CN107823258A - Preparation method, cinnamomum cassia extract and its application of cinnamomum cassia extract - Google Patents
Preparation method, cinnamomum cassia extract and its application of cinnamomum cassia extract Download PDFInfo
- Publication number
- CN107823258A CN107823258A CN201711127178.2A CN201711127178A CN107823258A CN 107823258 A CN107823258 A CN 107823258A CN 201711127178 A CN201711127178 A CN 201711127178A CN 107823258 A CN107823258 A CN 107823258A
- Authority
- CN
- China
- Prior art keywords
- cinnamomum cassia
- cassia extract
- preparation
- cinnamomum
- chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention provides a kind of preparation method of cinnamomum cassia extract, cinnamomum cassia extract and its application, is related to technical field of extraction of Chinese traditional medicine, and the preparation method of cinnamomum cassia extract comprises the following steps：First Chinese cassia tree is soaked in water, is separated by filtration after soak extraction, collects the Chinese cassia tree after soaked extracting solution and immersion respectively；The Chinese cassia tree after immersion is mixed with organic solvent again, carries out refluxing extraction, collects reflux extracting liquid；Finally soaked extracting solution is mixed with reflux extracting liquid; cinnamomum cassia extract is made; application of the above-mentioned cinnamomum cassia extract in prevention overweight people's virus flu medicine or health products are prepared; overweight people is alleviated when being attacked by influenza; resistance is poor; the technical problem that even some overweight peoples can get killed because epidemic virus is caught a cold; the immunity for improving overweight people is reached; strengthen it and resist the ability of virus flu; reduce mortality risk; the health of overweight people is protected, while the technique effect of the speed of weight increment of overweight people can also be slowed down.
Description
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, is extracted more particularly, to a kind of preparation method of cinnamomum cassia extract, Chinese cassia tree
Thing and its application.
Background technology
With the continuous improvement of people's living standards, the high high fat high-carbohydrate diet of oil takes in more and more, obese people
Gradually increase, the fat bodily form that not only influences is attractive in appearance, but also can reduce the immunity of human body, catches a cold and attacks in epidemic virus
When, overweight people is even more people at highest risk, or even some overweight peoples can get killed because epidemic virus is caught a cold, and therefore, how improve fertilizer
The immunity of fat person, strengthen the resistance of the pop viral influenza of overweight people, turn into those skilled in the art's urgent need to resolve
Technical problem.
In view of this, it is special to propose the present invention.
The content of the invention
It is an object of the invention to provide a kind of preparation method of cinnamomum cassia extract, cinnamomum cassia extract and its application, with slow
Overweight people is solved when being attacked by epidemic virus flu, resistance is poor, or even some overweight peoples can catch a cold because of epidemic virus
And the technical problem got killed.
The preparation method of cinnamomum cassia extract provided by the invention, comprises the following steps：
(a) Chinese cassia tree is soaked in water, be separated by filtration after soak extraction, collect the meat after soaked extracting solution and immersion respectively
Osmanthus；
(b) Chinese cassia tree after immersion is mixed with organic solvent, carries out refluxing extraction, collect reflux extracting liquid.
(c) soaked extracting solution is mixed with reflux extracting liquid, that is, cinnamomum cassia extract is made.
Further, the mass ratio of Chinese cassia tree and water is (1-2)：(2-20), it is preferably (1-2)：(2-5).
Further, the mass ratio of Chinese cassia tree and organic solvent is (1-2)：(6-60), it is preferably (1-2)：(6-15).
Further, the organic solvent is low-carbon alcohols, preferably ethanol.
Further, in step (a), the time of soak extraction is 12-24 hours, preferably 15-20 hours；Immersion carries
The temperature taken is 15-45 DEG C, preferably 20-35 DEG C.
Further, in step (b), the time of refluxing extraction is 3-6 hours, preferably 4-5 hours.
