CN107823593A - A kind of universal gynecologic cream and its preparation technology - Google Patents
A kind of universal gynecologic cream and its preparation technology Download PDFInfo
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- CN107823593A CN107823593A CN201711163290.1A CN201711163290A CN107823593A CN 107823593 A CN107823593 A CN 107823593A CN 201711163290 A CN201711163290 A CN 201711163290A CN 107823593 A CN107823593 A CN 107823593A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The present invention proposes a kind of universal gynecologic cream, and the universal gynecologic cream includes universal gynecologic cream medicinal extract, and the universal gynecologic cream medicinal extract is by bush, Ligusticum wallichii, rascal, radix ampelopsis, rhizoma zingiberis, piper wallichii, faenum graecum(Fry), Herba Lycopi, fennel seeds, Semen Leonuri, aspongopus, folium artemisiae argyi, the root of Dahurain angelica, adder-wort, safflower, Radix Angelicae Sinensis, eucalyptus oil etc. be made, the various raw materials for making universal gynecologic cream medicinal extract are according to quality parts ratio:Bush:9g;Ligusticum wallichii:18g;Rascal:9g;Radix ampelopsis:18g;Rhizoma zingiberis:9g;Piper wallichii:18g;Faenum graecum(Fry):9g;Herba Lycopi:21g;Fennel seeds:9g;Semen Leonuri:21g;Aspongopus:9g;Folium artemisiae argyi:24g;The root of Dahurain angelica:9g;Adder-wort:27g;Safflower:9g;Radix Angelicae Sinensis:36g, the universal gynecologic cream are sheet rubber cream, are easy to patient's external application to use, and easy to use, this medicine is sheet rubber cream, are easy to patient's external application to use, easy to use, solve the problem of gynecopathy therapeutic inconvenience.
Description
Technical field
The present invention relates to universal gynecologic cream technical field, specially a kind of universal gynecologic cream and its preparation technology.
Background technology
Gynecological disease, including vulva disease, vaginal disease, uterine disease, diseases of fallopian tubes, disease of ovary etc., gynaecology's disease
Disease is women common disease, frequently-occurring disease, but because many people lack due understanding to gynecological disease, lacks the health care to body,
In addition various bad life habits etc., make physiological health go from bad to worse, and cause some women's diseases to be burdened with, and obstinate, give
Normal life, work bring great inconvenience, so it is difficult to solve current treatment to need a kind of universal gynecologic cream.
The content of the invention
The technical problem to be solved in the present invention is to overcome the defects of existing, there is provided a kind of universal gynecologic cream and its preparation work
Skill, warming channel and expelling cold, promoting blood circulation and removing blood stasis, regulating qi-flowing for relieving pain, for irregular menstruation caused by palace cold stasis, bellyache in menstrual period, the cold Amenorrhea of abdomen, waist
Pain is with inferior.
To achieve the above object, the present invention proposes:A kind of universal gynecologic cream, the universal gynecologic cream soak including universal gynecologic cream
Cream, the universal gynecologic cream medicinal extract is by bush, Ligusticum wallichii, rascal, radix ampelopsis, rhizoma zingiberis, piper wallichii, faenum graecum(Fry), Herba Lycopi, fennel fruit
Perfume, Semen Leonuri, aspongopus, folium artemisiae argyi, the root of Dahurain angelica, adder-wort, safflower, Radix Angelicae Sinensis, eucalyptus oil etc. are made, then by universal gynecologic cream medicinal extract,
Rubber, rosin, zinc oxide, lanolin, atoleine, vaseline, eucalyptus oil etc., universal gynecologic cream is mixed and made into, makes gynaecology ten thousand
The various raw materials for answering cream medicinal extract are according to quality parts ratio:Bush:9g;Ligusticum wallichii:18g;Rascal:9g;Radix ampelopsis:18g;Rhizoma zingiberis:9g;
Piper wallichii:18g;Faenum graecum(Fry):9g;Herba Lycopi:21g;Fennel seeds:9g;Semen Leonuri:21g;Aspongopus:9g;Folium artemisiae argyi:24g;In vain
The root of Dahurian angelica:9g;Adder-wort:27g;Safflower:9g;Radix Angelicae Sinensis:36g;Make universal gynecologic cream various raw materials be according to quality parts ratio:Rubber
Glue:330g;Rosin:90g;Zinc oxide:440g;Lanolin:10g;Atoleine:15 g;Vaseline:35 g;Eucalyptus oil 0.02g.
