CN108051596A - A kind of Woundless blood sugar test paper and preparation method thereof - Google Patents
A kind of Woundless blood sugar test paper and preparation method thereof Download PDFInfo
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- CN108051596A CN108051596A CN201810049380.6A CN201810049380A CN108051596A CN 108051596 A CN108051596 A CN 108051596A CN 201810049380 A CN201810049380 A CN 201810049380A CN 108051596 A CN108051596 A CN 108051596A
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- test paper
- blood sugar
- confining bed
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
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Abstract
The present invention provides a kind of Woundless blood sugar test paper applied to blood glucose measurement product technical field, organic semiconductor film layer (5) is set between first electrode (2) and second electrode (3) on the test paper body (1) of Woundless blood sugar test paper of the present invention, glucose oxidase layer (6) is set on the 3rd electrode (4), the Woundless blood sugar test paper further includes confining bed (9), set test paper body (1) one side edge department of organic semiconductor film layer (5) and glucose oxidase layer (6) that concave part (10) is set, concave part (10) is arranged for one week along test paper body (1) edge department, confining bed (9) edge department is pasted with concave part (10) to be connected.The Woundless blood sugar test paper of the present invention, when can avoid the test paper from being not used inside organic semiconductor thin-film layer and glucose oxidase layer contacted with the external world, improve cleannes, improve testing precision in test paper use, raising blood glucose measurement performance.
Description
Technical field
The invention belongs to blood glucose measurement product technical fields, are to be related to a kind of Woundless blood sugar test paper more specifically,
The invention further relates to a kind of preparation methods of Woundless blood sugar test paper.
Background technology
Diabetes are to endanger one of four big diseases of human health, it is insulin relative or absolute deficiency and target in human body
Chronic disease caused by cell reduces insulin sensitivity.There is presently no the methods of thorough radical cure diabetes, clinically lead
It will be by jacking up monitoring blood sugar concentration come direction of medication usage.Except minimally invasive blood sugar detecting method, (this method needs to gather finger end
Blood is held, is made troubles to detected person and painful) outside, also there are many Woundless blood sugar measuring technologies now.And in the prior art
Woundless blood sugar tester when being tested, it is necessary to use test paper.A kind of noninvasive dynamics monitoring examination is disclosed in the prior art
Paper, for detecting the in vivo concentration of glucose of liquid, including：Test paper substrate, be arranged on first electrode on the test paper substrate,
Second electrode and the 3rd electrode are arranged on the organic semiconductor thin-film that first electrode and second electrode are connected on the test paper substrate
Material, the glucose oxidase being fixed on the 3rd electrode and covering are arranged on the insulating cover on the test paper substrate
Piece；The insulating cover on piece is provided with that the open slot of testing liquid, organic semiconductor thin-film material and grape glycosyloxy is added dropwise
Change enzyme to be exposed in the open slot simultaneously.The test paper of this structure, organic semiconductor thin-film material and grape are glycoxidative
Enzyme when test paper is not used, is easy to cause outside and receives pollution, and receives the test paper of pollution in use, can go out
The not accurate enough problem of existing test result.
The content of the invention
The technical problems to be solved by the invention are：There is provided it is a kind of simple in structure, when can effectively avoid the test paper from being not used
Internal organic semiconductor thin-film layer and glucose oxidase layer is contacted with the external world, improves cleannes, so as to when test paper uses
Testing precision is improved, improves the Woundless blood sugar test paper of blood glucose measurement performance.
Solve the problems, such as techniques discussed above, the technical solution that the present invention takes is：
The present invention is a kind of Woundless blood sugar test paper, and the Woundless blood sugar test paper includes test paper body, test paper
First electrode, second electrode, the 3rd electrode on body are set, organic semiconductor thin-film is set between first electrode and second electrode
Layer, glucose oxidase layer is set on the 3rd electrode, the test paper sheet of organic semiconductor film layer and glucose oxidase layer is set
Body one side sets insulation cover plate, and insulating cover on piece sets open slot, and organic semiconductor thin-film layer and glucose oxidase layer are located at
Open slot position, the Woundless blood sugar test paper further include confining bed, set organic semiconductor film layer and grape glycosyloxy
The test paper body one side edge department for changing enzyme layer sets concave part, and concave part is arranged for one week along test paper body edge department, confining bed side
It pastes and connects along portion and concave part.
