CN107748189A - A kind of biology sensor - Google Patents
A kind of biology sensor Download PDFInfo
- Publication number
- CN107748189A CN107748189A CN201710880146.3A CN201710880146A CN107748189A CN 107748189 A CN107748189 A CN 107748189A CN 201710880146 A CN201710880146 A CN 201710880146A CN 107748189 A CN107748189 A CN 107748189A
- Authority
- CN
- China
- Prior art keywords
- electrode
- array
- substrate
- electrod
- biology sensor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6831—Straps, bands or harnesses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Electrochemistry (AREA)
- Optics & Photonics (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention relates to bioengineering field, relate in particular to a kind of biology sensor, including substrate, electrod-array is printed with substrate, electrod-array includes multiple working electrodes for being used to detect tissue fluid composition, substrate includes working region and wire area, prevents that connect lead interferes to working region covered with insulating barrier on wire area, there is provided multi-group electrode array on the same substrate.Multiple working electrode sensors that the present invention provides on same electrod-array, the detection range of tissue fluid concentration can greatly be put forward.In addition, insulating barrier is covered on connecting line in the present invention, avoids interference of the connecting line electric signal to measurement result, improve detection accuracy.
Description
Technical field
The present invention relates to bioengineering field, relates in particular to a kind of biology sensor.
Background technology
When carrying out tissue fluid detection to human body or animal body, biology sensor, biology sensor one are often used
As be concentration for detecting composition in tissue fluid, the working electrode in biology sensor is different according to its size of current, is adapted to
There is also difference, such as same type of tissue fluid components utilising for Different Individual various concentrations scope in the accurate region of detection
Working electrode detected, easily there is the problem of test section is accurate.
For example, the blood sugar concentration for being mainly characterized by slowly persistently rising of diabetes, in order to detect human blood glucose concentration, city
There are a variety of blood sugar test instruments on.The Chinese patent of Application No. 201180063434.0 discloses a kind of side of detectable concentration
Method, the system for detecting blood sugar break epidermis by fine acupuncture, and direct monitoring tissue liquid blood sugar concentration, the degree of accuracy is higher, still
Need to puncture human body skin, belong to minimal invasive techniques, and consumptive material is extremely expensive.
Also a kind of bioelectrode by reverses iontophoresis method, reverses iontophoresis method in epidermis by applying electricity
, the Na ions in tissue fluid are to movable cathode, and the Cl ions Ghandler motion that faces south moves, and skin is negatively charged under normal circumstances, Na ions
As the ion stream of main carriers, neutral glucose molecule is carried to skin surface, realizes the purpose of noninvasive extraction.However,
Blood sugar test product based on reverses iontophoresis method, minimal irritation skin when extracting interstitial fluid be present, it is inconvenient wiring to be present,
The problem of working electrode measurement blood glucose range is narrow.
The content of the invention
In order to solve drawbacks described above, a kind of present invention connecting line of offer is not easy to produce interference, tissue fluid to working electrode
Constituent concentration detection range is big, detects more accurately biology sensor.In order to reach this effect, the technology that the present invention uses
Scheme is as follows：
A kind of biology sensor, including substrate, electrod-array is printed with the substrate, is provided with the electrod-array
Multiple working electrodes for being used to detect tissue fluid composition, the electrod-array are connected to edges of substrate part shape by connecting line
Into wire connecting portion, the substrate includes working region and wire area, prevents from connecing covered with insulating barrier on the wire area and draws
Line interferes to working region.Multiple working electrodes can measure various concentrations scope glycemic parameters, the connection of electrod-array
Line can be connected on substrate with electrod-array in the edge of the same face, can also be connected to the edge of reverse side.In order to avoid even
Pair of connecting wires electrod-array interferes, and covers insulating barrier on the non-active area that connecting line passes through, the insulating barrier also acts as
The problem of preventing connecting line short circuit.
