CN107744607A - A kind of anti-infection hemodialysis tube - Google Patents

A kind of anti-infection hemodialysis tube Download PDF

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Publication number
CN107744607A
CN107744607A CN201711119774.6A CN201711119774A CN107744607A CN 107744607 A CN107744607 A CN 107744607A CN 201711119774 A CN201711119774 A CN 201711119774A CN 107744607 A CN107744607 A CN 107744607A
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China
Prior art keywords
dialysis
infection
inner tube
ptfe
polytetrafluoroethylene
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CN201711119774.6A
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Chinese (zh)
Inventor
郑浩
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Chengdu Cedisen Biological Technology Co Ltd
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Chengdu Cedisen Biological Technology Co Ltd
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Priority to CN201711119774.6A priority Critical patent/CN107744607A/en
Publication of CN107744607A publication Critical patent/CN107744607A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/02—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/043—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1623—Disposition or location of membranes relative to fluids
    • A61M1/1625—Dialyser of the outside perfusion type, i.e. blood flow outside hollow membrane fibres or tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/76—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74
    • B01D71/80—Block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M2025/0039—Multi-lumen catheters with stationary elements characterized by lumina being arranged coaxially
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/12—Blood circulatory system

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Abstract

The invention discloses a kind of anti-infection hemodialysis tube, it is related to field of medical device.The anti-infection hemodialysis tube of the present invention includes dialysis outer pipe, dialysis inner tube and dialysis membrane, and the dialysis outer pipe is sheathed on the dialysis inner tube periphery and leaves space between dialysis inner tube, and the dialysis membrane is wrapped in the dialysis outer wall of inner tube；The dialysis inner tube is U-shaped or V-structure, opening are respectively inlet and liquid outlet；The dialysis outer pipe and the tubing of the dialysis inner tube are polytetrafluoroethylene (PTFE) polyurethane nano silver composite material.In the present invention, dialysis tubing is placed directly within intravascular, blood need not be extracted out external again through machine progress hemodialysis, the Nano Silver of tubing can effectively reduce the infection risk in blood dialysis, chitosan quaternary ammonium salt in dialysis membrane film makes composite membrane be in electropositive, positive charge barrier is formed, the bacterium effectively resisted in dialyzate enters blood, further reduces blood infection occurrence probability in dialysis procedure.

Description

A kind of anti-infection hemodialysis tube
Technical field
The present invention relates to field of medical device, especially a kind of anti-infection hemodialysis tube.
Background technology
Haemodialysis is the principle flowed using solute by the low side of the high lateral concentration of concentration, by blood and dialysis Both solution of liquid introduce the dialyzer with hollowfibre semi-permeable membrance simultaneously, allow blood to be located at the one of hollowfibre semi-permeable membrance Side, dialyzate are located at the opposite side of hollowfibre semi-permeable membrance, make the solution of film both sides by disperse and osmosis, to remove people In in body blood, small molecule toxins, meanwhile, the electrolyte in blood can also reach balance by osmosis, so as to reach To the purpose for realizing blood purification.
Haemodialysis is also treatment edema disease, acute and chronic Delayed graft function（Uremia）And acute drugs poisoning and agriculture The common method of medicine poisoning.China has the up to ten million Chronic Renal Failure Patients to need to remain raw with conventional hemodialysis every year at present Life, and have the trend increased year by year.
Traditional haemodialysis equipment usually requires to lead to the blood of patient in vitro, is dialysed in outside using dialysis apparatus Defeated time patient's body again afterwards.The process has the problem of following several respects：（1）Blood is in vitro, is likely to result in patient's body blood Capacity is drastically reduced or raised, and causes unstable blood pressure to even result in death；（2）Extracorporal dialysis process is typically only capable to persistently several small When, it can not continue, carry out haemodialysis for a long time, smoothly for patient；(3) extracorporal dialysis instrument is huge, it is difficult to which transport is, it is necessary to specially Goalkeeper patient is delivered to dialysate chamber, or huge extracorporal dialysis machine is transported to patient bedside, increase treatment difficulty.Then it is existing There is built-in hemodialysis tube, such dialysis tubing is placed directly within blood vessel, external again through machine without blood is extracted out Carry out hemodialysis.But the process has occurred the problem of new：Blood vessel is placed directly within, adds the risk of microorganism infection.