Further, the preparation method of the cinnamomum cassia extract also includes step (s), and the step (s) is arranged at step
(a) before, the step (s) is that Chinese cassia tree is ground into ground cinnamon, and the particle diameter of ground cinnamon is 5-15cm, preferably 8-12cm.
Cinnamomum cassia extract provided by the invention, it is prepared using the preparation method of above-mentioned cinnamomum cassia extract.
Cinnamomum cassia extract provided by the invention, including cinnamic acid, hexichol third pyridine -2- ketone, 2- methoxycinnamic aldehydes, α-can
Bar alkene and (-)-β-copaene.
Application of the cinnamomum cassia extract provided by the invention in prevention overweight people's virus flu health products or medicine is prepared.
The preparation method of cinnamomum cassia extract provided by the invention, the active component in Chinese cassia tree can be extracted, technique
Simply, it is easy to operate, big industrial production can be applied to.
Cinnamomum cassia extract provided by the invention can effectively improve the immunity of overweight people, strengthen it and resist virus flu
Ability, reduce mortality risk, protect the health of overweight people, while the speed of weight increment of overweight people can also be slowed down.
Brief description of the drawings
, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical scheme of the prior art
The required accompanying drawing used is briefly described in embodiment or description of the prior art, it should be apparent that, in describing below
Accompanying drawing is some embodiments of the present invention, for those of ordinary skill in the art, before creative work is not paid
Put, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the body weight increase curve of the high fat feeding mouse group that present invention experiment 1 provides and normal diet mouse group；
Fig. 2 is that the high fat feeding mouse group for the feeding Chinese cassia tree water that test example 1 of the present invention provides and the high fat of feeding pure water are fed
Eat the body weight increase curve of mouse group；
Fig. 3 is the changes of weight curve of three groups of mouse after influenza infection；
Fig. 4 is the Survival curves of three groups of mouse after influenza infection.
Embodiment
Technical scheme will be clearly and completely described below, it is clear that described embodiment is this hair
Bright part of the embodiment, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not having
There is the every other embodiment made and obtained under the premise of creative work, belong to the scope of protection of the invention.
Chinese cassia tree is recited as Chinese medicine and the existing long history of important flavoring, traditional Chinese medical science book：Mend gate of vitality's fire, soothing the liver logical four
Arteries and veins, guiding fire to origin, there are cardiac stimulant, stomach invigorating, the effectiveness of wind dispelling heresy antiemetic.
Chinese cassia tree is canella, is also often used in a kind of conventional Chinese medicine while food, is that common integration of drinking and medicinal herbs is planted
Thing.Extremely hot in nature, acrid-sweet flavor, have yang-tonifying, warm kidney, dispel cold, promote blood circulation, analgesic efficacy.Clinically it is usually used in mends fire supporing yang, cold scattering stops
Bitterly, invigorate blood circulation etc..
The scientist of recent domestic has found that Chinese cassia tree has extensive effect, has in human body and animal experiment corresponding
Effect, wherein in diabetes and antibiosis significant effect, but have no Chinese cassia tree in terms of pre- anti-fatness crowd's virus flu
Report.
According to an aspect of the present invention, the invention provides a kind of preparation method of cinnamomum cassia extract, including following step
Suddenly：
(a) Chinese cassia tree is soaked in water, be separated by filtration after soak extraction, collect the meat after soaked extracting solution and immersion respectively
Osmanthus；
(b) Chinese cassia tree after immersion is mixed with organic solvent, carries out refluxing extraction, collect reflux extracting liquid；
(c) soaked extracting solution is mixed with reflux extracting liquid, that is, cinnamomum cassia extract is made.
In the present invention, first Chinese cassia tree is mixed with water and soaked, extracted the saccharide active substances in Chinese cassia tree with water
Come, then the Chinese cassia tree after immersion be subjected to refluxing extraction using organic solvent, the grease active component in Chinese cassia tree is extracted,
To ensure the content of active material in cinnamomum cassia extract.