Preferably, the electrod-array also includes extracting electrode and reference electrode and electrode, the extraction electrode is used for
Tissue liquid to be detected is extracted, the reference electrode is used for the operating voltage of calibration electrode, described that electrode is used for
Loop is formed with working electrode.
Preferably, it is described extract electrode set electrod-array outermost and around inner side electrod-array by inner side
Including electrod-array " parcel ".Extract electrode and be arranged on the outermost of electrod-array, during work, extract the group that electrode extracts epidermis
Liquid is knitted, then tissue fluid is diffused into working electrode area to centre, is easy to working electrode absorption detecting tissue fluid composition.
Preferably, the extraction electrode is integrally in " falling U " types, the working electrode, reference electrode and electrode is respectively provided with
" falling in the extraction electrode of U " types, described " opening that the U " types that fall extract electrode is used for picking out lead." U " types that fall extract electrode
Setting cause internal work electrode distance extract electrode position it is all relatively near, aspirates tissue liquid is more uniformly accurate, is easy to carry
High detection precision.
Preferably, the area of multigroup working electrode is different, for testing different tissues liquid constituent concentration, multigroup work
The tissue fluid constituent concentration that electrode measures is analyzed with actual value, so as to obtain the data closest to actual value.Work
Electrode area is of different sizes, its operating current there is also difference, the working electrode of different operating electric current in measurement, what it was detected
The scope of the physiological parameters such as blood glucose is also different.Due to Different Individual or same individual within the different time cycle its tissue fluid
Constituent concentration has differences, and using the working electrode of different area size, its accurate testing degree is different, different operating electrode needle
Different range tissue fluid measurement of concetration effect is had differences.So same electrod-array uses multiple work in the present invention
Electrode, multiple working electrodes work simultaneously, can be accurately measured for the tissue fluid concentration range of various concentrations.
Preferably, multi-group electrode array is provided with the same substrate, and multi-group electrode array is covered on human body skin not
Same region detection.
Preferably, the working electrode on the multi-group electrode array for being covered in human body different zones staggeredly works.
Preferably, the electrod-array is two groups, and two arrays of electrodes array is symmetrical arranged.
Preferably, the working electrode on substrate, reference electrode, the region to electrode and tissue fluid absorption electrode are covered
Lid layer of gel disk, detection enzyme is provided with the gel disk.
Gel disk includes PEO, polyvinyl alcohol (PVA), chitosan or agarose；Detection enzyme component in gel disk
Also include bovine serum albumin (BSA) and/or buffer solution (PBS) and/or glucose oxidase (GOD) and/or preservative and/or guarantor
Humectant and/or penetrating agent and/or complexing agent and/or anti-interference agent.The specific composition of detection enzyme can detect people according to specific needs
Body biological parameter adjusts.
Preferably, the wire picked out on the substrate is connected in the control unit of substrate back, in described control unit
Bottom be additionally provided with fixing device for described control unit, substrate and gel disk to be fixed, connected in the fixing device
There is the fixing band for biology sensor to be fixed on to human body skin top layer.
The beneficial effects of the invention are as follows：Compared with existing biology sensor, what the present invention provided on same electrod-array
Multiple working electrode sensor constructions, the detection range and its detection accuracy of tissue fluid constituent concentration can greatly be improved.
In addition, covering insulating barrier in the present invention on connecting line, interference of the connecting line electric signal to measurement result is avoided, also another
On the one hand detection accuracy is improved.
Brief description of the drawings
Fig. 1 is electrode array configurations schematic diagram；
Fig. 2 is substrate face structural representation；
Fig. 3 is substrate back structural representation；
Fig. 4 is biological sensor fixing structure schematic diagram.
Wherein 1 is substrate, and 2 be electrod-array, and 3 be working electrode, and 4 is extract electrode, and 5 be reference electrode | to electrode, 6
It is wire connecting portion for connecting line, 61,7 be working region, and 8 be wire area, and 9 be insulating barrier, and 10 be gel disk, and 11 is single for control
Member, 12 be fixing device, and 13 be fixing band.
