CN107787220B - 用于皮肤清洁的无硫酸盐的配制品 - Google Patents
用于皮肤清洁的无硫酸盐的配制品 Download PDFInfo
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- CN107787220B CN107787220B CN201680034426.6A CN201680034426A CN107787220B CN 107787220 B CN107787220 B CN 107787220B CN 201680034426 A CN201680034426 A CN 201680034426A CN 107787220 B CN107787220 B CN 107787220B
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Abstract
本披露提供了一种清洁组合物，该清洁组合物包括按重量计从约20％至约40％)的主要阴离子表面活性剂；按重量计从约10％>至约30％)的两性乙酸盐；按重量计从约10％>至约30％>的磺基甜菜碱；以及按重量计从约0.5％至约2％的脂肪酸，其中这些量是基于该组合物的总重量并且该组合物不含阴离子烷基硫酸盐和烷基醚硫酸盐。
Description
相关申请的交叉引用
本申请根据35U.S.C.§119(e)要求于2015年4月13日提交的美国临时申请序列号62/146,498的优先权的权益，其全部披露内容通过援引方式并入本申请。
背景技术
目前，大多数可商购的个人护理组合物是基于含有硫酸盐的表面活性剂，如月桂基硫酸钠(SLS)、月桂基硫酸铵(ALS)、月桂醇聚醚硫酸钠(SLES)或月桂醇聚醚硫酸铵(ALES)。SLS、ALS、SLES和ALES是本领域中使用的最广泛的含有硫酸盐的表面活性剂，因为它们便宜并且因为它们同时展示出令人满意的清洁和发泡特性。
然而，包括含有硫酸盐的表面活性剂的个人护理组合物还呈现显著的缺点。事实上，已知含有硫酸盐的表面活性剂(如SLS)易于引起耐受性问题，尤其是在皮肤和眼睛上。含有硫酸盐的表面活性剂的另一个缺点是其剥离皮肤、头皮或头发在其表面处含有的其天然油脂、脂肪或蛋白质的倾向。从长远来看，重复使用包括含有硫酸盐的表面活性剂的个人护理组合物因此可能引起对皮肤或头皮的刺激和/或产生对头发纤维的损害。
在最近，因此，对于包括安全、环境友好和/或较温和的表面活性剂的个人护理组合物，并且尤其对于不含含有硫酸盐的表面活性剂的个人护理组合物存在日益增长的需求。
配制不含硫酸盐的个人护理组合物的主要挑战之一在于需要维持温和性、令人满意的清洁、调理和发泡特性，而不会不利地影响整体组合物的粘度。
发明内容
因此，本披露的目的是解决市场上对于不含含有硫酸盐的表面活性剂、而不会不利地影响粘度和发泡特性的个人护理组合物的不断增长的需求。
本披露提供了一种清洁组合物，该清洁组合物包括按重量计从约20％至约40％的主要阴离子表面活性剂；按重量计从约10％>至约30％的两性乙酸盐；按重量计从约10％>至约30％>的磺基甜菜碱；以及按重量计从约0.5％至约2％的脂肪酸，其中这些量是基于该组合物的总重量并且该组合物不含阴离子烷基硫酸盐和烷基醚硫酸盐。
还描述了一种皮肤清洁方法，该方法包括以下步骤：将根据本披露的清洁组合物施用于身体上的皮肤区域上；洗涤该身体上的皮肤区域；并且冲洗该身体上的皮肤区域。
附图说明
图1描绘了批次SI 172-24对比1％的SLES和1％的市场基准保湿沐浴液的泡沫分析。
