CN110278947A - A kind of novel agrochemical formulations and preparation method thereof - Google Patents
A kind of novel agrochemical formulations and preparation method thereof Download PDFInfo
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- CN110278947A CN110278947A CN201910689503.7A CN201910689503A CN110278947A CN 110278947 A CN110278947 A CN 110278947A CN 201910689503 A CN201910689503 A CN 201910689503A CN 110278947 A CN110278947 A CN 110278947A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
- A01N57/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing acyclic or cycloaliphatic radicals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
- A01N57/14—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing aromatic radicals
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Abstract
The present invention relates to a kind of preparation methods of novel agrochemical formulations, belong to pesticide field, it is characterized in that, four kinds of microcapsule suspending agent, suspending agent, aqueous emulsion and microemulsion dosage forms are respectively prepared in pesticide single dose first, slow-release medicament is blended with Quick-type medicament then and is made；The slow-release medicament uses microcapsule suspending agent or suspending agent, and the Quick-type medicament uses aqueous emulsion or microemulsion；The present invention is used in compounding by all kinds of different formulations of pesticide, control the time and the lasting effect for improving drug effect that drug effect plays, come realize more effectively play drug efficiency, so that it is had both the advantages that environment-friendly type is excellent, such environmental effects are small, stability is good, universality is wide, timeliness is long.
Description
Technical field
The present invention relates to technical field of pesticide, and in particular to a kind of novel agrochemical formulations and preparation method thereof.
Background technique
The success of one pesticide, half are dosage form.By that pesticide can be made to reach following purpose to Pesticide formulation:
A small amount of medicament is evenly distributed in wide farmland；The effect of pesticide is played to greatest extent；Overcome the shortcomings of pesticide it
Place；Improve the safety of user；It reduces to environmental pressure；Improve operating characteristics, accomplishes Labor-saving；Promote the function of existing medicament
Can, expand purposes.Especially current, with the continuous improvement of agent activity, novel pesticide structure becomes increasingly complex, it is necessary to have
The adaptable formulations of pesticide.Simultaneously as environmental requirement is continuously improved, new medicament exploitation registration expense and time are constantly passed
It rises, it also must be by modified form to prolong its service life to some old pesticide species.Simultaneously as occurring in agricultural production
Aging, womenization phenomenon, therefore disease pest and weed prevention and treatment in also will as possible reduce labour；Further more, also must to protect environment
It must reform in widely applied pesticidal preparations some, to adapt to the needs of current social development.For this reason, it is necessary to right
The formulations of pesticide carry out new design.
Some traditional formulations of pesticide the problems such as there is toxicity, dust, risk, it is much not suitable with current pesticide hair
The requirement of exhibition, it is extremely urgent to the transformation of conventional dosage forms.Main reform point are as follows: the preparation for using harmful organic solvent is realized
Water-borne modification, to reduce toxicity, phytotoxicity and risk；Granulating is realized to the preparation of fine powdery or uses water-soluble packaging bag, with
Prevent dust from sucking；Drift will also be prevented in addition to removing particle dust for pulvis, avoid generating adverse effect to environment；By
It is reduced in formulation rate or using the technology from ridge side dressing medicine, to accomplish laborsaving and light weight；Using control release technic, make preparation
Functionalization；It is administered targeted stronger.
In the preparation of pesticide, missible oil be using most conventional dosage forms, and the toxicity problem of its solvent for use be its most
Big obstacle, and obtain and a kind of have both the agriculture that environment-friendly type is excellent, such environmental effects are small, stability is good, universality is wide, timeliness is long
Pharmaceutically dosage form is the emphasis researched and developed at present.
Summary of the invention
The technical problem to be solved by the present invention is in view of the deficiencies of the prior art, provide one kind have both environment-friendly type it is excellent,
Such environmental effects are small, stability is good, universality is wide, novel agrochemical formulations that timeliness is long and preparation method thereof.
The technical scheme to solve the above technical problems is that a kind of preparation method of novel agrochemical formulations, special
Sign is, four kinds of microcapsule suspending agent, suspending agent, aqueous emulsion and microemulsion dosage forms are respectively prepared in pesticide single dose first, then will
Slow-release medicament is blended with Quick-type medicament to be made；The slow-release medicament uses microcapsule suspending agent or suspending agent, described quick
Type medicament uses aqueous emulsion or microemulsion.
