CN107715017A - One kind is dispelled pain ointment and its production technology - Google Patents

One kind is dispelled pain ointment and its production technology Download PDF

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Publication number
CN107715017A
CN107715017A CN201711206868.7A CN201711206868A CN107715017A CN 107715017 A CN107715017 A CN 107715017A CN 201711206868 A CN201711206868 A CN 201711206868A CN 107715017 A CN107715017 A CN 107715017A
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parts
production technology
plaster
pain
chinese medical
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陈秀娟
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A61K36/126—Drynaria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/732—Chaenomeles, e.g. flowering quince
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

Dispelled pain ointment and its production technology the invention discloses one kind, its production technology includes：(1) Chinese medical extract is produced：After raw material is mixed, clean, grind, then using solid-liquid ratio as 1:3 ratio adds hot-water soak 2h, and then continuous heating keeps 2h, separate fried liquid to 80 100 DEG C, concentrates；(2) mix：4000 parts of medical hot melt adhesives are added into Chinese medical extract, 2h is kept stirring under conditions of 80 DEG C, 100r/min；(3) it is coated with；(4) compound winding；(5) cut；Mixed using medical hot melt adhesive with Chinese medical extract, so that toothpaste product has the effect of easy sticker, use polyethylene film or release liners, make it have the effect easily taken off, using nonwoven cloth material, have compliance is good, compliance is good, good permeability, good waterproof performance, it is difficult for drop-off the characteristics of the pain ointment of dispelling it is high to pain cure rate caused by rheumatic arthritis, cervical vertebra pain, scapulohumeral periarthritis, protrusion of lumber intervertebral disc, osteoproliferation, traumatic injury.

Description

One kind is dispelled pain ointment and its production technology
Technical field
The present invention relates to pharmaceutical technology field, more particularly to one kind is dispelled pain ointment and its production technology.
Background technology
Plaster is one of main formulation of patch therapy in motherland's medical science external therapy, and traditional black plaster is due to simple with making Single, easy to use, the features such as curative effect is quick, cost is cheap, therefore among the people known widely thousand, be continuous and do not wane, and it is countless for basic unit Patient relieves slight illness, is still the main formulation that some basic units doctor and medical institutions make plaster at present.Black plaster is being treated It is especially evident in efficacy to rheumathritis, courbature, strain etc. in terms of disease.
But there are some shortcomings in general ointment：
1. it is not easy to peel after on medical ointment plaster；
2. the gas permeability of ointment is bad；
3. ointment can not be reused, once tearing, its viscosity substantially reduces；
4. water proofing property is bad；
5. drug effect is bad, course for the treatment of length.
The content of the invention
For the deficiencies in the prior art, easily taken off it is an object of the invention to provide a kind of easy sticker, compliance is good, soft Pliable good, good permeability, good waterproof performance, dispel pain ointment and its production technology that viscosity is good, pain of dispelling effect is good.
Present invention solves the technical problem that it can be realized using following technical scheme：
One kind is dispelled pain ointment and its production technology, and its production technology includes：
(1) Chinese medical extract is produced
The formula of Chinese medical extract is as follows：Smilax china L 140-160 parts, pawpaw 90-110 parts, leech 90-110 parts, fructus cannabis 90-110 parts, ground bettle 90-110 parts, dragon's blood 90-110 parts, root of Dahurain angelica 190-210 parts, notopterygium root 90-110 parts, rhizome of davallia 90-110 Part, windproof 190-210 parts, rhizoma atractylodis 90-110 parts, Radix Angelicae Sinensis 90-110 parts, bush 140-160 parts, teasel root 190-210 parts, rhizome of chuanxiong 140-160 parts, frankincense 190-210 parts, myrrh 190-210 parts, borneol 140-160 parts；
After above raw material is mixed, clean, grind, then using solid-liquid ratio as 1:3 ratio adds hot-water soak 2h, then Continuous heating keeps about 2h, separates fried liquid to 80-100 DEG C, and the dregs of a decoction filtered out continue to decoct (2-3 times), to fried liquid taste Road is thin out, merges each fried liquid, concentration；
(2) mix
4000 parts of medical hot melt adhesives are added into Chinese medical extract, are kept stirring under conditions of 80-90 DEG C, 100r/min 2h, from taking Jiao Kou to sample, visual observations sample, enter in next step after qualified；
(3) it is coated with
First pass through plaster coater and medicine core outside last layer is coated with separate paper, it is then that obtained plaster mixture is uniform Entirely it is applied to outer medicine core upper strata；
(4) compound winding
By compound winder will the winding of drug paste base fabric device on plaster mixture, formed up and down to its, it is compound smooth Drug paste base fabric device-plaster mixture-separate paper plaster structure；
(5) cut
The plaster structure of compound winding is divided and come, is directed at knife version, neat is cut into some size identical fritters；
(6) pack
The fritter of well cutting is wired up.
