CN107744146A - A kind of application of the Capsules with segmented intestine targeted function - Google Patents
A kind of application of the Capsules with segmented intestine targeted function Download PDFInfo
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- CN107744146A CN107744146A CN201711167950.3A CN201711167950A CN107744146A CN 107744146 A CN107744146 A CN 107744146A CN 201711167950 A CN201711167950 A CN 201711167950A CN 107744146 A CN107744146 A CN 107744146A
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- 239000002775 capsule Substances 0.000 title claims abstract description 32
- 210000000936 intestine Anatomy 0.000 title claims abstract description 22
- 229920002472 Starch Polymers 0.000 claims abstract description 22
- 235000019698 starch Nutrition 0.000 claims abstract description 22
- 239000008107 starch Substances 0.000 claims abstract description 22
- 238000007789 sealing Methods 0.000 claims abstract description 6
- 235000013376 functional food Nutrition 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 abstract description 12
- 229920000294 Resistant starch Polymers 0.000 abstract description 11
- 235000021254 resistant starch Nutrition 0.000 abstract description 11
- 241000894006 Bacteria Species 0.000 abstract description 10
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 10
- 230000036541 health Effects 0.000 abstract description 9
- 210000001072 colon Anatomy 0.000 abstract description 7
- 230000001580 bacterial effect Effects 0.000 abstract description 6
- 230000009286 beneficial effect Effects 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 6
- 230000000968 intestinal effect Effects 0.000 abstract description 5
- 230000029087 digestion Effects 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 230000000112 colonic effect Effects 0.000 abstract description 3
- 238000005538 encapsulation Methods 0.000 abstract description 3
- 230000033228 biological regulation Effects 0.000 abstract description 2
- 244000005709 gut microbiome Species 0.000 abstract description 2
- 230000007413 intestinal health Effects 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 238000006243 chemical reaction Methods 0.000 description 10
- 241000186000 Bifidobacterium Species 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 241000193830 Bacillus <bacterium> Species 0.000 description 5
- 239000013612 plasmid Substances 0.000 description 5
- 241000606125 Bacteroides Species 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000002550 fecal effect Effects 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000003753 real-time PCR Methods 0.000 description 3
- 210000000813 small intestine Anatomy 0.000 description 3
- 206010009944 Colon cancer Diseases 0.000 description 2
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- 229920002261 Corn starch Polymers 0.000 description 2
- 238000007400 DNA extraction Methods 0.000 description 2
- 241000305071 Enterobacterales Species 0.000 description 2
- 241000194033 Enterococcus Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000000246 agarose gel electrophoresis Methods 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
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- 229940099112 cornstarch Drugs 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
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- 238000013461 design Methods 0.000 description 2
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- 210000003608 fece Anatomy 0.000 description 2
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- 239000000203 mixture Substances 0.000 description 2
- 239000006041 probiotic Substances 0.000 description 2
- 235000018291 probiotics Nutrition 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
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- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 241000588914 Enterobacter Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
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- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
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- 238000002835 absorbance Methods 0.000 description 1
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- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000002060 circadian Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 101150024923 da gene Proteins 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 235000020995 raw meat Nutrition 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000009291 secondary effect Effects 0.000 description 1
- 235000021391 short chain fatty acids Nutrition 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 101150076304 spp gene Proteins 0.000 description 1
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- 238000011144 upstream manufacturing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/20—Making of laminated, multi-layered, stuffed or hollow foodstuffs, e.g. by wrapping in preformed edible dough sheets or in edible food containers
- A23P20/25—Filling or stuffing cored food pieces, e.g. combined with coring or making cavities
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to a kind of application of the Capsules with segmented intestine targeted function, belong to functional food processing technique field；Specifically 0.2 0.3g starch is fitted into the Capsules with segmented intestine targeted function, sealing；Colon can not be reached by small intestinal digestion using starch after the Capsules encapsulation with segmented intestine targeted function, after colonic absorption, beneficial bacterium largely increases in enteron aisle, and harmful bacterial content significantly reduces, realize regulation intestinal microflora, improve the effect of intestinal health, be particularly suitable for use in non-health crowd；This method substantially increases the use value of starch, the use of common starch is that can reach the effect of resistant starch, can effectively adjust gut flora health, method is simple, and cost is cheap.
Description
Technical field
The present invention relates to a kind of application of the Capsules with segmented intestine targeted function, belongs to functional food process technology neck
Domain.
