BR112016023394B1 - Composição cardioplégica e seu uso - Google Patents

Composição cardioplégica e seu uso Download PDF

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Publication number
BR112016023394B1
BR112016023394B1 BR112016023394-8A BR112016023394A BR112016023394B1 BR 112016023394 B1 BR112016023394 B1 BR 112016023394B1 BR 112016023394 A BR112016023394 A BR 112016023394A BR 112016023394 B1 BR112016023394 B1 BR 112016023394B1
Authority
BR
Brazil
Prior art keywords
heart
reperfusion
mmol
hearts
collected
Prior art date
Application number
BR112016023394-8A
Other languages
English (en)
Portuguese (pt)
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BR112016023394A2 (cg-RX-API-DMAC7.html
Inventor
Darren Freed
Christopher White
Larry Hryshko
Original Assignee
Darren Freed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Darren Freed filed Critical Darren Freed
Publication of BR112016023394A2 publication Critical patent/BR112016023394A2/pt
Publication of BR112016023394B1 publication Critical patent/BR112016023394B1/pt

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
BR112016023394-8A 2014-04-10 2015-04-10 Composição cardioplégica e seu uso BR112016023394B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461978132P 2014-04-10 2014-04-10
US61/978,132 2014-04-10
PCT/CA2015/050297 WO2015154193A1 (en) 2014-04-10 2015-04-10 Modulation of calcium ion homeostasis in harvested transplantable hearts

Publications (2)

Publication Number Publication Date
BR112016023394A2 BR112016023394A2 (cg-RX-API-DMAC7.html) 2017-08-15
BR112016023394B1 true BR112016023394B1 (pt) 2021-09-21

Family

ID=54287064

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016023394-8A BR112016023394B1 (pt) 2014-04-10 2015-04-10 Composição cardioplégica e seu uso

Country Status (8)

Country Link
US (1) US10327441B2 (cg-RX-API-DMAC7.html)
EP (1) EP3128836B1 (cg-RX-API-DMAC7.html)
CN (1) CN107734967B (cg-RX-API-DMAC7.html)
AU (1) AU2015245903A1 (cg-RX-API-DMAC7.html)
BR (1) BR112016023394B1 (cg-RX-API-DMAC7.html)
CA (1) CA2943797A1 (cg-RX-API-DMAC7.html)
ES (1) ES2834388T3 (cg-RX-API-DMAC7.html)
WO (1) WO2015154193A1 (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ600702A (en) 2004-10-07 2013-12-20 Transmedics Inc Systems and methods for ex-vivo organ care
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US8420380B2 (en) 2008-01-31 2013-04-16 Transmedics, Inc. Systems and methods for ex vivo lung care
DK4032401T3 (da) 2011-04-14 2025-12-15 Transmedics Inc Fremgangsmåde til fremstilling af en organplejeopløsning til maskinperfusion ex-vivo af donorlunger
US10433539B2 (en) * 2014-04-10 2019-10-08 Tevosol, Inc. Composition and solution with controlled calcium ion level, and related method and use for reperfusion
CN106659151B (zh) 2014-06-02 2021-06-08 特兰斯迈迪茨公司 离体器官护理系统
BR112017008076B1 (pt) * 2014-10-24 2021-06-29 Darren Freed Solução com nível de íon cálcio controlado, composição para preparação da solução e processo e uso relacionados para reperfusão
CA2970117A1 (en) 2014-12-12 2016-06-16 Darren FREED Apparatus and method for organ perfusion
CN107949419B (zh) 2015-09-09 2021-03-05 特兰斯迈迪茨公司 离体器官护理系统用的主动脉插管
CN114946834B (zh) 2016-05-30 2024-10-25 体沃索股份有限公司 利用变化的外部压力用于离体肺通气的装置和方法
CN109846464A (zh) * 2018-12-29 2019-06-07 曹乃钊 血液流动力学参数的无创测量系统和数据处理系统
CN113975377B (zh) * 2020-07-27 2023-11-10 成都青山利康药业股份有限公司 一种心脏停搏液
CN115400206B (zh) * 2021-05-26 2025-08-15 成都青山利康药业有限公司 一种细胞外液型含血心脏停搏液

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407793A (en) 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
US5405742A (en) 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
FR2785501B1 (fr) * 1998-11-10 2001-01-05 Centre Nat Rech Scient Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes
EP1207753A4 (en) 1999-06-17 2005-11-30 Univ California CONTINUOUS CARDIAL PERFUSION CONSERVATION WITH PEG-HB FOR IMPROVED HYPOTHERMAL STORAGE
US20030124503A1 (en) 2001-12-28 2003-07-03 Olivencia-Yurvati Albert H. Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof
AUPS312602A0 (en) 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
CA2551169A1 (en) 2002-12-23 2004-07-08 Global Cardiac Solutions Pty Ltd Organ preconditioning, arrest, protection, preservation and recovery
GB0903299D0 (en) * 2009-02-26 2009-04-08 Guys And St Thomas Nhs Foundat Composition and methods

Also Published As

Publication number Publication date
WO2015154193A1 (en) 2015-10-15
CA2943797A1 (en) 2015-10-15
CN107734967B (zh) 2021-07-16
CN107734967A (zh) 2018-02-23
BR112016023394A2 (cg-RX-API-DMAC7.html) 2017-08-15
AU2015245903A1 (en) 2016-11-17
EP3128836B1 (en) 2020-09-09
ES2834388T3 (es) 2021-06-17
EP3128836A4 (en) 2017-11-22
EP3128836A1 (en) 2017-02-15
US10327441B2 (en) 2019-06-25
US20170020127A1 (en) 2017-01-26

Similar Documents

Publication Publication Date Title
US10327441B2 (en) Modulation of calcium ion homeostasis in harvested transplantable hearts
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AU2015234580B2 (en) Apparatus for maintenance of harvested hearts for transplanting
BR112017008076B1 (pt) Solução com nível de íon cálcio controlado, composição para preparação da solução e processo e uso relacionados para reperfusão
Oshima et al. Celsior preserved cardiac mechanoenergetics better than popular solutions in canine hearts
Biagioli et al. Relationships between hemodynamic parameters and myocardial energy and antioxidant status in heart transplantation
Cobert Enhancing Metabolism of Donor Hearts for Cardiac Transplantation

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/04/2015, OBSERVADAS AS CONDICOES LEGAIS.

B25A Requested transfer of rights approved

Owner name: TEVOSOL, INC. (CA)