CN107789415A - A kind of heat stress that adjusts is laid eggs the Chinese medicine compound prescription and preparation method thereof of chicken intestinal flora - Google Patents
A kind of heat stress that adjusts is laid eggs the Chinese medicine compound prescription and preparation method thereof of chicken intestinal flora Download PDFInfo
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Abstract
The invention discloses a kind of heat stress that adjusts to lay eggs Chinese medicine compound prescription and preparation method thereof of chicken intestinal flora.The each component mass fraction of the Chinese medicine compound prescription is：20 ~ 30 parts of elscholtiza, 10 ~ 15 parts of radix scutellariae, 10 ~ 20 parts of the coptis, 10 ~ 15 parts of radix glycyrrhizae, 10 ~ 20 parts of radix bupleuri, 10 ~ 15 parts of Radix Angelicae Sinensis, 10 ~ 15 parts of the capsule of weeping forsythia, 10 ~ 20 parts of root of Chinese trichosanthes, 10 ~ 20 parts of cape jasmine, 10 ~ 20 parts of sweet wormwood.The invention provides a kind of heat stress that adjusts to lay eggs the Chinese medicine compound prescription of chicken intestinal flora, whole compound compatibility degree of having, the collaboration acted on by each component composition is promoted, effectively improve overall drug effect, with good sweating relieving summer-heat, heat-clearing and damp-drying drug, purging intense heat and detonicating effect, the diversity and richness of heat stress lower intestinal tract flora can be obviously improved, lifts the abundance of intestinal beneficial flora, alleviates negative effect caused by heat stress.
Description
Technical field
The invention belongs to field of natural medicinal chemistry, relate generally to a kind of heat stress that adjusts and lay eggs the Chinese medicine of chicken intestinal flora
Compound and preparation method thereof.
Background technology
Heat stress is always an important factor for influenceing aquaculture development, and it can reduce body feed intake, amount of drinking water, raw
Producing performance reduces, enteric flora disturbance, dyspepsia etc..Studies have reported that heat stress can have a strong impact on the life of laying hen
Produce performance, milk cow anti-oxidation function, influence the expression of heat shock protein etc. of sheep.And heat stress is outstanding to the Influence of production of laying hen
To be obvious, including laying rate, feed intake, egg quality, the immunocyte of laying hen, heat shock protein（Heat shock
Proteins, HSPs）, the many-side such as enteric microorganism.Research on enteric microorganism is more and more, represent gut flora with
The health of body has great relation, while finds that environmental stress can influence the structure of enteric microorganism, and heat stress can cause
Intestinal bleeding etc..Theory of traditional Chinese medical science thinks that heat stress belongs to the scope of warm heat disease, based on qi leel excessive heat syndrome, and then develop into battalion's heat,
Blood-heat syndrome, also it is believed that heat stress is due to summer-heat evil, damp evil intrusion body, gas consumption hinders Tianjin, checks mechanism of qi, be deep viscid etc..
Traditional Chinese veterinary medicine thinks that animal body is that unified entirety and natural environment are closely related, the growth and decline state in dynamic equilibrium, enteron aisle
Microorganism is also the entirety of a huge dynamic equilibrium, and body is healthy closely related.Heat stress is to laying hen productivity
The internal cause of the influence of energy etc. is really the diversity and richness that heat stress significantly reduces gut flora.
How to suppress the negative effect of gut flora caused by heat stress by means such as Chinese medicines, increase the more of gut flora
Sample and richness, the abundance of gut flora beneficial bacterium is adjusted, negative effect caused by alleviating heat stress, had for aquaculture
Important practical significance.
The content of the invention
It is an object of the invention to overcome deficiency of the prior art, there is provided one kind regulation heat stress is laid eggs chicken intestinal flora
Chinese medicine compound prescription, the Chinese medicine compound prescription can effectively improve the diversity and richness of heat stress lower intestinal tract flora, increases under heat stress
Healthy intestinal flora Bacillus acidi lactici, bacteroid, Faecalibacterium and Prey irrigate the richness of Pseudomonas, reduce under heat stress
HSP70 contents and Determination of cortisol in Laying-hen Serum, alleviate negative effect caused by heat stress.
