CN107751576A - A kind of B B-complex liquid and preparation method thereof - Google Patents
A kind of B B-complex liquid and preparation method thereof Download PDFInfo
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- CN107751576A CN107751576A CN201711112237.9A CN201711112237A CN107751576A CN 107751576 A CN107751576 A CN 107751576A CN 201711112237 A CN201711112237 A CN 201711112237A CN 107751576 A CN107751576 A CN 107751576A
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Abstract
A kind of B B-complex liquid and preparation method thereof, is related to vitamine supplement.B B-complex liquid includes：Vitamin A：6000000IU, vitamine D3：1000000IU, vitamin E：5g, Vitamin K3：2.4g, vitamin B1：3.6g, vitamin B2：1g, vitamin B6：2.4g, vitamin B12：0.06g, FA：0.4g, vitamin C：8g, vitamin B5：8.4g, vitamin B3 acid amides：30g, biotin：1g.1) compound of vitamin B2 and FA and 2,6 dimethyl beta cyclodextrin is prepared respectively；2) vitamin B2 and the compound of FA and 2,6 dimethyl beta cyclodextrin prepared step 1) is deployed into B B-complex liquid with other vitamins and additive.
Description
Technical field
The present invention relates to vitamine supplement, more particularly, to a kind of B B-complex liquid and preparation method thereof.
Background technology
Current domestic aquaculture development is very fast, and the scale of cultivation is also increasing, substantial amounts of livestock and poultry medicine and has
Evil additive is abused, and prevents and treats livestock and poultry with this, this has had a strong impact on the quality of the product of aquaculture.To improve
People's living standard, realizes the green and healthy development of aquaculture, green safe efficient livestock and poultry medicine and additive into
For the inexorable trend developed in the future.Wherein vitamin, amino acid etc. turn into the important selection pair of fowl poultry kind medicament research and development new product
As.
Vitamin plays extremely important effect in the health of human body and animal, can improve exempting from for human body and animal
Epidemic disease power, nutritive disease can be caused by being deficient in vitamin, and decreased growth, resistance decline etc..Vitamin products in the market
Majority is solid powder product, is difficult to be well mixed when batch mixing is launched, and it is insufficient or local excessive to easily cause vitamin supplement
Poisoning by vitamin phenomenon, influences growth of animal.Vitamin is generally divided into fat-soluble and water-soluble two kinds, wherein liposoluble vitamin
Solubility is very low in water, when the vitamin aqueous solution is made, also easily causes vitamin supplement deficiency, or some vitamins are taken the photograph
Enter the problem of excessive.Even if however, water soluble vitamin, vitamin B2 and FA therein dissolving in water at normal temperatures
Spend very low, only 0.08g/L and 0.0016g/L【Perhaps influence [J] of remote niacinamide and urea to vitamin B2 solubility is weighed
Foreign medical science pharmacy fascicles, 1997,1:026.】；【Lee's wave, Gao Qianhong, Wu Guozhong, wait folic acid hydroxypropyl-β-cyclodextrin bags
The preparation of compound and sign [J] medical research magazines, 2013,42 (8):98-101.】；Two kinds of vitamins are in animal health
But particularly important effect is played.Vitamin B2 and B9 content are all very low in the liquid vitamin product studied at present,
About 0.5g/L and 0.05g/L【A kind of composite vitamin emulsions of Liu Kefei, Xu Ke good fortune and preparation method thereof, CN
101297680A】；Application effect is not reached in use, it is difficult to meet the needs of market.
The content of the invention
It is an object of the invention in order to overcome deficiencies of the prior art, there is provided high concentration vitamin B2 and dimension
Raw plain B9 a kind of B B-complex liquid and preparation method thereof.
The B B-complex liquid includes：Vitamin A：6000000IU, vitamine D3：1000000IU, vitamin E：5g、
Vitamin K3：2.4g, vitamin B1：3.6g, vitamin B2：1g, vitamin B6：2.4g, vitamin B12：0.06g, vitamin
B9：0.4g, vitamin C：8g, vitamin B5：8.4g, vitamin B3 acid amides：30g, biotin：1g.
