CN107739200A - A kind of bioceramic material and preparation method thereof - Google Patents

A kind of bioceramic material and preparation method thereof Download PDF

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CN107739200A
CN107739200A CN201710990302.1A CN201710990302A CN107739200A CN 107739200 A CN107739200 A CN 107739200A CN 201710990302 A CN201710990302 A CN 201710990302A CN 107739200 A CN107739200 A CN 107739200A
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parts
calcium
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bioceramic material
preparation
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王金英
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Foshan Ruisheng Technology Co Ltd
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Foshan Ruisheng Technology Co Ltd
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Abstract

The invention provides a kind of bioceramic material and preparation method thereof.Preparation method is as follows：（1）Hydroxyapatite, calcium nitrate, calcium monohydrogen phosphate, calcium propionate, sodium metasilicate, microcrystalline cellulose and distilled water are mixed, ball milling is carried out in ball mill 26 30 hours；（2）Acrylic resin, nano titanium oxide, zirconium nitrate, Sodium Polyacrylate and polyanion cellulose are added, is stirred 56 hours under the 200r/min of rotating speed 150；（3）Lauroyl glutamate, silicone emulsion, resveratrol, polypropylene glycerol aether and polyethylene glycol are added, stirring is put into vacuum drying chamber after 30 40 minutes and vacuumizes carry out defoaming treatment；（4）Green compact must be freezed by pouring into freezing apparatus for pouring；（5）It is put into sintering furnace sinter 34 hours at 550 650 DEG C of temperature after being freeze-dried and produces.The bioceramic material of the present invention has extraordinary biocompatibility, while has good mechanical property again.

Description

A kind of bioceramic material and preparation method thereof
Technical field
The present invention relates to technical field of biological material, and in particular to a kind of bioceramic material and preparation method thereof.
Background technology
With the development of material science, biomaterial is due to the spy for being repaired, being substituted and being regenerated to body tissue Distinguished service energy, it has also become the important component in current biomedical engineering.Its research contents be related to material, medical physicses, The subjects such as biochemistry and Modern High-Tech field.And bioceramic material is as a kind of lithotroph medical material, with Biological tissue has good compatibility and excellent compatibility, the physicochemical properties stablized, can be sterilising and non-toxic etc. Advantage, increasingly it is valued by people.It refers to be used as specific biology or a kind of ceramic material of physiological function, i.e., direct Ceramic material for human body or biological, the medical, biochemistry related to human body etc..And it is the power for improving bioceramic material The performances such as performance, stability and biocompatibility are learned, bioceramic material and other materials progress is compound, it is excellent so as to protrude its Gesture, expand it and be applied to the focus developed for numerous enterprises and scholar's research.
The content of the invention
Technical problems to be solved：It is an object of the invention to provide a kind of bioceramic material, has extraordinary biology Compatibility, while there is good mechanical property again.
Technical scheme：A kind of bioceramic material, it is prepared by following component with parts by weight：Hydroxyapatite 10-20 Part, calcium nitrate 10-20 parts, calcium monohydrogen phosphate 10-20 parts, calcium propionate 5-10 parts, sodium metasilicate 2-5 parts, microcrystalline cellulose 1-2 parts, third Olefin(e) acid resin 1-3 parts, nano titanium oxide 0.2-0.5 parts, zirconium nitrate 1-3 parts, lauroyl glutamate 1-2 parts, silicone emulsion 1-2 parts, resveratrol 1-2 parts, polypropylene glycerol aether 1-2 parts, Sodium Polyacrylate 1-3 parts, polyanion cellulose 0.5-1 Part, polyethylene glycol 2-5 parts, distilled water 80-150 parts.