The present invention also provides a kind of preparation technology of universal gynecologic cream, comprises the following steps:
S1):Make universal gynecologic cream medicinal extract
By bush:9g;Ligusticum wallichii:18g;Rascal:9g;Radix ampelopsis:18g;Rhizoma zingiberis:9g;Piper wallichii:18g;Faenum graecum(Fry):9g;Pool
It is blue:21g;Fennel seeds:9g;Semen Leonuri:21g;Aspongopus:9g;Folium artemisiae argyi:24g;The root of Dahurain angelica:9g;Adder-wort:27g;Safflower:9g;Radix Angelicae Sinensis:
36g;After being weighed, 3h carries out first time alcohol extracting by 75% ethanol, 6 times of amounts, and 2h passes through 75% ethanol, 6 times of secondary alcohol extractings of flow control,
Concentration is fabricated to universal gynecologic cream medicinal extract twice;
S2):Weigh
Universal gynecologic cream medicinal extract:92g;Rubber:330g;Rosin:90g;Zinc oxide:440g;Lanolin:10g;Atoleine:15
g;Vaseline:35 g;Eucalyptus oil 0.02g;
S3):Launch batch mixing
A) with hilted broadsword oil pressure rubber cutter load weighted rubber cut into 4-7cm sheet rubbers and through rubber mixing machine refining reticulate or
Add in kneader and plasticated to without micelle after thin slice(40-70min);
B) load weighted rosin is added in kneader to the rubber plasticated with upper step mediate to sizing material exquisiteness, without unfused
Rosin grain(30-60min);
C) load weighted zinc oxide, lanolin, universal gynecologic cream medicinal extract are added in kneader and mediated with the mixed sizing material of upper step
It is consistent to sizing material color and luster, without the material particles not mixed(20-50min);
D load weighted atoleine, vaseline, eucalyptus oil) are added into sizing material mixed with upper step in kneader to continue to mediate, it is complete
The full glue cream pinched should be soft, the material particles that lustrous surface is fine and smooth, smooth nothing does not mix(20-50min), glue cream mediate finish
Kneader should be removed in time, be placed in the clean stainless steel pallet being ready for and dried after precise numeration in 24 hours
Glue;
S4):Drying glue
A incubator), is warming up to 80-105 DEG C;
B), the stainless steel pallet equipped with glue cream is put into and had warmed up to 80-105 DEG C of incubator, heats 60-100min, is dried
To glue cream in cellular or soft shape, rear of slightly foaming be can be taken off, and drying glue gluing cutting is carried out in 2 hours;
S5):Gluing is cut
A coating machine main power source) is opened before production, is 80-110 DEG C by upper blade temperature setting, lower heating roller temperature is arranged to
40-60 DEG C, it is 80-110 DEG C to contain offset plate temperature setting, regulates the spacing of bottom plate and scraper to suitable spacing, cutting knife spacing
Extremely it is not less than 100mm;
B) machine to be coated reaches temperature is set after preheated glue cream taken out into stand out of incubator be coated on cloth cover, inspection one
Cut normal rear beginning gluing;
C) setting paste containing amount makes paste containing amount in prescribed limit, i.e. gluing initial stage carries out paste containing amount measure 1 to 8 ointment volumes
It is secondary, if measuring paste containing amount meets prescribed limit, gluing can be continued, if measuring paste containing amount exceeds prescribed limit, should be adjusted again
Coating machine is tried, after measuring paste containing amount again and meeting prescribed limit, gluing can be continued, operating personnel should be every during gluing
20-30min is shut down to be determined 1 time to gluing paste containing amount, carries out alternate samples survey to 8 ointment volumes of gained with standard sampling container every time
It is fixed, ensure that 8 ointment volume of coating is determined, if the result of measure is against regulation, coating machine should be debugged again,
(Measure paste containing amount and 1.4g/70cm2The difference limit compared is that i.e. paste containing amount prescribed limit is more than -5%:More than 1.330g/
70cm2);
D) paste containing amount assay method:Standard sampling container is used after shutdown(7cm×10cm)Sampling, is placed in electronic balance and is claimed
Amount, the result of weighing is subtracted into known cloth weight/70cm2, as paste containing amount/70cm2;
E) paste containing amount calculation formula:Paste containing amount=;