The preparation method of the B B-complex liquid comprises the following steps：
1) vitamin B2 and FA and the compound of 2,6- dimethyl-β-cyclodextrins are prepared respectively；
In step 1), vitamin B2 and FA and the compound of 2,6- dimethyl-β-cyclodextrin of preparing
Specific method can be：
The mol ratio of vitamin B2 and FA respectively with 2,6- dimethyl-β-cyclodextrins is dissolved in for 1 ︰ (1~10)
Heated in dimethyl sulfoxide (DMSO) solvent, obtain solution, solution is transferred in autoclave, be passed through carbon dioxide, then diformazan is sub-
Sulfone removes clean and reclaims dimethyl sulfoxide, obtains vitamin B2 and FA and the compound of 2,6- dimethyl-β-cyclodextrin；
The temperature of the heating can be 60 DEG C, and the heat time can be 10min；The carbon dioxide that is passed through can adjust the pressure in autoclave
To 15MPa, temperature is adjusted to 60 DEG C, stirs 1h；Under normal temperature and pressure, gained vitamin B2 solubility in water reaches about 1.7g/L,
FA solubility in water reaches about 0.4g/L.
2) vitamin B2 and FA prepared step 1) and the compound of 2,6- dimethyl-β-cyclodextrins and other
Vitamin and additive are deployed into B B-complex liquid.
In step 2), the specific method for being deployed into B B-complex liquid can be：
(1) vitamin A, vitamine D3, vitamin E, Vitamin K3 are added in water, by addition 100mL in every liter of water
Tween 80, after heating, solution A is obtained, is placed stand-by；
In step 2) (1) part, the temperature of the heating can be 60 DEG C, and the heat time can be 1h.
(2) by vitamin B1, vitamin B6, vitamin B12, vitamin B5, the acid amides of vitamin B3, biotin and dimension
The compound of raw plain C, the vitamin B2 and FA obtained with step 1) and 2,6- dimethyl-β-cyclodextrin includes, then with
Different Vitamin C sodium is jointly soluble in water, obtains solution B；
In step 2) (2) part, the dosage of the different Vitamin C sodium is 2g.
(3) solution B that the solution A and step (2) obtained step (1) obtains merges, and supplies water, produces compound dimension
Raw plain liquid.
The present invention coordinates other vitamins by the solubilising to vitamin B2 and FA, proposes that one kind prepares height
The method of the B B-complex liquid of concentrations of vitamin B2 and FA.
Embodiment
The present invention is elaborated below in conjunction with specific embodiment.
Embodiment 1
Vitamin A, vitamine D3, vitamin E, Vitamin K3, vitamin B1, vitamin B2, vitamin B6, vitamin
B9, vitamin B12, vitamin C, vitamin B5, the acid amides of vitamin B3, biotin, Tween 80 come from Xiamen gummy shark medicine company collection
Group.2,6 dimethyl beta cyclodextrin, different Vitamin C sodium come from Shanghai Di Bai bio tech ltd.High concentration B B-complex liquid
Preparation process be：
Prepare vitamin B2 or B9 and the compound of 2,6- dimethyl-β-cyclodextrins：
1) by 2g vitamin B2s and 1g FAs, 1 ︰ 1 is dissolved in molar ratio with 2,6- dimethyl-β-cyclodextrins respectively
In 200mL dimethyl sulfoxides (DMSO) solvent, 60 DEG C are heated to about, stir about 10min obtains settled solution；
2) above-mentioned settled solution is transferred in autoclave, toward kettle in be passed through carbon dioxide, and pressure in kettle is adjusted to about
15MPa, temperature are adjusted to about 60 DEG C, in this condition lasting strong stirring 1h, then utilize the titanium dioxide under the temperature and pressure
DMSO is removed clean and is reclaimed DMSO by carbon, obtains the compound of dry vitamin B2 and 2,6- dimethyl-β-cyclodextrin about
The 8g and B9 and compound 3.6g of 2,6- dimethyl-β-cyclodextrins.
Allocate high concentration B B-complex liquid:1) vitamin A 6000000IU, vitamine D3 1000000IU, dimension life are taken
Plain E 5g Vitamin K3 2.4g, stirred in 60 DEG C of water of 100mL and form creamy base, add 100mL Tween 80s, stirring half
Hour set aside for use；2) vitamin B2 and FA and each 5g of inclusion compound (dimension lifes of 2,6- dimethyl-β-cyclodextrins are taken respectively
Plain B2 amounts 20%) and 1.6g (FA amount 25%), vitamin B1 3.6g, vitamin B6 2.4g, vitamin B12
0.06g, vitamin C 8g, pantothenic acid (vitamin B5) 8.4g, niacinamide (acid amides of vitamin B3) 30g, biotin (biotin)
1g, different Vitamin C sodium 2g are dissolved in 500mL water；3) merge two kinds of vitamin aqueous solution, supply deionized water to 1000mL, stir
Mix the B B-complex liquid for uniformly producing the present invention.