It is further preferred that a kind of described bioceramic material, is prepared by following component with parts by weight：Hydroxyapatite 15 parts, 15 parts of calcium nitrate, 15 parts of calcium monohydrogen phosphate, 7.5 parts of calcium propionate, 3.5 parts of sodium metasilicate, 1.5 parts of microcrystalline cellulose, acrylic acid tree 2 parts of fat, 0.35 part of nano titanium oxide, 2 parts of zirconium nitrate, 1.5 parts of lauroyl glutamate, 1.5 parts of silicone emulsion, resveratrol 1.5 parts, 1.5 parts of polypropylene glycerol aether, 2 parts of Sodium Polyacrylate, 0.75 part of polyanion cellulose, 3.5 parts of polyethylene glycol, steam 115 parts of distilled water.
The preparation method of above-mentioned bioceramic material comprises the following steps：
(1) hydroxyapatite, calcium nitrate, calcium monohydrogen phosphate, calcium propionate, sodium metasilicate, microcrystalline cellulose and distilled water are mixed, ball milling Ball milling 26-30 hours are carried out in machine；
(2) acrylic resin, nano titanium oxide, zirconium nitrate, Sodium Polyacrylate and polyanion cellulose are added, in rotating speed 5-6 hours are stirred under 150-200r/min；
(3) lauroyl glutamate, silicone emulsion, resveratrol, polypropylene glycerol aether and polyethylene glycol are added, stirs 30- It is put into after 40 minutes in vacuum drying chamber and vacuumizes carry out defoaming treatment；
(4) green compact must be freezed by pouring into freezing apparatus for pouring；
(5) it is put into after being freeze-dried in sintering furnace and carries out the sintering 3-4 hours at 550-650 DEG C of temperature and produce.
Further, milling time is 27-29 hours in step (1).
Further, rotating speed is 170r/min in step (2), and mixing time is 5.5 hours.
Further, sintering temperature is 600 DEG C in step (5), and sintering time is 3.5 hours.
Beneficial effect：The bioceramic material of the present invention has extraordinary biocompatibility, and cytotoxicity grade is only 0-1 Level, while it has a good mechanical property again, its compression strength and rupture strength highest respectively reach 50.1MPa with 182MPa。
Embodiment
Embodiment 1
A kind of bioceramic material, it is prepared by following component with parts by weight：10 parts of hydroxyapatite, 10 parts of calcium nitrate, phosphorus Sour 10 parts of hydrogen calcium, 5 parts of calcium propionate, 2 parts of sodium metasilicate, 1 part of microcrystalline cellulose, 1 part of acrylic resin, 0.2 part of nano titanium oxide, 1 part of zirconium nitrate, 1 part of lauroyl glutamate, 1 part of silicone emulsion, 1 part of resveratrol, 1 part of polypropylene glycerol aether, polypropylene Sour sodium 1-3 parts, 0.5 part of polyanion cellulose, 2 parts of polyethylene glycol, 80 parts of distilled water.
The preparation method of above-mentioned bioceramic material is：
(1) hydroxyapatite, calcium nitrate, calcium monohydrogen phosphate, calcium propionate, sodium metasilicate, microcrystalline cellulose and distilled water are mixed, ball milling Ball milling is carried out in machine 26 hours；
(2) acrylic resin, nano titanium oxide, zirconium nitrate, Sodium Polyacrylate and polyanion cellulose are added, in rotating speed Stirred 5 hours under 150r/min；
(3) lauroyl glutamate, silicone emulsion, resveratrol, polypropylene glycerol aether and polyethylene glycol are added, stirs 30 points It is put into after clock in vacuum drying chamber and vacuumizes carry out defoaming treatment；
(4) green compact must be freezed by pouring into freezing apparatus for pouring；
(5) it is put into sintering furnace sinter 3 hours at 550 DEG C of temperature after being freeze-dried and produces.
Embodiment 2
A kind of bioceramic material, it is prepared by following component with parts by weight：15 parts of hydroxyapatite, 15 parts of calcium nitrate, phosphorus Sour 15 parts of hydrogen calcium, 7.5 parts of calcium propionate, 3.5 parts of sodium metasilicate, 1.5 parts of microcrystalline cellulose, 2 parts of acrylic resin, nano titanium oxide 0.35 part, 2 parts of zirconium nitrate, 1.5 parts of lauroyl glutamate, 1.5 parts of silicone emulsion, 1.5 parts of resveratrol, polyoxypropylene glyceryl 1.5 parts of ether, 2 parts of Sodium Polyacrylate, 0.75 part of polyanion cellulose, 3.5 parts of polyethylene glycol, 115 parts of distilled water.