The content of the invention
The goal of the invention of the present invention is：For above-mentioned problem, there is provided a kind of anti-infection hemodialysis tube, this is saturating The part that analysis pipe is placed in blood vessel is made of polytetrafluoroethylene (PTFE)-polyurethane-nano silver composite material, the composite bio-compatible Property is good, and Nano Silver therein is effective against bacterium infection.
The technical solution adopted by the present invention is as follows：
A kind of anti-infection hemodialysis tube, it includes dialysis outer pipe, dialysis inner tube and dialysis membrane, the dialysis outer pipe and is sheathed on institute State dialysis inner tube periphery and leave space between dialysis inner tube, the dialysis membrane is wrapped in the dialysis outer wall of inner tube；It is described Inner tube of dialysing is U-shaped or V-structure, opening are respectively inlet and liquid outlet；The dialysis outer pipe and the dialysis inner tube Tubing be polytetrafluoroethylene (PTFE)-polyurethane-nano silver composite material.
A kind of anti-infection hemodialysis tube of the present invention, the original of the polytetrafluoroethylene (PTFE)-polyurethane-nano silver composite material Expect including polytetrafluoroethylene (PTFE) 54 parts of the dispersion liquid of concentration in terms of mass fraction, 38 parts of diisocyanate, 14 parts of polycaprolactone glycol, 0.8 part of Nano Silver, 0.08 part of BDO, 0.04 part of stannous octoate, 0.13 part of trimethyolol propane monoallyl ether, February 0.07 part of dilaurylate.
A kind of anti-infection hemodialysis tube of the present invention, the polytetrafluoroethylene (PTFE)-polyurethane-nano silver composite material pass through Following steps are prepared：
Step 1：Polytetrafluoroethylene (PTFE) is concentrated into dispersion liquid, diisocyanate, polycaprolactone glycol is heated to 80 after being stirred DEG C, BDO and stannous octoate are added, continues stirring and heating response 3h, then heats to 90 DEG C, and add three hydroxyl first Base propane mono allyl ether continues to react 3h, you can obtains polytetrafluoroethylene (PTFE)-compound polyurethane material；
Step 2：By polytetrafluoroethylene (PTFE)-compound polyurethane material be scattered in mass fraction be 8% IPDI/ In cyclohexane solution, dibutyl tin laurate is added, magnetic agitation reacts 4h at 25 DEG C, and product is rinsed with absolute ether, and Vacuum drying, obtains polytetrafluoroethylene (PTFE)-compound polyurethane material.
Step 3：Nano Silver is scattered in dimethyl sulfoxide, pH to 8.2 is adjusted with sodium carbonate liquor, adds to polytetrafluoroethyl-ne Alkene-compound polyurethane material, 4h is reacted at 25 DEG C, is first washed with absolute ether, then be washed with deionized water net, be dried in vacuo and produce Polytetrafluoroethylene (PTFE)-polyurethane-nano silver composite material.
By adopting the above-described technical solution, the dialysis tubing can be placed directly within blood vessel, it is external without blood is extracted out Hemodialysis is carried out through machine again, so that on human blood-pressure without influence, polytetrafluoroethylene (PTFE)-polyurethane-nano silver composite material biofacies Capacitive is high, and is fixed with Nano Silver in the composite, has good anti-microbial property, prevents and treats dialysis tubing related infection, And then extend indwelling time of the dialysis tubing in patient's body.