Embodiment
For the ease of the understanding of the present invention, it is described below in conjunction with the accompanying drawings：
As Figure 1-4, the present invention a kind of biology sensor of offer, including substrate 1, substrate 1 in specific application may be used
To be ceramics, glass, macromolecule or plastic or other material, electrod-array 2 is printed with substrate 1, is provided with electrod-array more
The individual working electrode 3 for being used to detect tissue fluid composition, the area of multiple working electrodes is different, for testing various concentrations scope
Tissue fluid constituent concentration.The size of working electrode 3 is different, and there is also difference, the work of different operating electric current for its operating current
For electrode in measurement, the scope of the physiological parameter such as its blood glucose detected is also different.Because Different Individual or same individual exist
Its tissue fluid concentration has differences in the different time cycle, and using the working electrode of different area size, its accurate testing degree differs
Sample, different operating electrode needle have differences to the measurement of concetration effect of the tissue fluid parameter such as different range blood glucose.So in this hair
Multiple working electrodes are used in bright on same electrod-array, multiple working electrodes work simultaneously, for the tissue of various concentrations
Liquid parameter area can accurately measure.After being measured, the tissue fluid composition that multiple working electrodes measure enters with actual value
Row comparative analysis, so as to obtain the data closest to actual value.
On substrate 1, electrod-array 2 is connected to the marginal portion of substrate 1 by connecting line 6 and forms wire connecting portion 61, substrate 1
Including working region 7 and wire area 8, because 6 have electric current by the way that current signal can be to biological electricity on the connecting line of wire area 8
The detection of pole interferes, in order to avoid this problem, covered with insulating barrier 9 on wire area 8.According to specifically used field
Scape, the connecting line of electrod-array can be connected on substrate with electrod-array in the edge of the same face, can also be connected to reverse side
Edge.In order to avoid connecting line interferes to electrod-array, insulation is covered on the non-active area that connecting line passes through
Layer.
In addition, electrod-array 2 extracts electrode 4 and is used to extract also including extraction electrode 4, reference electrode and to electrode 5
Tissue liquid to be detected, reference electrode 5 are used for the operating voltage of calibration electrode, electrode 5 are used for and working electrode
Form loop.In general, extract electrode 4 and be arranged on the outermost of electrod-array 2 and in the electrod-array general of inner side
Including the electrod-array " parcel " of side.Extract electrode 4 and be arranged on the outermost of electrod-array, during work, extract electrode 4 and extract table
The tissue fluid of skin, then tissue fluid be diffused into working electrode area to centre, be easy to the absorption detecting tissue fluid of working electrode 3 into
Point.
As a kind of embodiment, it is overall in " falling U " types, working electrode 3, reference electrode and electrode 5 is all provided with to extract electrode 4
Put and " falling in the extraction electrode of U " types, described " opening that the U " types that fall extract electrode is used for picking out lead." U " types that fall extract electricity
The setting of pole 4 make it that internal work electrode 3 is all relatively near apart from the position for extracting electrode 4, and extracting interstitial fluid is more uniformly accurate, just
Precision is detected in improving.Certainly " circle " type with opening can also be arranged to by extracting electrode 4, and its concrete shape can basis
Practical application scene and application demand adjustment.
In the present invention, multi-group electrode array is provided with the same substrate, and multi-group electrode array is covered in human body skin
Upper different zones detection, the working electrode being covered on the multi-group electrode array of human body different zones staggeredly work.
As one embodiment, electrod-array is two groups, and two arrays of electrodes array is symmetrical arranged.Certainly, the tool of electrod-array
Body quantity, and the method for distribution can adjust according to concrete application scene.
Working electrode 3 on substrate 1, reference electrode 5, to electrode 5 and the region overlay for extracting electrode 4 layer of gel
Disk 10, detection enzyme is provided with the gel disk 10.Detection enzyme reacted with tissue liquid, with reach detection tissue fluid into
Divide the purpose of concentration.