The vitamin liquid, which is placed 10 days, not to be precipitated.
Embodiment 2
Vitamin A. D. E, K3, B2, B9B1, B6, B12, C, pantothenic acid, niacinamide, biotin, Tween 80 come from Xiamen gummy shark
Medicine company group 2,6- dimethyl-β-cyclodextrins, different Vitamin C sodium come from Shanghai Di Bai bio tech ltd.
The preparation process of high concentration B B-complex liquid is：
Prepare vitamin B2 or B9 and the compound of 2,6- dimethyl-β-cyclodextrins：1) by 3g vitamin B2s and 1.5gB9
Respectively with 2,6- dimethyl-β-cyclodextrins in molar ratio 1:1 is dissolved in 250mL dimethyl sulfoxides (DMSO) solvent, is heated to about 60
DEG C, stir about 10min obtains settled solution；2) above-mentioned settled solution is transferred in autoclave, toward kettle in be passed through carbon dioxide, and
Pressure in kettle is adjusted to about 15MPa, temperature is adjusted to about 60 DEG C, in this condition lasting strong stirring 1h, then utilizes the temperature
With the carbon dioxide under pressure DMSO is removed clean and reclaims DMSO, obtain dry vitamin B2 and 2,6- dimethyl-β-
The compound of the cyclodextrin about 12.7g and B9 and compound 5.4g of 2,6- dimethyl-β-cyclodextrins.
Allocate high concentration B B-complex liquid:1) vitamin A 6000000IU, vitamine D3 are taken：1000000IU, vitamin
K3 2.4g, stirred in 60 DEG C of water of 100mL and form creamy base, add 100mL Tween 80s, stirring half an hour stands and treated
With；2) vitamin B2 and FA and inclusion compound each 5.6g (vitamin B2 amounts of 2,6- dimethyl-β-cyclodextrins are taken respectively
18%), 1.9g (FA amount 21%), vitamin B1 3.6g, vitamin B6 2.4g, vitamin B12 0.08g, vitamin
C 9g, pantothenic acid 8.4g, niacinamide 40g, biotin 1g, different Vitamin C sodium 2g are dissolved in 500mL water.And two kinds of vitamin water 3)
Solution, deionized water is supplied to 1000mL, B B-complex liquid of the invention can be obtained by stirring.
The vitamin liquid, which is placed 10 days, not to be precipitated.
Claims (9)
- A kind of 1. B B-complex liquid, it is characterised in that including：Vitamin A：6000000IU, vitamine D3：1000000IU, dimension Raw plain E：5g, Vitamin K3：2.4g, vitamin B1：3.6g, vitamin B2：1g, vitamin B6：2.4g, vitamin B12： 0.06g, FA：0.4g, vitamin C：8g, vitamin B5：8.4g, vitamin B3 acid amides：30g, biotin：1g.
- 2. a kind of preparation method of B B-complex liquid as claimed in claim 1, it is characterised in that comprise the following steps：1) vitamin B2 and FA and the compound of 2,6- dimethyl-β-cyclodextrins are prepared respectively；2) vitamin B2 and FA prepared step 1) and the compound of 2,6- dimethyl-β-cyclodextrins are given birth to other dimensions Element and additive are deployed into B B-complex liquid.
- A kind of 3. preparation method of B B-complex liquid as claimed in claim 2, it is characterised in that in step 1), the preparation The specific method of vitamin B2 and FA and the compound of 2,6- dimethyl-β-cyclodextrins is：The mol ratio of vitamin B2 and FA respectively with 2,6- dimethyl-β-cyclodextrins is dissolved in diformazan for 1 ︰ (1~10) Heated in sulfoxide solvent, obtain solution, solution is transferred in autoclave, be passed through carbon dioxide, then dimethyl sulfoxide is removed totally And dimethyl sulfoxide is reclaimed, obtain vitamin B2 and FA and the compound of 2,6- dimethyl-β-cyclodextrin.
- 4. a kind of preparation method of B B-complex liquid as claimed in claim 3, it is characterised in that the temperature of the heating is 60 DEG C, heat time 10min.
- 5. a kind of preparation method of B B-complex liquid as claimed in claim 3, it is characterised in that the carbon dioxide that is passed through will Pressure in autoclave is adjusted to 15MPa, and temperature is adjusted to 60 DEG C, stirs 1h.