Further, the formula each component of the microcapsule suspending agent and weight percent are as follows:
Pesticide single dose 1-30%
Nonpolar solvent 5-10%
Oiliness capsule skin 2-5%
Thickening stabilizing agent 0.5-2%
Preservative 0.1-0.5%
Defoaming agent 1-3%
Surplus pH adjusting agent, dispersing agent and water；
The nonpolar solvent uses saturated hydrocarbons, benzene, carbon tetrachloride or dichloroethanes, and thickening stabilizing agent uses xanthan gum
Or Kui aluminum magnesium silicate, preservative is using in benzoic acid and its esters, sorbic acid and its esters, lactate and nisin
At least one, defoaming agent use high-carbon alcohol defoaming agent, preferably tributyl phosphate, and pH adjusting agent uses hydrochloric acid, acetic acid, soda ash
Or sodium hydroxide, dispersing agent use anionic surfactant such as dodecyl sodium sulfate or amino acid type amphoteric surface-active
Agent；
The microcapsule suspending agent the preparation method is as follows:
A) preparation of microcapsules oiliness capsule skin: into container be added molar ratio be l:1.5-2.0 urea and formaldehyde and
Appropriate amount of deionized water adjusts pH to 8 with pH adjusting agent, is warming up to 7O DEG C or more and is stirred to react, obtain Lauxite pre-polymerization
Object aqueous solution, as microcapsules oiliness capsule skin；
B) oil is mutually prepared: with the pesticide single dose of the nonpolar solvent dissolution formula ratio of formula ratio, being heated to being completely dissolved, so
The oiliness capsule skin of 1/2 formula ratio is added afterwards, stirs evenly spare；
C) it water phase mixing shearing: will be sheared in the thickening stabilizing agent of formula ratio, preservative, defoaming agent, water investment cutting kettle
It is uniformly mixed；
D) high speed dispersion: oil made from step b) is mutually slowly added into water phase made from step c), the shearing of side edged,
Until obtaining partial size at 2-5 microns, remaining 1/2 oiliness capsule skin is then added, shearing is uniform to obtain suspension；
E) heat up packing: suspension made from step d) stops shearing, and is to slowly warm up to 59-62 DEG C under stiring, stops
It only heats, dispersing agent is added after continuing stirring heat preservation, cooling discharge after being stirred for uniformly.
Microcapsule suspending agent prepares pesticide micro capsule using the situ aggregation method that Lauxite is cyst material, has raw material
Abundant, technical maturity and feature at low cost, the microencapsulated rate prepared with the method is high, and property is stablized, water resistant infiltration, saturating ability
By force, shape is also preferable.Although this method reaction speed is slightly slow, its Encapsulating materials formaldehyde and urea are cheap chemical industry
Raw material, overall cost will be lower than interfacial polymerization techniques, and the application potential in pesticide industry is larger.In addition, the microencapsulation system
With certain versatility, suitable for preparing the pesticide species with benzene,toluene,xylene etc. for solvent, such as organic phosphorus, quasi- deinsectization
The microcapsule suspending agent of chrysanthemum ester insecticide.Compared with missible oil, microcapsule formulation can save a large amount of organic solvents.Insecticide it is normal
Be missible oil with dosage form, need to consume a large amount of dimethylbenzene, and microcapsule formulation needs a small amount of solvent only to dissolve raw medicine, it is comprehensive at
This is below or near to missible oil.From control efficiency, the sustained release performance that microcapsule suspending agent is shown can extend the lasting period, thus
Greatly improve integrated control benefit.