图2描绘了比较SI 172-24对比1％的SLES和1％的市场基准的玉米蛋白分析。
图3描绘了批次SI 172-140(“原型”)对比三种市场基准去角质沐浴液的泡沫分析。
图4描绘了本披露的保湿组合物(“索尔维(Solvay)”)对比市场基准保湿组合物的泡沫分析。
具体实施方式
本披露的目的之一是提供展示出良好的发泡特性并维持令人满意的粘度，而同时不含含有硫酸盐的表面活性剂的个人护理组合物。
总体上，根据本披露的清洁组合物包括按重量计从约20％至约40％的主要阴离子表面活性剂；按重量计从约10％至约30％的两性乙酸盐；按重量计从约10％至约30％的磺基甜菜碱；以及按重量计从约0.5％至约2％的脂肪酸，其中这些量是基于该组合物的总重量并且该组合物不含阴离子烷基硫酸盐和烷基醚硫酸盐。因此，以下阴离子表面活性剂优选地不存在于本披露的组合物中：烷基硫酸盐、烷基酰胺硫酸盐、烷基醚硫酸盐、烷基酰胺基醚硫酸盐、烷基芳基醚硫酸盐、甘油单酯硫酸盐。
尽管讨论了具体实施例，但是说明书仅是说明性的并且不是限制性的。在回顾本说明书时，本披露的许多变型对于本领域技术人员将变得明显。
除非以其他方式定义，否则在此使用的所有技术和科学术语具有与由本说明书涉及的领域中的技术人员通常理解的相同的含义。
如在本说明书和权利要求书中使用的，单数形式“一个/种(a/an)”和“该(the)”包括复数指示物，除非上下文另外清楚地指出。
如在此使用的，并且除非另外指明，术语“约”或“近似地”是指如由本领域普通技术人员确定的特定值的可接受的误差，其部分取决于如何测量或确定该值。在某些实施例中，术语“约”或“近似地”是指在1、2、3、或4个标准差内。在某些实施例中，术语“约”或“近似地”是指在给定的值或范围的50％、20％、15％、10％、9％、8％、7％、6％、5％、4％、3％、2％、1％、0.5％、或0.05％内。
另外，应理解在此列举的任何数值范围旨在包括包含于其中的全部子范围。例如，“1至10”的范围旨在包括在并且包括所列举的最小值1与所列举的最大值10之间的全部子范围；即，具有等于或大于1的最小值和等于或小于10的最大值。因为这些披露的数值范围是连续的，所以它们包括在最小值与最大值之间的每个值。除非另外清楚地指明，否则在本申请中指定的各个数值范围是近似值。
如在此使用的，短语“发泡特性”是指瞬间泡沫和泡沫体积，其在影响消费者关于泡沫品质的感知的主要因素之中。众所周知的测试，值得注意地如实验部分中描述的，可用于测量这些因素。
在某些实施例中，该组合物的pH在从7.5至10.4的范围内
在某些实施例中，该主要阴离子表面活性剂选自椰油酰基甘氨酸钠、甲基椰油酰基牛磺酸钠和月桂基甘氨酸钠。
在其他实施例中，该两性乙酸盐是月桂酰两性乙酸钠。
在其他实施例中，该磺基甜菜碱是椰油酰胺基丙基羟基磺基甜菜碱。
在某些实施例中，该脂肪酸是月桂酸。
在其他实施例中，该组合物进一步包括水。
根据本披露的组合物适用于各种清洁应用。在某些实施例中，该组合物是浓缩的沐浴液配制品。在其他实施例中，该浓缩的沐浴液配制品具有8.00的pH。
在某些实施例中，该组合物包括至少一种结构化剂。在一个方面，该结构化剂是疏水改性的碱可溶胀的乳液聚合物。在另一个方面，该结构化剂以按重量计从约5％至约10％的量存在并且该量是基于该组合物的总重量。
在某些方面，加入结构化剂允许将油结合到该组合物中，这将提供保湿益处。在某些实施例中，该油选自矿物来源的油、植物来源的油、以及其混合物或缔合物。在一些实施例中，该油以分散的颗粒或液滴的形式存在。
在某些实施例中，矿物来源的油选自(INCI名称)：矿脂、矿物油、氢化聚十二碳烯、氢化聚癸烯、聚癸烯及其组合。
