CN107782687A - A kind of medical integrated photometer device - Google Patents
A kind of medical integrated photometer device Download PDFInfo
- Publication number
- CN107782687A CN107782687A CN201711263075.9A CN201711263075A CN107782687A CN 107782687 A CN107782687 A CN 107782687A CN 201711263075 A CN201711263075 A CN 201711263075A CN 107782687 A CN107782687 A CN 107782687A
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- light source
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- cuvette
- cup
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- 230000003287 optical effect Effects 0.000 claims abstract description 11
- 238000006243 chemical reaction Methods 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 8
- 229920003023 plastic Polymers 0.000 claims abstract description 7
- 239000004033 plastic Substances 0.000 claims abstract description 7
- 238000001914 filtration Methods 0.000 claims abstract description 5
- 239000011521 glass Substances 0.000 claims abstract description 4
- 230000003321 amplification Effects 0.000 claims description 19
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 19
- 238000001514 detection method Methods 0.000 claims description 12
- 238000004891 communication Methods 0.000 claims description 10
- 230000005611 electricity Effects 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 230000004313 glare Effects 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 5
- 230000005693 optoelectronics Effects 0.000 claims description 4
- 238000010079 rubber tapping Methods 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 3
- 238000002835 absorbance Methods 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract 1
- 230000005906 menstruation Effects 0.000 abstract 1
- 238000013461 design Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000005622 photoelectricity Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 102000017011 Glycated Hemoglobin A Human genes 0.000 description 1
- 108010014663 Glycated Hemoglobin A Proteins 0.000 description 1
- 101001069810 Homo sapiens Psoriasis susceptibility 1 candidate gene 2 protein Proteins 0.000 description 1
- 102100034249 Psoriasis susceptibility 1 candidate gene 2 protein Human genes 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000002558 medical inspection Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/062—LED's
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
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- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
Abstract
The present invention discloses a kind of medical integrated photometer device, is primarily useful for the medicine detector device based on absorbance method or photolorimetry, and the invention includes light source module, colorimetric cup device, photoelectric switching circuit.Wherein light source constant-current source driving, in order to ensure light stability, by the way of controller plus constant-current driven chip, additional attenuation compensation circuit, lifts the stability and durability of light source using fixed wave length LED light source is provided.Cuvette be one by glass stand, cuvette cup, optical filter, trim ring, the composition such as felt pad, top board, lower platen, floor, plastic jacket a cavity.Photoelectric switching circuit realizes photoelectric conversion using photodiode, and puts big, filtering process and the signal transacting based on logafier before menstruation, signal is amplified to the manageable analog electrical signal of AD conversion chip.
Description
Technical field
The present invention relates to medical science biochemistry detection field, especially a kind of medical integrated photometer.
Background technology
In terms of medical research and medical inspection, absorbance method or colorimetric method be more conventional and effective detection liquid or
The common method of fluid biochemical characteristic.Such as to the calibrating of the compositions of the blood samples such as hemoglobin, glycosylated hemoglobin.How to have
Related Component has important Research Significance in the quick detection liquid fluid sample of effect.Existing photoelectric detection system often fills
Complexity, and mostly import are put, it is expensive while more single in terms of communication interface, fast integration can not be accomplished, simultaneously
It can not accomplish that the combined communication of more group controllers detects in real time.
The content of the invention
For overcome the deficiencies in the prior art, the invention provides a kind of medical integral photometer device, apparatus of the present invention
Easy and effective, precision is higher, and communication interface is enriched, relatively low using integrated design, cost.
A kind of medical integrated photometer device, including light source module, colorimetric cup device, photoelectric switching circuit, the light
Source module includes master controller, LED light source driver, the LED light source of fixed wave length, attenuation compensation circuit, communication interface circuit,
The colorimetric cup device includes glass stand, cuvette cup, optical filter, trim ring, felt pad, top board, lower platen, bottom plate, plastics
Cover, cuvette cup top set conduit circular hole, and cuvette cup middle part both ends set source ends circular hole and photosensitive end to justify respectively
Hole, tapping are closed by the way of sealing ring sealing and plastic jacket；The photoelectric switching circuit includes the pole of photoelectricity two
Pipe, signal amplification circuit；The LED light source of the fixed wave length stably launches fixed wave length under the driving of LED drive circuit
Light, veiling glare is filtered out by optical filter, be detected sample flow through cuvette through conduit, after the irradiation of light source, transmitted light quilt
Photodiode receives, and faint optical signal converted electric signal, electric signal is entered through signal processing circuit by photodiode
Row amplification filtering process.
