CN107823419A - A kind of capsule medicine and preparation method for being used to treat hepatitis B - Google Patents
A kind of capsule medicine and preparation method for being used to treat hepatitis B Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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Abstract
The invention belongs to field of traditional Chinese, it is therefore an objective to a kind of capsule medicine for being used to treat hepatitis B be provided according to the understanding mechanism of Chinese traditional treatment hepatitis B, each component and its mass parts ratio of the medicine are as follows：60~150g of the tuber of dwarf lilyturf, 250~550g of dewdrop grass, 150~550g of giant knotweed, 90~160g of Asiatic plantain, 150~300g of Radix Codonopsis, 90~160g of mock-strawberry, 90~350g of the Radix Astragali, 30~100g of scouring rush, 250~1000g of oldenlandia diffusa, 150~550g of Verbena officinalis, 80~160g of kuh-seng；Medicine provided by the invention is a good Chinese prescription.
Description
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of capsule medicine for being used to treat hepatitis B, particularly supply
The capsule medicine and the field of preparation method that hepatitis B patient uses.
Background technology
Motherland's medical science thinks：Hepatitis B, also known as virus B hepatitis, it is caused by hepatitis B (HBV), with liver
Based on inflammatory lesion, and a kind of disease of multiple organ injury can be caused.Due to " catalysis essential during body metabolism
Agent "-transaminase, is primarily present in liver cell, when liver cell is inflamed, downright bad or hepatitis B breaks out, can all cause
Liver cell is damaged, and transaminase will be discharged into blood, raise transaminase.It is hepatitis B and oxyhepatitis, chronic hepatitis, bilious
The diseases such as hepatitis, liver ascites, hepatic sclerosis, early find, early treatment.Hepatopath generally first sees a doctor trained in western medicine, and doctor trained in Western medicine is quick, but doctor trained in Western medicine
The shortcomings that be easy recurrent exerbation, effect is not ideal enough, it is impossible to fundamentally cures hepatitis B.The Chinese medicine of hepatitis B is now treated on the market
Have a lot, but effect is bad, without soothing the liver, dampness removing, tonifying spleen and stomach, blood stasis removing analgesic, strengthening the spleen and replenishing qi, elimination jaundice and clearing heat and detoxicating work(
Effect, it is impossible to thoroughly cure hepatitis B.So, it is this area skill with regard to how to find a kind of Chinese medicine composition that can effectively treat hepatitis B
The problem of art personnel are urgently to be resolved.
The content of the invention
With the continuous development of China's traditional Chinese medicine, in treatment hepatitis B, people gradually appreciate Chinese traditional treatment second
The advantages of liver, and good effect, the advantage such as quick, toxic side effect is small over the course for the treatment of, for existing western medical treatment hepatitis B
Present situation, the purpose of the present invention is to be to provide a kind of capsule medicine for being used to treat hepatitis B, extensive early to solve hepatitis B patient
The problem of rehabilitation health.The medicine is using common Chinese medicine as raw material, by selecting rational medicine and mass parts ratio, can effectively be controlled
Treat above-mentioned hepatitis B.
