CN107734967B - 在获得的可移植的心脏中调节钙离子稳态 - Google Patents

在获得的可移植的心脏中调节钙离子稳态 Download PDF

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Publication number
CN107734967B
CN107734967B CN201580030243.2A CN201580030243A CN107734967B CN 107734967 B CN107734967 B CN 107734967B CN 201580030243 A CN201580030243 A CN 201580030243A CN 107734967 B CN107734967 B CN 107734967B
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Prior art keywords
heart
reperfusion
composition
cardiac
hearts
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Chinese (zh)
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CN107734967A (zh
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C·怀特
D·弗里德
L·赫里什科
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Transmedics Inc
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Tevosol Inc
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
CN201580030243.2A 2014-04-10 2015-04-10 在获得的可移植的心脏中调节钙离子稳态 Active CN107734967B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461978132P 2014-04-10 2014-04-10
US61/978,132 2014-04-10
PCT/CA2015/050297 WO2015154193A1 (en) 2014-04-10 2015-04-10 Modulation of calcium ion homeostasis in harvested transplantable hearts

Publications (2)

Publication Number Publication Date
CN107734967A CN107734967A (zh) 2018-02-23
CN107734967B true CN107734967B (zh) 2021-07-16

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CN201580030243.2A Active CN107734967B (zh) 2014-04-10 2015-04-10 在获得的可移植的心脏中调节钙离子稳态

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US (1) US10327441B2 (cg-RX-API-DMAC7.html)
EP (1) EP3128836B1 (cg-RX-API-DMAC7.html)
CN (1) CN107734967B (cg-RX-API-DMAC7.html)
AU (1) AU2015245903A1 (cg-RX-API-DMAC7.html)
BR (1) BR112016023394B1 (cg-RX-API-DMAC7.html)
CA (1) CA2943797A1 (cg-RX-API-DMAC7.html)
ES (1) ES2834388T3 (cg-RX-API-DMAC7.html)
WO (1) WO2015154193A1 (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ600702A (en) 2004-10-07 2013-12-20 Transmedics Inc Systems and methods for ex-vivo organ care
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US8420380B2 (en) 2008-01-31 2013-04-16 Transmedics, Inc. Systems and methods for ex vivo lung care
DK4032401T3 (da) 2011-04-14 2025-12-15 Transmedics Inc Fremgangsmåde til fremstilling af en organplejeopløsning til maskinperfusion ex-vivo af donorlunger
US10433539B2 (en) * 2014-04-10 2019-10-08 Tevosol, Inc. Composition and solution with controlled calcium ion level, and related method and use for reperfusion
CN106659151B (zh) 2014-06-02 2021-06-08 特兰斯迈迪茨公司 离体器官护理系统
BR112017008076B1 (pt) * 2014-10-24 2021-06-29 Darren Freed Solução com nível de íon cálcio controlado, composição para preparação da solução e processo e uso relacionados para reperfusão
CA2970117A1 (en) 2014-12-12 2016-06-16 Darren FREED Apparatus and method for organ perfusion
CN107949419B (zh) 2015-09-09 2021-03-05 特兰斯迈迪茨公司 离体器官护理系统用的主动脉插管
CN114946834B (zh) 2016-05-30 2024-10-25 体沃索股份有限公司 利用变化的外部压力用于离体肺通气的装置和方法
CN109846464A (zh) * 2018-12-29 2019-06-07 曹乃钊 血液流动力学参数的无创测量系统和数据处理系统
CN113975377B (zh) * 2020-07-27 2023-11-10 成都青山利康药业股份有限公司 一种心脏停搏液
CN115400206B (zh) * 2021-05-26 2025-08-15 成都青山利康药业有限公司 一种细胞外液型含血心脏停搏液

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001001774A1 (en) * 1999-06-17 2001-01-11 Regents Of The University Of California Continuous cardiac perfusion preservation with peg-hb for improved hypothermic storage
US6524785B1 (en) * 1998-11-10 2003-02-25 Centre National De La Recherche Scientifique Perfusion and/or preservation and/or re-perfusion solution during organ transplant

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407793A (en) 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
US5405742A (en) 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
US20030124503A1 (en) 2001-12-28 2003-07-03 Olivencia-Yurvati Albert H. Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof
AUPS312602A0 (en) 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
CA2551169A1 (en) 2002-12-23 2004-07-08 Global Cardiac Solutions Pty Ltd Organ preconditioning, arrest, protection, preservation and recovery
GB0903299D0 (en) * 2009-02-26 2009-04-08 Guys And St Thomas Nhs Foundat Composition and methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524785B1 (en) * 1998-11-10 2003-02-25 Centre National De La Recherche Scientifique Perfusion and/or preservation and/or re-perfusion solution during organ transplant
WO2001001774A1 (en) * 1999-06-17 2001-01-11 Regents Of The University Of California Continuous cardiac perfusion preservation with peg-hb for improved hypothermic storage

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Eight hours of cold static storage with adenosine and lidocaine(Adenocaine) heart preservation solutions: Toward therapeutic suspended animation;Donna M.Rudd等;《The Journal of Thoracic and Cardiovascular Surgery》;20111231;第142卷(第6期);第1552-1561页 *

Also Published As

Publication number Publication date
WO2015154193A1 (en) 2015-10-15
CA2943797A1 (en) 2015-10-15
CN107734967A (zh) 2018-02-23
BR112016023394A2 (cg-RX-API-DMAC7.html) 2017-08-15
AU2015245903A1 (en) 2016-11-17
EP3128836B1 (en) 2020-09-09
ES2834388T3 (es) 2021-06-17
EP3128836A4 (en) 2017-11-22
EP3128836A1 (en) 2017-02-15
BR112016023394B1 (pt) 2021-09-21
US10327441B2 (en) 2019-06-25
US20170020127A1 (en) 2017-01-26

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