The attenuation compensation circuit is by the way of PWM light modulations.
The communication interface circuit includes CAN, USB, RS232 serial ports, SPI, IIC communication interface, for accessing it
His automatic detection system.
The signal amplification circuit is divided into two-stage amplification, and wherein one-level amplification is put by precision operational-amplifier AD549, two level
It is big to be collectively formed using integrated logarithmic amplification chip LOG112 and voltage follower.
The present invention is integrated by light source, signal transacting, and colorimetric cup device, it is possible to provide stable LED fixes ripple
Long light source, cuvette apparatus structure is simple, and signal transacting is by the way of multi-stage process and filtering process, effective faint telecommunications
Number amplification, the device provide multiple interfaces circuit conveniently can be linked into automatic control equipment, there is certain versatility.
Brief description of the drawings
Fig. 1 is the medical integrated photometer device mechanical construction drawing of the present invention.
Fig. 2 is apparatus of the present invention system architecture diagram.
Fig. 3 is light source driving circuit figure of the present invention.
Fig. 4 is opto-electronic conversion of the present invention and signal processing circuit figure.
Embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings.
Such as Fig. 1,2, a kind of medical integrated photometer device, including light source module, colorimetric cup device, opto-electronic conversion electricity
Road, the light source module include master controller, LED light source driver, the LED light source of fixed wave length, attenuation compensation circuit, communication
Interface circuit, the colorimetric cup device include glass stand 1, cuvette cup 2, LED light source 3, photocell 4, optical filter 5, light source electricity
Road plate 6, trim ring 7, felt pad 8, top board 9, lower platen 10, bottom plate 11, photosensitive circuit plate 12, plastic jacket 13, cuvette cup
2 tops set conduit circular hole, and the middle part both ends of cuvette cup 2 set source ends circular hole and photosensitive end circular hole respectively, and tapping is equal
Using sealing ring seal and plastic jacket by the way of close；The photoelectric switching circuit includes photodiode 15, signal amplifies
Circuit；The LED light source of the fixed wave length stably launches the light of fixed wave length under the driving of LED drive circuit, passes through filter
Mating plate filters out veiling glare, is detected sample and flows through cuvette through conduit 14, after the irradiation of light source, transmitted light is by photodiode
Receive, faint optical signal converted electric signal, filtering is amplified to electric signal through signal processing circuit by photodiode
Processing.
If Fig. 3 is light source driving circuit, for driving chip using CAT4101, the chip is a linear constant current LED
Driver, high current drive capability is specifically provided, the LED strip largely connected can be driven.In Fig. 3, CAT4101 uses 5V
Power supply, EN/PWM dim pin for enabled and PWM, and its logically high and logic low is more than 1.4V and below 0.4V respectively, when
When the pin puts high, enable and open, LED drive current reaches 400 times of RSET ends electric current.In the low electricity that this should hand over holding 5ms
Usually, then driving is off pattern.When using PWM light modulation when can external controller, pass through control output pulse duty factor adjust
Input voltage is saved, and then realizes the regulation to driving current.LED current passes through a non-essential resistance for being connected to REST pins
Set, the input resistance by adjusting the pin can accurately set LED drive current size, maximum up to 1A.
