CN107850537B - 辐射载体及其在光学传感器中的使用 - Google Patents

辐射载体及其在光学传感器中的使用 Download PDF

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Publication number
CN107850537B
CN107850537B CN201680039258.XA CN201680039258A CN107850537B CN 107850537 B CN107850537 B CN 107850537B CN 201680039258 A CN201680039258 A CN 201680039258A CN 107850537 B CN107850537 B CN 107850537B
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radiation
carrier
grating
interest
detector
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CN107850537A (zh
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D·韦克吕斯
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Interuniversitair Microelektronica Centrum vzw IMEC
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Interuniversitair Microelektronica Centrum vzw IMEC
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/49Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434Optical arrangements
    • G01N15/1436Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434Optical arrangements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484Optical investigation techniques, e.g. flow cytometry microstructural devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/0001Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
    • G02B6/0011Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being planar or of plate-like form
    • G02B6/0033Means for improving the coupling-out of light from the light guide
    • G02B6/0035Means for improving the coupling-out of light from the light guide provided on the surface of the light guide or in the bulk of it
    • G02B6/00362-D arrangement of prisms, protrusions, indentations or roughened surfaces
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B6/122Basic optical elements, e.g. light-guiding paths
    • G02B6/124Geodesic lenses or integrated gratings
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/26Optical coupling means
    • G02B6/30Optical coupling means for use between fibre and thin-film device
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1006Investigating individual particles for cytology
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N2021/0346Capillary cells; Microcells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6463Optics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6482Sample cells, cuvettes

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN201680039258.XA 2015-06-30 2016-06-30 辐射载体及其在光学传感器中的使用 Active CN107850537B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15174678 2015-06-30
EP15174678.1 2015-06-30
PCT/EP2016/065394 WO2017001609A1 (en) 2015-06-30 2016-06-30 Radiation carrier and use thereof in an optical sensor

Publications (2)

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CN107850537A CN107850537A (zh) 2018-03-27
CN107850537B true CN107850537B (zh) 2020-05-19

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US (2) US20180188152A1 (https=)
EP (1) EP3317641B1 (https=)
JP (1) JP6505260B2 (https=)
CN (1) CN107850537B (https=)
CA (1) CA2991087C (https=)
WO (1) WO2017001609A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2991087C (en) 2015-06-30 2019-12-03 Imec Vzw Radiation carrier and use thereof in an optical sensor
EP3488221B1 (en) * 2016-07-20 2023-10-25 IMEC vzw An integrated lens free imaging device
CN111527431B (zh) * 2017-12-29 2023-02-17 根特大学 温度不敏感滤波器
EP3775847B1 (en) 2018-03-29 2026-04-29 Illumina, Inc. Illumination for fluorescence imaging using objective lens
US11344884B2 (en) 2018-07-26 2022-05-31 Boe Technology Group Co., Ltd. Microfluidic apparatus, method of detecting substance in microfluidic apparatus, and spectrometer
CN109724952B (zh) * 2018-11-21 2022-02-11 华南师范大学 一种光纤探头及其制备方法、光纤传感器及其应用
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
US12251991B2 (en) 2020-08-20 2025-03-18 Denso International America, Inc. Humidity control for olfaction sensors
US12269315B2 (en) 2020-08-20 2025-04-08 Denso International America, Inc. Systems and methods for measuring and managing odor brought into rental vehicles
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US12377711B2 (en) 2020-08-20 2025-08-05 Denso International America, Inc. Vehicle feature control systems and methods based on smoking
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US12017506B2 (en) 2020-08-20 2024-06-25 Denso International America, Inc. Passenger cabin air control systems and methods
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
EP4012380B1 (en) 2020-12-08 2025-04-02 Imec VZW A light excitation and collection device and a method for light excitation and collection
TWI832469B (zh) * 2021-10-06 2024-02-11 中央研究院 檢測系統
DE102021212505A1 (de) 2021-11-08 2023-05-11 Robert Bosch Gesellschaft mit beschränkter Haftung Optische Vorrichtung zum Anregen einer Probe, Analysegerät und Verfahren zum Anregen einer Probe
CN115406817B (zh) * 2022-07-21 2024-12-10 西安交通大学 基于微流控的颗粒检测器

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006267052A (ja) * 2005-03-25 2006-10-05 Toshiba Corp 免疫反応測定用検査装置