Above-mentioned dispel pain ointment and its production technology, the separate paper are PEF film or release liners.
Above-mentioned dispel pain ointment and its production technology, the drug paste base fabric device are non-woven fabrics.
Above-mentioned dispel pain ointment and its production technology, the outer medicine core are produced：Added into obtained plaster mixture 200 parts of borneols and 200 portions of peppermints after grinding, continue to stir 30min.
Above-mentioned dispel pain ointment and its production technology, examines the quality of the production, free from admixture foreign is as qualified after cutting.
It is as follows the effect of each raw medicinal material in the present invention：
Smilax china L：There is the effect of wind-dispelling, promoting blood circulation, removing toxic substances；Control lumbago, skelalgia of rheumatism, traumatic injury, scrofula.
Pawpaw：Dry and stomach, taste spleen benefit lung；It is kind to control abdominal distension.
Leech：With treatment apoplexy, hypertension, desilting, traumatic injury etc..
Fructus cannabis：Cure mainly：Dry constipation of intestines, blood deficiency and depleted fluid.
Ground bettle：It is cold in nature, taste is salty, poisonous, can enter conscience spleen three and pass through, have by the stasis of blood, broken product, dredging collateral, reason wound and synthetism Continuous muscle, swelling and pain relieving, lower breast stimulate the menstrual flow and other effects.
Dragon's blood：It is sweet, have promoting blood circulation analgesic therapy, removing blood stasis and hemostasis, myogenic sore the effect of, for traumatic injury, trusted subordinate's stasis caused pain, Traumatism and bleeding etc..
The root of Dahurain angelica：It is warm-natured, acrid flavour, slight bitter；Major function:Wind-damp dispelling, apocenosis of invigorating blood circulation, myogenic pain relieving；For having a headache, having a toothache, Nasosinusitis, intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, pruitus.
Notopterygium root：It is warm-natured, dispellieg cold and dampness, for catch cold, have a headache lossless, cold-dampness numbness, upper limbs rheumatalgia pain..
The rhizome of davallia:It is odorless, lightly seasoned；The strong bone of kidney tonifying, continues and hinders pain relieving.
It is windproof：Acrid flavour, slightly warm in nature；Expel pathogenic wind from the body surface, the effect of expel endogenous wind to relieve convulsion.
Rhizoma atractylodis：It is acrid flavour, warm-natured；Drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.
Radix Angelicae Sinensis：With benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation, anticancer, anti-ageing the effect of preventing always, be immune.
Bush：It is sweet, Xin Liang；The effect of with promoting blood circulation, detumescence ding-tong.
Teasel root：Warm-natured, bitter；There is the effect of filling liver kidney, strengthening the bones and muscles, continuous injured.
Rhizome of chuanxiong：It is pungent, temperature.Return liver, courage, pericardium channel, blood-activating and qi-promoting, wind-expelling pain-stopping..
Frankincense：Acrid flavour, heat, micro- poison.Regulating qi and activating blood is cured mainly, analgesic therapy, is chased after poison, controls qi and blood stagnation, trusted subordinate's pain, ulcerative carbuncle swells Poison, traumatic injury, dysmenorrhoea, postpartum blood stasis stabbing pain..
Myrrh：Bitterly, temperature is nontoxic；Blood-breaking analgesic is cured mainly, treats metal-inflicted wound cane sore, all malignant sore anal fistula, sudden lower blood.
Borneol：Lead to all keys, dissipate stagnated fire, remove screen improving eyesight, swelling and pain relieving.
The beneficial effects of the invention are as follows：Mixed using medical hot melt adhesive with Chinese medical extract so that toothpaste product has easy The effect of patch, the one side of toothpaste product is attached to using polyethylene film or release liners, makes it have the effect easily taken off, use nothing Spin cloth material be used as drug paste base fabric device, with compliance is good, compliance is good, good permeability, good waterproof performance, spy difficult for drop-off Point, the setting of double medicine cores, interior medicine core heating, there is promoting blood circulation and removing blood stasis, softening and resolving hard mass, the effect of dispelling wind and eliminating dampness, outer medicine core has cold Deposited physiotherapy, enhancing vascular is penetrating, promotes the effect of microcirculation, and the pain ointment of dispelling is to rheumatic arthritis, cervical vertebra pain, scapulohumeral periarthritis, waist Disc herniation, osteoproliferation, pain cure rate caused by traumatic injury are high.
