CN107821390A - A kind of mesotrione oil-suspending agent and preparation method thereof - Google Patents
A kind of mesotrione oil-suspending agent and preparation method thereof Download PDFInfo
- Publication number
- CN107821390A CN107821390A CN201710952989.XA CN201710952989A CN107821390A CN 107821390 A CN107821390 A CN 107821390A CN 201710952989 A CN201710952989 A CN 201710952989A CN 107821390 A CN107821390 A CN 107821390A
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- China
- Prior art keywords
- oil
- mesotrione
- suspending agent
- parts
- agent
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/10—Sulfones; Sulfoxides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/66—1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms
- A01N43/68—1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms with two or three nitrogen atoms directly attached to ring carbon atoms
- A01N43/70—Diamino—1,3,5—triazines with only one oxygen, sulfur or halogen atom or only one cyano, thiocyano (—SCN), cyanato (—OCN) or azido (—N3) group directly attached to a ring carbon atom
Abstract
The invention belongs to Agrotechnical formulation technical field, more particularly to a kind of mesotrione oil-suspending agent and preparation method thereof；Mesotrione oil-suspending agent includes the component of following parts by weight：Mesotrione, 8~11 parts；1 (2 cyanoethyl) 4 methyl piperazines, 0.5~2 part；Emulsifying agent, 10~18 parts；Oil-suspending agent, 50~70 parts；Thickener, 3~4 parts；Mesotrione, 1 (2 cyanoethyl) 4 methyl piperazines, emulsifying agent, oil-suspending agent, thickener are used cooperatively, the resolution ratio of mesotrione is greatly reduced, enhances drug effect；And the addition of emulsifying agent can fully soak solid particle, shorten the time that grinding reaches qualified particle diameter；It is good to the emulsifying effectiveness of oil-suspending agent, it is uniformly dispersed, better stability of preparation；Facilitation is played to the storage resolution ratio for effectively reducing active compound；The preparation method of mesotrione oil-suspending agent of the present invention, preparation method is simple, and product condition is good, suitable for large-scale production.
Description
Technical field
The invention belongs to Agrotechnical formulation technical field, more particularly to a kind of mesotrione oil-suspending agent and its preparation side
Method.
Background technology
Mesotrione (Mesotrione) is new three ketones, soil processing herbicide before bud, low toxicity, belongs to environment-friendly
Property herbicide.It is suitable for turning over, covers and broadcast, Tie Zuo corn field managements of weeds, can effectively prevent and kill off annual a variety of broad leaved weeds and
Grassy weed.Mesotrione is under normal use dosage, to corn safety.
Existing pesticide oil suspension, which floats agent, two big series, and one kind is using mineral oil as medium, and another kind is using vegetable oil as medium.
, it is that the current oil that restricts hangs but the development difficulty of such preparation is larger mainly due to the alternative auxiliary agent of oil-suspending agent very little
The main bottleneck of floating preparation development.Due to pesticide oil suspension float agent in production use when to be diluted with water, therefore on formula should
This has the emulsifying agent of emulsion dispersion medium；And also to study shadow of the different emulsifiers to pesticidal preparations physicochemical stability performance
Ring.Dispersant in water-based system, can not be compatible well with decentralized medium because polarity is too strong, moreover, in non-water body
Peptizaiton mechanism in system can not be equal to the dispersion mechanism in water-based system.For other formulations, current oil is hanged
The research and development of floating agent is slow.Even if the oily suspension formulation developed, there is also poor storage stability, layering or flocculation are serious
The problems such as.Due in alternative nonaqueous systems at home emulsifying agent very little, especially for vegetable oil and mineral oil
Almost do not have, therefore the emulsifying agent used in anxious non-aqueous system to be developed.
Mesotrione in the market and its compounding oil-suspending agent, mesotrione resolution ratio is up in Storage period
15%~30%, heating storage decomposition is more severe, has a strong impact on the performance of drug effect.
The content of the invention
The present invention solve prior art present in above-mentioned technical problem, there is provided a kind of mesotrione oil-suspending agent and its
Preparation method.
To solve the above problems, technical scheme is as follows：
A kind of mesotrione oil-suspending agent, include the raw material of following parts by weight：
Mesotrione, 8~11 parts；
1- (2- cyanoethyls) -4- methyl piperazines, 0.5~2 part；
Emulsifying agent, 10~18 parts；
Oil-suspending agent, 50~70 parts；
Thickener, 3~4 parts.
Preferably, the emulsifying agent is：Alkylbenzenesulfonate, art mahogany sulfonate, alkylnaphthalene sulfonate, the polyoxyethylene moon
Osmanthus ether, NPE, alkylaryl APEO, polyoxyethylene carboxylate, PO-EO block polyethers, poly- carboxylic
Any one or several combination in hydrochlorate, Crodaret salt, styryl phosphate, sorbitol monooleate.