F) gluing should be uniform, the cloth cover coated should it is smooth, bright and clean, color and luster is consistent and brownish red is presented, the ointment volume Ying Song spooled
Tight suitable, both ends are neat;
G) ointment unloaded is provided on electronic scale after precise numeration, cut into slices in 5 hours, and in transfer process
In avoid pressing ointment batching face, prevent ointment degree of licking from sticking seep through and causing loss to waste;
H the time interval that the glue) being baked is cut to gluing must not exceed 2 hours;
S6):Section
A), ointment volume and separate paper are inserted on section machine bar traveller, regulate each position, section of driving, section is unilateral to answer color
Damp consistent, slice width should be not less than 70mm, and cut hole wants uniform ground;
B), in slicing processes, take a sample to check at any time and choose section defective work therein, certified products are neatly put into plastics week
Turn in basket, after precise numeration, move into subsequent processing or material temporary room in time;
C), ointment table storage points for attention:The ointment table cut is contained with plastics Turnround basket, is enumerated and is put, never must not be by week
Turn basket and the overlapped extruding of ointment table, patch has counted the temporary card of material, compound membrane bag is installed in three days, for being stored more than
The ointment table in time limit will censorship again;
S7):Inner packing
Load ointment table according to packing specification, install and sealed on rearmounted sealing machine.It is required that compound membrane bag sealing is tight, smooth, and
Choose at any time and wherein seal defective work, take out built-in qualified ointment table, repack;
A), operating personnel accurately check dress product quantity to be outsourced, sample censorship by QA inspector, remaining dress product to be outsourced moves to
Intermediate station directly moves into outer packing room;
B), packaging quantity should be accurate, and the use of compound membrane bag will meet regulation, its passing number, loss number, remainder sum and reality
Neck number should be consistent, and operating personnel check compound membrane bag presentation quality at any time, replace defective work to squad leader in time, so as to unified
Processing;
S8):Outer packing
A), lettering:Ink jet numbering machine, coder, stamp lot number, date of manufacture, the term of validity are set according to " batch outer packing instruction sheet "
Combined Deng numeral, carry out compound membrane bag, capsule, the work of big case lot number lettering, it is lot number, the date of manufacture, clear valid until writing,
Position is moderate and record count;
B), packaging process:Packed by packing specification;
a):Fill capsule(It is each small box-packed 4 bags, while load 1 specification)→ plastic packaging(Every 10 box)→ fill big case(Per case 200
Box, while it is put into 1 packing slip, 1 product inspection report)→ joint sealing(Strap is bundled into " well " font)→ storage;
b):Fill capsule(It is each small box-packed 2 bags, while load 1 specification)→ plastic packaging(Every 10 box)→ fill big case(Per case 200
Box, while it is put into 1 packing slip, 1 product inspection report)→ joint sealing(Strap is bundled into " well " font)→ storage.
Compared with prior art, the beneficial effects of the invention are as follows:The function that cures mainly of the medicine is warming channel and expelling cold, promoting blood circulationization
The stasis of blood, regulating qi-flowing for relieving pain, for irregular menstruation caused by palace cold stasis, bellyache in menstrual period, the cold Amenorrhea of abdomen, lumbago belt is inferior, this medicine gas
Taste fragrance, is sheet rubber cream, is easy to patient's external application to use, easy to use, is suitable for promoting the use of.
Brief description of the drawings
Fig. 1 is a kind of Making programme figure of universal gynecologic cream of the present invention.
In figure:S1 makes universal gynecologic cream medicinal extract, S2 is weighed, S3 launches batch mixing, S4 drying glues, the cutting of S5 gluings, S6 sections,
S7 inner packings, S8 outer packings.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other under the premise of creative work is not made
Embodiment, belong to the scope of protection of the invention.