Embodiment
, there are further understanding and understanding the effect of to make to architectural feature of the invention and being reached, to preferable Embodiment is described in detail, and is described as follows：
(1) case source
The patient 500 of diagnosis is selected, clinical manifestation has rheumatic arthritis, cervical vertebra pain, scapulohumeral periarthritis, lumber ertebral disc to dash forward Go out, pain caused by osteoproliferation, traumatic injury etc., patient is randomly divided into 10 groups, one of which uses common anodyne, separately The outer 9 groups formulation products using different components in the present invention.
(2) efficacy assessment standard
" healing "：Pain disappears；
" effective "：Pain symptom mitigates；
Engineering noise：There is no effect, still pain；
" cure rate "：Pain, which disappears, accounts for experimental group total number of persons percentage.
(3) treatment method
Release liners are torn, plaster face is attached into affected part lasts plaster of tearing after about 1h.
Embodiment 1：
One kind is dispelled pain ointment and its production technology, and its production technology includes：
(1) Chinese medical extract is produced
The formula of Chinese medical extract is as follows：140 parts of Smilax china L, 90 parts of pawpaw, 90 parts of leech, 90 parts of fructus cannabis, ground bettle 90 parts, 90 parts of dragon's blood, 190 parts of the root of Dahurain angelica, 90 parts of notopterygium root, 90 parts of the rhizome of davallia, windproof 190 parts, 90 parts of rhizoma atractylodis, 90 parts of Radix Angelicae Sinensis, bush 140 parts, 190 parts of teasel root, 140 parts of rhizome of chuanxiong, 190 parts of frankincense, 190 parts of myrrh, 140 parts of borneol；
After above raw material is mixed, clean, grind, then using solid-liquid ratio as 1:3 ratio adds hot-water soak 2h, then Continuous heating keeps 2h, separates fried liquid to 80 DEG C, and the dregs of a decoction filtered out continue to decoct 3 times, thin out to fried liquid taste, close And each fried liquid, concentration；
(2) mix
4000 parts of medical hot melt adhesives are added into Chinese medical extract, 2h is kept stirring under conditions of 80 DEG C, 100r/min, From taking Jiao Kou to sample, visual observations sample to sample free from admixture foreign；
The outer medicine core is produced：The 200 parts of borneols and 200 parts thin added into obtained plaster mixture after grinding Lotus, continue to stir 30min；
(3) it is coated with
First pass through plaster coater and medicine core outside last layer is coated with release liners, it is then that obtained plaster mixture is uniform Entirely it is applied to outer medicine core upper strata；
(4) compound winding
By compound winder will non-woven fabrics winding on plaster mixture, formed up and down to its, compound smooth nonwoven The plaster structure of cloth-plaster mixture-release liners；
(5) cut
The plaster structure of compound winding is divided and come, is directed at knife version, neat is cut into some size identical fritters；
(6) pack
Examine the quality of the production, free from admixture foreign, neat in edge, no marking, flawless, non-wrinkle, size accurately cut nothing Breach is as qualified, and quality wires up the fritter of well cutting after reaching a standard.
Embodiment 2：
One kind is dispelled pain ointment and its production technology, and its production technology includes：
(1) Chinese medical extract is produced
The formula of Chinese medical extract is as follows：150 parts of Smilax china L, 100 parts of pawpaw, 100 parts of leech, 100 parts of fructus cannabis, ground beetle 100 parts of worm, 100 parts of dragon's blood, 200 parts of the root of Dahurain angelica, 100 parts of notopterygium root, 100 parts of the rhizome of davallia, windproof 200 parts, 100 parts of rhizoma atractylodis, Radix Angelicae Sinensis 100 Part, 150 parts of bush, 200 parts of teasel root, 150 parts of rhizome of chuanxiong, 200 parts of frankincense, 200 parts of myrrh, 150 parts of borneol；
After above raw material is mixed, clean, grind, then using solid-liquid ratio as 1:3 ratio adds hot-water soak 2h, then Continuous heating keeps 2h, separates fried liquid to 80 DEG C, and the dregs of a decoction filtered out continue to decoct 3 times, thin out to fried liquid taste, close And each fried liquid, concentration；
(2) mix
4000 parts of medical hot melt adhesives are added into Chinese medical extract, 2h is kept stirring under conditions of 80 DEG C, 100r/min, From taking Jiao Kou to sample, visual observations sample to sample free from admixture foreign；
The outer medicine core is produced：The 200 parts of borneols and 200 parts thin added into obtained plaster mixture after grinding Lotus, continue to stir 30min；
(3) it is coated with
First pass through plaster coater and medicine core outside last layer is coated with release liners, it is then that obtained plaster mixture is uniform Entirely it is applied to outer medicine core upper strata；
(4) compound winding
By compound winder will non-woven fabrics winding on plaster mixture, formed up and down to its, compound smooth nonwoven The plaster structure of cloth-plaster mixture-release liners；
(5) cut
The plaster structure of compound winding is divided and come, is directed at knife version, neat is cut into some size identical fritters；
(6) pack
Examine the quality of the production, free from admixture foreign, neat in edge, no marking, flawless, non-wrinkle, size accurately cut nothing Breach is as qualified, and quality wires up the fritter of well cutting after reaching a standard.