Background technology
Capsules refers to that various medicinal powder, liquid, semisolid and tablet can be accommodated, and the capsule formed is saved by cap, body two
Shell, its developing history are long.It is attractive in appearance because having outward appearance clean and tidy, easily swallow, content bitter taste beastly, raw meat can be covered
Other bad smells such as smelly, it is in good taste, make consumer more be easily accepted by waiting many merits, the market share is constantly expanding.Colon is near
End easily produces lesion, such as constipation, Crow Hei Shi disease, ulcerative colitis and colon cancer, and after conventional formulation is oral, medicine exists
Body circulation will be rapidly absorbed into before reaching colon, diseased region can not be specifically acted on.And segmented intestine targeted capsule is taken
Medicine does not discharge in upper digestive tract afterwards, just starts disintegration to ileocecus or colon or corrosion discharges, play locally or systemically
Therapeutic action, the availability of medicine can be effectively increased, poison produced by reducing stimulation and the gastronintestinal system Absorption And Metabolism to stomach is secondary
Effect, is also gradually introduced to the market at present.
Starch is carbohydrate common in daily life, it is generally recognized that it can be inhaled in small intestine by complete digestion
Receive, later Englyst et al.（1993）The starch being embedded in insoluble diedairy fiber is found in quantitative analysis dietary fiber,
That is resistant starch（RS）.According to FAO (Food and Agriculture Organization of the United Nation)（FAO）The definition of 1992, resistant starch refers to can not be by healthy human body
Small intestine decomposes the general name of the starch utilized and its degradation product（Tester etc., 2004）.In recent years, resistant starch has become state
Ectendotrophy and the study hotspot of functional food expert, have fat-reducing, reduce blood glucose, treatment constipation, prevent colon cancer etc. it is more
Kind physiological function.
Modern study shows that gut flora is an important factor for influenceing health.Gut flora is with human body long-term
During common evolutionary, the relation for interdepending, interacting is formd, the health of human body be unable to do without the help of gut flora.
RS can not be digested and assimilated in small intestine, can be entered large intestine by physiological bacterial fermentation, be produced a variety of short chain fatty acids and gas, drop
PH value in low large intestine, suppress pathogenic bacteria growth and breeding, promote intestinal beneficial bacterium clump growth and breeding.Fang Jiandong（2014）It has studied RS
Influence to mouse intestinal flora, the results showed that RS can be obviously promoted Bacillus acidi lactici and Bifidobacterium propagation, suppress large intestine bar
Bacterium and enterococcus growth, wherein high content RS action effects become apparent from.
For cancer patient, beneficial bacteria of intestinal tract can be reduced largely during chemicotherapy, and most straightforward approach is by oral
Probiotics is supplemented, but if directly taking, because hydrochloric acid in gastric juice acts on, survival volume is limited, and probiotics is costly.Supplement
Resistant starch price is also a good approach, but resistant starch price is also higher, and is generally exceeded in processing temperature
Resistance function will be lost at 80 DEG C.Starch resource enriches, cheap, develops a kind of method and uses starch, not by
Small intestinal digestion is fermented after reaching colon, plays a part of improving gut flora, significant.
The content of the invention
The problem of present invention exists for prior art, there is provided a kind of Capsules with segmented intestine targeted function is answered
With the use of common starch being that can reach the effect of resistant starch, can effectively adjust gut flora health, method is simple, and cost is low
It is honest and clean.
In order to solve the above problems, the technical solution adopted in the present invention is：
A kind of application of the Capsules with segmented intestine targeted function, specific method are：0.2-0.3g starch, which is loaded, has knot
In the Capsules of intestines target function, sealing is edible.
Usage and dosage：Orally, 1 tablet each time, 2 times a day.
The beneficial effects of the invention are as follows：
（1）Colon can not be reached by small intestinal digestion using starch after the Capsules encapsulation with segmented intestine targeted function, quilt
After colonic absorption, beneficial bacterium largely increases in enteron aisle, and harmful bacterial content significantly reduces, and realizes regulation intestinal microflora,
Improve the effect of intestinal health, be particularly suitable for use in non-health crowd.
（2）Starch source enriches, cheap, and the application process can greatly improve its application value.
（3）The use of common starch is that can reach the effect of resistant starch, can effectively adjust gut flora health, method letter
Single, cost is cheap.
Embodiment
The present invention is described in further details below by embodiment, these embodiments are only used for illustrating the present invention, and
Do not limit the scope of the invention.
Embodiment 1
A kind of application of the Capsules with segmented intestine targeted function：0.2g starch is fitted into Capsules, sealing is edible.
