CN107746451A - 丙烯酰胺温敏性水凝胶的合成 - Google Patents

丙烯酰胺温敏性水凝胶的合成 Download PDF

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CN107746451A
CN107746451A CN201710981554.8A CN201710981554A CN107746451A CN 107746451 A CN107746451 A CN 107746451A CN 201710981554 A CN201710981554 A CN 201710981554A CN 107746451 A CN107746451 A CN 107746451A
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赵世芬
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Yantai Zhiben Intellectual Property Operation and Management Co Ltd
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08F289/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08J2351/00—Characterised by the use of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers

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Abstract

本发明涉及丙烯酰胺温敏性水凝胶的合成，包括：准确称取0.5g甲叉双丙烯酰胺和2.0g过硫酸铵分别配成50mL溶液待用，将N‑马来酰化明胶N‑MAGEL0.3‑0.5g溶于40℃的7.8mL去离子水中，然后将明胶溶液置于10℃以下的水溶液中冰浴3‑10min，加入0.8‑1.2g N‑异丙基丙烯酰胺和交联剂Bis 1.2mL，待溶解后充入N2鼓泡15‑30min，加入引发剂TEMED充分搅拌10‑30min后，再加入促引发剂APS，快速搅拌30s，置于10℃的恒温槽中静置反应24h，用去离子水洗涤产物后将产物冷冻干燥得到水凝胶。

Description

丙烯酰胺温敏性水凝胶的合成
技术领域
本发明涉及丙烯酰胺温敏性水凝胶的合成，属于合成化学领域。
背景技术
水凝胶是由高分子共价键交联而形成的三维网状结构，是普遍存在于自然界中的一种常见的物质形态。智能水凝胶是一种能够感知周围环境中微小的化学或物理刺激，并做出迅速响应，而且自身的很多性质能够发生明显变化的一类特殊的水凝胶。它能够在水中溶胀吸收大量的水分，但又不溶解于水这与生物机体的许多结构具有相似性，近年来水凝胶已涉及到生物医学、材料科学、农学等诸多领域，许多研究人员对水凝胶的合成、性质以及实际应用进行了广泛的研究。
经过近几年来的研究发现，天然高分子化合物如明胶、壳聚糖等，不仅来源丰富，而且具有非常好的生物相容性和可降解性，并且能够通过各种方式引入水凝胶体系中，极大地弥补了传统职能水凝胶细胞毒性大、难降解的缺点。天然高分子化合物的引入进一步打开了智能水凝胶在医药生物领域高速发展的大门，并被广泛应用于水凝胶的制备和性质研究当中。明胶是一种可以再生的天然高分子物质，它以胶原蛋白的形式存在于生物体中。胶原蛋白在高温、强酸、强碱等条件下，容易变性转化为明胶。由于明胶能够通过胶原蛋白制备，使得明胶拥有了极好的生物相容性和较低的细胞毒性，在生物体内易于降解等突出优点。明胶的分子骨架中具有诸如氨基、羧基、羟基等性质活泼的基团，使之具有良好的化学活性，为明胶提供了进行化学改性的可能。
发明内容
本发明所要解决的技术问题是提供丙烯酰胺温敏性水凝胶的合成，技术方案如下：准确称取0.5g甲叉双丙烯酰胺和2.0g过硫酸铵分别配成50mL溶液待用，将N-马来酰化明胶N-MAGEL0.3-0.5g溶于40℃的7.8mL去离子水中，然后将明胶溶液置于10℃以下的水溶液中冰浴3-10min，加入0.8-1.2gN-异丙基丙烯酰胺和交联剂Bis 1.2mL，待溶解后充入N2鼓泡15-30min，加入引发剂TEMED充分搅拌10-30min后，再加入促引发剂APS，快速搅拌30s，置于10℃的恒温槽中静置反应24h，用去离子水洗涤产物后将产物冷冻干燥得到水凝胶。
本发明的有益效果是：制备工艺简易环保，成本低，适用范围广。
具体实施方式
实施例1
准确称取0.5g甲叉双丙烯酰胺和2.0g过硫酸铵分别配成50mL溶液待用，将N-马来酰化明胶N-MAGEL0.3g溶于40℃的7.8mL去离子水中，然后将明胶溶液置于10℃以下的水溶液中冰浴3min，加入0.8g N-异丙基丙烯酰胺和交联剂Bis 1.2mL，待溶解后充入N2鼓泡15min，加入引发剂TEMED充分搅拌10min后，再加入促引发剂APS，快速搅拌30s，置于10℃的恒温槽中静置反应24h，用去离子水洗涤产物后将产物冷冻干燥得到水凝胶。
实施例2
准确称取0.5g甲叉双丙烯酰胺和2.0g过硫酸铵分别配成50mL溶液待用，将N-马来酰化明胶N-MAGEL0.5g溶于40℃的7.8mL去离子水中，然后将明胶溶液置于10℃以下的水溶液中冰浴10min，加入1.2g N-异丙基丙烯酰胺和交联剂Bis 1.2mL，待溶解后充入N2鼓泡30min，加入引发剂TEMED充分搅拌30min后，再加入促引发剂APS，快速搅拌30s，置于10℃的恒温槽中静置反应24h，用去离子水洗涤产物后将产物冷冻干燥得到水凝胶。
实施例3
准确称取0.5g甲叉双丙烯酰胺和2.0g过硫酸铵分别配成50mL溶液待用，将N-马来酰化明胶N-MAGEL0.4g溶于40℃的7.8mL去离子水中，然后将明胶溶液置于10℃以下的水溶液中冰浴8min，加入1.0g N-异丙基丙烯酰胺和交联剂Bis 1.2mL，待溶解后充入N2鼓泡20min，加入引发剂TEMED充分搅拌20min后，再加入促引发剂APS，快速搅拌30s，置于10℃的恒温槽中静置反应24h，用去离子水洗涤产物后将产物冷冻干燥得到水凝胶。
以上所述仅为本发明的较佳实施例，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (2)

