CN107815413A - 自体细胞多维成形装置 - Google Patents

自体细胞多维成形装置 Download PDF

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CN107815413A
CN107815413A CN201610886822.3A CN201610886822A CN107815413A CN 107815413 A CN107815413 A CN 107815413A CN 201610886822 A CN201610886822 A CN 201610886822A CN 107815413 A CN107815413 A CN 107815413A
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autogenous cell
module
implant
building mortion
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欧耿良
詹育豪
洪千惠
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3D Global Biotech Inc
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Abstract

本发明公开了一种自体细胞多维成形装置，将一自体细胞客制化成一人工植体。本发明自体细胞多维成形装置包含有一正压室、一自体细胞培养模块、一供料模块、一多轴成型模块以及一植体维持模块。自体细胞通过自体细胞培养模块培养后送至供料模块与高分子材料混合成混合自体细胞，多轴成型模块将混合自体细胞列印成人工植体并利用植体维持模块承载与保存。其中，上述的模块皆以密闭连通管连通并处于一气体压力大于外界气压的正压室内。相较于现有技术，本发明可客制化人工植体并有效提升制备人工植体的良率。

Description

自体细胞多维成形装置
技术领域
本发明关于一种成形装置，并且特别地，关于一种自体细胞多维成形装置。
背景技术
随着医疗技术的提升，人工植体如人工敷料与人造器官的使用越来越频繁。人工敷料常用于大范围烫伤或术后的患者，用以取代受损的皮肤，保护伤口免受污染物或细菌的感染及吸收自身渗液保持身体水分不致逃逸，并促进结缔组织的生长。人造器官如人工电子耳或人工血管，可用以模拟并取代原有器官的功能，或以半支援方式与原有器官共同维持身体机能。
但是，人工植体也可能对人体造成不良反应，因异质物质造成人体产生排他性，产生额外的免疫互斥问题。故后期均采用自体细胞做为人工植体的基材。
自体细胞组织的多维成形方法过去将成形用原料或细胞原料以装填方式装入料桶中，再置入多维成形装置原料区，由原料夹持器撷取后，进行人工植体的细胞及组织成形。
过程中，往往因为人为的移动与器皿的更换等，使原料容易受到污染而导致植体成型良率不高。且多维成形装置皆处于开放空间，此种现有流程让人工植体的制造容易因人员或环境而造成污染，进而导致人工植体的产品良率不高。因此，如何设计一种成形用的细胞原料与成形过程中皆不被外界所污染的细胞组织的多维成形装置，实为目前急迫解决的问题。
由此可见，上述现有技术仍有诸多缺陷，实非一良善的设计，而亟待加以改良。有鉴于此，本发明将提出一种自体细胞多维成形装置以利有效生产。
发明内容
本发明的一范畴在于提供一种自体细胞多维成形装置。根据本发明的一具体实施例，本发明自体细胞多维成形装置，用以将一自体细胞客制化(customized)成一人工植体，其包含有一正压室、一自体细胞培养模块、一供料模块、一多轴成型模块以及一植体维持模块。正压室用以通入一压力大于外界气压的气体。自体细胞培养模块设置于正压室内，其包含一培养器皿及一进料管道，培养器皿用以培养自体细胞成一培养后自体细胞，进料管道与培养器皿连接，并接收培养后自体细胞。供料模块设置于正压室内，其包含一蠕动式供料器与一出料管道，蠕动式供料器连接进料管道，用以接收培养后自体细胞并与一高分子材料混合成一混合自体细胞，而出料管道与蠕动式供料器连接，用以接收混合自体细胞。多轴成型模块设置于正压室内，多轴成型模块与出料管道连接，用以接收混合自体细胞并将混合自体细胞客制化列印成人工植体。植体维持模块设置于正压室内，置于多轴成型模块下方，用以承载与保存人工植体。其中，进料管道与出料管道均得为一密闭式输送管道。
再者，进料管道与培养器皿的连接、蠕动式供料器与进料管道的连接、出料管道与蠕动式供料器的连接以及多轴成型模块与出料管道的连接均得为一密闭式连接。
多轴成型模块包含一列印注料头、一图型接收元件及一六轴移动手臂。列印注料头与出料管道连接，用以输入混合自体细胞并列印人工植体。该图型接收元件用以接收一客制化图案，以及六轴移动手臂以电连接于图型接收元件，用以带动列印注料头的一客制化列印行程。
其中，六轴移动手臂的移动方式得为三维空间加上角度移动。
相较于现有技术，本发明自体细胞多维成形装置利用一正压室产生一不易被污染的生产环境，并利用密闭式连接方式将从自体细胞原料至人工植体成品的生产过程全程与外界做隔离，再利用六轴成型模块做一客制化自体细胞多维列印，以得到高良率的客制化人工植体，再者，亦可利用植体维持装置做一弹性时间与地点的人工植体的使用。
关于本发明的优点与精神可以通过以下的发明详述以及所附图式得到进一步的了解。
附图说明
图1绘示本发明的自体细胞多维成形装置的一具体实施例的示意图。
图2绘示本发明的自体细胞多维成形装置的一具体实施例的功能方块图。
图3绘示本发明的自体细胞多维成形装置的一具体实施例的培养器皿的示意图。
【符号说明】
1：自体细胞多维成形装置 1411：培养皿盖
12：正压室 1411A：细胞培养空间
14：自体细胞培养模块模块 1411B：垫圈
