CN107714967A - A kind of traditional Chinese medicinal composition with effect of reducing blood sugar containing blue or green money willow and preparation method thereof - Google Patents

A kind of traditional Chinese medicinal composition with effect of reducing blood sugar containing blue or green money willow and preparation method thereof Download PDF

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Publication number
CN107714967A
CN107714967A CN201710944999.9A CN201710944999A CN107714967A CN 107714967 A CN107714967 A CN 107714967A CN 201710944999 A CN201710944999 A CN 201710944999A CN 107714967 A CN107714967 A CN 107714967A
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selenium
mentioned
taken
rich
stirs
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马开
田萍
张迪文
周红艳
马龙
孙为
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HENAN PROVINCE CHINESE MEDICINE RESEARCH INSTITUTE
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HENAN PROVINCE CHINESE MEDICINE RESEARCH INSTITUTE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a kind of traditional Chinese medicinal composition with effect of reducing blood sugar, and it is made up of the raw material of following weight parts：Oyster meat 30 40, blue or green money willow 47, olive oil 0.1 0.3, the bighead atractylodes rhizome 23, Radix Codonopsis 34, linoleic acid 0.8 1, selenium-rich pumpkin 46 50, hypoglycemic emulsion 10 23, sodium chloride 190 200; blue or green money willow that the present invention adds, the bighead atractylodes rhizome, Radix Codonopsis, onion, the tuber of dwarf lilyturf, polished rice etc. effectively raise the effect of lowering blood sugar of finished product flavoring; improve immunity of organisms; by the way that selenium raw material is effectively combined with taurine, the nutritive value of finished product is improved.

Description

A kind of traditional Chinese medicinal composition with effect of reducing blood sugar containing blue or green money willow and preparation method thereof
Technical field
The invention belongs to Chinese medicine hypoglycemic field, and in particular to a kind of traditional Chinese medicinal composition with effect of reducing blood sugar and its system containing blue or green money willow Preparation Method.
Background technology
When blood glucose value exceed as defined in it is horizontal when will form hyperglycemia, blood glucose rise, glucose in urine increases, and can trigger infiltration Property diuresis, so as to cause the symptom of diuresis；Blood glucose rise, large quantity of moisture are lost, and blood osmotic pressure also can be raised accordingly, and high blood oozes can The thirst center of Hypothalamic Stimulation, so as to cause symptom that is thirsty, drinking more；Due to the relative or absolute shortage of insulin, cause Internal glucose can not be utilized, and protein and fat consumption increase, so as to cause weak, weight loss；In order to compensate loss Sugar, maintain body activities, it is necessary to feed more；Which forms typical " three-many-one-little " symptom.Diabetic it is more The order of severity of drink, diuresis symptom and the state of an illness is proportional.Moreover, it is noted that patient eats more, blood glucose is higher, Mistake sugar is also more in urine, and hunger is also more severe, has ultimately resulted in vicious circle.Therefore, in this case, with eat less for It is good, but daily 150 grams of staple foods can not be less than.But if diabetes are not alleviated, the appetite of patient reduces suddenly, now it should be noted that being No concurrent infection, ketosis and other complication；Strict glycemic control.Early stage efficiently controls infection.Strict glycemic control can subtract The incidence infected less.Control blood glucose, correct control and elimination that acid poisoning is advantageous to infection.Except the insulin used time adds during infection Big outer, the patient of OHA should use insulin instead, change back oral medicine after infection control again.Should to hyperglycemic patients infection With enough understanding and processing；
Hyperglycaemia can cause microangiopathies, make the microcirculation of patient have different degrees of exception.With the extension of the course of disease The exacerbation and development of microangiopathies can be promoted not in time with treatment, make patient's blinding, disable.Microangiopathies are mainly manifested in Retina, kidney, cardiac muscle, nerve fiber and toes, patient is set to experience ailing torment.Hyperglycaemia can also cause macroangiopathy.Sugar Urine characteristic of disease macroangiopathy refers to the Atherosclerosis such as sustainer, coronary artery, basilar artary, the arteria renalis and peripheral arterial Change.Wherein, the atherosclerosis state of an illness is heavier, case fatality rate is high.It is big that about 70%~80% diabetic dies from diabetic keratopathy Vascular lesion；
Flavouring is as modern people's daily necessities, if adding the raw material group of appropriate reduction blood glucose in flavouring Part, it can not only meet the needed seasoning class of people's body health, while seasoning, play and reduce blood glucose, enhancing is immunized The effect of power.