Preferably, the oil-suspending agent is：Soybean oil, rapeseed oil, cottonseed oil, castor oil, turpentine oil, enriching vegetable oil,
It is any one or several in methyl oleate, isooctyl oleate, sunflower oil, peanut oil, olive oil, palm oil, corn oil, paraffin oil
Combination.
Preferably, the thickener is：Aluminium-magnesium silicate, organobentonite, sodium carboxymethyl starch, xanthans, white carbon, height
Any one or several combination in the soil of ridge.
Preferably, the mesotrione oil-suspending agent also includes 20~30 parts of atrazine.
The preparation method of mesotrione oil-suspending agent, comprises the following steps：The emulsifying agent is dissolved in into the oil to suspend
In agent, under stirring or shear action, the mixture of mesotrione or mesotrione and atrazine is added portionwise, added
0.5-1 hours are stirred, is sanded with pump input sand mill, cutting kettle is transferred to after 10-20 minutes, thickener is added, is adjusted to close
Suitable viscosity shear uniformly discharges afterwards.
Relative to prior art, advantages of the present invention is as follows,
The present invention mesotrione oil-suspending agent by mesotrione, 1- (2- cyanoethyls) -4- methyl piperazines, emulsification
Agent, oil-suspending agent, thickener are used cooperatively, and are greatly reduced the resolution ratio of mesotrione, are enhanced drug effect；And emulsifying agent
Addition can fully soak solid particle, shorten the time that grinding reaches qualified particle diameter；It is good to the emulsifying effectiveness of oil-suspending agent, disperse
Uniformly, better stability of preparation；Facilitation is played to the storage resolution ratio for effectively reducing active compound；
The preparation method of mesotrione oil-suspending agent of the present invention, preparation method is simple, and product condition is good, suitable for big rule
Mould produces.
Embodiment
Embodiment 1：
A kind of mesotrione oil-suspending agent, include the raw material of following parts by weight：
Mesotrione, 8 parts；
1- (2- cyanoethyls) -4- methyl piperazines, 0.5 part；
Emulsifying agent, 10 parts；
Methyl oleate, 50 parts；
Organobentonite, 3 parts.
Wherein, the quality proportioning of the emulsifying agent is：
Alkylaryl APEO, 16.5%
PO-EO block polyethers, 53.0%
Alkylnaphthalene sulfonate, 30.5%
The preparation method of above-mentioned mesotrione oil-suspending agent, comprises the following steps：The emulsifying agent is dissolved in the oil
In suspending agent, under stirring or shear action, the mixture of mesotrione or mesotrione and atrazine is added portionwise,
Stirring 0.5-1 hours are added, is sanded with pump input sand mill, cutting kettle is transferred to after 10-20 minutes, adds thickener, is adjusted
Discharged after to appropriate viscosity shearing uniformly.
Embodiment 2：
With embodiment 1, following components (parts by weight) is only changed：
Mesotrione, 11 parts；
1- (2- cyanoethyls) -4- methyl piperazines, 2 parts；
Emulsifying agent, 18 parts；
Oil-suspending agent, 70 parts；
Thickener, 4 parts.
Wherein, the quality proportioning of the emulsifying agent is：
Alkylbenzenesulfonate, 21.4%
Polyoxyethylene laurel ether 57.6%
Sorbitol monooleate 21.0%
Wherein, the quality proportioning of the oil-suspending agent is：：
Cottonseed oil, 50%
Paraffin oil, 50%
Wherein, the thickener is：Xanthans.
Embodiment 3：
With embodiment 1, following components (parts by weight) is only changed：
Mesotrione, 9 parts；
1- (2- cyanoethyls) -4- methyl piperazines, 1 part；
Emulsifying agent, 14 parts；
Oil-suspending agent, 60 parts；
Thickener, 3.2 parts.
Atrazine, 25 parts
Wherein, the quality proportioning of the emulsifying agent is：
Art mahogany sulfonate, 13%
Fat acid polyoxyethylene ester, 25%
Polycarboxylate, 62%
Wherein, the oil-suspending agent is：Enriching vegetable oil.
Wherein, the thickener is：Sodium carboxymethyl starch.
Embodiment 4：
50 milliliters are respectively taken to be placed in a glass container with plug sealing the oil-suspending agent obtained by embodiment 1-3, point
It is not placed in 54 ± 2 DEG C of constant temperature ovens and carries out an experiment of the accelerating storage of two weeks by a definite date；The resolution ratio of mesotrione is high
Performance liquid chromatography judges.As a result it is as follows：
The oil-suspending agent resolution ratio of embodiment 1 is 2.1%；
The oil-suspending agent resolution ratio of embodiment 2 is 1.9%；
The oil-suspending agent resolution ratio of embodiment 3 is 1.4%；
It should be noted that above-described embodiment is only presently preferred embodiments of the present invention, it is not used for limiting the present invention's
Protection domain, the equivalent substitution or replacement made on the basis of the above belong to protection scope of the present invention.