The confining bed is structure made of paper material or plastic film material, and confining bed edge department is set along closing
The tear line of layer one week arrangement of edge department, tear line are arranged to be made of multiple circular holes by gap arrangement, also be set on confining bed
The burst bar of confining bed can be torn by putting.
Glue layer is set in the concave part of the test paper body, and confining bed edge department is fixed by glue layer and concave part
Connection, after confining bed edge department is fixedly connected by glue layer with concave part, confining bed edge department be arranged to be recessed extend in it is recessed
Structure in groove portion.
The confining bed includes front end and rear end portion, and burst bar one end is connected with front end or rear end portion adhesion, tears
Item is split for structure made of paper material or plastic film material.
The invention further relates to a kind of preparation method of Woundless blood sugar test paper, the systems of the Woundless blood sugar test paper
The preparation process of Preparation Method is：1) concave part is processed in test paper body edge department, test paper body is cleaned by alcohol,
Dry test paper body；2) first electrode, second electrode, the 3rd electrode, organic semiconductor thin-film are sequentially arranged on test paper body
Layer, glucose oxidase layer；3) confining bed identical with test paper body shape and size, the spreading glue in concave part are cut
Confining bed edge department by glue layer and concave part is pasted and connected by layer；4) confining bed portion of the pressure above concave part is applied
Position, the adhesion burst bar on confining bed, so as to complete the preparation of Woundless blood sugar test paper.
Technical solution using the present invention can obtain following advantageous effect：
Woundless blood sugar test paper and preparation method thereof of the present invention, on the basis of being test paper in the prior art
It is improved, when preparing test paper, first processes concave part in test paper body edge department, test paper body is carried out by alcohol
Cleaning, dry test paper body；Then first electrode, second electrode are sequentially arranged on test paper body, the 3rd electrode, organic is partly led
Thin-film layers, glucose oxidase layer form test paper；Then to test paper into closing, precedence is cut and test paper body
Confining bed edge department is passed through glue layer and concave part by the identical confining bed of shape and size, the spreading glue layer in concave part
Paste connection；Finally apply confining bed position of the pressure above concave part, the adhesion burst bar on confining bed, so as to complete nothing
Create the preparation of blood sugar test paper.Said structure, test paper is simple in structure, easy making process, can effectively to be not used when
The organic semiconductor thin-film layer and glucose oxidase layer of test paper play a protective role, and avoid outside contamination, improve test
Accuracy when test paper uses, and when using test paper, and can be ensured that test paper organic semiconductor thin-film layer and
Glucose oxidase layer is convenient and efficient outside, convenient for test liquid is substantially added dropwise in test, it is ensured that test paper is convenient
It uses.Test liquid of the present invention includes but not limited to saliva, urine, sweat, tissue fluid etc., in these test liquids
Comprising glucose, convenient for reacting blood sugar concentration by testing concentration of glucose.The present invention Woundless blood sugar test paper and
Its preparation method, can avoid test paper be not used when inside organic semiconductor thin-film layer and glucose oxidase layer connect with the external world
It touches, improves cleannes, testing precision is improved in test paper use, improve blood glucose measurement performance.
Description of the drawings
Brief description is made to the content expressed by each attached drawing of this specification and the mark in figure below：
Fig. 1 is the structure diagram of Woundless blood sugar test paper of the present invention；
Fig. 2 is structure diagram when Woundless blood sugar test paper of the present invention is not provided with confining bed；
Attached drawing acceptance of the bid, which is remembered, is respectively：1st, test paper body；2nd, first electrode；3rd, second electrode；4th, the 3rd electrode；5th, You Jiban
Conductor thin film layer；6th, glucose oxidase layer；7th, insulate cover plate；8th, open slot；9th, confining bed；10th, concave part；11st, tear line；
13rd, burst bar；14th, front end；15th, rear end portion.