The content of the invention
In view of the defects and deficiencies of the prior art, the present invention intends to provide in a kind of hypoglycemic containing blue or green money willow Drug composition and preparation method thereof.
To achieve the above object, the present invention uses following technical scheme：
A kind of traditional Chinese medicinal composition with effect of reducing blood sugar, it is made up of the raw material of following weight parts：
Oyster meat 30-40, blue or green money willow 4-7, olive oil 0.1-0.3, bighead atractylodes rhizome 2-3, Radix Codonopsis 3-4, linoleic acid 0.8-1, selenium-rich Pumpkin 46-50, hypoglycemic emulsion 10-23, sodium chloride 190-200.
What described hypoglycemic emulsion was made up of the raw material of following weight parts：
Onion 3-5, tuber of dwarf lilyturf 4-6, polished rice 10-15, sorbitan monostearate 0.07-0.1, vinasse 0.2-1, lemon 2-3.
The preparation method of described hypoglycemic emulsion comprises the following steps：
(1) onion, the tuber of dwarf lilyturf are taken, is added in compound weight 15-20 ethanol solution, stirs, at 70-75 DEG C Insulated and stirred 1-2 hours, filtering, obtain filtrate；
(2) polished rice is taken, adds boiling ripe, mixed mashing after lemon is removed the peel, mixes, stirs with above-mentioned filtrate, Above-mentioned vinasse are added, are sent in wooden barrel, the sealing thermal insulation 4-5 hours at 30-35 DEG C, discharging, obtain zymotic fluid；
(3) above-mentioned zymotic fluid is taken, is mixed with sorbitan monostearate, is stirred, ethanol is distilled off, obtains the drop Blood glucose emulsion.
A kind of preparation method of traditional Chinese medicinal composition with effect of reducing blood sugar, comprises the following steps：
(1) the above-mentioned bighead atractylodes rhizome, Radix Codonopsis mixing are taken, is added in the acetone of 40-50 times of compound weight, stirs, raise Temperature is 60-70 DEG C, insulated and stirred 1-2 hours, filtering, obtains filtrate；
(2) linoleic acid is taken, is added in above-mentioned filtrate, stirs, acetone is distilled off, obtains oleic acid extract solution；
(3) selenium-rich pumpkin is taken, is cooked, mashing, mixes, stirs with above-mentioned oleic acid extract solution, adds compound weight 3-4% protease, regulation temperature are 30-40 DEG C, insulated and stirred 2-3 hours, filtering, obtain selenium-rich extract solution；
(4) oyster meat, blue or green money willow mixing are taken, is added in above-mentioned selenium-rich extract solution, is ultrasonically treated 10-20 minutes, processing Temperature is 55-65 DEG C, power 500-600w, filtering, obtains selenium-rich slurries；
(5) above-mentioned selenium-rich slurries are taken, mixes, stirs with hypoglycemic emulsion, it is molten that the acetic acid that concentration is 1-2% is added dropwise Liquid, regulation pH are 1-2, stand 2-3 hours, centrifugation, take supernatant, obtain selenium-rich taurine；
(6) above-mentioned olive oil, sodium chloride mixing are taken, is added in above-mentioned selenium-rich taurine, stirs, be spray-dried, Produce the traditional Chinese medicinal composition with effect of reducing blood sugar.
Advantages of the present invention：
The present invention uses onion, the ethanol extract of the tuber of dwarf lilyturf then to be mixed for filtrate with polished rice, using vinasse fermentation, then Disperseed by sorbitan monostearate, obtained emulsion has aroma, and excellent storage stability, storage life limit for length；
The present invention is using selenium-rich pumpkin as raw material, using oleic acid extract solution as solvent, by Protease Treatment, obtains selenium-rich extraction Liquid, not only Se content enriches the selenium-rich extract solution, also high containing the compositions such as polypeptide, nutritive value；
The present invention is using oyster meat as raw material, using selenium-rich extract solution as solvent, by ultrasound, Extraction of acetic acid, and the ox that will be obtained Sulfonic acid is effectively distributed in selenium-rich solution, realizes the combination of selenium and taurine, effectively reduces loss；
Blue or green money willow that the present invention adds, the bighead atractylodes rhizome, Radix Codonopsis, onion, the tuber of dwarf lilyturf, polished rice etc. effectively raise finished product flavoring Effect of lowering blood sugar, immunity of organisms is improved, by the way that selenium raw material is effectively combined with taurine, improve the nutriture value of finished product Value；
The effect of lowering blood sugar of flavoring of the present invention is good, nutrient stabilizing, not easily runs off, and also with certain aroma, improves The mouthfeel of Tradition condiment, combination property are superior.