The preparation method of cinnamomum cassia extract provided by the invention, the active component in Chinese cassia tree can be extracted, technique
Simply, it is easy to operate, big industrial production can be applied to.
In the preferred embodiment of the present invention, the mass ratio of Chinese cassia tree and water is (1-2)：(2-20), it is preferably (1-
2)：(2-5).
It is (1-2) by controlling the mass ratio of Chinese cassia tree and water：(2-20), to enable saccharide active substances in Chinese cassia tree
It is leached out, especially when the mass ratio of Chinese cassia tree and water is (1-2)：(2-5), its extracting efficiency are higher.
In the preferred embodiment of the present invention, the mass ratio of Chinese cassia tree and organic solvent is (1-2)：(6-60), it is excellent
Elect as (1-2)：(6-15).
It is (1-2) by controlling the mass ratio of Chinese cassia tree and organic solvent：(6-60), to cause the esters active matter in Chinese cassia tree
Matter is leached out, especially when the mass ratio of Chinese cassia tree and organic solvent is (1-2)：(6-15), its refluxing extraction are more efficient.
In the preferred embodiment of the present invention, organic solvent is low-carbon alcohols, and the low-carbon alcohols are C2-C5 alcohol, excellent
Elect ethanol as.
It is demonstrated experimentally that formaldehyde can react with the aldehyde material in Chinese cassia tree, acetal is generated, causes active matter in Chinese cassia tree
The active ingredient of matter reduces, so in a preferred embodiment of the invention, from C2-C5 low-carbon alcohols as organic solvent,
In order to which the esters active component in Chinese cassia tree is extracted, it is demonstrated experimentally that being returned when from ethanol and Chinese cassia tree after immersion
During stream extraction, its extraction efficiency highest.
It should be noted that when the ethanol used is as organic solution, the concentration of ethanol is 65-75%, preferably 70%.
In the preferred embodiment of the present invention, in step (a), the time of soak extraction is 12-24 hours, excellent
Elect 15-20 hours as；The temperature of soak extraction is 15-45 DEG C, preferably 20-35 DEG C.
It it is 15-45 DEG C by controlling the temperature of soak extraction, the time of soak extraction is 12-24 hours, by Chinese cassia tree
Active component rapid extraction come out, improve the efficiency of extraction, especially when the temperature of soak extraction is 20-35 DEG C, immersion carries
It is 15-20 hours to take the time, and its extracting efficiency is higher.
In the preferred embodiment of the present invention, in step (b), the time of refluxing extraction is 3-6 hours, preferably
For 4-5 hours.
By being 3-6 hours by the time of refluxing extraction, to cause the esters active component in Chinese cassia tree to be extracted, especially
It is reflux extracting time when being 3-4 hours, extraction efficiency highest.
In a kind of typical but non-limiting refluxing extraction mode of the present invention, refluxing extraction is carried out in three times, often
Secondary 1-2 hours.
Also include step (s) in a kind of preparation method of typical but non-limiting cinnamomum cassia extract of the present invention, it is described
Step (s) is that Chinese cassia tree is ground into ground cinnamon, and the particle diameter of ground cinnamon is 5-15cm, preferably 8-12cm.
By setting steps (s), Chinese cassia tree is ground into ground cinnamon, so as to improve the extraction of active component in Chinese cassia tree effect
Rate.
According to the second aspect of the invention, the invention provides the meat prepared using above-mentioned cinnamomum cassia extract preparation method
Osmanthus extract.
The cinnamomum cassia extract that the preparation method of above-mentioned cinnamomum cassia extract is prepared carries out nuclear-magnetism detection, test result table
Bright cinnamomum cassia extract include cinnamic acid, hexichol third pyridine -2- ketone, 2- methoxycinnamic aldehydes, α-copaene and (-)-β-can bar
Alkene isoreactivity composition.
According to the third aspect of the present invention, the invention provides above-mentioned cinnamomum cassia extract viral in prevention overweight people
Application in cold medicine or health products.