It is prepared by the Chinese medicine compound prescription for laying eggs chicken intestinal flora another object of the present invention is to provide a kind of regulation heat stress
The application that regulation heat stress is laid eggs in chicken intestinal flora medicine.
Another object of the present invention is to provide a kind of egg feedstuff, laid eggs chicken intestinal bacterium added with the regulation heat stress
The Chinese medicine compound prescription of group.
The above-mentioned purpose of the present invention is achieved by following technical solution：
A kind of heat stress that adjusts is laid eggs the Chinese medicine compound prescription of chicken intestinal flora, and each component mass fraction is：20 ~ 30 parts of elscholtiza, radix scutellariae
10 ~ 15 parts, 10 ~ 20 parts of the coptis, 10 ~ 15 parts of radix glycyrrhizae, 10 ~ 20 parts of radix bupleuri, 10 ~ 15 parts of Radix Angelicae Sinensis, 10 ~ 15 parts of the capsule of weeping forsythia, root of Chinese trichosanthes 10 ~
20 parts, 10 ~ 20 parts of cape jasmine, 10 ~ 20 parts of sweet wormwood.
Contain sweet wormwood coumarinoids in sweet wormwood, sweet wormwood cumarin has antipyretic cooling effect.
Preferably, regulation heat stress lay eggs chicken intestinal flora Chinese medicine compound prescription in, each component mass fraction is：Elscholtiza 24
Part, 12 parts of radix scutellariae, 15 parts of the coptis, 12 parts of radix glycyrrhizae, 15 parts of radix bupleuri, 12 parts of Radix Angelicae Sinensis, 12 parts of the capsule of weeping forsythia, 15 parts of root of Chinese trichosanthes, 15 parts of cape jasmine,
15 parts of sweet wormwood.
The recipe quantity of the Chinese medicine compound prescription is with Chinese medicine crude drug Mass Calculation, under preferable each component compatibility, each component
Between coordination it is building performance more preferable, increase the diversity and richness of gut flora, adjust the abundance of gut flora beneficial bacterium, it is comprehensive
Closing improves the diversity and richness of heat stress lower intestinal tract flora, alleviates negative effect caused by heat stress.
Preferably, the lay eggs Chinese medicine compound prescription of chicken intestinal flora of the regulation heat stress is pulvis.
Chinese medicine powder in the application advantage of heat stress of layer to being Chinese medicine after crushing, sieving, the particle phase of medicine
Contrast more uniform, increase drug particles with stomach and intestine surface areas, be more beneficial for digesting and absorb, and Chinese medicine crush after adjust
Work is easy, and technique is relatively also fairly simple, has both improved the utilization rate of medicinal material while has also improved operating efficiency.
The lay eggs preparation method of Chinese medicine compound prescription of chicken intestinal flora of the regulation heat stress comprises the following steps：Weigh quality
The elscholtiza of number, radix scutellariae, the coptis, radix glycyrrhizae, radix bupleuri, Radix Angelicae Sinensis, the capsule of weeping forsythia, root of Chinese trichosanthes, cape jasmine, sweet wormwood, load disintegrating machine, smash repeatedly
Cross 80-100 mesh sieves.
The lay eggs Chinese medicine compound prescription of chicken intestinal flora of regulation heat stress is laid eggs the medicine of chicken intestinal flora preparing regulation heat stress
Application in thing.
Bacillus acidi lactici is beneficial bacterium and dominant bacteria important in enteron aisle, and many researchs find that the immunity energy of body can be strengthened
Power, the promotion effect of digesting and assimilating etc., Bacteroides can produce short chain fatty acids, to body glucostasis, body weight control and
The growth of enteric microorganism plays an important role, and Faecalibacterium bacterium are the producers of butyric acid, can reduce the generation of disease,
Prey, which irrigates Pseudomonas, can produce acetic acid, butanedioic acid, a small amount of lactic acid etc., belong to the profitable strain in enteron aisle, heat stress can drop
The content of profitable strain in low enteron aisle, but the addition of Chinese medicine compound prescription of the present invention can dramatically increase the abundance ratio of flora, very
Negative effect of the good alleviation heat stress to intestinal beneficial flora.