在某些实施例中，植物来源的油选自(INCI名称)：猴面包树(AdansoniaDigitata)籽油；艳山姜(Alpinia Speciosa)叶油；蓟罂粟(Argemone Mexicana)油；意大利甘蓝(Brassica Oleracea Italica)(花椰菜)籽油；好望角美树(Calodendrum Capense)胡桃油；琼崖海棠(Calophyllum Inophyllum)籽油；红花油茶(Camellia Chekiangoleosa)籽油；番木瓜籽油；雪松(Cedrus Deodara)籽油；椰子树(椰子)油；两节荠(CrambeAbyssinica)籽油；蛋黄油；草莓(Fragaria Ananassa)(草莓(Strawberry))籽油；氢化油茶籽油；氢化月见草油；氢化榛子油；氢化羊毛脂；氢化澳洲坚果籽油；氢化米糠油；氢化芝麻籽油；羟基荷荷芭油；异丁酸酯化的羊毛脂油羊毛脂油；雷斯克懒勒(LesquerellaFendleri)籽油；土拨鼠油；貂油；圣罗勒(Ocimum Tenuiflorum)油；考胡棕(OrbignyaCohune)籽油；鸵鸟油；新西兰麻(Phormium Tenax)籽油；PPG-40-PEG-60羊毛脂油；PPG-12-PEG-65羊毛脂油；无毛水黄皮(Pongamia Glabra)籽油；日本五针松(Pinus Parviflora)籽油；伯尔硬胡桃(Sclerocarya Birrea)籽油；印度无患子(Schleichera Trijuga)籽油；霍霍巴(荷荷芭)籽油；花楸树(Sorbus Aucuparia)籽油；玉蜀黍(玉米)油；巴西坚果(Bertholletia Excelsa)籽油PEG-8酯；椰子油甲基丙二醇酯；荷荷芭油PEG-8酯；氢化蓖麻油山嵛酯；氢化蓖麻油鲸蜡酯；氢化蓖麻油二聚二亚油酸酯；氢化蓖麻油硬脂酸酯；氢化橄榄油辛酰基酯；氢化橄榄油鲸蜡酯；氢化橄榄油癸酯；氢化橄榄油己酯；氢化橄榄油月桂酯；氢化橄榄油肉豆蔻酯；氢化橄榄油硬脂酯；巴巴苏(Orbignya Oleifera)籽油PEG-8酯；西番莲(Passiflora Edulis)/粉色西番莲(Passiflora Incarnata)籽油PEG-8酯；油菜(Brassica Campestris)(油菜籽)油不皂化物；花椰菜(Brassica Oleracea Botrytis)(菜花)油不皂化物；牛油果树(Butyrospermum Parkii)(乳木果油)不皂化物；菜籽油不皂化物；来檬(Citrus Aurantifolia)(青柠)籽油不皂化物；柑橘(Citrus Aurantium Dulcis)(甜橙)籽油不皂化物；沙田柚(Citrus Grandis)(葡萄柚)籽油不皂化物；氢化杏油不皂化物；氢化葡萄柚籽油不皂化物；氢化青柠籽油不皂化物；氢化橄榄油不皂化物；氢化橙籽油不皂化物；氢化甜杏仁油不皂化物；氢化小麦胚芽油不皂化物；向日葵(HelianthusAnnuus)(葵花(Sunflower))籽油不皂化物；白羽扇豆油不皂化物；紫苜蓿(MedicagoSativa)(苜蓿)油不皂化物；油橄榄(橄榄)油不皂化物；30油橄榄(橄榄)果实不皂化物；鳄梨(Persea Gratissima)(牛油果)油不皂化物；杏(Prunus Armeniaca)(杏子)核油不皂化物S；芝麻(esamum Indicum)(芝麻(Sesame))油不皂化物；小麦(Triticum Vulgare)(小麦(Wheat))胚芽油不皂化物；和玉蜀黍(玉米)油不皂化物。