The preparation method of above-mentioned bioceramic material is：
(1) hydroxyapatite, calcium nitrate, calcium monohydrogen phosphate, calcium propionate, sodium metasilicate, microcrystalline cellulose and distilled water are mixed, ball milling Ball milling is carried out in machine 27 hours；
(2) acrylic resin, nano titanium oxide, zirconium nitrate, Sodium Polyacrylate and polyanion cellulose are added, in rotating speed Stirred 5.5 hours under 170r/min；
(3) lauroyl glutamate, silicone emulsion, resveratrol, polypropylene glycerol aether and polyethylene glycol are added, stirs 35 points It is put into after clock in vacuum drying chamber and vacuumizes carry out defoaming treatment；
(4) green compact must be freezed by pouring into freezing apparatus for pouring；
(5) it is put into sintering furnace sinter 3.5 hours at 600 DEG C of temperature after being freeze-dried and produces.
Embodiment 3
A kind of bioceramic material, it is prepared by following component with parts by weight：17 parts of hydroxyapatite, 18 parts of calcium nitrate, phosphorus Sour 18 parts of hydrogen calcium, 8 parts of calcium propionate, 4 parts of sodium metasilicate, 1.5 parts of microcrystalline cellulose, 2 parts of acrylic resin, nano titanium oxide 0.4 Part, 2 parts of zirconium nitrate, 1.7 parts of lauroyl glutamate, 1.8 parts of silicone emulsion, 1.8 parts of resveratrol, polypropylene glycerol aether 1.5 parts, 1.5 parts of Sodium Polyacrylate, 0.8 part of polyanion cellulose, 4 parts of polyethylene glycol, 130 parts of distilled water.
The preparation method of above-mentioned bioceramic material is：
(1) hydroxyapatite, calcium nitrate, calcium monohydrogen phosphate, calcium propionate, sodium metasilicate, microcrystalline cellulose and distilled water are mixed, ball milling Ball milling is carried out in machine 28 hours；
(2) acrylic resin, nano titanium oxide, zirconium nitrate, Sodium Polyacrylate and polyanion cellulose are added, in rotating speed Stirred 5.5 hours under 180r/min；
(3) lauroyl glutamate, silicone emulsion, resveratrol, polypropylene glycerol aether and polyethylene glycol are added, stirs 35 points It is put into after clock in vacuum drying chamber and vacuumizes carry out defoaming treatment；
(4) green compact must be freezed by pouring into freezing apparatus for pouring；
(5) it is put into sintering furnace sinter 3.5 hours at 600 DEG C of temperature after being freeze-dried and produces.
Embodiment 4
A kind of bioceramic material, it is prepared by following component with parts by weight：20 parts of hydroxyapatite, 20 parts of calcium nitrate, phosphorus Sour 20 parts of hydrogen calcium, 10 parts of calcium propionate, 5 parts of sodium metasilicate, 2 parts of microcrystalline cellulose, 3 parts of acrylic resin, nano titanium oxide 0.5 Part, 3 parts of zirconium nitrate, 2 parts of lauroyl glutamate, 2 parts of silicone emulsion, 2 parts of resveratrol, 2 parts of polypropylene glycerol aether, poly- third 3 parts of olefin(e) acid sodium, 1 part of polyanion cellulose, 5 parts of polyethylene glycol, 150 parts of distilled water.
The preparation method of above-mentioned bioceramic material is：
(1) hydroxyapatite, calcium nitrate, calcium monohydrogen phosphate, calcium propionate, sodium metasilicate, microcrystalline cellulose and distilled water are mixed, ball milling Ball milling is carried out in machine 30 hours；
(2) acrylic resin, nano titanium oxide, zirconium nitrate, Sodium Polyacrylate and polyanion cellulose are added, in rotating speed Stirred 6 hours under 200r/min；
(3) lauroyl glutamate, silicone emulsion, resveratrol, polypropylene glycerol aether and polyethylene glycol are added, stirs 40 points It is put into after clock in vacuum drying chamber and vacuumizes carry out defoaming treatment；
(4) green compact must be freezed by pouring into freezing apparatus for pouring；
(5) it is put into sintering furnace sinter 4 hours at 650 DEG C of temperature after being freeze-dried and produces.