A kind of anti-infection hemodialysis tube of the present invention, the dialysis membrane is chitosan quaternary ammonium salt-polymeric lactic acid compound film, should The raw material of composite membrane is included according to the mass fraction：28 parts of chitosan quaternary ammonium salt, 109 parts of PLA, 32 parts of polyethylene glycol, heparin 0.6 part, 0.13 part of ethylenediamine, 0.6 part, N of GMA, 0.07 part of N- dicyclohexylcarbodiimides, fourth two 0.03 part of acid imide.
By adopting the above-described technical solution, chitosan quaternary ammonium salt-polymeric lactic acid compound film biocompatibility is high, fix thereon There is heparin that there is blood coagulation resisting function, improve the security of blood dialysis.In addition, the chitosan quaternary ammonium salt in composite membrane It is in electropositive to make composite membrane, forms positive charge barrier, and the bacterium effectively resisted in dialyzate enters blood, further reduces dialysis During blood infection occurrence probability.
Anti- infection hemodialysis tube provided by the invention can be according to the needs of patient, in vivo indwelling Or so fortnight, continuous dialysis is on the one hand realized, on the other hand avoid puncturing the injury to caused by patient repeatedly.
A kind of anti-infection hemodialysis tube of the present invention, it also includes connecting portion, and the connecting portion is connected to the dialysis Outer tube；The connecting portion is provided with regulating valve to open or close the inlet and/or liquid outlet and regulation flow velocity；It is described Regulating valve includes feed liquor regulating valve and goes out liquid regulating valve；Feed liquor regulating valve and/or go out liquid regulating valve and be respectively arranged at connecting portion Top or bottom.
The anti-infection hemodialysis tube of a kind of the present invention, the feed liquor regulating valve include cell body and roller；The roller It is arranged in the cell body；The cell body is obliquely installed, and two side is provided with roller rolling guide, and bottom sets flexible skin Bar；The inlet is arranged at the lower section in the middle part of the elastic leather strap.
By adopting the above-described technical solution, connecting portion realizes that dialysis tubing and extracorporal dialysis liquid import and guiding device Combination.In use, connecting portion is in vitro.The flow of inlet and/or liquid outlet can be adjusted for regulating valve, can also close Inlet and/or liquid outlet are closed to stop dialysing.The regulation of regulating valve is by adjusting squeezing for pair of rollers inlet and/or liquid outlet Pressure surface product is realized.The elastic leather strap set between roller and inlet and/or liquid outlet has cushioning effect, avoids roller from destroying Inlet and/or liquid outlet.
A kind of anti-infection hemodialysis tube of the present invention, the dialysis inner tube spiral are set.
By adopting the above-described technical solution, the dialysis inner tube that spiral is set can be effectively increased dialysis area, improve saturating Analyse efficiency.
A kind of anti-infection hemodialysis tube of the present invention, fixation is provided between the connecting portion and the dialysis outer pipe Portion, the fixed part include fixed seat and the fin being symmetricly set on for a pair in fixed seat.
As a result of above-mentioned technical side, the fin of fixed part can be effectively increased for fixed area, make device easy It is fixed, dialysis tubing is avoided in the harm that intra-arterial is mobile or slides.
A kind of anti-infection hemodialysis tube of the present invention, the dialysis outer pipe is engraved structure.
By adopting the above-described technical solution, the engraved structure of dialysis outer pipe, easily facilitates blood and enters in dialysis outer pipe Dialysis is carried out with the dialyzate in dialysis inner tube to exchange.
A kind of anti-infection hemodialysis tube of the present invention, the one end of the dialysis outer pipe away from inlet are provided with hard modeling Material head.
By adopting the above-described technical solution, dialysis portion insertion artery is being to play a part of to break through by rigid plastics head, prevent Only tube head is excessively soft, inserts and does not enter blood vessel.Rigid plastics can use the high material of biocompatibility, such as polycaprolactone in the prior art And Terlux.
