CN1078396A - Medicine for treating dermatosis and manufacture method thereof - Google Patents
Medicine for treating dermatosis and manufacture method thereof Download PDFInfo
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- CN1078396A CN1078396A CN 93103020 CN93103020A CN1078396A CN 1078396 A CN1078396 A CN 1078396A CN 93103020 CN93103020 CN 93103020 CN 93103020 A CN93103020 A CN 93103020A CN 1078396 A CN1078396 A CN 1078396A
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Abstract
The present invention relates to treat the medicine for external use " No. one, medicine for treating dermatosis " of various skin disease, this medicated bag is drawn together Calomelas, sulfur, Realgar, Aerugo, dried Alumen, Lu Ganshi, Borneolum Syntheticum, dens, Gypsum Fibrosum powder, Mentholum, Carassius auratus frost, Semen Vignae Radiatae flour, hydroxytetracycline tablet, dexamethasone tablet, and uses fluocinolone acetonide cream or halcinonidedcorten ointment or clotrimazole ointment double as blender.Because this medicine composition is reasonable, oiliness does not have no stimulation to skin and does not pollute skin, thereby the cure rate height.
Description
The present invention relates to topical drug that is used for the treatment of the various skin disease and preparation method thereof, particularly relate to medicine of various skin diseases such as the stubborn dermatitis (neurodermatitis) that is suitable for treating in the dermatosis, eczema, urticaria, seborrheic dermatitis, prurigo nodularis, skin pruritus and preparation method thereof.
As everybody knows, above-mentioned these refractory skins are difficult to thoroughly radical cure with regard to existing medical kind, for example normally used " fluocinonide ", " halcinonidedcorten ", " clotrimazole " though etc. ointment can alleviate condition of illness, can not thoroughly effect a radical cure these dermatosis.Aspect Chinese herbal medicine, also there are some to treat the proved recipe of this class disease, " side nine " in for example " efficient proved recipe 1000 head of external therapy of Chinese herb at all times " (Beijing science tech publishing house publishes in May, 1992) in the 243rd page " side one " and the 246th is mainly used in neurodermatitis, has certain curative effect.But the shortcoming of this class prescription is: (1) prescription is not enough very reasonable, thereby cure rate does not reach certain altitude (as greater than 90%); (2) be in harmonious proportion ointment with vaseline, because its oiliness is big, thereby can adsorbs dust and cause unhygienic and pollute, and bactericidal effect is reduced; (3) these prescriptions are primarily aimed at single neurodermatitis, be not suitable for the various skin disease, thereby the scope of application is narrow, also have some novel drugs, reach " a kind of manufacture method for the treatment of skin ulcer tinea medicine " as disclosed among Chinese patent CN91106054.5 and the CN89108691.9 " preparation of psoriasis ointment drugs and Therapeutic Method ", these medicines still have similar shortcoming, as adding leaf fat among the former, it has contamination as vaseline to skin, has reduced sterilizing ability; The latter needs to transfer with iodine tincture or water for powder, and transferring with iodine tincture has stimulation to skin, and the medicine adhesive force that water is transferred is little, thereby all can not reach very ideal curative effect.
Therefore, the objective of the invention is to overcome above-mentioned weak point, a kind of high curative rate that has be provided, non-stimulated to skin, have no side effect, pollution-free and medicine that is applicable to treatment various skin disease that sterilizing ability is strong and preparation method thereof.