Comparative example 1
The present embodiment and the difference of embodiment 1 are not containing lauroyl glutamate and silicone emulsion.Specifically：It is a kind of Bioceramic material, it is prepared by following component with parts by weight：10 parts of hydroxyapatite, 10 parts of calcium nitrate, calcium monohydrogen phosphate 10 Part, 5 parts of calcium propionate, 2 parts of sodium metasilicate, 1 part of microcrystalline cellulose, 1 part of acrylic resin, 0.2 part of nano titanium oxide, zirconium nitrate 1 Part, 1 part of resveratrol, 1 part of polypropylene glycerol aether, Sodium Polyacrylate 1-3 parts, 0.5 part of polyanion cellulose, polyethylene glycol 2 parts, 80 parts of distilled water.The preparation method of above-mentioned bioceramic material is：
(1) hydroxyapatite, calcium nitrate, calcium monohydrogen phosphate, calcium propionate, sodium metasilicate, microcrystalline cellulose and distilled water are mixed, ball milling Ball milling is carried out in machine 26 hours；
(2) acrylic resin, nano titanium oxide, zirconium nitrate, Sodium Polyacrylate and polyanion cellulose are added, in rotating speed Stirred 5 hours under 150r/min；
(3) resveratrol, polypropylene glycerol aether and polyethylene glycol are added, stirring is put into vacuum drying chamber after 30 minutes takes out very Sky carries out defoaming treatment；
(4) green compact must be freezed by pouring into freezing apparatus for pouring；
(5) it is put into sintering furnace sinter 3 hours at 550 DEG C of temperature after being freeze-dried and produces.
Comparative example 2
The present embodiment and the difference of embodiment 1 are not containing Sodium Polyacrylate and polyanion cellulose.Specifically：
A kind of bioceramic material, it is prepared by following component with parts by weight：10 parts of hydroxyapatite, 10 parts of calcium nitrate, phosphorus Sour 10 parts of hydrogen calcium, 5 parts of calcium propionate, 2 parts of sodium metasilicate, 1 part of microcrystalline cellulose, 1 part of acrylic resin, 0.2 part of nano titanium oxide, 1 part of zirconium nitrate, 1 part of lauroyl glutamate, 1 part of silicone emulsion, 1 part of resveratrol, 1 part of polypropylene glycerol aether, poly- second two 2 parts of alcohol, 80 parts of distilled water.
The preparation method of above-mentioned bioceramic material is：
(1) hydroxyapatite, calcium nitrate, calcium monohydrogen phosphate, calcium propionate, sodium metasilicate, microcrystalline cellulose and distilled water are mixed, ball milling Ball milling is carried out in machine 26 hours；
(2) acrylic resin, nano titanium oxide, zirconium nitrate, Sodium Polyacrylate and polyanion cellulose are added, in rotating speed Stirred 5 hours under 150r/min；
(3) lauroyl glutamate, silicone emulsion, resveratrol, polypropylene glycerol aether and polyethylene glycol are added, stirs 30 points It is put into after clock in vacuum drying chamber and vacuumizes carry out defoaming treatment；
(4) green compact must be freezed by pouring into freezing apparatus for pouring；
(5) it is put into sintering furnace sinter 3 hours at 550 DEG C of temperature after being freeze-dried and produces.
Mtt assay detects cytotoxicity.
Rupture strength is determined using standard GB/T 6569-86.