Regulation heat stress lay eggs chicken intestinal flora Chinese medicine compound prescription as or application in preparing feed addictive.
A kind of chicken feed of laying hen, the Chinese medicine compound prescription for chicken intestinal flora of being laid eggs added with described regulation heat stress.
Preferably, it is described regulation heat stress lay eggs chicken intestinal flora Chinese medicine compound prescription addition for mass ratio 1% ~
1.3%。。
Addition does not reach expected purpose very little, the increase that on the one hand can cause feed financial cost is excessively added, separately
One side overdose also brings along unfavorable side effect in itself.Capable of clearing heat and reducing internal heat class Chinese medicine taste bitter and cold, the traditional Chinese medical science have bitter cold to injure one's stomach
Saying, in the case that internal fire-evil heat toxin has been dispelled, excessively using cold and cool class Chinese medicine, tonifying yin is excessive, is converted into cold, and trembling with fear is
It is cloudy evil, normal impairment of yang gas.Yang-energy is the vigor of internal metabolism, the prosperity and decline of body yang-energy, often indicates the work of physiological function
Jump degree, cold-evil coerce yang-energy, and yang-energy is weak, and body physiological function will be suppressed, while to the yang-energy of other internal organs
There is damage.
Influence of the heat stress to lower laying hen is particularly evident, including many aspects such as heat shock protein and enteric microorganism,
And gut flora and other aspect it is in close relations, regulation heat stress lay eggs chicken intestinal flora Chinese medicine compound prescription by improving heat stress
The diversity and richness of lower intestinal tract flora can be very good to improve remission effect of the chicken feed to heat stress.
The present invention has following technique effect compared with prior art：
The invention provides a kind of heat stress that adjusts to lay eggs the Chinese medicine compound prescription of chicken intestinal flora, whole compound compatibility degree of having, passes through
The collaboration of each component composition effect is promoted, and effectively improves overall drug effect, has good sweating relieving summer-heat, heat-clearing and damp-drying drug, rushes down
Fiery detoxifying effect, the diversity and richness of heat stress lower intestinal tract flora can be obviously improved, lift the rich of intestinal beneficial flora
Degree, alleviate negative effect caused by heat stress.
Brief description of the drawings
Fig. 1 is gut flora Tags and OTU number analysis charts.
Fig. 2 is the Chao1 indexes of gut flora, Shannon value analysis charts.
Embodiment
With reference to embodiment, the present invention is further illustrated, but embodiment the present invention is not done it is any
The restriction of form.In order to further verify beneficial effects of the present invention.
The Chinese medicine compound prescription of embodiment 1 ~ 5
The lay eggs formula of Chinese medicine compound prescription of chicken intestinal flora of regulation heat stress according to table 1 weighs each components of parts by weight, will
Each group is distributed into medicinal herb grinder, crushed 80 mesh sieves repeatedly, obtains Chinese medicine compound prescription pulvis.
Table 1
Comparative example 1 ~ 4
Formula according to the comparative example Chinese medicine compound prescription of table 2 weighs each component of parts by weight, and each group is distributed into medicinal herb grinder,
80 mesh sieves are crushed repeatedly, obtain Chinese medicine compound prescription pulvis.
Table 2
The Chinese medicine compound prescription of embodiment 6 heat stress is laid eggs chicken intestinal flora influence clinical test
1st, experimental method
35 week old laying period Roman egghens are chosen in experiment, purchased from original breeding layer chicken Co., Ltd of Luoding City.
During elscholtiza, radix scutellariae, the coptis, radix glycyrrhizae, radix bupleuri, Radix Angelicae Sinensis, the capsule of weeping forsythia, root of Chinese trichosanthes, cape jasmine, sweet wormwood etc. are all in Chinese medicine compound prescription
Medicine is purchased from Guangzhou Li Kangtang pharmacies.