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
1. dialysis tubing be placed directly within it is intravascular, without blood extract out it is external carry out hemodialysis through machine again, due to having in tubing Nano Silver, reduce the infection risk in blood dialysis.
2. using a kind of new dialysis membrane, heparin is fixed with the dialysis membrane has blood coagulation resisting function, and it is saturating to improve blood The security of analysis process, the chitosan quaternary ammonium salt in film make composite membrane be in electropositive, form positive charge barrier, effectively resist dialysis Bacterium in liquid enters blood, further reduces blood infection occurrence probability in dialysis procedure.
Brief description of the drawings
Examples of the present invention will be described by way of reference to the accompanying drawings, wherein：
Fig. 1 is the schematic diagram that dialysis tubing, connecting portion and fixed part provided by the invention coordinate；
Fig. 2 is the schematic diagram of dialysis tubing；
Fig. 3 is the diagrammatic cross-section of liquid feed valve.
In figure, 1 is dialysis tubing, and 11 be dialysis outer pipe, and 12 dialysis inner tubes, 121 be inlet, and 122 be liquid outlet, and 2 be company Socket part, 21 be cell body, and 22 be roller, and 23 be elastic leather strap, and 3 be fixed part, and 31 be fixed seat, and 32 be fin.
Embodiment
All features disclosed in this specification, or disclosed all methods or during the step of, except mutually exclusive Feature and/or step beyond, can combine in any way.
This specification（Including any accessory claim, summary）Disclosed in any feature, unless specifically stated otherwise, Replaced by other equivalent or with similar purpose alternative features.I.e., unless specifically stated otherwise, each feature is a series of An example in equivalent or similar characteristics.
As Figure 1-3, the present embodiment provides a kind of hemodialysis system, and it includes dialysis tubing 1, is connected to dialysis tubing 1 Connecting portion 2, the fixed part 3 being arranged between dialysis tubing 1 and connecting portion 2, dialysis fluid container 4, peristaltic pump 5 and waste liquid cylinder 6. Dialysis fluid container 4 is connected to connecting portion by feed tube 41, and peristaltic pump 5 is connected to connecting portion by drain pipe, and waste liquid cylinder 6 passes through Conduit is connected to peristaltic pump 5.
Dialysis tubing 1 includes dialysis outer pipe 11, dialysis inner tube 12 and dialysis membrane.Dialysis outer pipe 11 is sheathed on dialysis inner tube 12 Periphery, space is left between dialysis outer pipe 11 and dialysis inner tube 12 in order to which blood circulation, the hollow out of dialysis outer pipe 11 are set, so as to In the space that blood enters dialysis outer pipe 11 between inner tube 12 of dialysing.Dialysis membrane wrap with dialysis inner tube 12 outer wall on, can Think that dialysis inner tube 12 plays support dialysis membrane or moulding for dialysis membrane.Circulation dialyzate, dialysis tubing in inner tube 12 of dialysing 12 U-shaped or V-structures, that is, two openings of inner tube 12 of dialysing are positioned at same one end of dialysis outer pipe 11, one of opening Inlet 121, another opening is liquid outlet 122.
Connecting portion 2 is connected to dialysis tubing 1, and dialysis inner tube 12 runs through connecting portion 1, and inlet 121 and liquid outlet 122 distinguish position In connecting portion, it is easy to dialysis tubing 1 and outside connection.Connecting portion 2, which is provided with, feed liquor regulating valve and goes out liquid regulating valve, to open or Inlet 121 and/or liquid outlet 122 are closed, or adjusts feed liquor and/or goes out liquid speed degree.Regulating valve may be provided at connecting portion Top or bottom.In the present embodiment, feed liquor regulating valve and go out the top that liquid regulating valve is symmetricly set on connecting portion, feed liquor regulating valve Including cell body 21 and roller 22, roller 22 is arranged in cell body 21, and the top droop of cell body 21 is set, and higher end is low, and two Side wall sets the guide rail for being provided with the rolling of roller 22, and the lower section of roller 22 sets flexible leather strap 23, and inlet 121 is located at elastic skin The lower section of bar 23.Roller 22 extrudes elastic leather strap 23 when being rolled on guide rail from higher one section of cell body 21 to relatively low one section The inlet 121 of lower section, in diverse location, squish area is different, so as to realize the fluid velocity of regulation inlet 121 or open Close.Go out liquid regulating valve to be symmetrical arranged with feed liquor regulating valve, structure is identical, repeats no more herein.