What described Capsules referred to the preparation of Chinese patent ZL201410313574.4 methods has segmented intestine targeted function
Capsules.
Embodiment 2
A kind of application of the Capsules with segmented intestine targeted function：0.3g starch is fitted into Capsules, sealing is edible.
What described Capsules referred to the preparation of Chinese patent ZL201410313574.4 methods has segmented intestine targeted function
Capsules.
Embodiment 3
A kind of application of the Capsules with segmented intestine targeted function：0.25g starch is fitted into Capsules, sealing is edible.
What described Capsules referred to the preparation of Chinese patent ZL201410313574.4 methods has segmented intestine targeted function
Capsules.
Embodiment 3
The starch capsule prepared for embodiment is verified.Using zoopery, SPF level males SD similar in selective body weight
Rat, it is divided into 4 groups：Normal group, cornstarch group, resistant starch of corn group, cornstarch capsule group；Starch feeding volume
2g/kg, it is continuous to feed 4 weeks.20 ~ 25 DEG C of environment temperature, indoor humidity are maintained at 40% ~ 70%, free water, circadian.
After experiment terminates, the excrement of rat is collected, and takes colonic contents to determine pH value, and faecal flora is divided
Analysis.
（1）Fecal bacteria Genome DNA extraction
5 parts of fresh excreta samples are taken, each 200mg, DNA extraction are carried out using excrement genome DNA extracting reagent kit, by reagent
Box specification is operated, and the STb gene of extraction is positioned in -20 DEG C of refrigerators and preserved.
（2）STb gene purity and concentration mensuration
Prepare 1% Ago-Gel, after heating and melting, be cooled to 65 DEG C or so, and add 0.8 μ L Golden View, after mixing
Groove, form glue-line.Draw 5 μ L fecal bacteria STb genes to be loaded, be powered electrophoresis immediately, 80V voltages 30 minutes, ultraviolet
Observed under lamp, DNA, which exists, then shows fluorescent bands, and is contrasted with Marker samples, detect the purity of STb gene with it is complete
Whole property.
Take 5 μ L DNA samples to be diluted with TE buffer solutions, using ultraviolet specrophotometer determine STb gene in 260nm and
Absorbance at 280nm, the concentration of STb gene is obtained, and calculate both ratio（OD260/ OD280）.
（3）PCR primer designs and Standard PCR reaction
It is corresponding according to Lactobacillus, Bifidobacterium, Bacteroides, Enterobacter and enterococcus spp gene order, design
PCR primer, selected primer sequence are shown in Table 1, and primer is synthesized by Hua Da Gene Tech. Company Limited.
The enteron aisle purpose flora PCR primer of table 1
The bacterial genomes DNA for randomly selecting fresh excreta extraction is template, carries out standard PCR amplification.
50 μ L PCR reaction systems：μ L, the 10umol/L PCR Forward Primer of 2 × Taq Master Mix 25
The μ L of 22 μ L, DNA templates of μ L, 10umol/L PCR Revers Primer of 210umol/L PCR Forward Primer 6,
ddH2O is supplemented to 50 μ L.
Amplified reaction program：94 DEG C of min of pre-degeneration 2；94 DEG C of denaturation 30s, 55 DEG C of annealing 30s, 72 DEG C of 50 s of extension, are followed
Ring 35 times, 72 DEG C of 2 min of extension.
Reaction is carried out in PCR thermal cyclers above, and all products reactions preserve under the conditions of -20 DEG C completely.
（4）PCR primer purifying recovery
PCR primer is to purify reclaim reagent in the century DNA of bio tech ltd using health after agarose gel electrophoresis
Box carries out the recovery of PCR primer, is operated according to kit specification step.
（5）Prepare plasmid standard
Bacillus acidi lactici, Bifidobacterium, bacteroid, enterobacteria and enterococcal pcr amplification product after above-mentioned purifying is reclaimed are made
For purpose DNA fragmentation, it is connected on pUC-T simple carriers, recombinant plasmid transformed to bacillus coli DH 5 alpha competent cell
In, through blue hickie screen, after obtaining positive colony, construction recombination plasmid, plasmid through agarose gel electrophoresis analyze and be sequenced after,
It can be used as standard items.The concentration for the DNA isolated is determined simultaneously, converses the copy number of various bacteriums.