Above-mentioned purpose of the present invention is to realize like this, on the basis of present normally used Calomelas, sulfur, Realgar, Aerugo, dried Alumen, add Lu Ganshi, Borneolum Syntheticum, dens, Gypsum Fibrosum powder, Mentholum, Carassius auratus frost, Semen Vignae Radiatae flour, hydroxytetracycline tablet, dexamethasone tablet again, and use fluocinolone acetonide cream or halcinonidedcorten ointment or clotrimazole ointment double as blender; The share of these medicines is as follows: Calomelas 12-20 gram, sulfur 5-10 gram, Realgar 5-10 gram, Aerugo 10-20 gram, dried Alumen 3-6 gram, Lu Ganshi 20-200 gram, Borneolum Syntheticum 5-10 gram, dens 30-300 gram, Gypsum Fibrosum powder 18-180 gram, Mentholum 5-10 gram, Carassius auratus frost 5-10 gram, Semen Vignae Radiatae flour 10-500 gram, hydroxytetracycline tablet 3-6 gram, dexamethasone tablet 2-4 gram, and fluocinolone acetonide cream or halcinonidedcorten ointment or clotrimazole ointment 1300-5000 gram, make " No. one, medicine for treating dermatosis " medicine.
Its method for making is: with above-mentioned various medicine compositions, except that fluocinolone acetonide cream or halcinonidedcorten ointment or clotrimazole ointment, fine grinding, cross 100 mesh sieves and mix homogeneously, again by 1-2 gram mediation fluocinolone acetonide cream or halcinonidedcorten ointment or clotrimazole ointment 10 grams, mix well the back by quantitative bottling, as every bottle 10 gram.
Must be pointed out that the Carassius auratus frost in the mentioned component is not the Chinese crude drug of using always, it composed as follows: Arsenicum sablimatum 30 grams, Radix Aconiti 9 grams, Radix Aconiti Kusnezoffii 9 grams, one of the Carassius auratus of Borneolum Syntheticum 3 grams and 800-1000 gram.Its method for making is: with mentioned component fine grinding altogether except that Carassius auratus, the Carassius auratus internal organs are all removed, then above-mentioned medicamental pulverata is packed in the fish maw and sew on and close fish maw, dried in the shade 49 days in temperature is lower than 15 ℃ shady and cool ventilation environment, again the frost of full fish and fish outside being made fine powder altogether is Carassius auratus frost.
The characteristics of " No. one, medicine for treating dermatosis " of the present invention medicine are prescription rationally, and the composition that wherein plays a major role is a Sal Nitri, Carassius auratus frost, Semen Vignae Radiatae flour, white plain sheet of soil and dexamethasone tablet.Wherein Sal Nitri is used for heat-clearing and toxic substances removing and detumescence, and Carassius auratus frost is used for anti-inflammatory analgetic, sterilization and antipruritic, and Semen Vignae Radiatae flour is used for heat-clearing and toxic substances removing, and oxytetracycline and dexamethasone are used for anti-inflammatory analgetic and antipruritic.Another characteristics are that this medicine adopts fluocinolone acetonide cream (or halcinonidedcorten ointment or clotrimazole ointment) double as blender, on the one hand because they have therapeutical effect, their oiliness (being different from vaseline or leaf fat) and not on the other hand to skin non-stimulated (being different from iodine tincture), therefore they neither can pollute skin Diazolidinyl Urea not again, well brought into play with regard to the effect that makes this medicine, because of face can be obtained good cure rate, according to up to now observation of curative effect to following various dermopathic obvious effective rates all more than 90%, see following table for details:
Therapeutic outcome table of medicine for treating dermatosis
| Treat routine number | Recover | Produce effects | Effectively | Invalid | Interrupt | Obvious effective rate in 30 days | |
| The limitation stubborn dermatitis | 256 | 243 | 4 | 6 | 2 | 1 | 96.48%(247/256) |