To reach the purpose of foregoing invention, the technical solution adopted in the present invention is：There is provided a kind of for treating hepatitis B
Capsule medicine and preparation method, it is characterised in that each component and mass parts of the medicine are than as follows：
60~150g of the tuber of dwarf lilyturf, 250~550g of dewdrop grass, 150~550g of giant knotweed, 90~160g of Asiatic plantain, 150~300g of Radix Codonopsis,
90~160g of mock-strawberry, 90~350g of the Radix Astragali, 30~100g of scouring rush, 250~1000g of oldenlandia diffusa, 150~550g of Verbena officinalis,
80~160g of kuh-seng, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
A kind of capsule medicine and preparation method for being used to treat hepatitis B, it is characterised in that each component of the medicine
And mass parts are than as follows：
70~130g of the tuber of dwarf lilyturf, 280~480g of dewdrop grass, 180~480g of giant knotweed, 100~140g of Asiatic plantain, 180~260g of Radix Codonopsis,
100~140g of mock-strawberry, 100~310g of the Radix Astragali, 38~90g of scouring rush, 280~850g of oldenlandia diffusa, 180~480g of Verbena officinalis,
90~140g of kuh-seng, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
A kind of capsule medicine and preparation method for being used to treat hepatitis B, it is characterised in that each component of the medicine
And mass parts are than as follows：
Tuber of dwarf lilyturf 115g, dewdrop grass 420g, giant knotweed 420g, Asiatic plantain 120g, Radix Codonopsis 230g, mock-strawberry 120g, Radix Astragali 260g, scouring rush
80g, oldenlandia diffusa 720g, Verbena officinalis 420g, kuh-seng 120g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
A kind of capsule medicine and preparation method for being used to treat hepatitis B, it is characterised in that methods described includes following step
Suddenly it is prepared：
A, after above-mentioned raw materials Chinese medicine being picked into impurity and dust, it is ground into according to mass parts than altogether（30~50 mesh）Graininess bag
Decoct；
B, 1. the raw material Chinese medicine wrapped is put into cold boiling water and soaks 55min, then soaked medicine is put into marmite again,
The cold boiling water for adding 8~9 times of raw material Chinese medicine weight carries out first time high heat decoction, when 18min is arrived in decoction, turns slow fire and boils
120min, leaching decoction；2. the cold boiling water for adding 7~8 times of raw material Chinese medicine weight in the dregs of a decoction again is fried by intense fire for the second time
Boil, when 15min is arrived in decoction, turn slow fire and boil 110min, leaching decoction；3. decoction mixing twice is condensed into relative density is
1.08 clear cream, then dry, grind and sterilize after it is standby；
C, the method for 1. preparing Chinese medicine capsules according to tradition, after smalls sieving ground in B, appropriate micro mist silicon is added
Glue, microcrystalline cellulose and starch, are mixed evenly, and are then prepared into capsule（Total length is 23.3mm after its capsule is sealed,
Medicinal powder capacity 0.4~0.5g/ grains）, 2. then polish, sterilize, sealed packaging produces.
It is a kind of to be used to treat the capsule medicine and preparation method of hepatitis B, it is characterised in that the instructions of taking is：Will system
The capsule medicine got ready is twice a day to take, and once a dose sooner or later, dosage 3g（6）/ time, half an hour warm water after meal
Take.10 days are a course for the treatment of, and 2~5 courses for the treatment of of taking medicine, symptom disappears, and disease obtains recovery from illness.Visit with more than 1 year, no relapse.
Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine
Carry.The present invention is raw material from most common of which Chinese medicine, gives full play to the pharmacological effect of each component：
The tuber of dwarf lilyturf, nature and flavor：Sweet, slight bitter, it is slightly cold, there is the effect of nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire, for treating dryness of the lung dry cough, consumptive disease
Cough, injury thirst, vexed insomnia, Heat Diabetes, dry constipation of intestines, pharyngeal diphtheria；
Dewdrop grass, nature and flavor：It is pungent, put down, there is the effect of clearing heat and promoting diuresis, removing toxicity for detumescence, for treating hepatitis, cholecystitis, dysentery, kidney
