CN107831811A - The fluid channel flow control apparatus and control method of a kind of micro-nano cellulose - Google Patents
The fluid channel flow control apparatus and control method of a kind of micro-nano cellulose Download PDFInfo
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- CN107831811A CN107831811A CN201710784763.3A CN201710784763A CN107831811A CN 107831811 A CN107831811 A CN 107831811A CN 201710784763 A CN201710784763 A CN 201710784763A CN 107831811 A CN107831811 A CN 107831811A
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- G—PHYSICS
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- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D27/00—Simultaneous control of variables covered by two or more of main groups G05D1/00 - G05D25/00
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0626—Fluid handling related problems using levitated droplets
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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Abstract
The invention discloses the fluid channel flow control apparatus and control method of a kind of micro-nano cellulose, device includes：Syringe pump, injection portion, sample-adding plug, micro-fluidic chip, diaphragm seal etc., method comprises the steps：Syringe pump quantitatively controls the uninterrupted of injection micro-nano cellulose suspension；Injection portion is injected into micro-fluidic chip to contain the suspension for having micro-nano cellulose and by micro-nano cellulose suspension；Sample-adding plug is embedded into fluid channel, is sealed after micro-fluidic chip injects micro-nano cellulose suspension；Micro-fluidic chip is used to carry different in width and the microchannel of shape；Diaphragm seal is covered in micro-fluidic chip upper surface.The present invention is easy to operate, need to only inject micro-nano cellulose suspension in fluid channel, and realization that can be quickly flows control to the fluid channel of micro-nano cellulose.
Description
Technical field
The present invention relates to the micro-nano fibre of the microfluidic control field of the nanofiber of flexible material, especially plant origin
Tie up the control device and control method of cellulosic material.
Background technology
Cellulose is the natural polymer formed by β-glucose condensation, be it is the abundantest in nature can be again
Production-goods source.Micro-nano cellulose has excellent property, green, natural reproducible, biocompatibility, while also has excellent
Different optical property and mechanical performance.Micro-fluidic chip (Microfluidics) is also known as micro-total analysis system, micro-fluidic chip
Laboratory or chip lab (Lab-on-a-chip).The characteristics of micro-fluidic chip and advantages for development are：Liquid flowing can
Control, the features such as sample and reagent are few, hundreds and thousands of times of ground of analyze speed improve is consumed, it manipulates micro fluid in minim channel
Or the system flowed in component, the wherein yardstick of passage and structure is tens microns to hundreds of microns.
Microfluid drive and flow process in control be microfluid system research in two key issues, it with it is grand
See the driving of fluid and flowing controls and there is very big difference, is related to the complicated heat and mass phenomenon of minute yardstick fluid, very
More phenomenons can broadly be attributed to scale effect and skin effect, and researcher is to micro fluid dynamcis and the hydrodynamics base of control
This problem and multiple technologies are studied.
However, routine techniques is difficult that the driving and control to microfluid are completed in microchannel, therefore, development is a kind of just
Micro fluid dynamcis prompt, quick, efficiently, inexpensive and control technology, it is that the one kind in the fields such as microfluid system is innovated, especially
It is the driving to including the microfluid of micro-nano cellulose and control field, this to realizing micro-nano cellulose in miniflow in the future
Enrichment, reaction and separation in passage have great meaning.
The content of the invention
The shortcomings that it is a primary object of the present invention to overcome prior art with deficiency, there is provided a kind of micro-nano cellulose it is micro-
Flow passage control device and control method.
In order to achieve the above object, the present invention uses following technical scheme：
A kind of fluid channel flow control apparatus of micro-nano cellulose of the present invention, including syringe pump, injection portion, sample-adding
Plug, micro-fluidic chip, microchannel and diaphragm seal, the syringe pump connect injection portion, and the injection portion is filled in sample-adding
Connection, the sample-adding are filled in the microchannel of embedded micro-fluidic chip, the micro-fluidic chip and sample-adding plug, injection portion company
Logical, the diaphragm seal is covered in the upper surface of micro-fluidic chip；
The syringe pump, for quantitatively controlling the uninterrupted of injection micro-nano cellulose suspension；
The injection portion, for temporarily storing the suspension for having micro-nano cellulose and by micro-nano cellulose suspension
It is injected into micro-fluidic chip；
The sample-adding plug, the suspension for closed injection micro-nano cellulose；
The micro-fluidic chip, for carrying the microchannel of different in width and shape；
The microchannel, the suspension of micro-nano cellulose are flowed in the microchannel；
The diaphragm seal, for being sealed to the fluid channel in micro-fluidic chip.