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351611A (en) * 1980-09-22 1982-09-28 Coulter Electronics, Inc. Monitoring of a detection zone utilizing zero order radiation from a concave reflecting grating
EP0266120A3 (en) 1986-10-31 1990-07-11 AT&T Corp. Generating an array of light spots having uniform intensity
US4906094A (en) 1987-04-23 1990-03-06 Sumitomo Chemical Co. Ltd. Fine particle measuring method and system and a flow cell for use in the system
GB8807486D0 (en) * 1988-03-29 1988-05-05 Ares Serono Res & Dev Ltd Waveguide sensor
US5303316A (en) * 1989-12-22 1994-04-12 David Sarnoff Research Center, Inc. Optical beam scanner
US5999256A (en) 1992-02-12 1999-12-07 Cambridge Consultants Limited Particle measurement system
DE4215908A1 (de) * 1992-05-14 1993-11-18 Ubbo Prof Dr Ricklefs Optische Einrichtung zur Bestimmung der Größe von Partikeln
WO1998022799A2 (de) * 1996-11-18 1998-05-28 Novartis Ag Messvorrichtung und deren verwendung
DE59811600D1 (de) * 1997-09-10 2004-07-29 Artificial Sensing Instr Asi A Optischer sensor und optisches verfahren zur charakterisierung einer chemischen und/oder biochemischen substanz
JP2003522578A (ja) * 2000-02-18 2003-07-29 アーゴス インク 不均質組織における空間的に平均された励起−発光マップの生成
US7630063B2 (en) 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
US6785433B2 (en) * 2000-08-09 2004-08-31 Artificial Sensing Instruments Asi Ag Waveguide grid array and optical measurement arrangement
AU2001290568A1 (en) 2000-08-25 2002-03-04 Amnis Corporation Measuring the velocity of small moving objects such as cells
WO2004001382A2 (en) 2002-06-24 2003-12-31 Tsi Incorporated Analysis systems detecting particle size and fluorescence
AU2003275942A1 (en) 2002-11-01 2004-05-25 Technical University Of Denmark A microfluidic system and a microdevice for velocity measurement, a method of performing measurements and use hereof
JP2006170853A (ja) * 2004-12-16 2006-06-29 Sekisui Chem Co Ltd 分析デバイス、読取装置及び情報管理システム
CZ299489B6 (cs) * 2005-01-12 2008-08-13 Ústav fotoniky a elektroniky AV CR, v. v. i. Zpusob spektroskopie povrchových plazmonu pro senzory s povrchovými plazmony a senzorový element k provádení tohoto zpusobu
US7551359B2 (en) 2006-09-14 2009-06-23 3M Innovative Properties Company Beam splitter apparatus and system
US8409509B2 (en) 2007-04-12 2013-04-02 Regents Of The University Of Minnesota Systems and methods for analyzing a particulate
JP2010539516A (ja) 2007-09-17 2010-12-16 ルミネックス コーポレーション フロー内の粒子を識別するためのシステム、記憶媒体、及び方法
JP5080186B2 (ja) * 2007-09-26 2012-11-21 富士フイルム株式会社 分子分析光検出方法およびそれに用いられる分子分析光検出装置、並びにサンプルプレート
CA2737505C (en) * 2008-09-16 2017-08-29 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
CN102165305B (zh) * 2008-09-25 2014-08-20 皇家飞利浦电子股份有限公司 检测系统与方法
JP5721940B2 (ja) * 2009-11-04 2015-05-20 オリンパス株式会社 光スペクトル検出方法
US8980550B2 (en) * 2009-12-15 2015-03-17 California Institute Of Technology Methods for measuring samples using consumer electronic devices and systems
US9029800B2 (en) 2011-08-09 2015-05-12 Palo Alto Research Center Incorporated Compact analyzer with spatial modulation and multiple intensity modulated excitation sources
CA2991087C (en) 2015-06-30 2019-12-03 Imec Vzw Radiation carrier and use thereof in an optical sensor
EP3339834B1 (en) 2016-12-22 2021-11-10 IMEC vzw Flow cytometer with multiple intensity peak design

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006267052A (ja) * 2005-03-25 2006-10-05 Toshiba Corp 免疫反応測定用検査装置

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Publication number Publication date
JP2018528390A (ja) 2018-09-27
US12031899B2 (en) 2024-07-09
WO2017001609A1 (en) 2017-01-05
CA2991087A1 (en) 2017-01-05
CA2991087C (en) 2019-12-03
EP3317641B1 (en) 2019-03-06
CN107850537A (zh) 2018-03-27
US20180188152A1 (en) 2018-07-05
EP3317641A1 (en) 2018-05-09
US20210072141A1 (en) 2021-03-11
JP6505260B2 (ja) 2019-04-24

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