Further, the formula each component of the suspending agent and weight percent are as follows:
Pesticide single dose 1-50%
Dispersing aid 5-10%
Thickening stabilizing agent 0.5-2%
Antifreezing agent 5-10%
Defoaming agent 1-3%
Surplus pH adjusting agent and water；
The dispersing aid uses the mixture of fatty alcohol ethylene oxide adduct sulfonate and nonionic surfactant,
Thickening stabilizing agent uses xanthan gum or Kui aluminum magnesium silicate, and antifreezing agent uses ethylene glycol, and defoaming agent uses high-carbon alcohol defoaming agent, excellent
Tributyl phosphate is selected, pH adjusting agent uses hydrochloric acid, acetic acid, soda ash or sodium hydroxide；
The suspending agent the preparation method is as follows:
A) pre-grinding: above-mentioned each component and the blending of part water are placed in ball mill and carry out pre-grinding, obtains fineness at 70 μm
Pre-grinding slurry below；
B) it is sanded and crushes: pre-grinding slurry and remaining water being transferred in sand mill, is crushed by being sanded, obtains fineness at 3 μm
Suspending agent below.
Suspending agent is the not dispersion of water soluble solid pesticide and immiscible liquids pesticide in water or in oil.The dosage form be with
Water is decentralized medium, and by raw medicine, auxiliary agent (wetting dispersing agent, thickener, stabilizer, pH adjusting agent and defoaming agent) is through wet process ultra micro
Crush the formulations of pesticide obtained.Advantage is can to mix dispersion with water with arbitrary proportion, not by water quality and Water Temperature, user
Just, environment not easy to pollute, spraying ideal dosage form after being direct or dilution.Suspending agent is that one kind is flowable, has certain viscosity
Liquid dosage forms, it use wet pulverizing, mixing, water and various auxiliary agents need to be added.
Further, the formula each component of the aqueous emulsion and weight percent are as follows:
Pesticide single dose 1-30%
Water and milk agent aid 5-15%
Excess water；
The water and milk agent aid uses anionic surfactant such as dodecyl sodium sulfate or amino acid type amphoteric surface
Activating agent；
The aqueous emulsion the preparation method is as follows:
Progress high speed shear mixing is added into cutter in each component of formula ratio to be made.
The characteristics of aqueous emulsion: co-emulsifiers dosage is few, and drug effect content is high；In soluble additive cost, produced far below missible oil
Product are a kind of environment-friendly type preparations of substitution missible oil that should be encouraged.
Further, the formula each component of the microemulsion and weight percent are as follows:
Pesticide single dose 1-30%
Micro emulsion agent aid 5-15%
Excess water；
The micro emulsion agent aid uses nonionic surfactant such as fatty acid glycerine esters of gallic acid surfactant；
The microemulsion the preparation method is as follows:
By each component of formula ratio be added to be mixed kettle in be mixed evenly it is obtained.
Further, the slow-release medicament and Quick-type medicament are compounded with the ratio of 1:1,1:2 or 2:3.
Further, the pesticide single dose uses the single dose of malathion, phoxim, DDVP or avermectin.
The characteristics of microemulsion: co-emulsifiers dosage is few, and drug effect content is high；Microemulsion compares water mostly on ageing stability
Stable emulsion.
And a kind of novel agrochemical formulations, which is characterized in that be made using preparation method as described above.
The beneficial effects of the present invention are: adjustment of the present invention by New-type adjuvant is reached using the allotment of different type medicament
The lasting effect of the time and raising drug effect that play to abundant control drug effect, realize the efficiency for more effectively playing drug, have both ring
The advantages that guarantor's type is excellent, such environmental effects are small, stability is good, universality is wide, timeliness is long.
