CN107847740A - 神经调节设备 - Google Patents

神经调节设备 Download PDF

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Publication number
CN107847740A
CN107847740A CN201680023560.6A CN201680023560A CN107847740A CN 107847740 A CN107847740 A CN 107847740A CN 201680023560 A CN201680023560 A CN 201680023560A CN 107847740 A CN107847740 A CN 107847740A
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CN
China
Prior art keywords
signal
patient
nerve
waveform
unnecessarily
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680023560.6A
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English (en)
Chinese (zh)
Inventor
布伦丹·J·坎宁
迈克尔·约翰·卡尔
玛丽安·克拉里克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galvani Biological Electronics Co Ltd
Johns Hopkins University
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Galvani Biological Electronics Co Ltd
Johns Hopkins University
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Publication date
Application filed by Galvani Biological Electronics Co Ltd, Johns Hopkins University filed Critical Galvani Biological Electronics Co Ltd
Publication of CN107847740A publication Critical patent/CN107847740A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0553—Paddle shaped electrodes, e.g. for laminotomy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/3611—Respiration control
    • A—HUMAN NECESSITIES
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    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/36139—Control systems using physiological parameters with automatic adjustment
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    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
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    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
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    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
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    • A61N5/0613—Apparatus adapted for a specific treatment
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
    • A61F2007/0075—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating using a Peltier element, e.g. near the spot to be heated or cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36189—Control systems using modulation techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A61N2007/0026—Stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Surgical Instruments (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201680023560.6A 2015-02-24 2016-02-24 神经调节设备 Pending CN107847740A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562119998P 2015-02-24 2015-02-24
US62/119,998 2015-02-24
PCT/US2016/019234 WO2016138066A1 (en) 2015-02-24 2016-02-24 Neuromodulation device

Publications (1)

Publication Number Publication Date
CN107847740A true CN107847740A (zh) 2018-03-27

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CN201680023560.6A Pending CN107847740A (zh) 2015-02-24 2016-02-24 神经调节设备

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US (2) US10441787B2 (enExample)
EP (2) EP3261711B1 (enExample)
JP (1) JP2018508329A (enExample)
KR (1) KR20180008397A (enExample)
CN (1) CN107847740A (enExample)
AU (1) AU2016222825A1 (enExample)
BR (1) BR112017018068A2 (enExample)
CA (1) CA2977517A1 (enExample)
ES (1) ES2855799T3 (enExample)
RU (1) RU2017129539A (enExample)
WO (1) WO2016138066A1 (enExample)

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CN109199359A (zh) * 2018-10-15 2019-01-15 暨南大学 光电联合刺激系统和光电联合刺激神经纤维方法

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US10029101B2 (en) 2013-01-09 2018-07-24 Mayo Foundation For Medical Education And Research Systems for the detection and delivery of neurochemical and electrical signals for functional restoration
AU2015237140A1 (en) * 2014-03-27 2016-10-13 Circuit Therapeutics, Inc. System and method for therapeutic management of cough
KR102445887B1 (ko) 2016-04-21 2022-09-21 아스트로사이트 파마슈티컬스, 인코포레이티드 신경계 및 심혈관계 병태 치료를 위한 화합물 및 방법
US11040197B2 (en) * 2017-06-22 2021-06-22 Mayo Foundation For Medical Education And Research Voltammetric neurochemical detection in whole blood
US11077314B1 (en) * 2020-04-29 2021-08-03 Multi Radiance Medical System and method for treating patients requiring mechanical ventilation
DE102020114745A1 (de) * 2020-06-03 2021-12-09 NeuroCare Group GmbH Körperzustandsabhängige Stimulation mit Echtzeitkommunikation zwischen einem Aktions- und einem Erfassungsmodul
WO2025079630A1 (ja) * 2023-10-13 2025-04-17 帝人ファーマ株式会社 咳嗽治療装置
EP4635557A1 (en) 2024-04-16 2025-10-22 Merck Patent GmbH System for inhibiting action potential conduction in a nerve

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US7747324B2 (en) * 2005-11-10 2010-06-29 Electrocore Llc Electrical stimulation treatment of bronchial constriction
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US20130238049A1 (en) * 2009-03-20 2013-09-12 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
CN103517732A (zh) * 2011-03-10 2014-01-15 电核有限责任公司 用于无创电容式电刺激的设备和方法以及它们用于对患者颈部的迷走神经刺激的用途
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US20140186341A1 (en) * 2012-12-27 2014-07-03 Holaira, Inc. Methods for improving drug efficacy
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US20040162594A1 (en) * 2001-05-17 2004-08-19 King Gary W. Apparatus and method for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated
US20070027496A1 (en) * 2005-07-28 2007-02-01 Cyberonics, Inc. Stimulating cranial nerve to treat pulmonary disorder
US20140371809A1 (en) * 2005-07-28 2014-12-18 Cyberonics, Inc. Stimulating cranial nerve to treat pulmonary disorder
US7747324B2 (en) * 2005-11-10 2010-06-29 Electrocore Llc Electrical stimulation treatment of bronchial constriction
US20100228318A1 (en) * 2005-11-10 2010-09-09 Electrocore Llc Electrical Stimulation Treatment of Bronchial Constriction
CN102553072A (zh) * 2006-01-23 2012-07-11 赤克邦外科有限公司 用于诊断和/或治疗目的的区分和/或鉴定由靶神经支配的组织区域的系统和方法
US20140222124A1 (en) * 2006-02-10 2014-08-07 ElectroCore, LLC Methods and apparatus for treating anaphylaxis using electrical modulation
US20140142653A1 (en) * 2008-01-25 2014-05-22 Flint Hills Scientific, L.L.C. Contingent cardio-protection for epilepsy patients
US20130238049A1 (en) * 2009-03-20 2013-09-12 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US20110301587A1 (en) * 2010-04-06 2011-12-08 Innovative Pulmonary Solutions, Inc. System and method for pulmonary treatment
CN103561815A (zh) * 2010-08-19 2014-02-05 电核有限责任公司 支气管收缩的无创处置
CN103517732A (zh) * 2011-03-10 2014-01-15 电核有限责任公司 用于无创电容式电刺激的设备和方法以及它们用于对患者颈部的迷走神经刺激的用途
US20120296389A1 (en) * 2011-05-19 2012-11-22 Neuros Medical, Inc. High-frequency electrical nerve block
US20140186341A1 (en) * 2012-12-27 2014-07-03 Holaira, Inc. Methods for improving drug efficacy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109199359A (zh) * 2018-10-15 2019-01-15 暨南大学 光电联合刺激系统和光电联合刺激神经纤维方法

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EP3808407A1 (en) 2021-04-21
JP2018508329A (ja) 2018-03-29
AU2016222825A1 (en) 2017-09-07
US20180043162A1 (en) 2018-02-15
CA2977517A1 (en) 2016-09-01
EP3261711A4 (en) 2019-02-20
BR112017018068A2 (pt) 2018-04-10
WO2016138066A1 (en) 2016-09-01
EP3261711B1 (en) 2020-12-16
EP3261711A1 (en) 2018-01-03
KR20180008397A (ko) 2018-01-24
RU2017129539A (ru) 2019-03-25
ES2855799T3 (es) 2021-09-24
US20200009384A1 (en) 2020-01-09
US10441787B2 (en) 2019-10-15

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Application publication date: 20180327