Embodiment 3：
One kind is dispelled pain ointment and its production technology, and its production technology includes：
(1) Chinese medical extract is produced
The formula of Chinese medical extract is as follows：160 parts of Smilax china L, 110 parts of pawpaw, 110 parts of leech, 110 parts of fructus cannabis, ground beetle 110 parts of worm, 110 parts of dragon's blood, 210 parts of the root of Dahurain angelica, 110 parts of notopterygium root, 110 parts of the rhizome of davallia, windproof 210 parts, 110 parts of rhizoma atractylodis, Radix Angelicae Sinensis 110 Part, 160 parts of bush, 210 parts of teasel root, 160 parts of rhizome of chuanxiong, 210 parts of frankincense, 210 parts of myrrh, 160 parts of borneol；
After above raw material is mixed, clean, grind, then using solid-liquid ratio as 1:3 ratio adds hot-water soak 2h, then Continuous heating keeps 2h, separates fried liquid to 80 DEG C, and the dregs of a decoction filtered out continue to decoct 3 times, thin out to fried liquid taste, close And each fried liquid, concentration；
(2) mix
4000 parts of medical hot melt adhesives are added into Chinese medical extract, 2h is kept stirring under conditions of 80 DEG C, 100r/min, From taking Jiao Kou to sample, visual observations sample to sample free from admixture foreign；
The outer medicine core is produced：The 200 parts of borneols and 200 parts thin added into obtained plaster mixture after grinding Lotus, continue to stir 30min；
(3) it is coated with
First pass through plaster coater and medicine core outside last layer is coated with release liners, it is then that obtained plaster mixture is uniform Entirely it is applied to outer medicine core upper strata；
(4) compound winding
By compound winder will non-woven fabrics winding on plaster mixture, formed up and down to its, compound smooth nonwoven The plaster structure of cloth-plaster mixture-release liners；
(5) cut
The plaster structure of compound winding is divided and come, is directed at knife version, neat is cut into some size identical fritters；
(6) pack
Examine the quality of the production, free from admixture foreign, neat in edge, no marking, flawless, non-wrinkle, size accurately cut nothing Breach is as qualified, and quality wires up the fritter of well cutting after reaching a standard.
Embodiment 4：
One kind is dispelled pain ointment and its production technology, and its production technology includes：
(1) Chinese medical extract is produced
The formula of Chinese medical extract is as follows：140 parts of Smilax china L, 90 parts of pawpaw, 90 parts of leech, 90 parts of fructus cannabis, ground bettle 90 parts, 90 parts of dragon's blood, 200 parts of the root of Dahurain angelica, 100 parts of notopterygium root, 100 parts of the rhizome of davallia, windproof 200 parts, 100 parts of rhizoma atractylodis, 100 parts of Radix Angelicae Sinensis, 160 parts of bush, 210 parts of teasel root, 160 parts of rhizome of chuanxiong, 210 parts of frankincense, 210 parts of myrrh, 160 parts of borneol；
After above raw material is mixed, clean, grind, then using solid-liquid ratio as 1:3 ratio adds hot-water soak 2h, then Continuous heating keeps 2h, separates fried liquid to 80 DEG C, and the dregs of a decoction filtered out continue to decoct 3 times, thin out to fried liquid taste, close And each fried liquid, concentration；
(2) mix
4000 parts of medical hot melt adhesives are added into Chinese medical extract, 2h is kept stirring under conditions of 80 DEG C, 100r/min, From taking Jiao Kou to sample, visual observations sample to sample free from admixture foreign；
The outer medicine core is produced：The 200 parts of borneols and 200 parts thin added into obtained plaster mixture after grinding Lotus, continue to stir 30min；
(3) it is coated with
First pass through plaster coater and medicine core outside last layer is coated with release liners, it is then that obtained plaster mixture is uniform Entirely it is applied to outer medicine core upper strata；
(4) compound winding
By compound winder will non-woven fabrics winding on plaster mixture, formed up and down to its, compound smooth nonwoven The plaster structure of cloth-plaster mixture-release liners；
(5) cut
The plaster structure of compound winding is divided and come, is directed at knife version, neat is cut into some size identical fritters；
(6) pack
Examine the quality of the production, free from admixture foreign, neat in edge, no marking, flawless, non-wrinkle, size accurately cut nothing Breach is as qualified, and quality wires up the fritter of well cutting after reaching a standard.