Specific embodiment
Medicament 11: the raw material of following component being added to cutter and carries out high speed shear mixing, and malathion water and milk is made
Agent
Medicament 12: the raw material of following component being added to cutter and carries out high speed shear mixing, and malathion water and milk is made
Agent
Medicament 13: the raw material of following component being added to cutter and carries out high speed shear mixing, and malathion water and milk is made
Agent
Medicament 21: the raw material of following component is added into mixing kettle and is mixed evenly, horse traction sulphur is made
Phosphorus microemulsion
Medicament 22: the raw material of following component is added into mixing kettle and is mixed evenly, horse traction sulphur is made
Phosphorus microemulsion
Medicament 23: the raw material of following component is added into mixing kettle and is mixed evenly, horse traction sulphur is made
Phosphorus microemulsion
Medicament 31: the method for being prepared as follows prepares malathion microcapsule suspending agent:
A) urea and formaldehyde that molar ratio is l:1.5 and appropriate the preparation of microcapsules oiliness capsule skin: are added into container
Deionized water adjusts pH to 8, is warming up to 7O DEG C or more and is stirred to react, obtain Lauxite prepolymer aqueous solution, as micro- glue
Capsule oiliness capsule skin；
B) oil is mutually prepared: being dissolved the malathion of 1 mass parts with the benzene of 5 mass parts, is heated to being completely dissolved, then be added
The oiliness capsule skin of 1 mass parts, stirs evenly spare；
C) water phase mixing shearing: 0.5 part of xanthan gum, 0.1 part of nisin, 1 part of tributyl phosphate and water are put into
Shear-mixed is uniform in cutting kettle；
D) high speed dispersion: oil made from step b) is mutually slowly added into water phase made from step c), the shearing of side edged,
Until obtaining partial size at 2-5 microns, remaining 1 mass parts oiliness capsule skin is then added, shearing is uniform to obtain suspension；
E) heat up packing: suspension made from step d) stops shearing, and is to slowly warm up to 59 DEG C or so under stiring, stops
It only heats, appropriate dodecyl sodium sulfate is added after continuing stirring heat preservation, cooling discharge after being stirred for uniformly.
Medicament 32: the method for being prepared as follows prepares malathion microcapsule suspending agent:
A) urea and formaldehyde that molar ratio is l:1.8 and appropriate the preparation of microcapsules oiliness capsule skin: are added into container
Deionized water adjusts pH to 8, is warming up to 7O DEG C or more and is stirred to react, obtain Lauxite prepolymer aqueous solution, as micro- glue
Capsule oiliness capsule skin；
B) oil is mutually prepared: the malathion of 15 mass parts is dissolved with the carbon tetrachloride of 7 mass parts, is heated to being completely dissolved,
Then the oiliness capsule skin of 2 mass parts is added, stirs evenly spare；
C) water phase mixing shearing: 1 part of xanthan gum, 0.3 part of sorbic acid, 2 parts of tributyl phosphates and water are put into cutting kettle
Shear-mixed is uniform；
D) high speed dispersion: oil made from step b) is mutually slowly added into water phase made from step c), the shearing of side edged,
Until obtaining partial size at 2-5 microns, remaining 2 mass parts oiliness capsule skins are then added, shearing is uniform to obtain suspension；
E) heat up packing: suspension made from step d) stops shearing, and is to slowly warm up to 60 DEG C or so under stiring, stops
It only heats, appropriate dodecyl sodium sulfate is added after continuing stirring heat preservation, cooling discharge after being stirred for uniformly.
Medicament 33: the method for being prepared as follows prepares malathion microcapsule suspending agent:
A) urea and formaldehyde that molar ratio is l:2.0 and appropriate the preparation of microcapsules oiliness capsule skin: are added into container
Deionized water adjusts pH to 8, is warming up to 7O DEG C or more and is stirred to react, obtain Lauxite prepolymer aqueous solution, as micro- glue
Capsule oiliness capsule skin；
B) oil is mutually prepared: the malathion of 30 mass parts is dissolved with the dichloroethanes of 10 mass parts, is heated to being completely dissolved,
Then the oiliness capsule skin of 2.5 mass parts is added, stirs evenly spare；
C) water phase mixing shearing: 2 parts of Kui aluminum magnesium silicates, 0.5 part of benzoic acid, 3 parts of tributyl phosphates and water are put into and sheared
Shear-mixed is uniform in kettle；
D) high speed dispersion: oil made from step b) is mutually slowly added into water phase made from step c), the shearing of side edged,
Until obtaining partial size at 2-5 microns, remaining 2.5 mass parts oiliness capsule skins are then added, shearing is uniform to obtain suspension；
E) heat up packing: suspension made from step d) stops shearing, and is to slowly warm up to 62 DEG C or so under stiring, stops
It only heats, appropriate dodecyl sodium sulfate is added after continuing stirring heat preservation, cooling discharge after being stirred for uniformly.