Tiangeng excrement genome extracts kit, lot number：DP328-021.
35 week old laying period Roman egghens are selected in experiment, and laying hen is cage mode, is distributed in same layer, free choice feeding and drink
Water, light application time 16h, room ventilation is good, and periodically sterilization is with sweeping.After adaptability raising 7d, Chinese medicine group is randomly divided into, heat is answered
Swash group, blank group, every group of 10 laying hens.For Chinese medicine group temperature control at 35 ± 2 DEG C, humidity is maintained at 75 ± 5%, is added in daily ration
1% Chinese medicine compound prescription powder；The temperature and humidity of heat stress group is consistent with Chinese medicine group, feeds basal diet；Blank group temperature
For degree at 24 ± 2 DEG C, humidity is 60 ± 5%, feeds basal diet.
Every group of 1d, 3d, 7d, 14d, 28d of experiment takes 6 laying hens, night to collect its excrement discharged after prohibiting feeding 12h at random
Just, the DNA of cecal content bacterium is extracted with DNA extraction kit, the gene extracted is detected using 1% agarose gel electrophoresis
Group DNA, is expanded with 16s rDNA V3 ~ V4 areas after quality inspection is qualified, Illumina Miseq sequencers, is finally carried out
Biological information is analyzed.Using the significance of difference between SPSS19.0 statistical analysis software one-way analysis of variance each groups, pass through
The new multipole difference methods of inspection of Duncan's carry out the Multiple range test of mean between each group, as a result use " average ± standard deviation "（±
S.D）Represent, wherein sample n=6, block diagram is made with GraphPad Prism5.
2nd, experimental result
As depicted in figs. 1 and 2, Chao1 indexes, Shannon are that evaluation gut flora is rich to the richness result of the test of gut flora
Fu Du and multifarious index, as a result show, heat stress can reduce its Chao1 index, Shannon values, and the addition of Chinese medicine can
To be obviously improved the diversity of gut flora and richness.Gut flora is a dynamic process, is constantly among change, Tags
The abundant degree of gut flora is tentatively illustrated with OUT data, gut flora is not always under the influence of heat stress and Chinese medicine
The change stopped.
It is the profitable strain in enteron aisle that wherein Bacillus acidi lactici, bacteroid, Faecalibacterium and Prey, which irrigate Pseudomonas, right
The abundance of these profitable strains is detected, and the influence of the Chinese medicine compound prescription of embodiment 1 ~ 5 and comparative example 1 ~ 4 to its abundance is shown in Table
3 to table 6.
The Bacillus acidi lactici abundance of table 3（%）
The bacteroid abundance of table 4（%）
The Faecalibacterium abundance of table 5（%）
The Prey of table 6 irrigates Pseudomonas abundance（%）
Under heat stress state, HSP70 albumen and Determination of cortisol in Laying-hen Serum can increase, and increasing for its content also can be right
Energetic supersession of laying hen etc. produces harmful effect, to HSP70 contents and skin in Laying-hen Serum in embodiment 1 ~ 5 and comparative example 1 ~ 4
Matter alcohol content is detected, and it the results are shown in Table 7 and table 8.
The change unit of HSP70 protein contents in the Laying-hen Serum of table 7：（Unit：ng/L
The change unit of Determination of cortisol in the Laying-hen Serum of table 8：（ng/mL）
The Chinese medicine compound prescription of embodiment 2 ~ 5 can also significantly improve the diversity, rich of gut flora, Bacillus acidi lactici, bacteroid,
The abundance that Faecalibacterium and Prey irrigate Pseudomonas is above heat stress group, HSP70 contents and cortex in Laying-hen Serum
Also there is obvious reduction in alcohol content, Chinese medicine compound prescription group is below heat stress group.Chinese medicine compound prescription is to gut flora in comparative example
The rich improvement of diversity and reduction to Determination of cortisol in Laying-hen Serum and HSP70 contents are also substantially not as implementing
Example, specific data are shown in Table 3 to table 8.Result above shows, the Chinese medicine compound prescription being made up of elscholtiza, radix scutellariae, the coptis, radix bupleuri etc. can be with
Increase the diversity and richness of gut flora, adjust the abundance of gut flora beneficial bacterium, alleviate negative shadow caused by heat stress
Ring.Each component in Chinese medicine compound prescription disclosed by the invention is can be seen that to compound group from above-described embodiment and comparative example data
The whole structure of compound has obvious synergistic function, and each component compatibility is also vital.