Virus flu is the Acute respiratory infectious disease as caused by influenza virus, and the incidence of disease of influenza gradually rises in recent years
Height, foreign countries report that for overweight people when being subjected to influenza virus attack, course of disease time is longer, or even can therefore get killed.
Cinnamomum cassia extract provided by the invention can effectively improve the immunity of overweight people, strengthen it and resist virus flu
Ability, reduce mortality risk, protect the health of overweight people, while also enough slow down the speed of weight increment of overweight people.
Cinnamomum cassia extract provided by the invention can not only strengthen the ability that overweight people resists H1N1 influenza viruses, and
The ability that overweight people resists the influenza viruses such as H2N2 and H3N2 can be strengthened.
Technical scheme provided by the invention is further described with reference to embodiment and comparative example.
Embodiment 1
A kind of cinnamomum cassia extract is present embodiments provided, is prepared in accordance with the following steps：
(s) 100g Chinese cassia trees are taken, are ground into the ground cinnamon that particle diameter is 15cm；
(a) ground cinnamon is soaked in 200mL water, in temperature 45 C, soaks 12 hours, be separated by filtration, collect leaching respectively
Chinese cassia tree and soaked extracting solution after bubble；
(b) Chinese cassia tree after immersion is mixed with the ethanol that 600g concentration is 75%, carries out refluxing extraction three times, every time backflow
The time of extraction is 1 hour；
(c) soaked extracting solution is mixed with reflux extracting liquid, that is, cinnamomum cassia extract is made.
Embodiment 2
A kind of cinnamomum cassia extract is present embodiments provided, is prepared in accordance with the following steps：
(s) 100g Chinese cassia trees are taken, are ground into the ground cinnamon that particle diameter is 5cm；
(a) ground cinnamon is soaked in 2000mL water, in 15 DEG C of temperature, soaks 24 hours, be separated by filtration, collect leaching respectively
Chinese cassia tree and soaked extracting solution after bubble；
(b) Chinese cassia tree after immersion is mixed with the ethanol that 6000g concentration is 65%, carries out refluxing extraction three times, return every time
The time of stream extraction is 2 hours；
(c) soaked extracting solution is mixed with reflux extracting liquid, that is, cinnamomum cassia extract is made.
Embodiment 3
A kind of cinnamomum cassia extract is present embodiments provided, is prepared in accordance with the following steps：
(s) 100g Chinese cassia trees are taken, are ground into the ground cinnamon that particle diameter is 8cm；
(a) ground cinnamon is soaked in 500mL water, in 35 DEG C of temperature, soaks 15 hours, be separated by filtration, collect leaching respectively
Chinese cassia tree and soaked extracting solution after bubble；
(b) Chinese cassia tree after immersion is mixed with the ethanol that 1500g concentration is 70%, carries out refluxing extraction three times, return every time
The time of stream extraction is 1.5 hours；
(c) soaked extracting solution is mixed with reflux extracting liquid, that is, cinnamomum cassia extract is made.
Embodiment 4
A kind of cinnamomum cassia extract is present embodiments provided, is prepared in accordance with the following steps：
(s) 100g Chinese cassia trees are taken, are ground into the ground cinnamon that particle diameter is 12cm；
(a) ground cinnamon is soaked in 300mL water, in 20 DEG C of temperature, soaks 20 hours, be separated by filtration, collect leaching respectively
Chinese cassia tree and soaked extracting solution after bubble；
(b) Chinese cassia tree after immersion is mixed with the ethanol that 1000g concentration is 70%, carries out refluxing extraction three times, return every time
The time of stream extraction is 1.5 hours；
(c) soaked extracting solution is mixed with reflux extracting liquid, that is, cinnamomum cassia extract is made.