Fixed part 3 is arranged between dialysis tubing 1 and connecting portion 2, for fixing dialysis tubing 1.Fixed part 3 includes fixed seat 31 With a pair of fins 32 being symmetricly set in fixed seat 31, fin 32 is used to increase fixed-area, and fin 32 can be relative to fixation Seat 31 rotates, and easily facilitates fixation.
Before being dialysed to patient, puncture is first passed through, dialysis tubing 1 is inserted into femoral artery in human body with seal wire or sheath Or in radial artery, then with one with adhesive tape by fixed part 3 fix on a patient body, by dialyse inner tube 12 inlet 121 with Outside feeding device connection, the liquid outlet 122 for inner tube 12 of dialysing is connected with outside liquid discharge device, what outside feeding device provided Dialyzate enters dialysis inner tube 12 and dialysed with the blood in dialysis outer pipe 11 through dialysis membrane, excessive moisture and small molecule in blood Toxin is sustainable to be infiltrated through in dialyzate, leaves blood, and as dialyzate through liquid outlet 122 flows out the external mesh for reaching dialysis 's.During dialysis, can by adjust feed liquor regulating valve and/or go out liquid adjust valve regulation dialyzate flow velocity with adjust dialysis speed Rate.After dialysis terminates, be first shut off feed liquor regulating valve and going out liquid regulating valve, be then turned off inlet 121 and liquid outlet 122 with The connection of outside feeding device and liquid discharge device.Dialysis tubing 1 can be according to the needs of patient, indwelling fortnight in vivo Left and right.
Embodiment 2
The present embodiment provides a kind of polytetrafluoroethylene (PTFE)-polyurethane-nano silver composite material and preparation method thereof, the polytetrafluoroethyl-ne Alkene-polyurethane-nano silver composite material has good biocompatibility and antibiotic property, and it is saturating that it is used as the built-in property of haemodialysis Analysis pipe has good application prospect.Polytetrafluoroethylene (PTFE)-polyurethane-the nano silver composite material is made by the steps：
Step 1：Polytetrafluoroethylene (PTFE) concentration dispersion liquid 54g, diisocyanate 38g are weighed, polycaprolactone glycol 14g, is stirred After be heated to 80 DEG C, thereto add BDO 0.08g and stannous octoate 0.06g, continue to stir and maintain heating-up temperature 3h is reacted, then heats to 90 DEG C, and adds 0.13g trimethyolol propane monoallyl ethers and continues to react 3h, you can is gathered Tetrafluoroethene-compound polyurethane material；
Step 2：Polytetrafluoroethylene (PTFE)-the compound polyurethane material obtained in step 1 is scattered in the different Buddhist that mass fraction is 8% In your ketone diisocyanate/cyclohexane solution, 0.07g dibutyl tin laurates are added thereto, and magnetic agitation is anti-at 25 DEG C 4h is answered, after the completion of reaction, product is rinsed with absolute ether, and is dried in vacuo, and obtains polytetrafluoroethylene (PTFE)-compound polyurethane material.
Step 3：0.8g Nano Silvers are scattered in dimethyl sulfoxide, pH to 8.2 is adjusted with sodium carbonate liquor, are added to step Rapid two obtained polytetrafluoroethylene (PTFE)-compound polyurethane materials, 4h are reacted at 25 DEG C, product is first washed with absolute ether, then is spent Ionized water is cleaned, and is dried in vacuo and is produced polytetrafluoroethylene (PTFE)-polyurethane-nano silver composite material.