| The diffusibility stubborn dermatitis | 156 | 149 | 3 | 2 | 1 | 1 | 97.43%(152/156) |
| Prurigo nodularis | 45 | 42 | 1 | 2 | 95.55%(43/45) | ||
| Eczema | 51 | 46 | 2 | 1 | 1 | 1 | 94.11%(48/51) |
| Eczema-like dermatitis | 48 | 43 | 2 | 1 | 1 | 1 | 93.75%(45/48) |
| Seborrheic dermatitis | 54 | 47 | 2 | 3 | 1 | 1 | 90.74%(49/54) |
| Urticaria | 46 | 40 | 2 | 2 | 1 | 1 | 91.30%(42/46) |
| Add up to | 656 | 610 | 16 | 17 | 7 | 6 | 95.42%(626/656) |
Be further described below in conjunction with a preferred embodiment of the present invention.The composition and the share of " No. one, medicine for treating dermatosis " medicine of the preferred embodiment are: Lu Ganshi 20 grams, Borneolum Syntheticum 5 grams, Sal Nitri 30 grams, Gypsum Fibrosum powder 18 grams, Mentholum 5 grams, Carassius auratus frost 5 grams, Semen Vignae Radiatae flour 10 grams, Aerugo 10 grams, Calomelas 12 grams, Realgar 5 grams, sulfur 5 grams, dried Alumen 3 grams, hydroxytetracycline tablet 3 grams, loose sheet 2 grams of ground plug, fluocinonide ointment 1330 grams.Its method for making is with the fine grinding except that fluocinonide of above each medicine, crosses 100 mesh sieves and mix homogeneously, per 1 gram mediation fluocinonide ointment, 10 grams, and the bottling of mediation back, every bottle 10 restrains.
Character after this medicine is made is green, khaki emulsifiable paste.Its function is sterilizing and itch-relieving, the softening infiltration and anti-inflammatory analgetic.It cures mainly: stubborn dermatitis (neurodermatitis), comprise limitation stubborn dermatitis, diffusibility stubborn dermatitis, eczema-like dermatitis, eczema, prurigo nodularis, urticaria, skin pruritus, seborrheic dermatitis, acne tinea manus and pedis etc.Usage is an affected part of exterior coating, every day 1-2 time, but suppurate in the affected part, usefulness is avoided at rotten to the corn place.
When utilizing " No. one, medicine for treating dermatosis " medicine of this embodiment of the invention to do test the model case of treatment enumerate two as follows:
1) Liu Baojian, man, 25 years old age, June 5 nineteen eighty-two time, address: the Dong Chengyang village, Heze, Shandong.
Check characteristic of disease: left and right sides epigastrium respectively has skin lesion 25cm
2, hand skin lesion 30cm
2, cervical region skin lesion 20cm
2, chest skin lesion 23cm
2, pruritus tuberosity, desquamation scratch, medical history 3 years.
Be diagnosed as: stubborn dermatitis (neurodermatitis).
Treatment: be coated with this " No. one, medicine for treating dermatosis " ointment outward, treated one month, transference cure and fully recovering.Investigate not recurrence in 11 years now.
2) Sun Hongliang, man, 43 years old age, 8 months July of 85 year time, address, Heze Gao Zhuan township grandson building 2 teams.
Check the state of an illness: head, beard and eyebrow place skin lesion spread all over, and the tuberosity Pruritus is scratched back stream yellow fluid, medical history 3 years.
Be diagnosed as: seborrheic dermatitis.
Treatment: " No. one, medicine for treating dermatosis " ointment is somebody's turn to do in external, treats recovery from illness in 20 days.
Another preferred embodiment of the present invention is: Lu Ganshi 20 grams, Borneolum Syntheticum 10 grams, dens 100 grams, Gypsum Fibrosum powder 20 grams, Mentholum 5 grams, Carassius auratus frost 10 grams, Semen Vignae Radiatae flour 290 grams, Aerugo 10 grams, Calomelas 12 grams, Realgar 5 grams, sulfur 5 grams, dried Alumen 3 grams, hydroxytetracycline tablet 6 grams, dexamethasone tablet 4 grams, fluocinolone acetonide cream 3000 grams.Its method for making is crossed 100 mesh sieves and mix homogeneously for the equal fine grinding except that fluocinonide of above each medicine, per 1.667 gram mediation fluocinonide ointments, 10 grams, and the bottling of mediation back, every bottle 10 restrains.