Embodiment 5
A kind of cinnamomum cassia extract is present embodiments provided, is prepared in accordance with the following steps：
(s) 100g Chinese cassia trees are taken, are ground into the ground cinnamon that particle diameter is 10cm；
(a) ground cinnamon is soaked in 300mL water, in 30 DEG C of temperature, soaks 18 hours, be separated by filtration, collect leaching respectively
Chinese cassia tree and soaked extracting solution after bubble；
(b) Chinese cassia tree after immersion is mixed with the ethanol that 1000g concentration is 70%, carries out refluxing extraction three times, return every time
The time of stream extraction is 1.5 hours；
(c) soaked extracting solution is mixed with reflux extracting liquid, that is, cinnamomum cassia extract is made.
The cinnamomum cassia extract that above-described embodiment 1-5 is provided analyzes active constituent content using NMR, as a result such as
Shown in table 1 below：
The cinnamomum cassia extract principle active component content data table of table 1
As it can be seen from table 1 the cinnamic aldehyde content in the cinnamomum cassia extract that 1-5 of the embodiment of the present invention is provided is left 75%
The right side, two phenylpropyl alcohol pyran-2-one contents be 15% or so, 2- methoxycinnamates aldehyde 2% or so, this explanation present invention
The preparation method of the cinnamomum cassia extract of offer, the extracts active ingredients in Chinese cassia tree can be come out, and active component will not be destroyed
Performance.In addition, analyzed by NMR, cinnamomum cassia extract that embodiment 1-5 is provided also containing α-copaene and (-)-
β-copaene.
Test example 1
The female c57BL/6N mouse of 3 week old wean are randomly divided into two groups, every group of animal 20, first group of mouse given
High fat diet (45%kcal fat), another group is normally chewed rodent diet.Two groups of mouse are raised in SPF animals
Fang Zhong, it is 23 ± 1 DEG C and 12 hours illumination/days to control room temperature.Once every mouse weight is measured weekly, and calculates two groups of mouse
Average weight, the average weight growth curve of two groups of mouse is as shown in figure 1, it will be seen from figure 1 that carry out the small of high fat feeding
Mouse group starts body weight in 4 week old and starts mouse group apparently higher than diet, during to 7 week old, high fat diet group mouse
Average weight has reached 25kg, and the average weight of normal diet group mouse is 20kg, illustrate fat mouse model it has been established that with
The extension of nursing time, when mouse age is 18 weeks, the average weight of high fat diet group mouse is 45kg, and normal diet group
The average weight of mouse be 20kg, the body weight increase speed of this explanation high fat diet mouse group is far above normal diet mouse
Group.
It is another to take the female c57BL/6N mouse of 3 week old wean to be randomly divided into two groups, every group of animal 20, two groups of mouse are given
Give high fat diet (45%kcal fat), and raise in SPF Animal Houses, control room temperature be 23 ± 1 DEG C and illumination in 12 hours/
My god.When mouse age is 7 weeks, one group of mouse is fed with the aqueous solution 1mL of the cinnamomum cassia extract of the offer of embodiment 5 daily, and (concentration is
5mg/mL), another group of mouse is fed with the pure water of same dose daily, and two groups are persistently fed with high fat diet, measure weekly once
Every mouse weight, and calculate the average weight of every group of mouse, the average weight growth curves of two groups of mouse as shown in Fig. 2 from
The speedup that Fig. 2 can be seen that the body weight of the mouse group of the aqueous solution for the cinnamomum cassia extract that feeding embodiment 5 provides substantially less than is fed
The body weight speedup of the mouse group of pure water is raised, this illustrates that cinnamomum cassia extract provided by the invention can slow down the body weight increasing of obesity mice
Speed.
It should be noted that in fig. 2, the aqueous solution for the cinnamomum cassia extract that Chinese cassia tree water refers to.