As preferable technical scheme, the microchannel high unity in the micro-fluidic chip is 10um, channel shape
Point have linear pattern passage, shaped form passage, Trident Type passage, a helical duct, microchannel width include 100um, 200um,
Tri- levels of 300um.
As preferable technical scheme, the concrete methods of realizing of the microfluidic control chip bearing microchannel is as follows：
First, drawn with autoCAD softwares, the passage of different shape and width is sketched the contours on microfluidic control chip, then
By pattern with high resolution printed, it is bonded on quartz glass, mask plate is made；
Then, photosensitive glue pattern plate is made on monocrystalline silicon substrate of photoetching process；
Finally, after silicon chip upper liquid macroimolecule material PDMS, Polymer material solidification, itself and template are peeled off
Just obtain the substrate of microchannel afterwards, then sealed with substrate, obtain internal including the micro-fluidic of many different shapes and width
Chip.
Present invention also offers a kind of control method of the fluid channel flow control apparatus of micro-nano cellulose, including it is following
Step：
(1) suspension of the good micro-nano cellulose of decentralized processing is aspirated with micro-syringe, micro-syringe is positioned over note
Penetrate on pump, connect sample-adding plug by the syringe needle connecting conduit of micro-syringe and by the conduit other end, open micro-fluidic chip upper surface
Diaphragm seal；
(2) quantitatively being controlled using syringe pump promotes micro-syringe to be injected into the microchannel of micro-fluidic chip by scattered
The micro-nano cellulose suspension handled well；
(3) micro-nano cellulose suspension is injected into the linear pattern passage of different in width respectively, in 100um channel widths
Middle holding syringe pump initial injection flow is 30uL/min, and it is 60uL/ that initial injection flow is kept in 200um channel widths
Min, it is 90uL/min that initial injection flow is kept in 300um channel widths；
(4) existed by adjusting the injection speed of syringe pump with reaching the different micro-nano cellulose of adjustment control size
Nowed forming and flowing velocity in suspension.
As preferable technical scheme, in step (2), syringe pump restocking is provided with syringe, is learnt according to syringe model
The aperture of syringe, then on syringe pump set syringe aperture numerical value, syringe pump according to the uninterrupted of promotion with
And the size in syringe aperture is converted into the speed of promotion, by controlling the screw thread on rotary injection bar slowly to promote injection rod,
The speed that accurate control injection rod promotes, then realize the flow value of accurate control injection.
The present invention compared with prior art, has the following advantages that and beneficial effect：
(1) current routine techniques is difficult to realize in fluid channel driving and control to microfluid, particularly includes
The heterogeneous fluid of micro-nano cellulose, by means of the invention it is also possible to the fluid channel of realization quickly to micro-nano cellulose
Flowing control.
(2) the technology of the present invention simple operation, control are got up quickly, efficiently.
(3) the technology of the present invention can be with parameters such as measuring speed, flows, and the field in terms of micro fluid dynamics has wide
General application prospect.
Brief description of the drawings
Fig. 1 is the structure chart of control device of the present invention
Fig. 2 is the flow chart of the fluid channel flow control method of micro-nano cellulose of the present invention；
Fig. 3 is to be not implemented before flowing controls and the velocity contour after realization flowing control
Embodiment
With reference to embodiment and accompanying drawing, the present invention is described in further detail, but embodiments of the present invention are unlimited
In this.
Embodiment
As shown in figure 1, a kind of fluid channel flow control apparatus of micro-nano cellulose of the present embodiment, including syringe pump 1, note
Penetrate part 2, sample-adding plug, micro-fluidic chip 3, microchannel and diaphragm seal, the syringe pump and connect injection portion, the injection
Part connect with sample-adding plug, in the microchannel of the embedded micro-fluidic chip of the sample-adding plug, the micro-fluidic chip fills in sample-adding,
Injection portion connects, and the diaphragm seal is covered in the upper surface of micro-fluidic chip；
The syringe pump 1, for quantitatively controlling the uninterrupted of injection micro-nano cellulose suspension；
The injection portion 2, for temporarily storing the suspension for having micro-nano cellulose and micro-nano cellulose is suspended
Liquid is injected into micro-fluidic chip；
The sample-adding plug, the suspension for closed injection micro-nano cellulose；
The micro-fluidic chip 3, for carrying the microchannel of different in width and shape；
The microchannel, the suspension of micro-nano cellulose are flowed in the microchannel；
The diaphragm seal, for being sealed to the fluid channel in micro-fluidic chip.