Referring to Fig. 1, the present invention provides following technical scheme:
S1):Make universal gynecologic cream medicinal extract
By bush:9g;Ligusticum wallichii:18g;Rascal:9g;Radix ampelopsis:18g;Rhizoma zingiberis:9g;Piper wallichii:18g;Faenum graecum(Fry):9g;Pool
It is blue:21g;Fennel seeds:9g;Semen Leonuri:21g;Aspongopus:9g;Folium artemisiae argyi:24g;The root of Dahurain angelica:9g;Adder-wort:27g;Safflower:9g;Radix Angelicae Sinensis:
36g;After being weighed, 3h carries out first time alcohol extracting by 75% ethanol, 6 times of amounts, and 2h passes through 75% ethanol, 6 times of secondary alcohol extractings of flow control,
Concentration is fabricated to universal gynecologic cream medicinal extract twice;
S2):Weigh
Universal gynecologic cream medicinal extract:92g;Rubber:330g;Rosin:90g;Zinc oxide:440g;Lanolin:10g;Atoleine:15
g;Vaseline:35 g;Eucalyptus oil 0.02g;
S3):Launch batch mixing
A) with hilted broadsword oil pressure rubber cutter load weighted rubber cut into 4-7cm sheet rubbers and through rubber mixing machine refining reticulate or
Add in kneader and plasticated to without micelle after thin slice(40-70min);
B) load weighted rosin is added in kneader to the rubber plasticated with upper step mediate to sizing material exquisiteness, without unfused
Rosin grain(30-60min);
C) load weighted zinc oxide, lanolin, universal gynecologic cream medicinal extract are added in kneader and mediated with the mixed sizing material of upper step
It is consistent to sizing material color and luster, without the material particles not mixed(20-50min);
D load weighted atoleine, vaseline, eucalyptus oil) are added into sizing material mixed with upper step in kneader to continue to mediate, it is complete
The full glue cream pinched should be soft, the material particles that lustrous surface is fine and smooth, smooth nothing does not mix(20-50min), glue cream mediate finish
Kneader should be removed in time, be placed in the clean stainless steel pallet being ready for and dried after precise numeration in 24 hours
Glue;
S4):Drying glue
A incubator), is warming up to 80-105 DEG C;
B), the stainless steel pallet equipped with glue cream is put into and had warmed up to 80-105 DEG C of incubator, heats 60-100min, is dried
To glue cream in cellular or soft shape, rear of slightly foaming be can be taken off, and drying glue gluing cutting is carried out in 2 hours;
S5):Gluing is cut
A coating machine main power source) is opened before production, is 80-110 DEG C by upper blade temperature setting, lower heating roller temperature is arranged to
40-60 DEG C, it is 80-110 DEG C to contain offset plate temperature setting, regulates the spacing of bottom plate and scraper to suitable spacing, cutting knife spacing
Extremely it is not less than 100mm;
B) machine to be coated reaches temperature is set after preheated glue cream taken out into stand out of incubator be coated on cloth cover, inspection one
Cut normal rear beginning gluing;
C) setting paste containing amount makes paste containing amount in prescribed limit, i.e. gluing initial stage carries out paste containing amount measure 1 to 8 ointment volumes
It is secondary, if measuring paste containing amount meets prescribed limit, gluing can be continued, if measuring paste containing amount exceeds prescribed limit, should be adjusted again
Coating machine is tried, after measuring paste containing amount again and meeting prescribed limit, gluing can be continued, operating personnel should be every during gluing
20-30min is shut down to be determined 1 time to gluing paste containing amount, carries out alternate samples survey to 8 ointment volumes of gained with standard sampling container every time
It is fixed, ensure that 8 ointment volume of coating is determined, if the result of measure is against regulation, coating machine should be debugged again,
(Measure paste containing amount and 1.4g/70cm2The difference limit compared is that i.e. paste containing amount prescribed limit is more than -5%:More than 1.330g/
70cm2);
D) paste containing amount assay method:Standard sampling container is used after shutdown(7cm×10cm)Sampling, is placed in electronic balance and is claimed
Amount, the result of weighing is subtracted into known cloth weight/70cm2, as paste containing amount/70cm2;
E) paste containing amount calculation formula:Paste containing amount=;
F) gluing should be uniform, the cloth cover coated should it is smooth, bright and clean, color and luster is consistent and brownish red is presented, the ointment volume Ying Song spooled
Tight suitable, both ends are neat;
G) ointment unloaded is provided on electronic scale after precise numeration, cut into slices in 5 hours, and in transfer process
In avoid pressing ointment batching face, prevent ointment degree of licking from sticking seep through and causing loss to waste;
H the time interval that the glue) being baked is cut to gluing must not exceed 2 hours;
S6):Section