Test example 2
Take the female c57BL/6N mouse of 3 week old wean to be randomly divided into three groups, every group of animal 20, two groups of mouse are given
High fat diet (45%kcal fat) is given, one group is given normal chewing rodent diet, and raised in SPF Animal Houses
In, it is 23 ± 1 DEG C and 12 hours illumination/days to control room temperature.When mouse age is 7 weeks, one group of high fat diet mouse is fed with reality daily
The aqueous solution 1mL (concentration 5mg/mL) of the cinnamomum cassia extract of the offer of example 5 is applied, another group of high fat diet mouse is fed with same dose
Pure water, two groups continue be fed with high fat diet, the 3rd group of normal diet mouse continues to give chewing rodent diet, in mouse
During 23 weeks ages, three groups of mouse pass through intranasal vaccination 100PFU popularity H1N1 influenza viruses.After virus infection, monitoring sense daily
The body weight of mouse is contaminated, is monitored 14 days, original body mass is designated as 100%, and the changes of weight rule of three groups of mouse is as shown in figure 3, survival
Rate is as shown in Figure 4.
From figure 3, it can be seen that after inoculation influenza virus, the body weight of three groups of mouse is decreased obviously, but fat administration
The Body weight loss speed of group (high fat feeding is simultaneously fed with cinnamomum cassia extract solution) mouse significantly lower than fat group, (simultaneously feed by high fat feeding
Raise water) mouse, at the 15th day, the body weight of fat group is reduced to the 75% of substance weight, and fat administration group body weight is reduced to substance weight
80%, this illustrates that cinnamomum cassia extract provided by the invention can significantly improve the resisiting influenza virus ability of mouse.
From fig. 4, it can be seen that only 20% survival rate of fat group mouse, and the survival rate of the mouse of fat administration group
For 57%, it is significantly higher than the survival rate of fat group mouse, this illustrates that cinnamomum cassia extract provided by the invention can show and improves mouse
Resisiting influenza virus ability, reduce the death rate of mouse.
Test example 3
3 people of the overweight people for being susceptible to suffer from virus flu 3 are randomly selected, carry out 1 year tracing detection, preceding 6 months 3 people protect
Normal diet is held, since 7th month, it was 5mg/mL's that 3 people drink 50mL concentration daily while normal diet is kept
Cinnamomum cassia extract solution (cinnamomum cassia extract provided by embodiment 5 is prepared), record three people in 1 year times of common cold and
Catch a cold the duration, it is as a result as shown in table 2 below：
The clinical effectiveness tables of data of the cinnamomum cassia extract of table 2
From table 2 it can be seen that 3 overweight peoples for being susceptible to suffer from virus flu take cinnamomum cassia extract provided by the invention
After the aqueous solution, its immunity significantly improves, and its times of common cold significantly reduces, and the flu duration substantially shortens, and this illustrates this hair
The cinnamomum cassia extract of bright offer can effectively improve the immunity of overweight people, strengthen it and resist the ability of virus flu, reduce
Mortality risk, protect the health of overweight people.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. a kind of preparation method of cinnamomum cassia extract, it is characterised in that comprise the following steps：
(a) Chinese cassia tree is soaked in water, be separated by filtration after soak extraction, collect the Chinese cassia tree after soaked extracting solution and immersion respectively；
(b) Chinese cassia tree after immersion is mixed with organic solvent, carries out refluxing extraction, collect reflux extracting liquid；
(c) soaked extracting solution is mixed with reflux extracting liquid, that is, cinnamomum cassia extract is made.
2. the preparation method of cinnamomum cassia extract according to claim 1, it is characterised in that the mass ratio of Chinese cassia tree and water is
(1-2)：(2-20), it is preferably (1-2)：(2-5).
3. the preparation method of cinnamomum cassia extract according to claim 1, it is characterised in that the quality of Chinese cassia tree and organic solvent
Than for (1-2)：(6-60), it is preferably (1-2)：(6-15).
4. the preparation method of the cinnamomum cassia extract according to claim any one of 1-3, it is characterised in that the organic solvent
For low-carbon alcohols, preferably ethanol.
5. the preparation method of the cinnamomum cassia extract according to claim any one of 1-3, it is characterised in that in step (a),
The time of soak extraction is 12-24 hours, preferably 15-20 hours；The temperature of soak extraction is 15-45 DEG C, preferably 20-35
℃。
6. the preparation method of the cinnamomum cassia extract according to claim any one of 1-3, it is characterised in that in step (b),
The time of refluxing extraction is 3-6 hours, preferably 4-5 hours.