在某些实施例中，该组合物包括一种或多种添加剂，该一种或多种添加剂选自维生素、植物提取物、保湿剂、润肤剂、防腐剂、去角质剂和香料。
在某些方面，该一种或多种添加剂选自花生油、蓖麻油、可可脂、椰子油、玉米油、棉籽油、橄榄油、棕榈仁油、菜籽油、红花籽油、芝麻籽油和大豆油，酯，包括肉豆蔻酸丁酯、棕榈酸鲸蜡酯、癸基油酸酯、月桂酸甘油酯、甘油蓖麻醇酸酯、硬脂酸甘油酯、异硬脂酸甘油酯、月桂酸己酯、棕榈酸异丁酯、硬脂酸异鲸蜡酯、异硬脂酸异丙酯、月桂酸异丙酯、亚油酸异丙酯、肉豆蔻酸异丙酯、棕榈酸异丙酯、硬脂酸异丙酯、单月桂酸丙二醇酯、丙二醇蓖麻醇酸酯、硬脂酸丙二醇酯、和异硬脂酸丙二醇酯，动物脂肪，包括乙酰化的羊毛脂醇、羊毛脂、猪油、貂油和牛脂，以及脂肪酸和醇，包括山萮酸、棕榈酸、硬脂酸、山嵛醇、鲸蜡醇、二十烷醇(eicosanyl alcohol)和异鲸蜡醇；维生素或它们的衍生物，如复合维生素B，包括硫胺素、烟酸、生物素、泛酸、胆碱、核黄素、维生素B6、维生素B12、吡哆醇、肌醇、肉毒碱，维生素A、C、D、E、K和它们的衍生物，如维生素A棕榈酸酯，和维生素原，例如泛醇(维生素原B5)、泛醇三乙酸酯以及其混合物；抗氧化剂；自由基清除剂；研磨剂，天然的或合成的；抗UV试剂，如丁基甲氧基二苯甲酰基甲烷、甲氧基肉桂酸辛酯、羟苯甲酮、奥克立林、水杨酸辛酯、苯基苯并咪唑磺酸、氨基苯甲酸乙基羟丙酯、邻氨基苯甲酸甲酯、氨基苯甲酸、西诺沙酯、二乙醇胺甲氧基肉桂酸酯、氨基苯甲酸甘油酯、二氧化钛、氧化锌、羟苯甲酮、辛基二甲基PABA(帕地马酯O)、红凡士林；抗微生物剂；抗菌剂，如杆菌肽、红霉素、三氯生、新霉素、四环素、金霉素、苄索氯铵、苯酚、对氯间二甲苯酚(PCMX)、三氯卡班(TCC)、葡萄糖酸氯己定(CHG)、吡硫锌、二硫化硒；抗真菌剂；黑色素调节剂；晒黑加速剂；脱色素剂，如维生素A酸类(如视黄醇)、曲酸以及其衍生物(例如像，曲酸二棕榈酸酯)、氢醌以及其衍生物(如熊果苷)、氨甲环酸，维生素(如烟酸、维生素C和其衍生物)、壬二酸、placertia、甘草、提取物(如春黄菊和绿茶)，其中视黄醇、曲酸和氢醌是优选的；皮肤增亮剂，如氢醌、儿茶酚和其衍生物、抗坏血酸以及其衍生物；皮肤着色剂，如二羟基丙酮；脂肪调节剂；减重剂；抗痘剂；抗皮脂溢剂；抗衰老剂；抗皱剂；角质溶解剂；抗炎剂；抗痘剂，如维甲酸、异维甲酸、莫维A胺、阿达帕林、他扎罗汀、壬二酸、视黄醇、水杨酸、过氧化苯甲酰、间苯二酚，抗生素，如四环素和其异构体、红霉素，抗炎剂，如布洛芬、萘普生、亥普芬(hetprofen)，植物提取物，如桤木属、山金车、茵陈蒿、萍叶细辛属根、金盏花属、甘菊、蛇床属、紫草科植物、茴香、五倍子、山楂、鱼腥草、金丝桃属、枣属、猕猴桃、甘草、木兰属、橄榄、薄荷、喜林芋、鼠尾草属、白边华箬竹属(sasaalbomarginata)，咪唑，如酮康唑和新康唑，那些抗痘剂描述于Gollnick,H.等人，196(1)皮肤学皮脂腺、痤疮和相关的紊乱(Dermatology Sebaceous Glands,Acne and RelatedDisorders)119-157(1998)中，将其通过援引方式并入本申请，达到这样的程度以至其不与本申请不一致；清新剂；愈合剂；脉管保护剂；用于减少头皮屑、脂溢性皮炎、或牛皮癣的试剂，如吡硫锌，页岩油和其衍生物，如磺化的页岩油、二硫化硒、硫、水杨酸、煤焦油、聚维酮碘，咪唑，如酮康唑、二氯苯基咪唑酮碘昔兰(dichlorophenyl