A), ointment volume and separate paper are inserted on section machine bar traveller, regulate each position, section of driving, section is unilateral to answer color
Damp consistent, slice width should be not less than 70mm, and cut hole wants uniform ground;
B), in slicing processes, take a sample to check at any time and choose section defective work therein, certified products are neatly put into plastics week
Turn in basket, after precise numeration, move into subsequent processing or material temporary room in time;
C), ointment table storage points for attention:The ointment table cut is contained with plastics Turnround basket, is enumerated and is put, never must not be by week
Turn basket and the overlapped extruding of ointment table, patch has counted the temporary card of material, compound membrane bag is installed in three days, for being stored more than
The ointment table in time limit will censorship again;
S7):Inner packing
Loading ointment table according to packing specification, install and sealed on rearmounted sealing machine, it is desirable to compound membrane bag sealing is tight, smooth, and
Choose at any time and wherein seal defective work, take out built-in qualified ointment table, repack;
A), operating personnel accurately check dress product quantity to be outsourced, sample censorship by QA inspector, remaining dress product to be outsourced moves to
Intermediate station directly moves into outer packing room;
B), packaging quantity should be accurate, and the use of compound membrane bag will meet regulation, its passing number, loss number, remainder sum and reality
Neck number should be consistent, and operating personnel check compound membrane bag presentation quality at any time, replace defective work to squad leader in time, so as to unified
Processing;
S8):Outer packing
A), lettering:Ink jet numbering machine, coder, stamp lot number, date of manufacture, the term of validity are set according to " batch outer packing instruction sheet "
Combined Deng numeral, carry out compound membrane bag, capsule, the work of big case lot number lettering, it is lot number, the date of manufacture, clear valid until writing,
Position is moderate and record count;
B), packaging process:Packed by packing specification;
a):Fill capsule(It is each small box-packed 4 bags, while load 1 specification)→ plastic packaging(Every 10 box)→ fill big case(Per case 200
Box, while it is put into 1 packing slip, 1 product inspection report)→ joint sealing(Strap is bundled into " well " font)→ storage;
b):Fill capsule(It is each small box-packed 2 bags, while load 1 specification)→ plastic packaging(Every 10 box)→ fill big case(Per case 200
Box, while it is put into 1 packing slip, 1 product inspection report)→ joint sealing(Strap is bundled into " well " font)→ storage.
Benefit of the present invention:The function that cures mainly of the medicine is warming channel and expelling cold, promoting blood circulation and removing blood stasis, regulating qi-flowing for relieving pain, for palace cold stasis
Caused irregular menstruation, bellyache in menstrual period, the cold Amenorrhea of abdomen, lumbago belt is inferior, this medicine fragrant odour, is sheet rubber cream, is easy to
Patient's external application uses, easy to use, is suitable for promoting the use of, this medicine fragrant odour, is sheet rubber cream, is easy to patient's external application
Use, it is easy to use, solve the problem of gynecopathy therapeutic inconvenience, be suitable for promoting the use of.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of changes, modification can be carried out to these embodiments, replace without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (2)
- A kind of 1. universal gynecologic cream, it is characterised in that:The universal gynecologic cream includes universal gynecologic cream medicinal extract, the universal gynecologic cream Medicinal extract is by bush, Ligusticum wallichii, rascal, radix ampelopsis, rhizoma zingiberis, piper wallichii, faenum graecum(Fry), Herba Lycopi, fennel seeds, Semen Leonuri, aspongopus, Chinese mugwort Leaf, the root of Dahurain angelica, adder-wort, safflower, Radix Angelicae Sinensis, eucalyptus oil etc. are made, then by universal gynecologic cream medicinal extract, rubber, rosin, zinc oxide, sheep Hair fat, atoleine, vaseline, eucalyptus oil etc., are mixed and made into universal gynecologic cream, and the various raw materials for making universal gynecologic cream medicinal extract are pressed It is according to quality parts ratio:Bush:9g;Ligusticum wallichii:18g;Rascal:9g;Radix ampelopsis:18g;Rhizoma zingiberis:9g;Piper wallichii:18g;Faenum graecum (Fry):9g;Herba Lycopi:21g;Fennel seeds:9g;Semen Leonuri:21g;Aspongopus:9g;Folium artemisiae argyi:24g;The root of Dahurain angelica:9g;Adder-wort:27g;It is red Flower:9g;Radix Angelicae Sinensis:36g;Make universal gynecologic cream various raw materials be according to quality parts ratio:Rubber:330g;Rosin:90g;Oxygen Change zinc:440g;Lanolin:10g;Atoleine:15 g;Vaseline:35 g;Eucalyptus oil 0.02g.