If Fig. 4 is opto-electronic conversion and signal processing circuit, electrooptical device uses photoelectric diode, and photodiode is
A kind of photosensitive component that can convert optical signals to electric signal, the present invention is using silicon photoelectric diode, the type photoelectricity
Diode response is fast, high sensitivity, stable performance, measurement good linearity, noise is low is widely used in photoelectric detective circuit, wherein
The spectral response range of photoelectric diode should include the spectral characteristic of detection light source.In the present invention, photodiode is by transmitted light
Ultra-weak electronic signal is converted to, because photoelectric conversion belongs to low level light signal detection, the weak output signal that not only exports but also is wherein had
Various noise jammings, this just needs to ensure to ensure to reduce as far as possible at light source incidence end in Photoelectric Detection incident light by veiling glare
Interference, enter again in the related one-level amplifying circuit of Photoelectric Detection end design.In incident light source, we employ optical filter
Veiling glare filter out and ensures the relatively pure of incident light source, at the same ensure as far as possible in terms of environment detect it is closed to reduce outside
Disturb in portion.Signal amplification circuit is mainly made up of AD549 and LOGl12.D3 is Photoelectric Detection electricity receiver, and switching current passes through for D
The output current crossed after AD549 amplifications, scope is between 100pA to 500uA；One-level level amplification module is by operational amplifier
AD549（Such as U2 in Fig. 4）, feedback resistance R1 and C1 composition, the output voltage of the one-level amplification of the amplifying circuit is u=SPR1, its
Middle S is the sensitivity of photodiode, and P is the luminous power of incident light.R1 provides gain amplifier, because low-light detection in general turns
It is even lower for mV levels to change signal, so generally large according to required amplification range R1 value.Due to the input of amplifier
Bias current and input offset voltage IBiasingAnd VImbalanceThe influence of one-level amplification output voltage is respectively IBiasingR1 and（1+R1/Rs）
VImbalance, wherein Rs is the internal resistance of photodiode.Can reduce when R1 reduces it can be seen from more than input bias current and
Influence of the input offset voltage to output voltage, but the gain of amplifier can also reduce simultaneously.Now need to examine when selecting amplifier
Consider relevant parameter.Two level amplification uses Integrated Logarithmic Amplifiers LOG112.In Fig. 4, LM4040A-2.5 is one accurate
Voltage-reference a, there is provided reference current that accurately reference voltage V REF, LM4040A-2.5 and precision resistance R6 are provided
I2, C2 are frequency compensation capacitance, and its size has the span by I1 and I2 to determine；LOGll2 uses ± 5V power supply power supply,
According to the recommendation for employing TI companies, using voltage conversion chip TPS60400, its can by+5V photovoltaic conversion for-
5V voltage.VLOGOUT=(0.5V) LOG (I1/I2), output voltage Vm=- (R 1/R2) VLOGOUT, extinction is realized by hardware
The measurement of rate value.
Claims (4)
1. a kind of medical integrated photometer device, it is characterised in that including light source module, colorimetric cup device, opto-electronic conversion electricity
Road, the light source module include master controller, LED light source driver, the LED light source of fixed wave length, attenuation compensation circuit, communication
Interface circuit, the colorimetric cup device include glass stand, cuvette cup, optical filter, trim ring, felt pad, top board, lower platen,
Bottom plate, plastic jacket, cuvette cup top set conduit circular hole, in the middle part of cuvette cup both ends set respectively source ends circular hole and
Photosensitive end circular hole, tapping are closed by the way of sealing ring sealing and plastic jacket；The photoelectric switching circuit includes light
Electric diode, signal amplification circuit；The LED light source of the fixed wave length is stably launched solid under the driving of LED drive circuit
The light of standing wave length, veiling glare is filtered out by optical filter, is detected sample and is flowed through cuvette through conduit, after the irradiation of light source, thoroughly
Penetrate light to be received by photodiode, faint optical signal converted electric signal by photodiode, through signal processing circuit to electricity
Signal is amplified filtering process.
2. the medical integrated photometer device of one kind according to claim 1, it is characterised in that the attenuation compensation circuit
By the way of PWM light modulations.
3. the medical integrated photometer device of one kind according to claim 1, it is characterised in that the communication interface circuit
Including CAN, USB, RS232 serial ports, SPI, IIC communication interface, for accessing other automatic detection systems.