Scorching oedema, urinary infection, stone in urinary system, tonsillitis, traumatic injury；
Giant knotweed, nature and flavor：It is bitter, flat, there is wind-dispelling, dampness removing, broken stasis of blood, the effect of stimulating the menstrual flow, for treating rheumatism arthralgia and myalgia, damp and hot Huang
Under subcutaneous ulcer, stranguria with turbid discharge band, women's Amenorrhea, lochiostasis, a lump in the abdomen causing distension and pain, blood, injury from falling down, scald, malignant sore tinea under anal fistula；
Asiatic plantain, nature and flavor：It is sweet, be slightly cold, have reducing fever and causing diuresis, excreting dampness is treating stranguria, improving eyesight, eliminating the phlegm the effect of, it is swollen for treating oedema
Full, puckery pain of heat gonorrhea, summer heat damp diarrhea, red eye, swell pain, phlegm-heat cough；
Radix Codonopsis, nature and flavor：It is sweet, mild-natured, there is the effect of strengthening the spleen and tonifying the lung, nourishing generate fluid, for treating weakness of the spleen and the stomach, deficiency of food just
The diseases such as half congealed, limbs fatigue, the deficiency syndrome of the lung are breathed with cough, shortness of breath spontaneous perspiration, gas micro- two lose；
Mock-strawberry, nature and flavor：It is sweet, bitter, cold in nature, have clearing heat and detoxicating, eliminating stasis to subdue swelling, cooling blood and hemostasis the effect of, for treat pyreticosis,
Frightened epilepsy, flu, dysentery, jaundice, hot eyes, aphtha, pharyngalgia, mumps, furuncle, venomous snake bite, haematemesis, uterine bleeding, irregular menstruation, boiling hot fire
Wound, treating swelling and pain by traumatic injury；
The Radix Astragali, nature and flavor：Sweet, tepor, there is the effect of invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation, for treating the deficiency of vital energy
Weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, burst for a long time and does not holds back,
The diseases such as flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes, chronic rephrilis protinuria, diabetes；
Scouring rush, nature and flavor：It is sweet, bitter, flat, there is wind-dispelling heat-dissipating, expelling pathogenic factors from muscles and skin, move back the effect of screen, for treating mesh life cloudiness, windward set
The disease such as tear, discharging fresh blood stool, bloody flux, de- liver, malaria, laryngalgia, carbuncle swells；
Oldenlandia diffusa, nature and flavor：It is sweet, light, cool, there is the effect of clearing heat and detoxicating, inducing diuresis to remove edema, promoting blood circulation and stopping pain, for treating intestines
Carbuncle（Appendicitis）, sore furuncle poison, jaundice with damp-heat pathogen, disease, the external application such as difficult urination control boil carbuncle swells, venomous snake bite；
Verbena officinalis, nature and flavor：It is bitter, cool, have clearing heat and detoxicating, promoting blood circulation to remove blood stasis, inducing diuresis for removing edema the effect of, for treat fever caused by exogenous pathogens,
The diseases such as jaundice with damp-heat pathogen, oedema, dysentery, malaria, diphtheria, larynx numbness, gonorrhoea, Amenorrhea, abdominal mass, carbuncle sore tumefacting virus, noma；
Kuh-seng, nature and flavor：It is bitter, cold, have heat-clearing, eliminating dampness, desinsection the effect of, for treat toxic-heat and blood stasis, discharging fresh blood stool, jaundice,
Leukorrhea with reddish discharge, infantile pneumonia, infantile malnutrition due to digestive disturbances or intestinalparasites, acute tonsillitis, anal fistula, prolapse of the anus, pruitus, scabies leprosy malignant sore, the erosion of vulva is wet to itch, scrofula
Scrofula, scald, control trichomonas vaginitis outside.
Medicine of the present invention is the principle based on Chinese traditional treatment hepatitis B, is recognized from the pathomechanism according to hepatitis B and pharmacological action
For：Hepatitis B one is demonstrate,proved, each raw material herbal medicine efficacy in medicine provided by the present invention is played altogether, has good treatment to above-mentioned disease
Effect.