- A kind of 2. preparation technology of universal gynecologic cream, it is characterised in that:Comprise the following steps:S1):Make universal gynecologic cream medicinal extractBy bush:9g;Ligusticum wallichii:18g;Rascal:9g;Radix ampelopsis:18g;Rhizoma zingiberis:9g;Piper wallichii:18g;Faenum graecum(Fry):9g;Pool It is blue:21g;Fennel seeds:9g;Semen Leonuri:21g;Aspongopus:9g;Folium artemisiae argyi:24g;The root of Dahurain angelica:9g;Adder-wort:27g;Safflower:9g;Radix Angelicae Sinensis: 36g;After being weighed, 3h carries out first time alcohol extracting by 75% ethanol, 6 times of amounts, and 2h passes through 75% ethanol, 6 times of secondary alcohol extractings of flow control, Concentration is fabricated to universal gynecologic cream medicinal extract twice;S2):WeighUniversal gynecologic cream medicinal extract:92g;Rubber:330g;Rosin:90g;Zinc oxide:440g;Lanolin:10g;Atoleine:15 g;Vaseline:35 g;Eucalyptus oil 0.02g;S3):Launch batch mixingA) with hilted broadsword oil pressure rubber cutter load weighted rubber cut into 4-7cm sheet rubbers and through rubber mixing machine refining reticulate or Add in kneader and plasticated to without micelle after thin slice(40-70min);B) load weighted rosin is added in kneader to the rubber plasticated with upper step mediate to sizing material exquisiteness, without unfused Rosin grain(30-60min);C) load weighted zinc oxide, lanolin, universal gynecologic cream medicinal extract are added in kneader and mediated with the mixed sizing material of upper step It is consistent to sizing material color and luster, without the material particles not mixed(20-50min);D load weighted atoleine, vaseline, eucalyptus oil) are added into sizing material mixed with upper step in kneader to continue to mediate, it is complete The full glue cream pinched should be soft, the material particles that lustrous surface is fine and smooth, smooth nothing does not mix(20-50min), glue cream mediate finish Kneader should be removed in time, be placed in the clean stainless steel pallet being ready for and dried after precise numeration in 24 hours Glue;S4):Drying glueA incubator), is warming up to 80-105 DEG C;B), the stainless steel pallet equipped with glue cream is put into and had warmed up to 80-105 DEG C of incubator, heats 60-100min, is dried To glue cream in cellular or soft shape, rear of slightly foaming be can be taken off, and drying glue gluing cutting is carried out in 2 hours;S5):Gluing is cutA coating machine main power source) is opened before production, is 80-110 DEG C by upper blade temperature setting, lower heating roller temperature is arranged to 40-60 DEG C, it is 80-110 DEG C to contain offset plate temperature setting, regulates the spacing of bottom plate and scraper to suitable spacing, cutting knife spacing Extremely it is not less than 100mm;B) machine to be coated reaches temperature is set after preheated glue cream taken out into stand out of incubator be coated on cloth cover, inspection one Cut normal rear beginning gluing;C) setting paste containing amount makes paste containing amount in prescribed limit, i.e. gluing initial stage carries out paste containing amount measure 1 to 8 ointment volumes It is secondary, if measuring paste containing amount meets prescribed limit, gluing can be continued, if measuring paste containing amount exceeds prescribed limit, should be adjusted again Coating machine is tried, after measuring paste containing amount again and meeting prescribed limit, gluing can be continued, operating personnel should be every during gluing 20-30min is shut down to be determined 1 time to gluing paste containing amount, carries out alternate samples survey to 8 ointment volumes of gained with standard sampling container every time It is fixed, ensure that 8 ointment volume of coating is determined, if the result of measure is against regulation, coating machine should be debugged again, (Measure paste containing amount and 1.4g/70cm2The difference limit compared is that i.e. paste containing amount prescribed limit is more than -5%:More than 1.330g/ 70cm2);D) paste containing amount assay method:Standard sampling container is used after shutdown(7cm×10cm)Sampling, is placed in electronic balance and is claimed Amount, the result of weighing is subtracted into known cloth weight/70cm2, as paste containing amount/70cm2,E) paste containing amount calculation formula:Paste containing amount=;F) gluing should be uniform, the cloth cover coated should it is smooth, bright and clean, color and luster is consistent and brownish red is presented, the ointment volume Ying Song spooled Tight suitable, both ends are neat;G) ointment