Gel disk includes PEO, polyvinyl alcohol (PVA), chitosan or agarose；Detection enzyme component in gel disk
Also include bovine serum albumin (BSA) and/or buffer solution (PBS) and/or glucose oxidase (GOD) and/or preservative and/or guarantor
Humectant and/or penetrating agent and/or complexing agent and/or anti-interference agent.The specific composition of detection enzyme can detect people according to specific needs
Body biological parameter adjusts.
The wire picked out on substrate 1 is connected in the control unit 11 of substrate back, in the bottom of described control unit
The fixing device 12 for described control unit, substrate and gel disk to be fixed is additionally provided with, use is connected with the fixing device
In the fixing band 13 that biology sensor is fixed on to human body skin top layer, in general, viscose is provided with the fixing band, can be straight
Connect and paste on human body skin, it is easy to use.
Above example is only present pre-ferred embodiments, not limiting the present invention, it is noted that all
Any modification, equivalent substitution and improvements made within the spirit and principles in the present invention etc. protection scope of the present invention it
It is interior.
Claims (10)
1. a kind of biology sensor, it is characterised in that including substrate, be printed with electrod-array, the electrode over the substrate
Multiple working electrodes for being used to detect tissue fluid constituent concentration are provided with array, the electrod-array is connected to institute by connecting line
State edges of substrate part and form wire connecting portion, the substrate includes working region and wire area, covered on the wire area
There is insulating barrier to prevent that connect lead interferes to working region.
2. a kind of biology sensor according to claim 1, it is characterised in that the electrod-array also includes extracting electricity
Pole, reference electrode and to electrode；
The extraction electrode is used to extract tissue liquid to be detected；
The reference electrode is used for the operating voltage of calibration electrode；
It is described that electrode is used to form loop with working electrode.
3. a kind of biology sensor according to claim 2, it is characterised in that the extraction electrode is arranged on electrod-array
Outermost and around medial electrode array by including medial electrode array " parcel ".
A kind of 4. biology sensor according to claim 3, it is characterised in that it is described extraction electrode integrally in " fall U " types,
The working electrode, reference electrode and electrode is arranged at " fall U " types extraction electrode in, it is described " fall U " types extract electrode
Opening be used for pick out lead.
A kind of 5. biology sensor according to any one in claim 1-4, it is characterised in that the multiple work electricity
The area of pole is different, and the tissue fluid composition of various concentrations scope is detected.
6. a kind of biology sensor according to any one in claim 1-5, it is characterised in that set on the same substrate
Multi-group electrode array is equipped with, multi-group electrode array is covered in different zones on human body skin and detected.
7. a kind of biology sensor according to claim 8, it is characterised in that described to be covered in the more of human body different zones
Working electrode on group electrod-array staggeredly works.
8. a kind of biology sensor according to claim 7, it is characterised in that the electrod-array is two groups, two groups of electricity
Pole array is symmetrical arranged.
9. a kind of biology sensor according to claim 2, it is characterised in that the working electrode on substrate, ginseng
The region overlay layer of gel disk of electrode is drawn than electrode, to electrode and tissue fluid, detection enzyme is provided with the gel disk.