Specific embodiment
Below against attached drawing, by the description of the embodiment, each structure for example involved to the specific embodiment of the present invention
The works such as mutual alignment and connection relation, the effect of each several part and operation principle between the shape of part, construction, each several part are further
Detailed description：
It is of the invention for a kind of Woundless blood sugar test paper, the Woundless blood sugar test paper as shown in attached drawing 1, attached drawing 2
Including test paper body 1, first electrode 2, second electrode 3, the 3rd electrode 4,2 and second electricity of first electrode are set on test paper body 1
Organic semiconductor film layer 5 between pole 3 is set, glucose oxidase layer 6 is set on the 3rd electrode 4, organic semiconductor film is set
The test paper body 1 of film layer 5 and glucose oxidase layer 6 sets insulation cover plate 7 on one side, sets open slot 8 on the cover plate 7 that insulate, has
Machine semiconductor film layer 5 and glucose oxidase layer 6 are located at 8 position of open slot, and the Woundless blood sugar test paper further includes
Confining bed 9 sets organic semiconductor film layer 5 and 1 one side edge department of the test paper body of glucose oxidase layer 6 to set concave part
10, concave part 10 is arranged for one week along 1 edge department of test paper body, and 9 edge department of confining bed is pasted with concave part 10 to be connected.Above-mentioned knot
Structure is improved on the basis of test paper in the prior art, when preparing test paper, first on 1 side of test paper body
Concave part 10 is processed along portion, test paper body 1 is cleaned by alcohol, dry test paper body 1；Then in test paper body 1
On be sequentially arranged first electrode 2, second electrode 3, the 3rd electrode 4, organic semiconductor thin-film layer 5, glucose oxidase layer 6, shape
Into test paper；Then to test paper into closing, precedence cuts the confining bed 9 identical with 1 shape and size of test paper body,
9 edge department of confining bed by glue layer with concave part 10 is pasted and is connected by spreading glue layer in concave part 10；Finally apply pressure
9 position of confining bed above concave part 10, the adhesion burst bar 13 on confining bed 9, so as to complete Woundless blood sugar test paper
Preparation.Said structure, test paper is simple in structure, easy making process, can effectively to be not used when test paper it is organic
Semiconductor film layer and glucose oxidase layer play a protective role, and avoid outside contamination, improve essence when test paper uses
Exactness, and when using test paper, and can be ensured that the organic semiconductor thin-film layer and glucose oxidase layer of test paper
It is convenient and efficient exposed to outer, convenient for test liquid is substantially added dropwise in test, it is ensured that test paper is easy to use.It is of the present invention
Test liquid, include but not limited to saliva, urine, sweat, tissue fluid etc., comprising glucose in these test liquids, just
In reacting blood sugar concentration by testing concentration of glucose.The Woundless blood sugar test paper of the present invention, can avoid test paper from not making
Organic semiconductor thin-film layer and glucose oxidase layer inside used time are contacted with the external world, cleannes are improved, when test paper uses
Testing precision is improved, improves blood glucose measurement performance.
The confining bed 9 is structure made of paper material or plastic film material, and 9 edge department of confining bed is set along envelope
The tear line 11 of 9 edge department of layer, one week arrangement is closed, tear line 11 is arranged to be made of multiple circular holes by gap arrangement, confining bed
The burst bar 13 of confining bed 10 can be torn by being also set up on 9.Said structure, the material selection of confining bed so that confining bed is being surveyed
Have a try paper when not in use can reliable closed test test paper body, avoid organic semiconductor thin-film layer and the grape on test paper body
Oxidase enzyme layer is contacted with the external world, so as to play a protective role, and when needing using test paper, and it is quick convenient for confining bed
It is laborsaving to tear.
Glue layer is set in the concave part 10 of the test paper body 1, and 9 edge department of confining bed passes through glue layer and concave part
10 are fixedly connected, and after 9 edge department of confining bed is fixedly connected by glue layer with concave part 10,9 edge department of confining bed is arranged to recessed
Into the structure extended in concave part 10.Test paper of the present invention with Woundless blood sugar tester, it is necessary to be used cooperatively,
Blood sugar concentration numerical value can be read out.After concave part is set, after confining bed is torn, even if confining bed edge department has residue to stay in
In concave part, test paper body surface will not be protruded from, in this way, when test paper is inserted into Woundless blood sugar tester, test
Confining bed residue on test paper is located in concave part, and the inserting for not interfering with test paper and Woundless blood sugar tester uses.