Embodiment
A kind of Chinese medicine preparation that the present invention proposes aiming at the treatment of above-mentioned hepatitis B, the medicine prepared using the formula
Good drug efficacy, it is quick, it is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the specific implementation of the present invention
Mode is described in further detail：
Embodiment 1：
A kind of capsule medicine for being used to treat hepatitis B, it is characterised in that each component and mass parts ratio of the medicine are as follows
It is shown：
Tuber of dwarf lilyturf 115g, dewdrop grass 420g, giant knotweed 420g, Asiatic plantain 120g, Radix Codonopsis 230g, mock-strawberry 120g, Radix Astragali 260g, scouring rush
80g, oldenlandia diffusa 720g, Verbena officinalis 420g, kuh-seng 120g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
Embodiment 2：
A kind of capsule medicine for being used to treat hepatitis B, it is characterised in that each component and mass parts ratio of the medicine are as follows
It is shown：
Tuber of dwarf lilyturf 130g, dewdrop grass 480g, giant knotweed 480g, Asiatic plantain 140g, Radix Codonopsis 260g, mock-strawberry 140g, Radix Astragali 310g, scouring rush
90g, oldenlandia diffusa 850g, Verbena officinalis 480g, kuh-seng 140g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
Embodiment 3：
A kind of capsule medicine for being used to treat hepatitis B, it is characterised in that each component and mass parts ratio of the medicine are as follows
It is shown：
Tuber of dwarf lilyturf 150g, dewdrop grass 550g, giant knotweed 550g, Asiatic plantain 160g, Radix Codonopsis 300g, mock-strawberry 160g, Radix Astragali 350g, scouring rush
100g, oldenlandia diffusa 1000g, Verbena officinalis 550g, kuh-seng 160g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
Model case
Through clinical conditions hepatitis B patient totally 1195, the age is 770 of more than 61 years old, and only 288 are less than 61 years old.
907 to be fully recovered in 1195 patients, effective 192, invalid 96.Total effective rate is up to 92%.
Claims (3)
- A kind of 1. capsule medicine for being used to treat hepatitis B, it is characterised in that each component and its mass parts ratio of the medicine It is as follows：60~150g of the tuber of dwarf lilyturf, 250~550g of dewdrop grass, 150~550g of giant knotweed, 90~160g of Asiatic plantain, 150~300g of Radix Codonopsis, 90~160g of mock-strawberry, 90~350g of the Radix Astragali, 30~100g of scouring rush, 250~1000g of oldenlandia diffusa, 150~550g of Verbena officinalis, 80~160g of kuh-seng, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
- 2. the capsule medicine according to claim 1 for being used to treat hepatitis B, it is characterised in that each group of the medicine Divide and its mass parts are than as follows：70~130g of the tuber of dwarf lilyturf, 280~480g of dewdrop grass, 180~480g of giant knotweed, 100~140g of Asiatic plantain, 180~260g of Radix Codonopsis, 100~140g of mock-strawberry, 100~310g of the Radix Astragali, 38~90g of scouring rush, 280~850g of oldenlandia diffusa, 180~480g of Verbena officinalis, 90~140g of kuh-seng, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
- 3. being used for according to claim 1 to 2 treats the capsule medicine of hepatitis B, it is characterised in that the medicine it is each Individual component and its mass parts are than as follows：Tuber of dwarf lilyturf 115g, dewdrop grass 420g, giant knotweed 420g, Asiatic plantain 120g, Radix Codonopsis 230g, mock-strawberry 120g, Radix Astragali 260g, scouring rush 80g, oldenlandia diffusa 720g, Verbena officinalis 420g, kuh-seng 120g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.
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| CN201711044951.9A CN107823419A (en) | 2017-10-31 | 2017-10-31 | A kind of capsule medicine and preparation method for being used to treat hepatitis B |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711044951.9A CN107823419A (en) | 2017-10-31 | 2017-10-31 | A kind of capsule medicine and preparation method for being used to treat hepatitis B |
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| CN107823419A true CN107823419A (en) | 2018-03-23 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109730974A (en) * | 2019-03-15 | 2019-05-10 | 贵州百灵企业集团制药股份有限公司 | One kind is for fragrant safe tablet and preparation method thereof |
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2017
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109730974A (en) * | 2019-03-15 | 2019-05-10 | 贵州百灵企业集团制药股份有限公司 | One kind is for fragrant safe tablet and preparation method thereof |
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