Embodiment 3
The present embodiment provides a kind of chitosan quaternary ammonium salt-polymeric lactic acid compound film and preparation method thereof, the chitosan quaternary ammonium salt-poly- breast Sour composite membrane is electropositive hollow-fibre membrane, and it is used as the dialysis membrane of haemodialysis and had a good application prospect.The chitosan Quaternary ammonium salt-polymeric lactic acid compound film is made by the steps：
Step 1：Chitosan quaternary ammonium salt 28g, PLA 109g, polyethylene glycol 32g are taken, 1L diformazans Asia is dissolved under the conditions of 50 DEG C PLA mixed liquor is obtained in sulfone；GMA 0.6g is added into PLA mixed liquor, is passed through nitrogen 0.001g azodiisobutyronitriles are added after 30min, 60 DEG C is warming up to and carries out Raolical polymerizable 20h under nitrogen protection, obtain To the chitosan quaternary ammonium salt-PLA casting solution for being mixed with GMA.
Step 2：Reactor will be poured into after chitosan quaternary ammonium salt in step 1-PLA casting solution deaeration filtering, used Dry/wet induction phase inversion is spun into hollow-fibre membrane；By in chitosan quaternary ammonium salt-polylactic acid hollow fiber membrane deionized water 24h is soaked, except the dimethyl sulfoxide remained on striping, dries, is prepared into chitosan quaternary ammonium salt-polylactic acid hollow fiber membrane component； 0.13g ethylenediamines are dissolved in the PBS that 1L concentration is 0.1mol/L, inject the hollow fibre of chitosan quaternary ammonium salt-PLA The reaction that membrane module inner chamber carries out epoxide group and amino is tieed up, 36h is reacted at 4 DEG C, obtains the chitosan season that ethylenediamine was modified Ammonium salt-polylactic acid hollow fiber membrane；Unreacted ethylenediamine is washed with deionized water.
Step 3：Taking heparin 0.6g, it is dissolved in the 0.1mol/L PBSs that pH is 4, adds N, N- dicyclohexyls Carbodiimide 0.07g and succimide 0.03g；Heparin is activated into 8h in advance at 2 DEG C, the heparin injection after activation was modified Chitosan quaternary ammonium salt-polylactic acid hollow fiber membrane inner chamber, react 48h at 4 DEG C, produce.
The invention is not limited in foregoing embodiment.The present invention, which expands to, any in this manual to be disclosed New feature or any new combination, and disclose any new method or process the step of or any new combination.

Claims (10)

1. a kind of anti-infection hemodialysis tube, it is characterised in that it includes dialysis outer pipe, dialysis inner tube and dialysis membrane, described Analysis outer tube sleeve leaves space located at the dialysis inner tube periphery and between dialysis inner tube, and the dialysis membrane is wrapped in the dialysis Outer wall of inner tube；The dialysis inner tube is U-shaped or V-structure, opening are respectively inlet and liquid outlet；The dialysis outer pipe with The tubing of the dialysis inner tube is polytetrafluoroethylene (PTFE)-polyurethane-nano silver composite material.
2. anti-infection hemodialysis tube according to claim 1, it is characterised in that the polytetrafluoroethylene (PTFE)-polyurethane-is received Rice silver composite material raw material include in terms of mass fraction polytetrafluoroethylene (PTFE) concentration 54 parts of dispersion liquid, 38 parts of diisocyanate, 14 parts of polycaprolactone glycol, 0.8 part of Nano Silver, 0.08 part of BDO, 0.04 part of stannous octoate, trimethylolpropane monoene 0.13 part of propyl ether, 0.07 part of dibutyl tin laurate.