A kind of 10. biology sensor according to claim 9, it is characterised in that the wire connection picked out on the substrate
In the control unit of substrate back, be additionally provided with the bottom of described control unit for by described control unit, substrate and
The fixing device that gel disk is fixed, it is connected with for biology sensor to be fixed on into consolidating for human body skin top layer in the fixing device
Determine band.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710423131.4A CN107064266A (en) | 2017-06-07 | 2017-06-07 | A kind of many working electrode glucose sensors and its manufacture method |
| CN2017104231314 | 2017-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107748189A true CN107748189A (en) | 2018-03-02 |
Family
ID=59615861
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710423131.4A Pending CN107064266A (en) | 2017-06-07 | 2017-06-07 | A kind of many working electrode glucose sensors and its manufacture method |
| CN201710885671.4A Pending CN107607599A (en) | 2017-06-07 | 2017-09-26 | A kind of biology sensor and its detection method |
| CN201710880146.3A Pending CN107748189A (en) | 2017-06-07 | 2017-09-26 | A kind of biology sensor |
| CN201721239301.5U Active CN207439993U (en) | 2017-06-07 | 2017-09-26 | A kind of biosensor |
| CN201721240002.3U Active CN207336426U (en) | 2017-06-07 | 2017-09-26 | A kind of biology sensor |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710423131.4A Pending CN107064266A (en) | 2017-06-07 | 2017-06-07 | A kind of many working electrode glucose sensors and its manufacture method |
| CN201710885671.4A Pending CN107607599A (en) | 2017-06-07 | 2017-09-26 | A kind of biology sensor and its detection method |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721239301.5U Active CN207439993U (en) | 2017-06-07 | 2017-09-26 | A kind of biosensor |
| CN201721240002.3U Active CN207336426U (en) | 2017-06-07 | 2017-09-26 | A kind of biology sensor |
Country Status (1)
| Country | Link |
|---|---|
| CN (5) | CN107064266A (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107064266A (en) * | 2017-06-07 | 2017-08-18 | 杭州暖芯迦电子科技有限公司 | A kind of many working electrode glucose sensors and its manufacture method |
| CN109384456A (en) * | 2018-11-23 | 2019-02-26 | 王俊杰 | A kind of ceramic sanitary appliance production technology |
| TWI696451B (en) * | 2019-01-15 | 2020-06-21 | 邱裕中 | Glucose detection system with band-pass infrared light |
| CN109655513B (en) * | 2019-01-25 | 2023-10-17 | 天津大学 | Self-calibration glucose continuous monitoring system and preparation method thereof |
| US12023150B2 (en) * | 2019-08-02 | 2024-07-02 | Bionime Corporation | Implantable micro-biosensor |
| CN112595763B (en) * | 2020-12-09 | 2022-10-14 | 华中科技大学 | Chemically modified electrode array sensor for detecting heavy metal ions in water body |
| CN113042345A (en) * | 2021-03-09 | 2021-06-29 | 京东方科技集团股份有限公司 | Sound wave transduction unit, manufacturing method thereof and sound wave transducer |
| CN114166910A (en) * | 2021-11-26 | 2022-03-11 | 北京大学 | Biosensor and manufacturing method thereof |
| CN114184661A (en) * | 2021-11-26 | 2022-03-15 | 北京大学 | Electrochemical sensor and manufacturing method thereof |
| CN217156402U (en) * | 2022-04-14 | 2022-08-09 | 深圳可孚生物科技有限公司 | Electrochemical sensor based on associated sensor |
| CN114557694B (en) * | 2022-04-28 | 2022-09-23 | 中国科学院大学 | Noninvasive subcutaneous tissue fluid extraction-detection device and extraction-detection method |
| CN114894865A (en) * | 2022-05-24 | 2022-08-12 | 四川大学 | High-precision glucose sensor and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0942278A2 (en) * | 1998-03-13 | 1999-09-15 | Cygnus, Inc. | Biosensor, iontophoretic sampling system and methods of use thereof |
| CN1497256A (en) * | 2002-09-19 | 2004-05-19 | 王湘生 | Non-invasive method for monitoring blood sugar and its device |
| CN2783321Y (en) * | 2002-09-19 | 2006-05-24 | 王湘生 | Wound free blood sugar monitoring device |
| CN105486731A (en) * | 2015-08-12 | 2016-04-13 | 成都市亿泰科技有限公司 | Terahertz-enhanced noninvasive blood-sugar detection probe |