7. the preparation method of the cinnamomum cassia extract according to claim any one of 1-3, it is characterised in that also including step
(s), the step (s) is arranged at before step (a), and the step (s) is that Chinese cassia tree is ground into ground cinnamon, the particle diameter of ground cinnamon
For 5-15cm, preferably 8-12cm.
8. a kind of cinnamomum cassia extract, it is characterised in that using the preparation side of the cinnamomum cassia extract described in claim any one of 1-7
Method is prepared.
9. cinnamomum cassia extract according to claim 8, it is characterised in that including cinnamic acid, hexichol third pyridine -2- ketone, 2-
Methoxycinnamic aldehyde, α-copaene and (-)-β-copaene.
10. cinnamomum cassia extract according to claim 8 or claim 9 is preparing prevention overweight people's virus flu medicine or health products
In application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711127178.2A CN107823258A (en) | 2017-11-15 | 2017-11-15 | Preparation method, cinnamomum cassia extract and its application of cinnamomum cassia extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711127178.2A CN107823258A (en) | 2017-11-15 | 2017-11-15 | Preparation method, cinnamomum cassia extract and its application of cinnamomum cassia extract |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107823258A true CN107823258A (en) | 2018-03-23 |
Family
ID=61655421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711127178.2A Pending CN107823258A (en) | 2017-11-15 | 2017-11-15 | Preparation method, cinnamomum cassia extract and its application of cinnamomum cassia extract |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107823258A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109646407A (en) * | 2018-12-17 | 2019-04-19 | 江西赣隆药业有限公司 | For the preparation method of calm, cooling, decompression Cortex Cinnamomi granule and by the granule of this method preparation |
| CN111013190A (en) * | 2020-01-14 | 2020-04-17 | 三益创价生物科技(深圳)有限公司 | Method and device for extracting composition rich in cinnamaldehyde from cinnamon leaves |
| US20230110299A1 (en) * | 2021-10-08 | 2023-04-13 | Qifeng Ma | Hygiene Base Composition, and Production Method and Application Method Thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2551454A1 (en) * | 2003-12-24 | 2005-07-07 | Ramot At Tel-Aviv University Ltd. | Antiviral preparations obtained from a natural cinnamon extract |
| CN102114076A (en) * | 2006-10-25 | 2011-07-06 | 中国科学院上海生命科学研究院 | Preparation method of cassia bark extract, cassia bark extract and composition and application thereof |
| CN106236834A (en) * | 2016-08-09 | 2016-12-21 | 武汉正百泰谷药业有限公司 | The preparation method of Cortex Cinnamomi extract, Cortex Cinnamomi extract, a combination thereof thing and application |
| CN106606539A (en) * | 2016-12-16 | 2017-05-03 | 昆药集团股份有限公司 | Application of cinnamon polyphenol composition |
-
2017
- 2017-11-15 CN CN201711127178.2A patent/CN107823258A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2551454A1 (en) * | 2003-12-24 | 2005-07-07 | Ramot At Tel-Aviv University Ltd. | Antiviral preparations obtained from a natural cinnamon extract |
| CN1897958A (en) * | 2003-12-24 | 2007-01-17 | 特拉维夫大学拉玛特有限公司 | Antiviral preparations obtained from a natural cinnamon extract |
| CN102114076A (en) * | 2006-10-25 | 2011-07-06 | 中国科学院上海生命科学研究院 | Preparation method of cassia bark extract, cassia bark extract and composition and application thereof |
| CN106236834A (en) * | 2016-08-09 | 2016-12-21 | 武汉正百泰谷药业有限公司 | The preparation method of Cortex Cinnamomi extract, Cortex Cinnamomi extract, a combination thereof thing and application |
| CN106606539A (en) * | 2016-12-16 | 2017-05-03 | 昆药集团股份有限公司 | Application of cinnamon polyphenol composition |