The confining bed 9 includes front end 14 and rear end portion 15,13 one end of burst bar and front end 14 or rear end portion 15
Adhesion connects, and burst bar 13 is structure made of paper material or plastic film material.The setting of burst bar is being needed using survey
Have a try paper when, convenient for along pull burst bar, tear confining bed from tear line.
The invention further relates to a kind of preparation method of Woundless blood sugar test paper, the systems of the Woundless blood sugar test paper
The preparation process of Preparation Method is：1) concave part 10 is processed in 1 edge department of test paper body, test paper body 1 is carried out by alcohol
Cleaning, dry test paper body 1；2) first electrode 2, second electrode 3, the 3rd electrode 4, organic is sequentially arranged on test paper body 1
Semiconductor film layer 5, glucose oxidase layer 6；3) confining bed 9 identical with 1 shape and size of test paper body is cut, in groove
9 edge department of confining bed by glue layer with concave part 10 is pasted and is connected by spreading glue layer in portion 10；4) pressure is applied in groove
9 position of confining bed of 10 top of portion, the adhesion burst bar 13 on confining bed 9, so as to complete the preparation of Woundless blood sugar test paper.
In use, can coordinate mating Woundless blood sugar tester, operation principle is noninvasive dynamics monitoring test paper of the present invention,
Test paper is inserted to after mating Woundless blood sugar tester, and Woundless blood sugar tester adds between the first electrode and the second electrode
One operating voltage (source-drain voltage), measurement pass through the electric current (channel current) of organic semiconductor thin-film layer, Woundless blood sugar test
Instrument adds another operating voltage (gate voltage), the raceway groove electricity of thin film transistor (TFT) between first electrode, the 3rd electrode at the same time
Stream can be regulated and controled be subject to gate voltage, when testing liquid is added drop-wise in the open slot of test paper, testing liquid and organic semiconductor
The thin bed of material and glucose oxidase layer contact simultaneously, at this time the glucose oxidase on the glucose and gate electrode in testing liquid
Electrochemical reaction forms electron exchange on gate electrode so that the interfacial potential of gate electrode changes, so as to cause Bao Tiguan
Channel current change.The concentration of glucose contained in the changing value and testing liquid of channel current is in certain relation,
Therefore the concentration of glucose contained in testing liquid can be reflected by measuring the electric current between first electrode, second electrode.
Since the test paper of the present invention make use of the principle that product body pipe signal amplifies, TFT has higher detection sensitivity and lower
Detectable limit.Heretofore described test paper and mating Woundless blood sugar tester are all of the prior art existing
Matured product, the present invention are that the defects of matured product is further improved.Therefore, innovation of the invention is embodied in existing
The local improvement of product.
Woundless blood sugar test paper and preparation method thereof of the present invention, on the basis of being test paper in the prior art
It is improved, when preparing test paper, first processes concave part in test paper body edge department, test paper body is carried out by alcohol
Cleaning, dry test paper body；Then first electrode, second electrode are sequentially arranged on test paper body, the 3rd electrode, organic is partly led
Thin-film layers, glucose oxidase layer form test paper；Then to test paper into closing, precedence is cut and test paper body
Confining bed edge department is passed through glue layer and concave part by the identical confining bed of shape and size, the spreading glue layer in concave part
Paste connection；Finally apply confining bed position of the pressure above concave part, the adhesion burst bar on confining bed, so as to complete nothing
Create the preparation of blood sugar test paper.Said structure, test paper is simple in structure, easy making process, can effectively to be not used when
The organic semiconductor thin-film layer and glucose oxidase layer of test paper play a protective role, and avoid outside contamination, improve test
Accuracy when test paper uses, and when using test paper, and can be ensured that test paper organic semiconductor thin-film layer and
Glucose oxidase layer is convenient and efficient outside, convenient for test liquid is substantially added dropwise in test, it is ensured that test paper is convenient
It uses.Test liquid of the present invention includes but not limited to saliva, urine, sweat, tissue fluid etc., in these test liquids
Comprising glucose, convenient for reacting blood sugar concentration by testing concentration of glucose.The present invention Woundless blood sugar test paper and
Its preparation method, can avoid test paper be not used when inside organic semiconductor thin-film layer and glucose oxidase layer connect with the external world
It touches, improves cleannes, testing precision is improved in test paper use, improve blood glucose measurement performance.