4. the medical integrated photometer device of one kind according to claim 1, it is characterised in that amplified signal level is divided into two
Level amplification, wherein one-level amplification by precision operational-amplifier AD549, two level amplification use integrate logarithmic amplification chip LOG112 with
And voltage follower collectively forms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711263075.9A CN107782687A (en) | 2017-12-04 | 2017-12-04 | A kind of medical integrated photometer device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711263075.9A CN107782687A (en) | 2017-12-04 | 2017-12-04 | A kind of medical integrated photometer device |
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| Publication Number | Publication Date |
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| CN107782687A true CN107782687A (en) | 2018-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201711263075.9A Pending CN107782687A (en) | 2017-12-04 | 2017-12-04 | A kind of medical integrated photometer device |
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| CN (1) | CN107782687A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108801958A (en) * | 2018-08-01 | 2018-11-13 | 常州市武进区半导体照明应用技术研究院 | A kind of biochemical substances detecting instrument and its detection method based on optical means |
| CN108801957A (en) * | 2018-08-01 | 2018-11-13 | 常州市武进区半导体照明应用技术研究院 | A kind of biochemical substances detecting instrument and its calibration method based on optical means |
| CN109060678A (en) * | 2018-08-27 | 2018-12-21 | 北京雪迪龙科技股份有限公司 | A kind of absorbance measuring circuit |
Citations (5)
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|---|---|---|---|---|
| CN2503484Y (en) * | 2001-11-19 | 2002-07-31 | 国家海洋局海洋技术研究所 | Pumping photometric meter of sea water nutrient salt field automatic analyser |
| CN2755605Y (en) * | 2004-11-23 | 2006-02-01 | 河北先河科技发展有限公司 | Flow on-line ratio color detector |
| CN2901298Y (en) * | 2006-04-05 | 2007-05-16 | 北京尚精光电技术有限公司 | Spectrophotometer |
| CN102753956A (en) * | 2009-12-16 | 2012-10-24 | 布尔医疗设备有限公司 | Miniature flow-through cuvette and spectrophotometer containing the same |
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-
2017
- 2017-12-04 CN CN201711263075.9A patent/CN107782687A/en active Pending
Patent Citations (5)
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|---|---|---|---|---|
| CN2503484Y (en) * | 2001-11-19 | 2002-07-31 | 国家海洋局海洋技术研究所 | Pumping photometric meter of sea water nutrient salt field automatic analyser |
| CN2755605Y (en) * | 2004-11-23 | 2006-02-01 | 河北先河科技发展有限公司 | Flow on-line ratio color detector |
| CN2901298Y (en) * | 2006-04-05 | 2007-05-16 | 北京尚精光电技术有限公司 | Spectrophotometer |
| CN102753956A (en) * | 2009-12-16 | 2012-10-24 | 布尔医疗设备有限公司 | Miniature flow-through cuvette and spectrophotometer containing the same |
| CN207423798U (en) * | 2017-12-04 | 2018-05-29 | 江苏博权医疗科技有限公司 | A kind of medical integrated photometer device |
Non-Patent Citations (1)
| Title |
|---|
| 付仁凤: "基于吸光度法的全自动血凝仪中光电检测系统的研究", 中国优秀硕士学位论文全文数据库 医药卫生科技辑, no. 03, pages 3 - 5 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108801958A (en) * | 2018-08-01 | 2018-11-13 | 常州市武进区半导体照明应用技术研究院 | A kind of biochemical substances detecting instrument and its detection method based on optical means |
| CN108801957A (en) * | 2018-08-01 | 2018-11-13 | 常州市武进区半导体照明应用技术研究院 | A kind of biochemical substances detecting instrument and its calibration method based on optical means |
| CN108801957B (en) * | 2018-08-01 | 2023-12-26 | 常州市武进区半导体照明应用技术研究院 | Biochemical substance detection instrument based on optical method and calibration method thereof |
| CN109060678A (en) * | 2018-08-27 | 2018-12-21 | 北京雪迪龙科技股份有限公司 | A kind of absorbance measuring circuit |
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Application publication date: 20180309 |