Embodiment 5：
One kind is dispelled pain ointment and its production technology, and its production technology includes：
(1) Chinese medical extract is produced
The formula of Chinese medical extract is as follows：140 parts of Smilax china L, 90 parts of pawpaw, 90 parts of leech, 90 parts of fructus cannabis, ground bettle 90 parts, 90 parts of dragon's blood, 190 parts of the root of Dahurain angelica, 90 parts of notopterygium root, 90 parts of the rhizome of davallia, windproof 190 parts, 90 parts of rhizoma atractylodis, 90 parts of Radix Angelicae Sinensis, bush 160 parts, 210 parts of teasel root, 160 parts of rhizome of chuanxiong, 210 parts of frankincense, 210 parts of myrrh, 160 parts of borneol；
After above raw material is mixed, clean, grind, then using solid-liquid ratio as 1:3 ratio adds hot-water soak 2h, then Continuous heating keeps 2h, separates fried liquid to 80 DEG C, and the dregs of a decoction filtered out continue to decoct 3 times, thin out to fried liquid taste, close And each fried liquid, concentration；
(2) mix
4000 parts of medical hot melt adhesives are added into Chinese medical extract, 2h is kept stirring under conditions of 80 DEG C, 100r/min, From taking Jiao Kou to sample, visual observations sample to sample free from admixture foreign；
The outer medicine core is produced：The 200 parts of borneols and 200 parts thin added into obtained plaster mixture after grinding Lotus, continue to stir 30min；
(3) it is coated with
First pass through plaster coater and medicine core outside last layer is coated with release liners, it is then that obtained plaster mixture is uniform Entirely it is applied to outer medicine core upper strata；
(4) compound winding
By compound winder will non-woven fabrics winding on plaster mixture, formed up and down to its, compound smooth nonwoven The plaster structure of cloth-plaster mixture-release liners；
(5) cut
The plaster structure of compound winding is divided and come, is directed at knife version, neat is cut into some size identical fritters；
(6) pack
Examine the quality of the production, free from admixture foreign, neat in edge, no marking, flawless, non-wrinkle, size accurately cut nothing Breach is as qualified, and quality wires up the fritter of well cutting after reaching a standard.
Embodiment 6：
One kind is dispelled pain ointment and its production technology, and its production technology includes：
(1) Chinese medical extract is produced
The formula of Chinese medical extract is as follows：150 parts of Smilax china L, 100 parts of pawpaw, 100 parts of leech, 100 parts of fructus cannabis, ground beetle 100 parts of worm, 100 parts of dragon's blood, 200 parts of the root of Dahurain angelica, 100 parts of notopterygium root, 100 parts of the rhizome of davallia, windproof 200 parts, 100 parts of rhizoma atractylodis, Radix Angelicae Sinensis 100 Part, 160 parts of bush, 210 parts of teasel root, 160 parts of rhizome of chuanxiong, 210 parts of frankincense, 210 parts of myrrh, 160 parts of borneol；
After above raw material is mixed, clean, grind, then using solid-liquid ratio as 1:3 ratio adds hot-water soak 2h, then Continuous heating keeps 2h, separates fried liquid to 80 DEG C, and the dregs of a decoction filtered out continue to decoct 3 times, thin out to fried liquid taste, close And each fried liquid, concentration；
(2) mix
4000 parts of medical hot melt adhesives are added into Chinese medical extract, 2h is kept stirring under conditions of 80 DEG C, 100r/min, From taking Jiao Kou to sample, visual observations sample to sample free from admixture foreign；
The outer medicine core is produced：The 200 parts of borneols and 200 parts thin added into obtained plaster mixture after grinding Lotus, continue to stir 30min；
(3) it is coated with
First pass through plaster coater and medicine core outside last layer is coated with release liners, it is then that obtained plaster mixture is uniform Entirely it is applied to outer medicine core upper strata；
(4) compound winding
By compound winder will non-woven fabrics winding on plaster mixture, formed up and down to its, compound smooth nonwoven The plaster structure of cloth-plaster mixture-release liners；
(5) cut
The plaster structure of compound winding is divided and come, is directed at knife version, neat is cut into some size identical fritters；
(6) pack
Examine the quality of the production, free from admixture foreign, neat in edge, no marking, flawless, non-wrinkle, size accurately cut nothing Breach is as qualified, and quality wires up the fritter of well cutting after reaching a standard.