imidazolodioxalan)、克霉唑、伊曲康唑、咪康唑、氯咪巴唑、噻康唑、硫康唑、布康唑、氟康唑、亚硝酸咪康唑以及其任何可能的立体异构和衍生物，如蒽林、吡罗克酮乙醇胺(Octopirox)、二硫化硒、环吡酮胺，抗牛皮癣试剂，如维生素D类似物，例如卡泊三醇、骨化三醇、以及他卡西醇(tacaleitrol)，维生素A类似物，如维生素A的酯类，包括维生素A棕榈酸酯，维生素A酸类，视黄醇，以及视黄酸，皮质甾类，如氢化可的松、丁氯倍他松、丙酸氯倍他索；止汗剂或除臭剂，如氢氧氯化铝、氢氧氯化锆铝(aluminum zirconium chlorohydrate)；免疫调节剂；滋养剂；脱毛剂，如巯基乙酸钙、巯基乙酸镁、巯基乙酸钾、巯基乙酸锶；用于对抗脱发的试剂；以及反射剂，如云母、氧化铝、硅酸钙、二醇二油酸酯、二醇二硬脂酸酯、二氧化硅、氟硅酸镁钠。
在某些方面，将该组合物结合到身体清洁剂、面部清洁剂或洗手皂配制品中。在其他实施例中，通过将该组合物稀释至8％-10％固体，将该组合物结合到泡沫洗剂中。
在某些实施例中，本披露的组合物使用浓缩的可流动的表面活性剂组合物来制备。某些实施例包括适于制备本披露的组合物的浓缩物。包括表面活性剂的混合物的浓缩物是有利的，因为它们的使用将减少运输多种单独组分的需要。
个人护理组合物通常通过混合单独的表面活性剂和任何附加的成分来制备。这些组分可以作为进行稀释的浓缩溶液供应和/或由配方者以适当的比率组合。本披露涵盖有待被用作制备本披露的组合物的组成成分的任何表面活性剂浓缩物，并且尤其是含有限定水平的水的表面活性剂浓缩物(从成本和环境的观点来看更有利的)。
在此还描述了一种皮肤清洁方法，该方法包括：将根据本披露的清洁组合物施用于身体上的皮肤区域上；洗涤该身体上的皮肤区域；并且冲洗该身体上的皮肤区域。
将通过参考以下实例来进一步说明本披露。以下实例仅是说明性的并且不旨在是限制性的。除非另外指明，否则所有百分比均是按总组合物的重量计。
实例1
组合物的制备。
将水和阴离子表面活性剂(椰油酰基甘氨酸钠或甲基椰油酰基牛磺酸钠)混合在一起。将该混合物加热至65℃。在65℃下，将脂肪酸(月桂酸)加入并混合直至它完全熔化并且形成均匀的溶液。此时，将加热关闭以冷却该批次。加入两性表面活性剂(月桂酰两性乙酸钠和椰油酰胺基丙基羟基磺基甜菜碱)，并且将该混合物冷却至室温(25℃)。检查并记录pH。使用50％的氢氧化钠溶液进行调节至9.5-10.4的pH。在反应工艺结束时获得透明配制品。
表1.组成细节。(示出的量是活性百分比)。
实例2-进一步研究。
对组合物SI 172-24进行进一步研究。一些结果提供在表2中。
表2.pH对SI 172-24共混物的粘度和稳定性的影响。
| pH | 粘度* | 颜色加德纳 | 稳定性 |
| 7.5 | 8,150 | 1.00 | FT和45下的沉淀物 |
| 8.5 | 1200 | 0.5 | 稳定的 |
| 9.5 | 320 | 0.5 | 稳定的 |
| 10.5 | 380 | 0.5 | 稳定的 |
*使用布氏粘度计LV#3在3rpm下进行所有粘度测量。
稳定性研究在3个月的周期和3次冻融循环内进行。在稳定性研究的持续时间期间在所有温度下观察到粘度的增加。如表2中看出的，浓缩物在7.5的pH下是不稳定的，并且因此停止在此pH范围下的研究。8.5-10.00的pH对于此共混物的发展是最佳的。
实例3-该组合物的规格评估。
表3示出了浓缩物SI 172-24的规格评估。所有读数都在pH 9.5下进行。
表3.规格开发。
| 外观 | 透明可流动的液体 |
| 照原样的pH | 9.5 |
| 粘度25℃ LV#3在6rpm下 | 560cps |
| 25℃下的颜色加德纳 | 0.7 |