16：供料模块模块 1412：培养皿座
18：多轴成型模块模块 1412A：连通道I
19：植体维持模块模块 1412B：通气道
141：培养器皿 1413：传动轴
142：进料管道 1413A：连通道II
143：马达 1414：轴承组
161：蠕动式供料器 1415：固定盖组
162：出料管道 1416：传动齿轮
181：列印注料头 1417：回转接头
182：图案接收元件 1417A：连通道III
183：六轴移动手臂
具体实施方式
为使本发明的目的、技术方案及优点更加清楚明白，以下参照附图并举实施例，对本发明作进一步详细说明。
请参阅图1及图2，图1绘示本发明的自体细胞多维成形装置1的一具体实施例的示意图，图2绘示本发明的自体细胞多维成形装置1的一具体实施例的功能方块图。在本发明的一实施例中，本发明自体细胞多维成形装置1包含有一正压室12、一自体细胞培养模块模块14、一供料模块模块16、一多轴成型模块模块18以及一植体维持模块模块19。正压室12用以通入一压力大于外界气压的气体。自体细胞培养模块模块14设置于正压室12内，其包含一培养器皿141及一进料管道142，培养器皿141用以培养自体细胞成一培养后自体细胞，进料管道142与培养器皿141连接，并接收培养后自体细胞。供料模块模块16设置于正压室12内，其包含一蠕动式供料器161与一出料管道162，蠕动式供料器161连接进料管道142，用以接收培养后自体细胞并与一高分子材料混合成一混合自体细胞，而出料管道162与蠕动式供料器161连接，用以接收混合自体细胞。多轴成型模块模块18设置于正压室12内，多轴成型模块模块18与出料管道162连接，用以接收混合自体细胞并将混合自体细胞客制化列印成人工植体。植体维持模块模块19设置于正压室12内，置于多轴成型模块模块18下方，用以承载与保存人工植体。其中，进料管道142与出料管道162均得为一密闭式输送管道。
再者，进料管道142与培养器皿141的连接、蠕动式供料器161与进料管道142的连接、出料管道162与蠕动式供料器161的连接以及多轴成型模块模块18与出料管道162的连接均得为一密闭式连接。
其中，正压室12通入的气体得为一适合培养自体细胞的气体。
自体细胞培养模块模块14还包含一马达143，马达143连接于培养器皿141，用以带动培养器皿141使培养器皿141产生一离心旋转。
于实际应用中，适当的气体与离心旋转方式可促进自体细胞加速成长与分离该培养后自体细胞。
请参阅图3，图3绘示本发明的自体细胞多维成形装置1的一具体实施例的培养器皿141的示意图。培养皿盖1411与培养皿座1412相结合以形成一细胞培养空间1411A，两者间通过一垫圈1411B形成密合状态。培养皿座1412底部与传动轴1413结合，两者更以连通道I(1412A)与连通道II(1413A)相通，使培养后自体细胞得以送出培养器皿141。当培养后自体细胞送出细胞培养空间1411A时，通气道1412B用以让细胞培养空间1411A保持压力平衡。传动轴1413的适当部位安置一轴承组1414与固定盖组1415，用以使传动轴1413得以转动，进而使培养器皿141中的自体细胞获得无重力环境，以利自体细胞得以快速成长。传动轴1413更与传动齿轮1416结合，以获得转动所需的动力。传动轴1413尾端与一回转接头1417相连接，两者间利用连通道II(1413A)与连通道III(1417A)相互连通，使培养器皿141中的培养后自体细胞可由进料管道142送至蠕动式供料器161中。
于实际应用中，蠕动式供料器161的吸取动力可将培养后自体细胞由入料管道142吸入至蠕动式供料器161，并与适当的高分子材料混合成所需的混合自体细胞，而后蠕动式供料器161压缩动力将混合自体细胞透过出料管道162送至多轴成型模块模块18中。
多轴成型模块模块18包含一列印注料头181，列印注料头181与出料管道162连接，用以输入混合自体细胞并列印人工植体。
其中，多轴成型模块模块18得为一六轴成型模块模块，该六轴成型模块模块包含一图型接收元件182及一六轴移动手臂183，图型接收元件182用以接收一客制化图案，六轴移动手臂183以电连接于图型接收元件182，用以带动列印注料头181的一客制化列印行程。
再者，图型接收元件182可利用蓝芽、乙太区域网路、WiFi无线区域网路、无线移动通讯模块模块或其他可存取的移动式储存设备接收所需的客制化图案资料。
所述的六轴移动手臂183的移动方式得为三维空间加上角度移动。
于实际应用上，通过多轴成型模块模块18的三维空间加角度移动，将混合自体细胞披覆于人工组织结构上，使细胞得以在结构上成形生长，而形成人工植体。
植体维持模块模块19具有一适合该人工植体的密闭储存环境，其得为一移动式装置。
通过植体维持模块模块19位于正压室12以产生一不易污染的环境，并利用植体维持模块模块19自身的合适的无菌密闭储存环境，可有效避免人工植体发生污染状况，以确保人工植体具有一定的活性与功效。于实际应用上，人工植体(如：人工敷料、人工血管、义乳)从制备完成到患者实际使用期间，往往需要等待患者到场的时间或将人工植体移至合适场地的移动，植体维持模块模块19可保存待使用的人工植体并送至偏远地区或以随身携带方式做为使用，使得人工植体在使用场合与时间上更为弹性。
相较于现有技术，本发明自体细胞多维成形装置利用一正压室产生一不易被污染的生产环境，并利用密闭式连接方式将从自体细胞原料至人工植体成品的生产过程全程与外界做隔离，再利用六轴成型模块模块做一客制化自体细胞多维列印，以得到高良率的客制化人工植体。再者，亦可利用植体维持装置做一弹性时间与地点的人工植体的使用。
通过以上较佳具体实施例的详述，希望能更加清楚描述本发明的特征与精神，而并非以上述所公开的较佳具体实施例来对本发明的范畴加以限制。相反地，其目的是希望能涵盖各种改变及具相等性的安排于本发明所欲申请的专利范围的范畴内。