When utilizing " No. one, medicine for treating dermatosis " medicine of this embodiment to do test the model case of treatment enumerate one as follows:
Liu Baoquan, man, 25 years old, time: on August 2nd, 85, unit: Jinan automobile head factory, address: in Jinan four tunnel unit henries No..
Check the state of an illness: the skin lesion whole body distributes, pruritus, tuberosity, desquamation, scratch, medical history 3 years.
Diagnosis: general stubborn dermatitis (diffusibility neurodermatitis).
Treatment: " No. 1, medicine for treating dermatosis " is somebody's turn to do in external, recovery from illness after treatment in 40 days.
In sum, " No. one, medicine for treating dermatosis " of the present invention thereby obtained very high curative effect because prescription rationally, and adopts skin is had no side effect and medicable blender. Its summary of benefits is as follows: (1) to refractory skin described above, the cure rate height. Have no side effect, can reach the purpose of radical cure. (2) this medicine affected part of exterior coating patient that has no stimulation is not painful, and does not have oiliness and do not inhale dust, does not pollute skin and clothes, and patient easily accepts. (3) this medicine cost is lower, and manufacturing process is simple, easy to implement and popularization. (4) this medicine can be treated multiple dermatosis, and curative effect is fast, and general dermatitis is coated with first and second outward and just can cures.
Claims (4)
1, a kind of " No. one, medicine for treating dermatosis " medicine for the treatment of the various skin disease, it comprises Calomelas, sulfur, Realgar, Aerugo, dried Alumen, it is characterized in that: this medicine also comprises Lu Ganshi, Borneolum Syntheticum, dens, Gypsum Fibrosum powder, Mentholum, Carassius auratus frost, Semen Vignae Radiatae flour, hydroxytetracycline tablet, dexamethasone tablet, and use fluocinolone acetonide cream or halcinonidedcorten ointment or clotrimazole ointment double as blender, their share is as follows: Calomelas 12-20 gram, sulfur 5-10 gram, Realgar 5-10 gram, Aerugo 10-20 gram, dried Alumen 3-6 gram, Lu Ganshi 20-200 gram, Borneolum Syntheticum 5-10 gram, dens 30-300 gram, Gypsum Fibrosum powder 18-180 gram, Mentholum 5-10 gram, Carassius auratus frost 5-10 gram, Semen Vignae Radiatae flour 10-500 gram, hydroxytetracycline tablet 3-6 gram, dexamethasone tablet 2-4 gram, and fluocinolone acetonide cream or halcinonidedcorten ointment or clotrimazole ointment 1300-5000 gram.
2, " No. one, medicine for treating dermatosis " according to claim 1 medicine, it is characterized in that: wherein the composition of Carassius auratus frost and share are: Arsenicum sablimatum 30 gram, Radix Aconiti 9 grams, Radix Aconiti Kusnezoffii 9 grams, Borneolum Syntheticum 3 grams, and one of the Carassius auratus of 800-1000 gram.
3, a kind of manufacture method for the treatment of " No. one, medicine for treating dermatosis " medicine of various skin disease, it is characterized in that: with the composition of following share: Calomelas 12-20 gram, sulfur 5-10 gram, Realgar 5-10 gram, Aerugo 10-20 gram, dried Alumen 3-6 gram, Lu Ganshi 20-200 gram, Borneolum Syntheticum 5-10 gram, dens 30-300 gram, Gypsum Fibrosum powder 18-180 gram, Mentholum 5-10 gram, Carassius auratus frost 5-10 gram, Semen Vignae Radiatae flour 10-500 gram, hydroxytetracycline tablet 3-6 gram, dexamethasone tablet 2-4 restrains equal fine grinding, crosses 100 mesh sieves and mix homogeneously, again by every 1-2 gram mediation fluocinolone acetonide cream or halcinonidedcorten ointment or clotrimazole ointment 10 grams, mix well the back by quantitative bottling, as every bottle 10 gram.