Medicament 41: the method for being prepared as follows prepares malathion suspending agent:
A) pre-grinding: by 1-50 mass parts malathion, 5-10 mass parts dispersing aid, 0.5-2 mass parts xanthan gum, 5-10
Mass parts ethylene glycol, 1-3 tributyl phosphate and the blending of part water are placed in ball mill and carry out pre-grinding, obtain fineness 70 μm with
Under pre-grinding slurry；Wherein dispersing aid is using the mixed of fatty alcohol ethylene oxide adduct sulfonate and nonionic surfactant
Close object
B) it is sanded and crushes: pre-grinding slurry and remaining water being transferred in sand mill, is crushed by being sanded, obtains fineness at 3 μm
Suspending agent below
Medicament 42: the method for being prepared as follows prepares malathion suspending agent:
A) pre-grinding: by 1-50 mass parts malathion, 5-10 mass parts dispersing aid, 0.5-2 mass parts xanthan gum, 5-10
Mass parts ethylene glycol, 1-3 tributyl phosphate and the blending of part water are placed in ball mill and carry out pre-grinding, obtain fineness 70 μm with
Under pre-grinding slurry；Wherein dispersing aid is using the mixed of fatty alcohol ethylene oxide adduct sulfonate and nonionic surfactant
Close object
B) it is sanded and crushes: pre-grinding slurry and remaining water being transferred in sand mill, is crushed by being sanded, obtains fineness at 3 μm
Suspending agent below.
Medicament 43: the method for being prepared as follows prepares malathion suspending agent:
A) pre-grinding: by 1-50 mass parts malathion, 5-10 mass parts dispersing aid, 0.5-2 mass parts Kui aluminum magnesium silicate,
5-10 mass parts ethylene glycol, 1-3 tributyl phosphate and the blending of part water are placed in ball mill and carry out pre-grinding, obtain fineness 70
μm pre-grinding slurry below；Wherein dispersing aid uses fatty alcohol ethylene oxide adduct sulfonate and nonionic surfactant
Mixture
B) it is sanded and crushes: pre-grinding slurry and remaining water being transferred in sand mill, is crushed by being sanded, obtains fineness at 3 μm
Suspending agent below.
Embodiment 1: medicament 11 is mixed to prepare with medicament 31 with 1:2
Embodiment 2: medicament 12 is mixed to prepare with medicament 32 with 1:4
Embodiment 3: medicament 13 is mixed to prepare with medicament 41 with 2:1
Embodiment 4: medicament 21 is mixed to prepare with medicament 33 with 4:1
Embodiment 5: medicament 22 is mixed to prepare with medicament 42 with 2:3
Embodiment 6: medicament 23 is mixed to prepare with medicament 43 with 1:1
Comparative example 1: medicament 12 is used
Comparative example 2: medicament 22 is used
Comparative example 3: medicament 32 is used
Comparative example 4: medicament 42 is used
By the bridging worm controlling experiment that embodiment 1-6 is used on soybean crops: it sprays in the breaking-out of soybean bridging worm, according to
Insect pest state of development is primary every 15 days sprays, and medical fluid is uniformly sprayed on plant leaf front and back sides, seen by continuous spray 3 times
Malathion preparation is examined to the prevention and treatment situation of soybean bridging worm.
Application method: it is watered conventional spraying.
Safety: observing during test, and using the malathion preparation of test dose to water spray, soybean growth is normal,
No phytotoxicity occurs, and specific drug effect situation is shown in Table 1.
1 drug effect situation of table
From the data in table 1, it can be seen that the formulations of pesticide prepared by the present invention are no matter in terms of quick-acting or lasting effect, for big
In the control efficiency of beans bridging worm, far win the use of independent dosage form, i.e., pesticidal preparations of the invention have both drug effect quick-acting and
Lasting effect, timeliness is long, and the preparation process feature of environmental protection is excellent, such environmental effects are small, stability is good.
Pesticide single dose malathion in above-described embodiment 1-6 and comparative example 1-4 is substituted for phoxim, and is respectively used to
Wheat aphid controlling experiment: spraying in wheat aphid breaking-out, primary every ten days sprays according to insect pest state of development, continuous to spray
Medicine 3 times, medical fluid is uniformly sprayed on to plant leaf front and back sides, prevention and treatment situation of the observation phoxim preparation to wheat aphid.
