae argyi, 6 parts of rhizoma cyperi, green onion White 7 parts, 12 parts of silkworm excrement, 45 parts of honey.
4. the combination application of a kind of acute mastitis according to claim 1, it is characterised in that folium artemisiae argyi, rhizoma cyperi, Bulbus Allii Fistulosi are used Amount ratio is 2:1:1.
5. the combination application of a kind of acute mastitis according to claim 1, it is characterised in that folium artemisiae argyi is fresh folium artemisiae argyi, fragrant Attached is prepared RHIZOMA CYPERI with vinegar.
6. the preparation method of the combination application of a kind of acute mastitis as described in claim 1-5, it is characterised in that including pre- Prepared by masking liquid and prepared by application plaster, and prepared by application plaster comprises the following steps:
A, pre-process, take pawpaw one, along away from being cut at the 1/4-1/3 of top, after steaming 3-5 minutes, after remove seed, pawpaw meat is scraped In pawpaw shell, the parts by weight of pawpaw meat are 20-25 parts;It is 2 in proportion by folium artemisiae argyi, rhizoma cyperi, Bulbus Allii Fistulosi:1:1 mixing, crush, Grinding;Dandelion, rheum officinale, madder are pulverized, and sponge gourd is smashed;
B, mix, add silkworm excrement to the pawpaw shell for having pawpaw meat, after stirring, cover the upper part of incision, continue to steam 1-2 minutes; The folium artemisiae argyi pre-processed, rhizoma cyperi, Bulbus Allii Fistulosi, dandelion, rheum officinale, madder, sponge gourd are added in pawpaw shell again, stirred;
C, heat, the pawpaw shell after step B processing is heated into 1-2h;
D, cool down, after step C heating, after pawpaw shell surface covering honey, natural cooling, stirring, be sealed.
A kind of 7. combination application of acute mastitis according to claim 6, it is characterised in that pre-coating solution preparation process bag Include:
A, preheat, after cactus mud is mixed with peppermint oil, be heated to 50-60 DEG C;
B, mix, by the mixture after being preheated in step a, add in the white wine of normal temperature and be uniformly mixed, be sealed.
A kind of 8. combination application of acute mastitis according to claim 6, it is characterised in that folium artemisiae argyi in the step A, What rhizoma cyperi, Bulbus Allii Fistulosi mixed concretely comprises the following steps, and after folium artemisiae argyi, Bulbus Allii Fistulosi mixed grinding juice, adds Nutgrass Galingale Rhizome, stirs.
9. the combination application of a kind of acute mastitis according to claim 6, it is characterised in that heated in the step C Temperature be 60-80 DEG C.
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