Claims (6)
1. a kind of mesotrione oil-suspending agent, it is characterised in that include the raw material of following parts by weight：
Mesotrione, 8~11 parts；
1- (2- cyanoethyls) -4- methyl piperazines, 0.5~2 part；
Emulsifying agent, 10~18 parts；
Oil-suspending agent, 50~70 parts；
Thickener, 3~4 parts.
2. mesotrione oil-suspending agent as claimed in claim 1, it is characterised in that the emulsifying agent is：Alkyl benzene sulphonate
Salt, art mahogany sulfonate, alkylnaphthalene sulfonate, polyoxyethylene laurel ether, NPE, alkylaryl polyoxyethylene
Ether, polyoxyethylene carboxylate, PO-EO block polyethers, polycarboxylate, Crodaret salt, styryl phosphoric acid
Any one or several combination in salt, sorbitol monooleate.
3. mesotrione oil-suspending agent as claimed in claim 1, it is characterised in that the oil-suspending agent is：Soybean oil, dish
Seed oil, cottonseed oil, castor oil, turpentine oil, enriching vegetable oil, methyl oleate, isooctyl oleate, sunflower oil, peanut oil, olive
Any one or several combination in oil, palm oil, corn oil, paraffin oil.
4. mesotrione oil-suspending agent as claimed in claim 1, it is characterised in that the thickener is：Aluminium-magnesium silicate, have
Any one or several combination in machine bentonite, sodium carboxymethyl starch, xanthans, white carbon, kaolin.
5. mesotrione oil-suspending agent as claimed in claim 1, it is characterised in that the mesotrione oil-suspending agent is also
Including 20~30 parts of atrazine.
6. the preparation method of the mesotrione oil-suspending agent as described in claim any one of 1-5, it is characterised in that including with
Lower step：The emulsifying agent is dissolved in the oil-suspending agent, under stirring or shear action, by mesotrione or methyl sulphur
The mixture of humulone and atrazine is added portionwise, and adds stirring 0.5-1 hours, is sanded with pump input sand mill, 10-20 points
Cutting kettle is transferred to after clock, adds thickener, is discharged after being adjusted to appropriate viscosity shearing uniformly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710952989.XA CN107821390A (en) | 2017-10-13 | 2017-10-13 | A kind of mesotrione oil-suspending agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710952989.XA CN107821390A (en) | 2017-10-13 | 2017-10-13 | A kind of mesotrione oil-suspending agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN107821390A true CN107821390A (en) | 2018-03-23 |
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| CN201710952989.XA Pending CN107821390A (en) | 2017-10-13 | 2017-10-13 | A kind of mesotrione oil-suspending agent and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4113727A (en) * | 1977-04-26 | 1978-09-12 | Sandoz, Inc. | Process for the preparation of substituted isoxazolo[4,5-c]pyridin-4-(5H)-ones |
| CN101971805A (en) * | 2010-11-17 | 2011-02-16 | 南京扬子鸿利源化学品有限责任公司 | Oil-suspension agricultural mesotrione preparation as well as preparation method and applications thereof |
| CN102827192A (en) * | 2012-09-16 | 2012-12-19 | 罗梅 | Zinc complex |
| CN103703005A (en) * | 2011-02-28 | 2014-04-02 | 艾伯维公司 | Tricyclic inhibitors of kinases |
| EP2868196A1 (en) * | 2013-11-05 | 2015-05-06 | Basf Se | Herbicidal compositions |
-
2017
- 2017-10-13 CN CN201710952989.XA patent/CN107821390A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4113727A (en) * | 1977-04-26 | 1978-09-12 | Sandoz, Inc. | Process for the preparation of substituted isoxazolo[4,5-c]pyridin-4-(5H)-ones |
| CN101971805A (en) * | 2010-11-17 | 2011-02-16 | 南京扬子鸿利源化学品有限责任公司 | Oil-suspension agricultural mesotrione preparation as well as preparation method and applications thereof |
| CN103703005A (en) * | 2011-02-28 | 2014-04-02 | 艾伯维公司 | Tricyclic inhibitors of kinases |
| CN102827192A (en) * | 2012-09-16 | 2012-12-19 | 罗梅 | Zinc complex |
| EP2868196A1 (en) * | 2013-11-05 | 2015-05-06 | Basf Se | Herbicidal compositions |
Non-Patent Citations (1)
| Title |
|---|
| CHRIS J. HAMILTON等: "Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase", 《BIOORGANIC & MEDICINAL CHEMISTRY》 * |
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Application publication date: 20180323 |
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