Microchannel high unity in the micro-fluidic chip is 10um, and channel shape point has linear pattern passage, curve
Type passage, Trident Type passage, helical duct, microchannel width include tri- levels of 100um, 200um, 300um.
The concrete methods of realizing of the microfluidic control chip bearing microchannel is as follows：
First, drawn with autoCAD softwares, the passage of different shape and width is sketched the contours on microfluidic control chip, then
By pattern with high resolution printed, it is bonded on quartz glass, mask plate is made；
Then, photosensitive glue pattern plate is made on monocrystalline silicon substrate of photoetching process；
Finally, after silicon chip upper liquid macroimolecule material PDMS, Polymer material solidification, itself and template are peeled off
Just obtain the substrate of microchannel afterwards, then sealed with substrate, obtain internal including the micro-fluidic of many different shapes and width
Chip.
The present embodiment includes, and embodiment during flowing control is not implemented, comprises the following steps：
The suspension of micro-nano cellulose is subjected to decentralized processing, contains micro-nano cellulose using micro-syringe suction
Suspension, micro-syringe syringe needle is injected in the microchannel of micro-fluidic chip, obtained VELOCITY DISTRIBUTION is Line 1 institute in Fig. 3
Show.
In addition, as shown in Fig. 2 the present embodiment realize fluid channel flowing control after embodiment, comprise the following steps：
With the suspension of the good micro-nano cellulose of micro-syringe suction decentralized processing, micro-syringe is positioned over syringe pump
On, sample-adding plug is connected by the syringe needle connecting conduit of micro-syringe and by the conduit other end, opens the close of micro-fluidic chip upper surface
Sealer.
Quantitatively being controlled using syringe pump promotes micro-syringe to be injected into the microchannel of micro-fluidic chip by scattered place
The micro-nano cellulose suspension managed.
Micro-nano cellulose suspension is injected into the linear pattern passage of different in width respectively, in 100um channel widths
It is 30um/min to keep syringe pump initial injection speed, and obtained VELOCITY DISTRIBUTION is shown in No. 2 line in Fig. 3；Lead in 200um width
It is 60um/min that initial injection speed is kept in road, and obtained VELOCITY DISTRIBUTION is shown in No. 3 line in Fig. 3；In 300um channel widths
Middle holding initial injection speed is 90um/min, and obtained VELOCITY DISTRIBUTION is shown in No. 4 line in Fig. 3.
Reach the different micro-nano cellulose of adjustment control size outstanding by adjusting the injection speed of syringe pump
Nowed forming and flowing velocity in supernatant liquid.
From the speed represented in Fig. 3, when unrealized fluid channel flows and controlled, micro-nano cellulose particle is in passage
Interior velocity interval is 100-600um/s, and VELOCITY DISTRIBUTION is very confusing, and diffusivity is big；And realizing fluid channel flowing
After control, in the fluid channel of three different in width, the velocity interval of the micro-nano cellulose particle under different injection speeds exists
0-130um/s, and VELOCITY DISTRIBUTION keeps very consistent.This explanation more accurately can drive and control after control is realized
Flowing velocity of the micro-nano cellulose particle processed in micro-fluidic chip, it is easy to operate.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (5)
1. the fluid channel flow control apparatus of a kind of micro-nano cellulose, it is characterised in that including syringe pump, injection portion, add
Sample plug, micro-fluidic chip, microchannel and diaphragm seal, the syringe pump connect injection portion, the injection portion and sample-adding
Plug connection, the sample-adding are filled in the microchannel of embedded micro-fluidic chip, the micro-fluidic chip and sample-adding plug, injection portion company
Logical, the diaphragm seal is covered in the upper surface of micro-fluidic chip；
The syringe pump, for quantitatively controlling the uninterrupted of injection micro-nano cellulose suspension；
The injection portion, injected for temporarily storing the suspension for having micro-nano cellulose and by micro-nano cellulose suspension
Enter in micro-fluidic chip；
The sample-adding plug, the suspension for closed injection micro-nano cellulose；
The micro-fluidic chip, for carrying the microchannel of different in width and shape；
The microchannel, the suspension of micro-nano cellulose are flowed in the microchannel；
The diaphragm seal, for being sealed to the fluid channel in micro-fluidic chip.