（6）Real-time fluorescence quantitative PCR reacts
Bacillus acidi lactici, Bifidobacterium, bacteroid, enterobacteria and continuous 5 times of enterococcal plasmid standard are serially diluted respectively,
Form 107-103Positive template is used as after copy/μ L, carries out real-time fluorescence quantitative PCR reaction, when being reacted according to each standard items
Amplified fluorescence signal obtains standard curve.Wherein abscissa represents the logarithm value of different positive template bacterial copy numbers（lg C0）,
Ordinate, which is represented in PCR reactions, there is the initial cycle number of fluorescence signal（Ct）.
The μ L of reaction system 20：SYBR premix（2×）10 μ L, 10 μm of ol/L upstream and downstream primers each 0.5 μ L, it is to be measured
DNA sample or standard items 2 μ L, ddH2O 7 μL。
Reaction condition：（1）Pre-degeneration：95℃30 s；（2）PCR reacts, and circulates 40 times：95 DEG C of 10 s of denaturation, 60 DEG C of annealing
30 s, 72 DEG C of 30 s of extension；（3）Melt：95 DEG C of 15 s, 60 DEG C of 1 min, 95 DEG C of 15 s；（4）Cooling：60℃15 s.
This reaction system and reaction condition are pressed simultaneously, it is anti-that fecal bacteria DNA sample is also carried out to real-time fluorescence quantitative PCR
Should, and each sample does a multiple holes, does negative control and positive control.Finally reacted by standard curve and sample in PCR
The Ct values of the middle initial cycle number for fluorescence signal occur, can draw contained Bacillus acidi lactici, Bifidobacterium, bacteroid, intestines in sample
Bacillus and enterococcal quantity.
The comparison of each group Bacteria from Gl Tract of Rats of table 2
Note：Compared with Normal group,aP ＜ 0.05;Compared with resistant starch group,bP ＜ 0.05.
As shown in Table 2, the Bifidobacterium of starch Capsules group rat dramatically increases（P<0.05）, it is harmful to bacterial content also relatively
It is low, eaten after illustrating the Capsules encapsulation starch with segmented intestine targeted function, it is micro- that starch compared with resistant starch is more beneficial for colon
The fermentation of biology utilizes, and adjusts the health of gut flora.
Claims (1)
- A kind of 1. application of the Capsules with segmented intestine targeted function, it is characterised in that：With the hollow of segmented intestine targeted function Application of the capsule in terms of functional food, its application are that 0.2-0.3g starch is loaded into the Capsules with segmented intestine targeted function In, sealing is edible.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711167950.3A CN107744146A (en) | 2017-11-21 | 2017-11-21 | A kind of application of the Capsules with segmented intestine targeted function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711167950.3A CN107744146A (en) | 2017-11-21 | 2017-11-21 | A kind of application of the Capsules with segmented intestine targeted function |
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| Publication Number | Publication Date |
|---|---|
| CN107744146A true CN107744146A (en) | 2018-03-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711167950.3A Pending CN107744146A (en) | 2017-11-21 | 2017-11-21 | A kind of application of the Capsules with segmented intestine targeted function |
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| Country | Link |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682699A (en) * | 2005-02-28 | 2005-10-19 | 潮州市强基制药厂 | Colon soluble and intestine soluble hollow hard capsule and producing process |
| CN102613559A (en) * | 2012-04-11 | 2012-08-01 | 江苏四环生物制药有限公司 | Composite protein powder capsule and preparation method thereof |
| CN103566142A (en) * | 2012-08-11 | 2014-02-12 | 姚友平 | Enteric capsule having functions of improving intestinal function and eliminating vivotoxin |
| CN104055750A (en) * | 2014-07-03 | 2014-09-24 | 王荣辉 | Empty targeting capsule and preparation method thereof |
-
2017
- 2017-11-21 CN CN201711167950.3A patent/CN107744146A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682699A (en) * | 2005-02-28 | 2005-10-19 | 潮州市强基制药厂 | Colon soluble and intestine soluble hollow hard capsule and producing process |
| CN102613559A (en) * | 2012-04-11 | 2012-08-01 | 江苏四环生物制药有限公司 | Composite protein powder capsule and preparation method thereof |
| CN103566142A (en) * | 2012-08-11 | 2014-02-12 | 姚友平 | Enteric capsule having functions of improving intestinal function and eliminating vivotoxin |
| CN104055750A (en) * | 2014-07-03 | 2014-09-24 | 王荣辉 | Empty targeting capsule and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 吕倩等: "控释淀粉载体形式及其在食品工业中的应用", 《食品与饲料工业》 * |
| 朱平等: "抗性淀粉在食品中的应用及功效研究进展", 《核农学报》 * |
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