| ％固体(微波法) | 33.94 |
| pH，5％溶液 | 9.92 |
| 盐，％ | 5.29 |
实例4-稳定性研究。
对批次SI 172-24进行完全的稳定性研究持续3个月的周期。将样品在25℃、45℃和冻融下老化，并且以2、4、8和12周的间隔测试pH、粘度和色移。在老化周期内存在粘度的稳定增加，这很可能归因于
Ultra L-32。在老化循环期间没有观察到主要的变色。
表4.具有下限和上限的规格表。
| 规格 | 最小 | 最大 |
| 外观 | 透明可倾倒的液体 | |
| pH | 9.5 | 10.4 |
| 粘度(LV#3，在6rpm下) | 最大5000cps | |
| 颜色加德纳 | 2最大 | |
| ％固体(微波) | 33.5 | 35.5 |
| ％NaCl | 4.5 | 6.5 |
通过其中每一次将该表面活性剂装载过量了10％的装载过量实验挑战了这些限制。测试了这些规格并且发现虽然存在粘度和％固体的增加，但其仍在规格内。在浓缩物上进行的很多的变化提供了类似的结果。
实例5-泡沫高度分析。
用Kruss DFA100动态泡沫分析仪进行泡沫测试。实验根据SOPCRTB-SOP-0147进行。制备了200mL的1％的基准和原型的溶液。将50mL的测试溶液精确地称量到测试圆柱中。将气流量设定为0.3L/min并且泵送气体持续25秒。泡沫高度固定持续6分钟。
泡沫高度分析是对比1％的SLES溶液在pH 10下和市场基准保湿沐浴液对1％、0.75％和0.5％的批次SI 172-24的溶液进行的。图1示出了1％的SI172-24与1％的SLES溶液(
ES-2/K)的泡沫高度比较。浓缩物的初始泡沫高度高于SLES溶液的初始泡沫高度。进一步地，甚至在300秒之后，泡沫高度没有显著地降低，表明稳定的泡沫。
实例6-玉米蛋白分析。
玉米蛋白测试是用于分析表面活性剂或产品的皮肤刺激可能性的方法。玉米蛋白分析根据SOP CRTB-SOP-0146进行。
将0.4g玉米蛋白蛋白质加入到1％的测试溶液中并混合60分钟。然后将该溶液用滤纸过滤。将在滤纸上收集的固体在45℃烘箱中干燥过夜。取玉米蛋白的最终重量，并使用以下公式计算溶解的玉米蛋白百分比：
加入到溶液中的总玉米蛋白(g)-在干燥之后未溶解的玉米蛋白(g)
0.5[表面活性剂的总克数]
＝溶解的玉米蛋白克数/表面活性剂的克数
玉米蛋白分析是对比1％的SLES溶液和1％的市场基准保湿沐浴液对1％、0.75％和0.5％的SI 172-24的溶液进行的。如图2中看出的，SI 172-24的玉米蛋白数目(甚至在1％下)显著低于1％的SLES的玉米蛋白数目，表明SI172-24比SLES更温和。
实例7-去角质组合物。
将水与聚丙烯酸酯-33组合并混合20分钟。将SI 172-24与水性聚丙烯酸酯-33混合物共混直到该共混物完全均匀化。用50％的苛性碱溶液将pH调节至7.0-7.5。将云母和杏磨砂珠粒加入到该共混物中并混合直到均匀分布在该批次中。最后，将香料和防腐剂混合到该批次(SI 172-140)中。SI 172-140展示出在从7.0至7.5范围内的pH以及在从7,000至15,000cps范围内的粘度(布氏粘度计LV#3)。
表5.组成细节。(示出的量是活性百分比)。
泡沫高度分析是对比三种市场基准去角质沐浴液对SI 172-140(“原型”)进行的。图3示出了泡沫高度比较。SI 172-140的泡沫高度与比较的市场基准相等。
实例8-保湿组合物。
将水与聚丙烯酸酯-33组合并充分混合在主烧杯中。将乙酰胺MEA和乳酰胺MEA(