Application method: it is watered conventional spraying.
Safety: observing during test, and using the phoxim preparation of test dose to water spray, wheat is normal, no phytotoxicity
Occur, test result shows the formulations of pesticide prepared by the present invention no matter in terms of quick-acting or lasting effect, for small wheat aphid
In the control efficiency of worm, far win the use of independent dosage form.
Pesticide single dose malathion in above-described embodiment 1-6 and comparative example 1-4 is substituted for DDVP, and is respectively used to
Soybean cabbage caterpillar controlling experiment: spraying in the breaking-out of soybean cabbage caterpillar, primary every ten days sprays according to insect pest state of development, even
Medical fluid is uniformly sprayed on plant leaf front and back sides, prevention and treatment feelings of the observation DDVP preparation to soybean cabbage caterpillar by continuous spray 3 times
Condition.
Application method: it is watered conventional spraying.
Safety: observing during test, and using the DDVP preparation of test dose to water spray, soybean is normal, no phytotoxicity
Occur, test result shows the formulations of pesticide prepared by the present invention no matter in terms of quick-acting or lasting effect, for soybean dish
In the control efficiency of green worm, far win the use of independent dosage form.
Pesticide single dose malathion in above-described embodiment 1-6 and comparative example 1-4 is substituted for avermectin, and is used respectively
In the controlling experiment of rice red spider: spraying in the breaking-out of rice red spider, according to insect pest state of development every ten days sprays one
Secondary, medical fluid is uniformly sprayed on plant leaf front and back sides by continuous spray 3 times, and observation phoxim preparation prevents rice red spider
Control situation.
Application method: it is watered conventional spraying.
Safety: observing during test, and using the phoxim preparation of test dose to water spray, rice is normal, no phytotoxicity
Occur, test result shows the formulations of pesticide prepared by the present invention no matter in terms of quick-acting or lasting effect, red for rice
In the control efficiency of spider, far win the use of independent dosage form.
Claims (8)
1. a kind of preparation method of novel agrochemical formulations, which is characterized in that first by pesticide single dose be respectively prepared microcapsule suspending agent,
Then slow-release medicament is blended with Quick-type medicament and is made by four kinds of suspending agent, aqueous emulsion and microemulsion dosage forms；The slow-release
Medicament uses microcapsule suspending agent or suspending agent, and the Quick-type medicament uses aqueous emulsion or microemulsion.
2. the preparation method of novel agrochemical formulations according to claim 1, which is characterized in that the microcapsule suspending agent is matched
Square each component and weight percent are as follows:
Pesticide single dose 1-30%
Nonpolar solvent 5-10%
Oiliness capsule skin 2-5%
Thickening stabilizing agent 0.5-2%
Preservative 0.1-0.5%
Defoaming agent 1-3%
Surplus pH adjusting agent, dispersing agent and water；
The nonpolar solvent uses saturated hydrocarbons, benzene, carbon tetrachloride or dichloroethanes, and thickening stabilizing agent uses xanthan gum or Kui
Aluminum magnesium silicate, preservative use in benzoic acid and its esters, sorbic acid and its esters, lactate and nisin at least
One kind, defoaming agent use high-carbon alcohol defoaming agent, and pH adjusting agent uses hydrochloric acid, acetic acid, soda ash or sodium hydroxide, and dispersing agent is adopted
With anionic surfactant or amino acid type amphoteric surfactant；
The microcapsule suspending agent the preparation method is as follows:
A) urea and formaldehyde that molar ratio is l:1.5-2.0 and appropriate the preparation of microcapsules oiliness capsule skin: are added into container
Deionized water adjusts pH to 8 with pH adjusting agent, is warming up to 7O DEG C or more and is stirred to react, obtain Lauxite prepolymer water
Solution, as microcapsules oiliness capsule skin；
B) oil is mutually prepared: with the pesticide single dose of the nonpolar solvent of formula ratio dissolution formula ratio, be heated to being completely dissolved, then plus
The oiliness capsule skin for entering 1/2 formula ratio, stirs evenly spare；
C) water phase mixing shearing: by shear-mixed in the thickening stabilizing agent of formula ratio, preservative, defoaming agent, water investment cutting kettle
Uniformly；
D) high speed dispersion: oil made from step b) is mutually slowly added into water phase made from step c), the shearing of side edged, until
Partial size is obtained at 2-5 microns, remaining 1/2 oiliness capsule skin is then added, shearing is uniform to obtain suspension；
E) heat up packing: suspension made from step d) stops shearing, and is to slowly warm up to 59-62 DEG C under stiring, stops adding
Dispersing agent is added after continuing stirring heat preservation, cooling discharge after being stirred for uniformly in heat.