| WO2016067037A1 (en) * | 2014-10-31 | 2016-05-06 | Inside Biometrics Limited | Method of using an electrochemical device |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4874282B2 (en) * | 2008-03-20 | 2012-02-15 | 株式会社デンソー | Gas sensor control device |
| CN102905621A (en) * | 2009-12-30 | 2013-01-30 | 马奎特急救护理股份公司 | Sensor arrangement for continuously measuring analytes in a biological fluid |
| CN105445339B (en) * | 2014-07-31 | 2018-07-06 | 天津大学 | A kind of flexibility differential type array electrochemical glucose sensor and application method |
| CN107064266A (en) * | 2017-06-07 | 2017-08-18 | 杭州暖芯迦电子科技有限公司 | A kind of many working electrode glucose sensors and its manufacture method |
-
2017
- 2017-06-07 CN CN201710423131.4A patent/CN107064266A/en active Pending
- 2017-09-26 CN CN201710885671.4A patent/CN107607599A/en active Pending
- 2017-09-26 CN CN201710880146.3A patent/CN107748189A/en active Pending
- 2017-09-26 CN CN201721239301.5U patent/CN207439993U/en active Active
- 2017-09-26 CN CN201721240002.3U patent/CN207336426U/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0942278A2 (en) * | 1998-03-13 | 1999-09-15 | Cygnus, Inc. | Biosensor, iontophoretic sampling system and methods of use thereof |
| CN1497256A (en) * | 2002-09-19 | 2004-05-19 | 王湘生 | Non-invasive method for monitoring blood sugar and its device |
| CN2783321Y (en) * | 2002-09-19 | 2006-05-24 | 王湘生 | Wound free blood sugar monitoring device |
| WO2016067037A1 (en) * | 2014-10-31 | 2016-05-06 | Inside Biometrics Limited | Method of using an electrochemical device |
| CN105486731A (en) * | 2015-08-12 | 2016-04-13 | 成都市亿泰科技有限公司 | Terahertz-enhanced noninvasive blood-sugar detection probe |
Also Published As
| Publication number | Publication date |
|---|---|
| CN207336426U (en) | 2018-05-08 |
| CN107064266A (en) | 2017-08-18 |
| CN107607599A (en) | 2018-01-19 |
| CN207439993U (en) | 2018-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN207439993U (en) | A kind of biosensor | |
| US10206604B2 (en) | Arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing | |
| US20050096520A1 (en) | Extracting device, extracting method, analyzer and analyzing method | |
| US20060178573A1 (en) | System and method for piercing dermal tissue | |
| US20070251836A1 (en) | Electrochemical sensor and method for analyzing liquid sample | |
| CN105445339B (en) | A kind of flexibility differential type array electrochemical glucose sensor and application method | |
| WO2014188070A1 (en) | An arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing | |
| EP1656881A1 (en) | Extraction device, analyser, extraction method, and analysis method | |
| JPH10506293A (en) | Ion introduction sampling apparatus and method | |
| CN109655513B (en) | Self-calibration glucose continuous monitoring system and preparation method thereof | |
| CN109730695A (en) | Tissue fluid detection device | |
| CN107328830B (en) | A kind of biosensor | |
| Ito et al. | A novel blood glucose monitoring system based on an ISFET biosensor and its application to a human 75 g oral glucose tolerance test | |
| CN210347520U (en) | Self-calibration glucose continuous monitoring system | |
| CN106404864A (en) | Method for detecting methyl jasmonate in plants on basis of microelectrode biosensing technique | |
| CN106645345A (en) | Flexible bioelectrode | |
| CN116429854A (en) | Method for improving glucose monitoring accuracy in reverse iontophoresis technology | |
| Sun et al. | Ionic components of wound current at mouse skin incisional wounds | |
| WO2020117170A1 (en) | Glucose biosensor based on polyphosphonoundecyl acrylate-co-polyvinylimidazole-co-polyvinylferrocene-co-polyglycidyl methacrylate tetra block copolymer | |
| US20210001119A1 (en) | Implantable integrated sensor device | |
| CN2228659Y (en) | Two-pole blood-sugar quick testing stripe | |
| CN206177872U (en) | Flexible bioelectrode | |
| CN106501331B (en) | PH sensor, preparation method and purposes | |
| CN108051596A (en) | A kind of Woundless blood sugar test paper and preparation method thereof | |
| CN116381014A (en) | Cortisol detection electrode system based on interstitial fluid and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180302 |