- 6. a kind of preparation method of B B-complex liquid as claimed in claim 3, it is characterised in that gained vitamin B2 is in water Solubility reaches 1.7g/L, and FA solubility in water reaches 0.4g/L.
- 7. a kind of preparation method of B B-complex liquid as claimed in claim 2, it is characterised in that described to be deployed into step 2) The specific method of B B-complex liquid is：(1) vitamin A, vitamine D3, vitamin E, Vitamin K3 are added in water, by the tween that 100mL is added in every liter of water 80, after heating, solution A is obtained, is placed stand-by；(2) by vitamin B1, vitamin B6, vitamin B12, vitamin B5, the acid amides of vitamin B3, biotin and vitamin The compound inclusion of C, the vitamin B2 and FA obtained with step 1) and 2,6- dimethyl-β-cyclodextrin, then resist with different Bad blood sodium is jointly soluble in water, obtains solution B；(3) solution B that the solution A and step (2) obtained step (1) obtains merges, and supplies water, produces B B-complex Liquid.
- 8. a kind of preparation method of B B-complex liquid as claimed in claim 7, it is characterised in that in step 2) (1) part In, the temperature of the heating is 60 DEG C, heat time 1h.
- 9. a kind of preparation method of B B-complex liquid as claimed in claim 7, it is characterised in that in step 2) (2) part In, the dosage of the different Vitamin C sodium is 2g.
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| CN201711112237.9A CN107751576A (en) | 2017-11-13 | 2017-11-13 | A kind of B B-complex liquid and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991400A (en) * | 2020-10-10 | 2020-11-27 | 西南医科大学 | Vitamin B complex and application thereof in preventing and treating fungal infection |
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| EP0427078A1 (en) * | 1989-10-31 | 1991-05-15 | MAGIS FARMACEUTICI S.p.A. | Folinic acid-cyclodextrin inclusion compound |
| WO2003043602A1 (en) * | 2001-11-20 | 2003-05-30 | Korea Dds Pharmaceutical Co., Ltd. | Solid dispersions containing substituted cyclodextrin and insoluble drug and their preparations |
| CN101564384A (en) * | 2008-07-14 | 2009-10-28 | 烟台绿叶动物保健品有限公司 | Multivitamin aqueous solution preparation |
| CN101692871A (en) * | 2009-09-25 | 2010-04-14 | 河南工业大学 | Vitamin premix compound for aquatic feed |
| CN103830743A (en) * | 2014-03-13 | 2014-06-04 | 齐鲁工业大学 | Clathrate compound of Beta-menadione and hydrophilic Beta-cyclodextrin derivative and preparation method of clathrate compound |
| CN106265596A (en) * | 2016-10-12 | 2017-01-04 | 中国药科大学 | Supercritical anti-solvent prepares the method for naringenin/hydroxypropyl beta cyclodextrin microcapsule |
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2017
- 2017-11-13 CN CN201711112237.9A patent/CN107751576A/en active Pending
Patent Citations (6)
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|---|---|---|---|---|
| EP0427078A1 (en) * | 1989-10-31 | 1991-05-15 | MAGIS FARMACEUTICI S.p.A. | Folinic acid-cyclodextrin inclusion compound |
| WO2003043602A1 (en) * | 2001-11-20 | 2003-05-30 | Korea Dds Pharmaceutical Co., Ltd. | Solid dispersions containing substituted cyclodextrin and insoluble drug and their preparations |
| CN101564384A (en) * | 2008-07-14 | 2009-10-28 | 烟台绿叶动物保健品有限公司 | Multivitamin aqueous solution preparation |
| CN101692871A (en) * | 2009-09-25 | 2010-04-14 | 河南工业大学 | Vitamin premix compound for aquatic feed |
| CN103830743A (en) * | 2014-03-13 | 2014-06-04 | 齐鲁工业大学 | Clathrate compound of Beta-menadione and hydrophilic Beta-cyclodextrin derivative and preparation method of clathrate compound |
| CN106265596A (en) * | 2016-10-12 | 2017-01-04 | 中国药科大学 | Supercritical anti-solvent prepares the method for naringenin/hydroxypropyl beta cyclodextrin microcapsule |
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| 杨克迪等: "β-环糊精对叶酸的包合作用研究", 《高校化学工程学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991400A (en) * | 2020-10-10 | 2020-11-27 | 西南医科大学 | Vitamin B complex and application thereof in preventing and treating fungal infection |
| CN111991400B (en) * | 2020-10-10 | 2021-09-17 | 西南医科大学 | Vitamin B complex and application thereof in preventing and treating fungal infection |
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