3. the preparation method of novel agrochemical formulations according to claim 1, which is characterized in that the formula of the suspending agent is each
Component and weight percent are as follows:
Pesticide single dose 1-50%
Dispersing aid 5-10%
Thickening stabilizing agent 0.5-2%
Antifreezing agent 5-10%
Defoaming agent 1-3%
Surplus pH adjusting agent and water；
The dispersing aid uses the mixture of fatty alcohol ethylene oxide adduct sulfonate and nonionic surfactant, thickening
Stabilizer uses xanthan gum or Kui aluminum magnesium silicate, and antifreezing agent uses ethylene glycol, and defoaming agent uses high-carbon alcohol defoaming agent, preferably phosphorus
Sour tributyl, pH adjusting agent use hydrochloric acid, acetic acid, soda ash or sodium hydroxide；
The suspending agent the preparation method is as follows:
A) pre-grinding: above-mentioned each component and the blending of part water are placed in ball mill and carry out pre-grinding, obtains fineness at 70 μm or less
Pre-grinding slurry；
B) it is sanded and crushes: pre-grinding slurry and remaining water being transferred in sand mill, is crushed by being sanded, obtains fineness at 3 μm or less
Suspending agent.
4. the preparation method of novel agrochemical formulations according to claim 1, which is characterized in that the formula of the aqueous emulsion is each
Component and weight percent are as follows:
Pesticide single dose 1-30%
Water and milk agent aid 5-15%
Excess water；
The water and milk agent aid uses anionic surfactant or amino acid type amphoteric surfactant；
The aqueous emulsion the preparation method is as follows:
Progress high speed shear mixing is added into cutter in each component of formula ratio to be made.
5. the preparation method of novel agrochemical formulations according to claim 1, which is characterized in that the formula of the microemulsion is each
Component and weight percent are as follows:
Pesticide single dose 1-30%
Micro emulsion agent aid 5-15%
Excess water；
The micro emulsion agent aid uses nonionic surfactant；
The microemulsion the preparation method is as follows:
By each component of formula ratio be added to be mixed kettle in be mixed evenly it is obtained.
6. the preparation method of novel agrochemical formulations according to claim 1, which is characterized in that the slow-release medicament and fast
Fast type medicament is mixed with the ratio of 1:1,1:2 or 2:3.
7. the preparation method of novel agrochemical formulations according to claim 1, which is characterized in that the pesticide single dose uses horse
Draw the single dose of sulphur phosphorus, phoxim, DDVP or avermectin.
8. a kind of novel agrochemical formulations, which is characterized in that be made using the preparation method such as claim 1-7.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111838145A (en) * | 2020-08-03 | 2020-10-30 | 安徽康宇生物科技工程有限公司 | Detention slow-release suspension disinfectant and preparation method thereof |
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| CN105532658A (en) * | 2015-08-02 | 2016-05-04 | 江苏辉丰农化股份有限公司 | Encapsulated pesticide composition |
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| CN1194780A (en) * | 1997-03-27 | 1998-10-07 | 王玉万 | Plant protection pesticide containing avermectin |
| CN103070166A (en) * | 2012-12-26 | 2013-05-01 | 南通联农农药制剂研究开发有限公司 | Micro-capsule suspension-water emulsion ZW and preparation method thereof |
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| CN111838145A (en) * | 2020-08-03 | 2020-10-30 | 安徽康宇生物科技工程有限公司 | Detention slow-release suspension disinfectant and preparation method thereof |
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