LAME-100)和聚甘油-3加入到该混合物中。然后将所得混合物加热至65℃。将SI 172-24加入到主烧杯中的混合物中并混合直到完全均匀。在单独的烧杯中，将矿脂加热至65℃。当两相都在65℃下时，将矿脂加入到主烧杯中并充分混合直到完全均匀。然后将所得批次冷却至室温，并且将pH调节至7.0。在40℃下，加入二氧化钛、香料和防腐剂。所得组合物展示出具有在从10,000至15,000cps(布氏粘度计LV#3)范围内的粘度的“白色洗剂”外观。
表6.组成细节。(示出的量是活性百分比)。
泡沫高度分析是对比市场基准保湿组合物对本披露的保湿组合物(“索尔维”)进行的。图4示出了泡沫高度比较。该保湿组合物的泡沫高度好于市场基准的泡沫高度。
所披露的主题已经参考其具体实施例的具体细节进行描述。此类细节不旨在被认为是对所披露的主题的范围的限制，除了它们被包括在所附权利要求书的范围内的程度。
因此，在此描述的示例性实施例很好地进行适配以便达到提及的目的和优点以及其中固有的那些。以上披露的具体实施例仅仅是说明性的，因为在此描述的示例性实施例可以以受益于在此的传授内容的对本领域技术人员明显的不同但等效的方式进行修改和实践。此外，除了如在下面的权利要求中描述的，并不旨在对在此示出的结构或设计的细节有所限制。因此明显的是可以改变、结合或修改以上披露的具体的说明性实施例并且全部的此类变化被认为落入在此描述的示例性实施例的范围和精神内。可以在不存在没有在此具体披露的任何要素和/或在此披露的任何任选要素的情况下适当地实践在此说明性地披露的在此描述的示例性实施例。虽然组合物和方法是以“包含(comprising)”、“含有(containing)”或“包括(including)”各种组分或步骤描述的，这些组合物和方法还可以“基本上由以下各项组成”或“由以下各项组成”：各种组分、物质和步骤。如在此使用的，术语“基本上由以下各项组成”应该理解为意在包括所列出的组分、物质或步骤以及不实质性地影响该组合物或方法的基本和新颖特性的这样的额外的组分、物质或步骤。在一些实施例中，根据本披露的实施例的“基本上由以下各项组成”的组合物：所列举的组分或物质，不包括改变该组合物的基本和新颖特性的任何额外的组分或物质。如果在本说明书以及可通过援引的方式并入本申请中的一个或多个专利或其他文献中存在词或术语的使用上的任何冲突，应采用与本说明书一致的定义。
Claims (13)
1.一种液体清洁组合物，包含：
a.按重量计从20％至40％的主要阴离子表面活性剂，其中主要阴离子表面活性剂选自下组，该组由以下各项组成：椰油酰基甘氨酸钠、甲基椰油酰基牛磺酸钠和月桂基甘氨酸钠；
b.按重量计从10％至30％的两性乙酸盐；
c.按重量计从10％至30％的磺基甜菜碱；以及
d.按重量计从0.5％至2％的脂肪酸；
其中这些量是基于该组合物的总重量并且该组合物不含阴离子烷基硫酸盐和烷基醚硫酸盐，其中pH在从7.5至10.4的范围内。
2.如权利要求1所述的组合物，其中该主要阴离子表面活性剂是椰油酰基甘氨酸钠。
3.如权利要求1所述的组合物，其中该主要阴离子表面活性剂是甲基椰油酰基牛磺酸钠。
4.如权利要求1所述的组合物，其中该主要阴离子表面活性剂是月桂基甘氨酸钠。
5.如权利要求1所述的组合物，其中该两性乙酸盐是月桂酰两性乙酸钠。
6.如权利要求1所述的组合物，其中该磺基甜菜碱是椰油酰胺基丙基羟基磺基甜菜碱。
7.如权利要求1所述的组合物，其中该脂肪酸是月桂酸。
8.如权利要求1所述的组合物，其中该组合物进一步包含水。
9.如权利要求1所述的组合物，进一步包含至少一种结构化剂。