The partial properties index of the bioceramic material of table 1
Name of product Cytotoxicity grade Compression strength (MPa) Rupture strength (MPa)
Embodiment 1 0-1 49.4 178
Embodiment 2 0-1 50.1 182
Embodiment 3 0-1 49.6 179
Embodiment 4 0-1 49.5 182
Comparative example 1 0-1 44.5 167
Comparative example 2 0-1 43.8 161
The partial properties index result of bioceramic material of the present invention as shown above, it will be seen that this material have it is non- Often good biocompatibility, cytotoxicity grade is only 0-1 levels, while it has good mechanical property, its compression strength again 50.1MPa and 182MPa are respectively reached with rupture strength highest.

Claims (6)

  1. A kind of 1. bioceramic material, it is characterised in that：It is prepared by following component with parts by weight：Hydroxyapatite 10-20 Part, calcium nitrate 10-20 parts, calcium monohydrogen phosphate 10-20 parts, calcium propionate 5-10 parts, sodium metasilicate 2-5 parts, microcrystalline cellulose 1-2 parts, third Olefin(e) acid resin 1-3 parts, nano titanium oxide 0.2-0.5 parts, zirconium nitrate 1-3 parts, lauroyl glutamate 1-2 parts, silicone emulsion 1-2 parts, resveratrol 1-2 parts, polypropylene glycerol aether 1-2 parts, Sodium Polyacrylate 1-3 parts, polyanion cellulose 0.5-1 Part, polyethylene glycol 2-5 parts, distilled water 80-150 parts.
  2. A kind of 2. bioceramic material according to claim 1, it is characterised in that：By following component with parts by weight prepare and Into：15 parts of hydroxyapatite, 15 parts of calcium nitrate, 15 parts of calcium monohydrogen phosphate, 7.5 parts of calcium propionate, 3.5 parts of sodium metasilicate, microcrystalline cellulose 1.5 parts, 2 parts of acrylic resin, 0.35 part of nano titanium oxide, 2 parts of zirconium nitrate, 1.5 parts of lauroyl glutamate, silicone emulsion 1.5 parts, it is 1.5 parts of resveratrol, 1.5 parts of polypropylene glycerol aether, 2 parts of Sodium Polyacrylate, 0.75 part of polyanion cellulose, poly- 3.5 parts of ethylene glycol, 115 parts of distilled water.
  3. 3. a kind of preparation method of bioceramic material described in any one of claim 1 to 2, comprises the following steps：
    （1）Hydroxyapatite, calcium nitrate, calcium monohydrogen phosphate, calcium propionate, sodium metasilicate, microcrystalline cellulose and distilled water are mixed, ball Ball milling 26-30 hours are carried out in grinding machine；
    （2）Acrylic resin, nano titanium oxide, zirconium nitrate, Sodium Polyacrylate and polyanion cellulose are added, in rotating speed 5-6 hours are stirred under 150-200r/min；
    （3）Lauroyl glutamate, silicone emulsion, resveratrol, polypropylene glycerol aether and polyethylene glycol are added, stirs 30- It is put into after 40 minutes in vacuum drying chamber and vacuumizes carry out defoaming treatment；
    （4）Green compact must be freezed by pouring into freezing apparatus for pouring；
    （5）It is put into after being freeze-dried in sintering furnace and carries out the sintering 3-4 hours at 550-650 DEG C of temperature and produce.
  4. A kind of 4. preparation method of bioceramic material according to claim 3, it is characterised in that：The step（1）In Milling time is 27-29 hours.
  5. A kind of 5. preparation method of bioceramic material according to claim 3, it is characterised in that：The step（2）In Rotating speed is 170r/min, and mixing time is 5.5 hours.
  6. A kind of 6. preparation method of bioceramic material according to claim 3, it is characterised in that：The step（5）In Sintering temperature is 600 DEG C, and sintering time is 3.5 hours.
CN201710990302.1A 2017-10-20 2017-10-20 A kind of bioceramic material and preparation method thereof Withdrawn CN107739200A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111377729A (en) * 2020-03-21 2020-07-07 杭州书瓷手作文化创意有限公司 Environment-friendly biological ceramic material and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111377729A (en) * 2020-03-21 2020-07-07 杭州书瓷手作文化创意有限公司 Environment-friendly biological ceramic material and preparation method thereof

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Application publication date: 20180227