Embodiment 7：
One kind is dispelled pain ointment and its production technology, and its production technology includes：
(1) Chinese medical extract is produced
The formula of Chinese medical extract is as follows：150 parts of Smilax china L, 100 parts of pawpaw, 100 parts of leech, 100 parts of fructus cannabis, ground beetle 100 parts of worm, 100 parts of dragon's blood, 190 parts of the root of Dahurain angelica, 90 parts of notopterygium root, 90 parts of the rhizome of davallia, windproof 190 parts, 90 parts of rhizoma atractylodis, 90 parts of Radix Angelicae Sinensis, 150 parts of bush, 200 parts of teasel root, 150 parts of rhizome of chuanxiong, 200 parts of frankincense, 200 parts of myrrh, 150 parts of borneol；
After above raw material is mixed, clean, grind, then using solid-liquid ratio as 1:3 ratio adds hot-water soak 2h, then Continuous heating keeps 2h, separates fried liquid to 80 DEG C, and the dregs of a decoction filtered out continue to decoct 3 times, thin out to fried liquid taste, close And each fried liquid, concentration；
(2) mix
4000 parts of medical hot melt adhesives are added into Chinese medical extract, 2h is kept stirring under conditions of 80 DEG C, 100r/min, From taking Jiao Kou to sample, visual observations sample to sample free from admixture foreign；
The outer medicine core is produced：The 200 parts of borneols and 200 parts thin added into obtained plaster mixture after grinding Lotus, continue to stir 30min；
(3) it is coated with
First pass through plaster coater and medicine core outside last layer is coated with release liners, it is then that obtained plaster mixture is uniform Entirely it is applied to outer medicine core upper strata；
(4) compound winding
By compound winder will non-woven fabrics winding on plaster mixture, formed up and down to its, compound smooth nonwoven The plaster structure of cloth-plaster mixture-release liners；
(5) cut
The plaster structure of compound winding is divided and come, is directed at knife version, neat is cut into some size identical fritters；
(6) pack
Examine the quality of the production, free from admixture foreign, neat in edge, no marking, flawless, non-wrinkle, size accurately cut nothing Breach is as qualified, and quality wires up the fritter of well cutting after reaching a standard.
Embodiment 8：
One kind is dispelled pain ointment and its production technology, and its production technology includes：
(1) Chinese medical extract is produced
The formula of Chinese medical extract is as follows：160 parts of Smilax china L, 110 parts of pawpaw, 110 parts of leech, 110 parts of fructus cannabis, ground beetle 110 parts of worm, 110 parts of blood, 200 parts of the root of Dahurain angelica, 100 parts of notopterygium root, 100 parts of the rhizome of davallia, windproof 200 parts, 100 parts of rhizoma atractylodis, Radix Angelicae Sinensis 100 Part, 160 parts of bush, 210 parts of teasel root, 160 parts of rhizome of chuanxiong, 210 parts of frankincense, 210 parts of myrrh, 160 parts of borneol；
After above raw material is mixed, clean, grind, then using solid-liquid ratio as 1:3 ratio adds hot-water soak 2h, then Continuous heating keeps 2h, separates fried liquid to 80 DEG C, and the dregs of a decoction filtered out continue to decoct 3 times, thin out to fried liquid taste, close And each fried liquid, concentration；
(2) mix
4000 parts of medical hot melt adhesives are added into Chinese medical extract, 2h is kept stirring under conditions of 80 DEG C, 100r/min, From taking Jiao Kou to sample, visual observations sample to sample free from admixture foreign；
The outer medicine core is produced：The 200 parts of borneols and 200 parts thin added into obtained plaster mixture after grinding Lotus, continue to stir 30min；
(3) it is coated with
First pass through plaster coater and medicine core outside last layer is coated with release liners, it is then that obtained plaster mixture is uniform Entirely it is applied to outer medicine core upper strata；
(4) compound winding
By compound winder will non-woven fabrics winding on plaster mixture, formed up and down to its, compound smooth nonwoven The plaster structure of cloth-plaster mixture-release liners；
(5) cut
The plaster structure of compound winding is divided and come, is directed at knife version, neat is cut into some size identical fritters；
(6) pack
Examine the quality of the production, free from admixture foreign, neat in edge, no marking, flawless, non-wrinkle, size accurately cut nothing Breach is as qualified, and quality wires up the fritter of well cutting after reaching a standard.