Claims (10)

1.一种自体细胞多维成形装置，用以将一自体细胞客制化成一人工植体，其包含有：
一正压室，用以通入一压力大于外界气压的气体；
一自体细胞培养模块，设置于该正压室内，其包含一培养器皿及一进料管道，该培养器皿用以培养该自体细胞成一培养后自体细胞，该进料管道与该培养器皿连接，并接收该培养后自体细胞；
一供料模块，设置于该正压室内，其包含一蠕动式供料器与一出料管道，该蠕动式供料器连接该进料管道，用以接收该培养后自体细胞并与一高分子材料混合成一混合自体细胞，而该出料管道与该蠕动式供料器连接，用以接收该混合自体细胞；
一多轴成型模块，设置于该正压室内，该多轴成型模块与该出料管道连接，用以接收该混合自体细胞并将该混合自体细胞客制化列印成该人工植体；以及一植体维持模块，设置于该正压室内，置于该多轴成型模块下方，用以承载与保存该人工植体；
其中，该进料管道与该出料管道均得为一密闭式输送管道。
2.如权利要求1所述的自体细胞多维成形装置，其中该进料管道与该培养器皿的连接、该蠕动式供料器与该进料管道的连接、该出料管道与该蠕动式供料器的连接以及该多轴成型模块与该出料管道的连接均得为一密闭式连接。
3.如权利要求1所述的自体细胞多维成形装置，其中该正压室通入的该气体得为一适合培养该自体细胞的气体。
4.如权利要求1所述的自体细胞多维成形装置，其中该自体细胞培养模块包含一马达，该马达连接于该培养器皿，用以带动该培养器皿使该培养器皿产生一离心旋转。
5.如权利要求1所述的自体细胞多维成形装置，其中该多轴成型模块包含一列印注料头，该列印注料头与该出料管道连接，用以输入该混合自体细胞并列印该人工植体。
6.如权利要求5所述的自体细胞多维成形装置，其中该多轴成型模块得为一六轴成型模块，该六轴成型模块包含一图型接收元件及一六轴移动手臂，该图型接收元件用以接收一客制化图案，以及该六轴移动手臂以电连接于该图型接收元件，用以带动该列印注料头的一客制化列印行程。
7.如权利要求6所述的自体细胞多维成形装置，其中该图型接收元件可利用蓝芽、乙太区域网路、WiFi无线区域网路、无线移动通讯模块或其他可存取的移动式储存设备接收该客制化图案。
8.如权利要求6所述的自体细胞多维成形装置，其中该六轴移动手臂的移动方式得为三维空间加上角度移动。
9.如权利要求1所述的自体细胞多维成形装置，其中该植体维持模块具有一适合该人工植体的密闭储存环境。
10.如权利要求9所述的自体细胞多维成形装置，其中该植体维持模块得为一移动式装置。
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