2. the fluid channel flow control apparatus of micro-nano cellulose according to claim 1, it is characterised in that described micro-fluidic
Microchannel high unity in chip is 10um, channel shape point have linear pattern passage, shaped form passage, Trident Type passage,
Helical duct, microchannel width include tri- levels of 100um, 200um, 300um.
3. the fluid channel flow control apparatus of micro-nano cellulose according to claim 1, it is characterised in that described micro-fluidic
The concrete methods of realizing of chip bearing microchannel processed is as follows：
First, drawn with autoCAD softwares, the passage of different shape and width is sketched the contours on microfluidic control chip, then will figure
Case is bonded on quartz glass, mask plate is made with high resolution printed；
Then, photosensitive glue pattern plate is made on monocrystalline silicon substrate of photoetching process；
Finally, after silicon chip upper liquid macroimolecule material PDMS, Polymer material solidification, after it is peeled off with template just
The substrate of microchannel is obtained, then is sealed with substrate, obtains the internal micro-fluidic chip for including many different shapes and width.
4. according to the control method of the fluid channel flow control apparatus of micro-nano cellulose any one of claim 1-3,
It is characterised in that it includes following step：
(1) suspension of the good micro-nano cellulose of decentralized processing is aspirated with micro-syringe, micro-syringe is positioned over syringe pump
On, sample-adding plug is connected by the syringe needle connecting conduit of micro-syringe and by the conduit other end, opens the close of micro-fluidic chip upper surface
Sealer；
(2) quantitatively control promotion micro-syringe to be injected into the microchannel of micro-fluidic chip using syringe pump and pass through decentralized processing
Good micro-nano cellulose suspension；
(3) micro-nano cellulose suspension is injected into the linear pattern passage of different in width respectively, is protected in 100um channel widths
It is 30uL/min to hold syringe pump initial injection flow, and it is 60uL/min that initial injection flow is kept in 200um channel widths,
It is 90uL/min that initial injection flow is kept in 300um channel widths；
(4) suspended by adjusting the injection speed of syringe pump with reaching the different micro-nano cellulose of adjustment control size
Nowed forming and flowing velocity in liquid.
5. the control method of the fluid channel flow control apparatus of micro-nano cellulose according to claim 4, it is characterised in that
In step (2), syringe pump restocking is provided with syringe, the aperture of syringe is learnt according to syringe model, then on syringe pump
The numerical value in the aperture of syringe is set, and syringe pump is converted into promotion according to the uninterrupted of promotion and the size in syringe aperture
Speed, by controlling the screw thread on rotary injection bar slowly to promote injection rod, the accurate speed for controlling injection rod to promote, then
Realize the flow value of accurate control injection.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710784763.3A CN107831811A (en) | 2017-09-04 | 2017-09-04 | The fluid channel flow control apparatus and control method of a kind of micro-nano cellulose |
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| CN201710784763.3A CN107831811A (en) | 2017-09-04 | 2017-09-04 | The fluid channel flow control apparatus and control method of a kind of micro-nano cellulose |
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Cited By (4)
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| CN109232749A (en) * | 2018-04-10 | 2019-01-18 | 华南理工大学 | A method of separation cellulose is classified using microchannel |
| CN110256584A (en) * | 2019-06-10 | 2019-09-20 | 华南理工大学 | A kind of nano micro crystal cellulose preparation method based on micro-fluidic chip |
| CN111504406A (en) * | 2020-05-15 | 2020-08-07 | 大连理工大学 | Flow detection chip and detection method for ultramicro small-flow liquid |
| WO2023087777A1 (en) | 2021-11-17 | 2023-05-25 | 江苏液滴逻辑生物技术有限公司 | System device and method for quantitatively injecting tested sample into chip, and use |
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Cited By (5)
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| CN110256584A (en) * | 2019-06-10 | 2019-09-20 | 华南理工大学 | A kind of nano micro crystal cellulose preparation method based on micro-fluidic chip |
| CN111504406A (en) * | 2020-05-15 | 2020-08-07 | 大连理工大学 | Flow detection chip and detection method for ultramicro small-flow liquid |
| WO2023087777A1 (en) | 2021-11-17 | 2023-05-25 | 江苏液滴逻辑生物技术有限公司 | System device and method for quantitatively injecting tested sample into chip, and use |
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