Illustrative description is carried out to the present invention above in conjunction with attached drawing, it is clear that concrete implementation of the present invention and from above-mentioned
The limitation of mode, as long as employing the various improvement or not improved by this of inventive concept and technical scheme of the present invention progress
The design of invention and technical solution directly apply to other occasions, within the scope of the present invention.
Claims (5)
1. a kind of Woundless blood sugar test paper, it is characterised in that：The Woundless blood sugar test paper includes test paper body (1),
First electrode (2), second electrode (3), the 3rd electrode (4), first electrode (2) and second electrode (3) are set on test paper body (1)
Between organic semiconductor film layer (5) is set, glucose oxidase layer (6) on the 3rd electrode (4) is set, organic semiconductor is set
The test paper body (1) of film layer (5) and glucose oxidase layer (6) one side sets insulation cover plate (7), is set on insulation cover plate (7)
Open slot (8) is put, organic semiconductor thin-film layer (5) and glucose oxidase layer (6) are located at open slot (8) position, the nothing
Wound blood sugar test paper further includes confining bed (9), sets the examination of organic semiconductor film layer (5) and glucose oxidase layer (6)
Hard copy body (1) one side edge department sets concave part (10), and concave part (10) is arranged for one week along test paper body (1) edge department, closing
Layer (9) edge department is pasted with concave part (10) to be connected.
2. Woundless blood sugar test paper according to claim 1, it is characterised in that：The confining bed (9) is papery material
Structure made of material or plastic film material, confining bed (9) edge department set the tear along one week arrangement of confining bed (9) edge department
Line (11), tear line (11) are arranged to be made of multiple circular holes by gap arrangement, and envelope can be torn by being also set up on confining bed (9)
Close the burst bar (13) of layer (10).
3. Woundless blood sugar test paper according to claim 1 or 2, it is characterised in that：The test paper body (1) it is recessed
Glue layer is set in groove portion (10), and confining bed (9) edge department is fixedly connected by glue layer with concave part (10), confining bed (9)
After edge department is fixedly connected by glue layer with concave part (10), confining bed (9) edge department is arranged to recessed and extends in concave part
(10) structure in.
4. Woundless blood sugar test paper according to claim 2, it is characterised in that：The confining bed (9) includes front end
Portion (14) and rear end portion (15), burst bar (13) one end are connected with front end (14) or rear end portion (15) adhesion, burst bar (13)
For structure made of paper material or plastic film material.
5. a kind of preparation method of Woundless blood sugar test paper, it is characterised in that：The preparation of the Woundless blood sugar test paper
The preparation process of method is：1) in test paper body (1), edge department processes concave part (10), by alcohol to test paper body (1)
It is cleaned, dry test paper body (1)；2) first electrode (2), second electrode (3), are sequentially arranged on test paper body (1)
Three electrodes (4), organic semiconductor thin-film layer (5), glucose oxidase layer (6)；3) cut and test paper body (1) shape and size
Confining bed (9) edge department in the interior spreading glue layer of concave part (10), is passed through glue layer and concave part by identical confining bed (9)
(10) connection is pasted；4) confining bed (9) position of pressure above concave part (10) is applied, the adhesion tear on confining bed (9)
Item (13), so as to complete the preparation of Woundless blood sugar test paper.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810049380.6A CN108051596A (en) | 2018-01-18 | 2018-01-18 | A kind of Woundless blood sugar test paper and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810049380.6A CN108051596A (en) | 2018-01-18 | 2018-01-18 | A kind of Woundless blood sugar test paper and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108051596A true CN108051596A (en) | 2018-05-18 |
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ID=62127830
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810049380.6A Withdrawn CN108051596A (en) | 2018-01-18 | 2018-01-18 | A kind of Woundless blood sugar test paper and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN108051596A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114563557A (en) * | 2022-04-08 | 2022-05-31 | 艾康生物技术(杭州)有限公司 | Multi-row detection device |
-
2018
- 2018-01-18 CN CN201810049380.6A patent/CN108051596A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114563557A (en) * | 2022-04-08 | 2022-05-31 | 艾康生物技术(杭州)有限公司 | Multi-row detection device |
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Application publication date: 20180518 |
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