1.丙烯酰胺温敏性水凝胶的合成，其特征在于，包括：准确称取0.5g甲叉双丙烯酰胺和2.0g过硫酸铵分别配成50mL溶液待用，将N-马来酰化明胶N-MAGEL0.3-0.5g溶于40℃的7.8mL去离子水中，然后将明胶溶液置于10℃以下的水溶液中冰浴3-10min，加入0.8-1.2gN-异丙基丙烯酰胺和交联剂Bis 1.2mL，待溶解后充入N2鼓泡15-30min，加入引发剂TEMED充分搅拌10-30min后，再加入促引发剂APS，快速搅拌30s，置于10℃的恒温槽中静置反应24h，用去离子水洗涤产物后将产物冷冻干燥得到水凝胶。
2.根据权利要求1所述的合成方法，其特征在于，所述反应温度为40度。
CN201710981554.8A 2017-10-20 2017-10-20 丙烯酰胺温敏性水凝胶的合成 Withdrawn CN107746451A (zh)

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Publication number Priority date Publication date Assignee Title
CN109513038A (zh) * 2018-12-14 2019-03-26 华南理工大学 负载铜金属有机骨架纳米粒子的温敏水凝胶及其制备方法
CN112029056A (zh) * 2020-07-31 2020-12-04 绍兴诺鼎卫浴洁具股份有限公司 一种多重交联型高强度温敏性水凝胶及其制法

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CN102911311A (zh) * 2012-11-06 2013-02-06 中国科学院长春应用化学研究所 一种共聚物水凝胶及其制备方法
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CN102911311A (zh) * 2012-11-06 2013-02-06 中国科学院长春应用化学研究所 一种共聚物水凝胶及其制备方法
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109513038A (zh) * 2018-12-14 2019-03-26 华南理工大学 负载铜金属有机骨架纳米粒子的温敏水凝胶及其制备方法
CN112029056A (zh) * 2020-07-31 2020-12-04 绍兴诺鼎卫浴洁具股份有限公司 一种多重交联型高强度温敏性水凝胶及其制法

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Application publication date: 20180302