Claims (8)
1. a kind of heat stress that adjusts is laid eggs the Chinese medicine compound prescription of chicken intestinal flora, it is characterised in that each component mass fraction is：Elscholtiza
20 ~ 30 parts, 10 ~ 15 parts of radix scutellariae, 10 ~ 20 parts of the coptis, 10 ~ 15 parts of radix glycyrrhizae, 10 ~ 20 parts of radix bupleuri, 10 ~ 15 parts of Radix Angelicae Sinensis, the capsule of weeping forsythia 10 ~ 15
Part, 10 ~ 20 parts of root of Chinese trichosanthes, 10 ~ 20 parts of cape jasmine, 10 ~ 20 parts of sweet wormwood.
2. Chinese medicine compound prescription as claimed in claim 1, it is characterised in that each component mass fraction is：24 parts of elscholtiza, 12 parts of radix scutellariae,
15 parts of the coptis, 12 parts of radix glycyrrhizae, 15 parts of radix bupleuri, 12 parts of Radix Angelicae Sinensis, 12 parts of the capsule of weeping forsythia, 15 parts of root of Chinese trichosanthes, 15 parts of cape jasmine, 15 parts of sweet wormwood.
3. Chinese medicine compound prescription as claimed in claim 1, it is characterised in that the lay eggs Chinese medicine of chicken intestinal flora of the regulation heat stress is answered
Side is pulvis.
4. the Chinese medicine compound prescription as described in any one of claims 1 to 3, it is characterised in that its preparation method comprises the following steps：Weigh
The elscholtiza of parts by weight, radix scutellariae, the coptis, radix glycyrrhizae, radix bupleuri, Radix Angelicae Sinensis, the capsule of weeping forsythia, root of Chinese trichosanthes, cape jasmine, sweet wormwood, load disintegrating machine, repeatedly
Smashed 80-100 mesh sieves.
5. any one of claims 1 to 3 Chinese medicine compound prescription is in the medicine that regulation heat stress lays eggs chicken intestinal flora is prepared
Using.
6. any one of claims 1 to 3 it is described regulation heat stress lay eggs chicken intestinal flora Chinese medicine compound prescription as or prepare raise
Application in feed additives.
7. a kind of chicken feed of laying hen, it is characterised in that added with the regulation heat stress described in any one of the claims 1 ~ 3
The Chinese medicine compound prescription of chicken intestinal of laying eggs flora.
8. the chicken feed of laying hen as described in above-mentioned claim 7, it is characterised in that the regulation heat stress is laid eggs chicken intestinal flora
The addition of Chinese medicine compound prescription be mass ratio 1% ~ 1.3%.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110403965A (en) * | 2018-04-28 | 2019-11-05 | 珠海岐微生物科技有限公司 | Radix Angelicae Sinensis is adjusting the purposes in enteric microorganism |
| CN116808109A (en) * | 2023-07-07 | 2023-09-29 | 华南农业大学 | Traditional Chinese medicine compound for resisting chronic heat stress of broiler chickens and preparation and application thereof |
| CN116870091A (en) * | 2023-07-13 | 2023-10-13 | 华南农业大学 | Traditional Chinese medicine compound for resisting LPS stress of broiler chickens as well as preparation and application thereof |
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| CN116808109B (en) * | 2023-07-07 | 2024-03-12 | 华南农业大学 | Traditional Chinese medicine compound for resisting chronic heat stress of broiler chickens and preparation and application thereof |
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Application publication date: 20180313 |