4, the manufacture method of " No. one, medicine for treating dermatosis " according to claim 3 medicine, it is characterized in that: the method for making of wherein said Carassius auratus frost composition is, with Arsenicum sablimatum 30 grams, Radix Aconiti 9 grams, Radix Aconiti Kusnezoffii 9 grams, Borneolum Syntheticum 3 gram fine grindings altogether, and one of the Carassius auratus of getting 800 grams-1000 grams are all removed its internal organs, then above-mentioned medicamental pulverata is packed in the fish maw and sew on and close fish maw, in being lower than 15 ℃ shady and cool ventilation environment, temperature dried in the shade 49 days, again the frost of full fish and fish outside is made fine powder altogether, Carassius auratus frost.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93103020 CN1078396A (en) | 1993-03-24 | 1993-03-24 | Medicine for treating dermatosis and manufacture method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93103020 CN1078396A (en) | 1993-03-24 | 1993-03-24 | Medicine for treating dermatosis and manufacture method thereof |
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| Publication Number | Publication Date |
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| CN1078396A true CN1078396A (en) | 1993-11-17 |
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| CN 93103020 Pending CN1078396A (en) | 1993-03-24 | 1993-03-24 | Medicine for treating dermatosis and manufacture method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083272C (en) * | 1998-10-12 | 2002-04-24 | 范永昌 | Oral medicine for treating dermatosis |
| CN101683369B (en) * | 2008-09-25 | 2011-03-23 | 谢志丹 | Medicament for treating skin tinea disease |
| CN102641291A (en) * | 2012-05-07 | 2012-08-22 | 鲁道宗 | Mastic for treating herpes zoster and preparation method thereof |
| CN103919811A (en) * | 2014-05-03 | 2014-07-16 | 周午贤 | Boneless pill |
| CN104116766A (en) * | 2014-07-15 | 2014-10-29 | 李兴常 | Compound preparation for controlling exanthema |
| CN104189053A (en) * | 2014-08-12 | 2014-12-10 | 朱金凤 | Externally applied powder for treating ulcer and furunculosis |
| CN104606227A (en) * | 2013-11-05 | 2015-05-13 | 蒋世芬 | External application mixing medicine for treating stubborn dermatitis |
| CN109453192A (en) * | 2018-12-06 | 2019-03-12 | 沧州爱农生物科技有限公司 | A kind of compound hydrochloric acid terramycin alumen borneol effervescent tablet and preparation method thereof |
-
1993
- 1993-03-24 CN CN 93103020 patent/CN1078396A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083272C (en) * | 1998-10-12 | 2002-04-24 | 范永昌 | Oral medicine for treating dermatosis |
| CN101683369B (en) * | 2008-09-25 | 2011-03-23 | 谢志丹 | Medicament for treating skin tinea disease |
| CN102641291A (en) * | 2012-05-07 | 2012-08-22 | 鲁道宗 | Mastic for treating herpes zoster and preparation method thereof |
| CN104606227A (en) * | 2013-11-05 | 2015-05-13 | 蒋世芬 | External application mixing medicine for treating stubborn dermatitis |
| CN103919811A (en) * | 2014-05-03 | 2014-07-16 | 周午贤 | Boneless pill |
| CN104116766A (en) * | 2014-07-15 | 2014-10-29 | 李兴常 | Compound preparation for controlling exanthema |
| CN104189053A (en) * | 2014-08-12 | 2014-12-10 | 朱金凤 | Externally applied powder for treating ulcer and furunculosis |
| CN109453192A (en) * | 2018-12-06 | 2019-03-12 | 沧州爱农生物科技有限公司 | A kind of compound hydrochloric acid terramycin alumen borneol effervescent tablet and preparation method thereof |
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