10.如权利要求9所述的组合物，其中该结构化剂以按重量计从5％至10％的量存在并且该量是基于该组合物的总重量。
11.如权利要求9所述的组合物，其中该结构化剂是疏水改性的碱可溶胀的乳液聚合物。
12.如权利要求1所述的组合物，进一步包含一种或多种选自下组的添加剂，该组由以下各项组成：维生素、植物提取物、保湿剂、润肤剂、防腐剂、去角质剂、油和香料。
13.一种皮肤清洁方法，该方法包括将如权利要求1所述的清洁组合物施用于身体上的皮肤区域上；洗涤该身体上的皮肤区域；并且冲洗该身体上的皮肤区域，其中该清洁组合物的pH值为7.0至7.5之间。
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| US201562146498P | 2015-04-13 | 2015-04-13 | |
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| PCT/US2016/027202 WO2016168241A1 (en) | 2015-04-13 | 2016-04-13 | Sulfate-free formulations for skin cleansing |
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| US (1) | US10709908B2 (zh) |
| EP (1) | EP3283048A4 (zh) |
| CN (1) | CN107787220B (zh) |
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| DE102019123202B4 (de) | 2019-08-29 | 2021-05-27 | Kässbohrer Transport Technik Gmbh | Fahrzeugtransporter |
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| DE60100032T2 (de) * | 2000-07-13 | 2003-02-27 | Oreal | Kosmetisches Reinigungszusammensetzung |
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| CN1640384A (zh) * | 2003-08-28 | 2005-07-20 | 强生消费者公司 | 温和有效的清洁组合物 |
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| Publication number | Publication date |
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| EP3283048A1 (en) | 2018-02-21 |
| EP3283048A4 (en) | 2018-10-03 |
| WO2016168241A1 (en) | 2016-10-20 |
| CN107787220A (zh) | 2018-03-09 |
| US10709908B2 (en) | 2020-07-14 |
| US20160296446A1 (en) | 2016-10-13 |
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