Embodiment 9：
One kind is dispelled pain ointment and its production technology, and its production technology includes：
(1) Chinese medical extract is produced
The formula of Chinese medical extract is as follows：160 parts of Smilax china L, 110 parts of pawpaw, 110 parts of leech, 110 parts of fructus cannabis, ground beetle 110 parts of worm, 110 parts of dragon's blood, 190 parts of the root of Dahurain angelica, 90 parts of notopterygium root, 90 parts of the rhizome of davallia, windproof 190 parts, 90 parts of rhizoma atractylodis, 90 parts of Radix Angelicae Sinensis, 150 parts of bush, 200 parts of teasel root, 150 parts of rhizome of chuanxiong, 200 parts of frankincense, 200 parts of myrrh, 150 parts of borneol；
After above raw material is mixed, clean, grind, then using solid-liquid ratio as 1:3 ratio adds hot-water soak 2h, then Continuous heating keeps 2h, separates fried liquid to 80 DEG C, and the dregs of a decoction filtered out continue to decoct 3 times, thin out to fried liquid taste, close And each fried liquid, concentration；
(2) mix
4000 parts of medical hot melt adhesives are added into Chinese medical extract, 2h is kept stirring under conditions of 80 DEG C, 100r/min, From taking Jiao Kou to sample, visual observations sample to sample free from admixture foreign；
The outer medicine core is produced：The 200 parts of borneols and 200 parts thin added into obtained plaster mixture after grinding Lotus, continue to stir 30min；
(3) it is coated with
First pass through plaster coater and medicine core outside last layer is coated with release liners, it is then that obtained plaster mixture is uniform Entirely it is applied to outer medicine core upper strata；
(4) compound winding
By compound winder will non-woven fabrics winding on plaster mixture, formed up and down to its, compound smooth nonwoven The plaster structure of cloth-plaster mixture-release liners；
(5) cut
The plaster structure of compound winding is divided and come, is directed at knife version, neat is cut into some size identical fritters；
(6) pack
Examine the quality of the production, free from admixture foreign, neat in edge, no marking, flawless, non-wrinkle, size accurately cut nothing Breach is as qualified, and quality wires up the fritter of well cutting after reaching a standard.
Experimental result：
1. the cure rate of this product is apparently higher than the cure rate of common anodyne；
2. with the increase of the time using this product, cure rate is improved；
3. this product material rate is most preferably embodiment 2 (A-R is 2).
Mixed using medical hot melt adhesive with Chinese medical extract so that toothpaste product has the effect of easy sticker, uses polyethylene Film or release liners are attached to the one side of toothpaste product, make it have the effect easily taken off, and drug paste base is used as using nonwoven cloth material Cloth apparatus, have compliance is good, compliance is good, good permeability, good waterproof performance, it is difficult for drop-off the characteristics of, the setting of double medicine cores is interior Medicine core is generated heat, and has promoting blood circulation and removing blood stasis, softening and resolving hard mass, the effect of dispelling wind and eliminating dampness, and there is outer medicine core cold compress physiotherapy, enhancing vascular to lead to Thoroughly, the effect of microcirculation is promoted, the pain ointment of dispelling is to rheumatic arthritis, cervical vertebra pain, scapulohumeral periarthritis, protrusion of lumber intervertebral disc, hyperostosis Pain cure rate is high caused by raw, traumatic injury.
General principle, principal character and the advantages of the present invention of the present invention has been shown and described above.The technology of the industry For personnel it should be appreciated that the present invention is not limited to the above embodiments, that described in above-described embodiment and specification is the present invention Principle, various changes and modifications of the present invention are possible without departing from the spirit and scope of the present invention, these change and Improvement is both fallen within the range of claimed invention.The protection domain of application claims by appended claims and its Equivalent defines.