Non-Patent Citations (3)
| Title |
|---|
| 芮景 等: "《全科医师实用手册》", 31 January 2008, 安徽科学技术出版社 * |
| 马振亚: "《中药抗病毒抗菌作用研究》", 31 January 2005, 中国医药科技出版社 * |
| 高天 等: "舒筋止痛涂膜剂中川芎和肉桂提取工艺研究", 《成都中医药大学学报》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109646407A (en) * | 2018-12-17 | 2019-04-19 | 江西赣隆药业有限公司 | For the preparation method of calm, cooling, decompression Cortex Cinnamomi granule and by the granule of this method preparation |
| CN111013190A (en) * | 2020-01-14 | 2020-04-17 | 三益创价生物科技(深圳)有限公司 | Method and device for extracting composition rich in cinnamaldehyde from cinnamon leaves |
| US20230110299A1 (en) * | 2021-10-08 | 2023-04-13 | Qifeng Ma | Hygiene Base Composition, and Production Method and Application Method Thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103798308B (en) | A kind of natural traditional Chinese medicine mosquito-repellent incense | |
| CN105230685B (en) | Herbaceous plant essential oil composition with repelling effect | |
| CN107823258A (en) | Preparation method, cinnamomum cassia extract and its application of cinnamomum cassia extract | |
| CN105076233B (en) | It is a kind of to prevent eliminating aphis and its preparation technology of the plant insecticide of acarid | |
| CN104304679B (en) | A kind of B B-complex C, E immune polysaccharide microemulsion preparation and its preparation method and application | |
| CN106420876A (en) | Drinking liquid with uric acid decreasing and lipid lowering effects and preparation method of drinking liquid | |
| CN104222680B (en) | Loach specific complex immunostimulant and its preparation method | |
| CN104095154B (en) | A kind of Cynoglossus semilaevis special immune reinforcing agent | |
| Mughal | PEPPERMINT OIL, ITS USEFUL, AND ADVERSE EFFECTS ON HUMAN HEALTH: A REVIEW | |
| CN104873579A (en) | Application of piper sarmentosum roxb extract | |
| CN101342266A (en) | Anti-newcastle disease virus traditional Chinese medicine oral liquid and preparation method thereof | |
| CN100546606C (en) | A kind of medicine of preventing and treating fowl's respiratory tract diseases and preparation method thereof that is used to | |
| CN103652341A (en) | Special feed for promoting growth of anti-shell river crab | |
| CN112843101B (en) | Application of Thelephora ganbajun zang in protecting liver injury | |
| CN103478843B (en) | A kind of alcohol-decomposing beverage and preparation method thereof | |
| CN102973730B (en) | Chinese medicament for animals with functions of clearing heat and removing toxicity, resisting virus and improving body immunity and preparation method thereof | |
| CN105076234A (en) | Preparation process of botanical insecticide capable of preventing and treating maize weevil | |
| CN106359203A (en) | Method for improving quality of fish | |
| Adejoh et al. | Effect of aqueous leaf extract of Anogeissus leiocarpus against experimental models of pain and pyrexia | |
| CN105341534A (en) | Feed additive for preventing white-spot disease of parrot fishes and preparation method thereof | |
| CN103918705A (en) | Pesticidal composition containing spirotetramat and lambda-cyhalothrin and application thereof | |
| CN104146116A (en) | Prunus serrulata leaf tea, preparation method thereof and application thereof to treatment of diabetes | |
| JP2002363012A (en) | Insecticidal and anti-swarm agent for plant and method for its use | |
| CN105267188A (en) | Application of 10-gingerol to preparation of medicines for preventing and treating epizoic ciliates of fishes | |
| CN101502529B (en) | Application of vincetoxicoside B in preparing antidiabetic medicament |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180323 |
|
| RJ01 | Rejection of invention patent application after publication |