unloaded is provided on electronic scale after precise numeration, cut into slices in 5 hours, and in transfer process In avoid pressing ointment batching face, prevent ointment degree of licking from sticking seep through and causing loss to waste;H the time interval that the glue) being baked is cut to gluing must not exceed 2 hours;S6):SectionA), ointment volume and separate paper are inserted on section machine bar traveller, regulate each position, section of driving, section is unilateral to answer color Damp consistent, slice width should be not less than 70mm, and cut hole wants uniform ground;B), in slicing processes, take a sample to check at any time and choose section defective work therein, certified products are neatly put into plastics week Turn in basket, after precise numeration, move into subsequent processing or material temporary room in time;C), ointment table storage points for attention:The ointment table cut is contained with plastics Turnround basket, is enumerated and is put, never must not be by week Turn basket and the overlapped extruding of ointment table, patch has counted the temporary card of material, compound membrane bag is installed in three days, for being stored more than The ointment table in time limit will censorship again;S7):Inner packingLoading ointment table according to packing specification, install and sealed on rearmounted sealing machine, it is desirable to compound membrane bag sealing is tight, smooth, and Choose at any time and wherein seal defective work, take out built-in qualified ointment table, repack;A), operating personnel accurately check dress product quantity to be outsourced, sample censorship by QA inspector, remaining dress product to be outsourced moves to Intermediate station directly moves into outer packing room;B), packaging quantity should be accurate, and the use of compound membrane bag will meet regulation, its passing number, loss number, remainder sum and reality Neck number should be consistent, and operating personnel check compound membrane bag presentation quality at any time, replace defective work to squad leader in time, so as to unified Processing;S8):Outer packingA), lettering:Ink jet numbering machine, coder, stamp lot number, date of manufacture, the term of validity are set according to " batch outer packing instruction sheet " Combined Deng numeral, carry out compound membrane bag, capsule, the work of big case lot number lettering, it is lot number, the date of manufacture, clear valid until writing, Position is moderate and record count;B), packaging process:Packed by packing specification;a):Fill capsule(It is each small box-packed 4 bags, while load 1 specification)→ plastic packaging(Every 10 box)→ fill big case(Per case 200 Box, while it is put into 1 packing slip, 1 product inspection report)→ joint sealing(Strap is bundled into " well " font)→ storage;b):Fill capsule(It is each small box-packed 2 bags, while load 1 specification)→ plastic packaging(Every 10 box)→ fill big case(Per case 200 Box, while it is put into 1 packing slip, 1 product inspection report)→ joint sealing(Strap is bundled into " well " font)→ storage.
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Cited By (2)
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CN113576911A (en) * | 2021-08-06 | 2021-11-02 | 安徽金马药业股份有限公司 | Device for decocting gynecological wanying plaster liquid and preparation method of gynecological wanying plaster |
CN114259528A (en) * | 2021-12-17 | 2022-04-01 | 南方医科大学 | Application of ampelopsis japonica extract in preparation of medicine for preventing and/or treating polycystic ovarian syndrome |
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CN102218129A (en) * | 2010-08-13 | 2011-10-19 | 辽宁玉皇药业有限公司 | New drug delivery system of gynaecologic panchrest plaster |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113576911A (en) * | 2021-08-06 | 2021-11-02 | 安徽金马药业股份有限公司 | Device for decocting gynecological wanying plaster liquid and preparation method of gynecological wanying plaster |
CN113576911B (en) * | 2021-08-06 | 2024-04-26 | 安徽金马药业股份有限公司 | Device for decocting gynecological universal plaster liquid and preparation method of gynecological universal plaster |
CN114259528A (en) * | 2021-12-17 | 2022-04-01 | 南方医科大学 | Application of ampelopsis japonica extract in preparation of medicine for preventing and/or treating polycystic ovarian syndrome |
CN114259528B (en) * | 2021-12-17 | 2024-01-16 | 南方医科大学 | Application of Ampelopsis japonica extract in preparation of medicines for preventing and/or treating polycystic ovary syndrome |
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