Claims (5)

  1. Pain ointment and its production technology 1. one kind is dispelled, it is characterised in that its production technology includes：
    (1) Chinese medical extract is produced
    The formula of Chinese medical extract is as follows：Smilax china L 140-160 parts, pawpaw 90-110 parts, leech 90-110 parts, fructus cannabis 90- 110 parts, ground bettle 90-110 parts, dragon's blood 90-110 parts, root of Dahurain angelica 190-210 parts, notopterygium root 90-110 parts, rhizome of davallia 90-110 parts, Windproof 190-210 parts, rhizoma atractylodis 90-110 parts, Radix Angelicae Sinensis 90-110 parts, bush 140-160 parts, teasel root 190-210 parts, rhizome of chuanxiong 140- 160 parts, frankincense 190-210 parts, myrrh 190-210 parts, borneol 140-160 parts；
    After above raw material is mixed, clean, grind, then using solid-liquid ratio as 1:3 ratio adds hot-water soak 2h, then continues 80-100 DEG C is heated to, about 2h is kept, separates fried liquid, the dregs of a decoction filtered out continue to decoct (2-3 times), become to fried liquid taste It is light, merge each fried liquid, concentration；
    (2) mix
    4000 parts of medical hot melt adhesives are added into Chinese medical extract, 2h is kept stirring under conditions of 80-90 DEG C, 100r/min, From taking Jiao Kou to sample, visual observations sample, enter in next step after qualified；
    (3) it is coated with
    First pass through plaster coater and medicine core outside last layer is coated with separate paper, then by obtained plaster mixture uniform ground Ground is applied to outer medicine core upper strata；
    (4) compound winding
    By compound winder will the winding of drug paste base fabric device on plaster mixture, formed up and down to its, compound smooth medicine Paste the plaster structure of base fabric device-plaster mixture-separate paper；
    (5) cut
    The plaster structure of compound winding is divided and come, is directed at knife version, neat is cut into some size identical fritters；
    (6) pack
    The fritter of well cutting is wired up.
  2. 2. pain ointment and its production technology according to claim 1 of dispelling, it is characterised in that the separate paper is that PEF is thin Film or release liners.
  3. 3. pain ointment and its production technology according to claim 1 of dispelling, it is characterised in that the drug paste base fabric device is nothing Spin cloth.
  4. 4. pain ointment and its production technology according to claim 1 of dispelling, it is characterised in that the outer medicine core is produced：To The 200 parts of borneols and 200 portions of peppermints added after grinding in obtained plaster mixture, continue to stir 30min.
  5. 5. pain ointment and its production technology according to claim 1 of dispelling, it is characterised in that examined the quality of the production after cutting.
CN201711206868.7A 2017-11-27 2017-11-27 One kind is dispelled pain ointment and its production technology Pending CN107715017A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711206868.7A CN107715017A (en) 2017-11-27 2017-11-27 One kind is dispelled pain ointment and its production technology

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711206868.7A CN107715017A (en) 2017-11-27 2017-11-27 One kind is dispelled pain ointment and its production technology

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Publication Number Publication Date
CN107715017A true CN107715017A (en) 2018-02-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
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Country Link
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101361975A (en) * 2008-09-25 2009-02-11 桂林天和药业股份有限公司 Medical plaster hot-melt adhesive ground substance, traditional Chinese medicine plaster using the ground substance and preparation method thereof
CN102000276A (en) * 2010-11-15 2011-04-06 李清珠 External plaster for promoting blood circulation and removing blood stasis and preparation method thereof
CN103479841A (en) * 2013-09-18 2014-01-01 李阳 External use medicament for treating traumatic injuries and preparation method thereof
CN104997980A (en) * 2015-07-21 2015-10-28 朱留臣 Traditional Chinese medicine unguent for treating scapulohumeral periarthritis, cervical spondylosis and knee-joint hyperplasia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101361975A (en) * 2008-09-25 2009-02-11 桂林天和药业股份有限公司 Medical plaster hot-melt adhesive ground substance, traditional Chinese medicine plaster using the ground substance and preparation method thereof
CN102000276A (en) * 2010-11-15 2011-04-06 李清珠 External plaster for promoting blood circulation and removing blood stasis and preparation method thereof
CN103479841A (en) * 2013-09-18 2014-01-01 李阳 External use medicament for treating traumatic injuries and preparation method thereof
CN104997980A (en) * 2015-07-21 2015-10-28 朱留臣 Traditional Chinese medicine unguent for treating scapulohumeral periarthritis, cervical spondylosis and knee-joint hyperplasia

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