3. anti-infection hemodialysis tube according to claim 2, it is characterised in that the polytetrafluoroethylene (PTFE)-polyurethane-is received Rice silver composite material, which is made by the steps, to be formed：
Step 1：Polytetrafluoroethylene (PTFE) is concentrated into dispersion liquid, diisocyanate, polycaprolactone glycol is heated to 80 after being stirred DEG C, BDO and stannous octoate are added, continues stirring and heating response 3h, then heats to 90 DEG C, and add three hydroxyl first Base propane mono allyl ether continues to react 3h, you can obtains polytetrafluoroethylene (PTFE)-compound polyurethane material；
Step 2：By polytetrafluoroethylene (PTFE)-compound polyurethane material be scattered in mass fraction be 8% IPDI/ In cyclohexane solution, dibutyl tin laurate is added, magnetic agitation reacts 4h at 25 DEG C, and product is rinsed with absolute ether, and Vacuum drying, obtains polytetrafluoroethylene (PTFE)-compound polyurethane material；
Step 3：Nano Silver is scattered in dimethyl sulfoxide, pH to 8.2 is adjusted with sodium carbonate liquor, is added to polytetrafluoroethylene (PTFE)-poly- Urethane composite, 4h is reacted at 25 DEG C, is first washed with absolute ether, then be washed with deionized water net, be dried in vacuo and produce poly- four PVF-polyurethane-nano silver composite material.
4. the anti-infection hemodialysis tube according to any one of claim 1-3, it is characterised in that the dialysis membrane is shell Glycan quaternary ammonium salt-polymeric lactic acid compound film, the raw material of the composite membrane are included according to the mass fraction：28 parts of chitosan quaternary ammonium salt, gather 109 parts of lactic acid, 32 parts of polyethylene glycol, 0.6 part of heparin, 0.13 part of ethylenediamine, 0.6 part of GMA, N, N- 0.07 part of dicyclohexylcarbodiimide, 0.03 part of succimide.
5. anti-infection hemodialysis tube according to claim 4, it is characterised in that it also includes connecting portion, the connection Portion is connected to the dialysis outer pipe；The connecting portion is provided with regulating valve to open or close the inlet and/or liquid outlet And regulation flow velocity；The regulating valve includes feed liquor regulating valve and goes out liquid regulating valve；Feed liquor regulating valve and/or go out liquid regulating valve point The top or bottom of connecting portion are not arranged at.
6. anti-infection hemodialysis tube according to claim 5, it is characterised in that the feed liquor regulating valve include cell body and Roller；The roller is arranged in the cell body；The cell body is obliquely installed, and two side is provided with roller rolling guide, bottom Flexible leather strap is set；The inlet is arranged at the lower section in the middle part of the elastic leather strap.
7. anti-infection hemodialysis tube according to claim 6, it is characterised in that the dialysis inner tube spiral is set.
8. anti-infection hemodialysis tube according to claim 7, it is characterised in that the connecting portion and the dialysis outer pipe Between be provided with fixed part, the fixed part includes fixed seat and the fin being symmetricly set on for a pair in fixed seat.
9. anti-infection hemodialysis tube according to claim 8, it is characterised in that the dialysis outer pipe is engraved structure.
10. anti-infection hemodialysis tube according to claim 9, it is characterised in that the dialysis outer pipe is away from inlet One end be provided with rigid plastics head.
CN201711119774.6A 2017-11-14 2017-11-14 A kind of anti-infection hemodialysis tube Withdrawn CN107744607A (en)

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Application Number Priority Date Filing Date Title
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112494116A (en) * 2020-11-26 2021-03-16 鹰潭荣嘉集团医疗器械实业有限公司 Disposable arteriovenous puncture ware

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112494116A (en) * 2020-11-26 2021-03-16 鹰潭荣嘉集团医疗器械实业有限公司 Disposable arteriovenous puncture ware

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Application publication date: 20180302