Embodiment
Embodiment 1
A kind of traditional Chinese medicinal composition with effect of reducing blood sugar, it is made up of the raw material of following weight parts：
Oyster meat 40, blue or green money willow 7, olive oil 0.3, the bighead atractylodes rhizome 3, Radix Codonopsis 4, linoleic acid 1, selenium-rich pumpkin 50, hypoglycemic emulsion 23rd, sodium chloride 200.
What described hypoglycemic emulsion was made up of the raw material of following weight parts：
Onion 5, the tuber of dwarf lilyturf 6, polished rice 15, sorbitan monostearate 0.1, vinasse 1, lemon 3.
The preparation method of described hypoglycemic emulsion comprises the following steps：
(1) onion, the tuber of dwarf lilyturf are taken, is added in compound weight 15-20 ethanol solution, stirs, is protected at 775 DEG C Temperature stirring 2 hours, filtering, obtains filtrate；
(2) polished rice is taken, adds boiling ripe, mixed mashing after lemon is removed the peel, mixes, stirs with above-mentioned filtrate, Above-mentioned vinasse are added, are sent in wooden barrel, sealing thermal insulation 5 hours at 35 DEG C, discharging, obtain zymotic fluid；
(3) above-mentioned zymotic fluid is taken, is mixed with sorbitan monostearate, is stirred, ethanol is distilled off, obtains the drop Blood glucose emulsion.
A kind of preparation method of traditional Chinese medicinal composition with effect of reducing blood sugar, comprises the following steps：
(1) the above-mentioned bighead atractylodes rhizome, Radix Codonopsis mixing are taken, is added in the acetone of 50 times of compound weight, stirs, raise temperature For 70 DEG C, insulated and stirred 2 hours, filtering, filtrate is obtained；
(2) linoleic acid is taken, is added in above-mentioned filtrate, stirs, acetone is distilled off, obtains oleic acid extract solution；
(3) selenium-rich pumpkin is taken, is cooked, mashing, mixes, stirs with above-mentioned oleic acid extract solution, adds compound weight 4% protease, regulation temperature are 40 DEG C, insulated and stirred 3 hours, filtering, obtain selenium-rich extract solution；
(4) oyster meat, blue or green money willow mixing are taken, is added in above-mentioned selenium-rich extract solution, is ultrasonically treated 20 minutes, treatment temperature For 65 DEG C, power 600w, filtering, selenium-rich slurries are obtained；
(5) above-mentioned selenium-rich slurries are taken, mixes, stirs with hypoglycemic emulsion, the acetum that concentration is 2% is added dropwise, It is 2 to adjust pH, stands 3 hours, centrifugation, takes supernatant, obtains selenium-rich taurine；
(6) above-mentioned olive oil, sodium chloride mixing are taken, is added in above-mentioned selenium-rich taurine, stirs, be spray-dried, Produce the traditional Chinese medicinal composition with effect of reducing blood sugar.
Embodiment 2
A kind of traditional Chinese medicinal composition with effect of reducing blood sugar, it is made up of the raw material of following weight parts：
Oyster meat 30, blue or green money willow 4, olive oil 0.1, the bighead atractylodes rhizome 2, Radix Codonopsis 3, linoleic acid 0.8, selenium-rich pumpkin 46, hypoglycemic breast Liquid 10, sodium chloride 190.
What described hypoglycemic emulsion was made up of the raw material of following weight parts：
Onion 3, the tuber of dwarf lilyturf 4, polished rice 10, sorbitan monostearate 0.07, vinasse 0.2, lemon 2.
The preparation method of described hypoglycemic emulsion comprises the following steps：
(1) onion, the tuber of dwarf lilyturf are taken, is added in the ethanol solution of compound weight 15, stirs, is incubated and stirs at 70 DEG C Mix 1 hour, filter, obtain filtrate；
(2) polished rice is taken, adds boiling ripe, mixed mashing after lemon is removed the peel, mixes, stirs with above-mentioned filtrate, Above-mentioned vinasse are added, are sent in wooden barrel, sealing thermal insulation 4 hours at 30 DEG C, discharging, obtain zymotic fluid；
(3) above-mentioned zymotic fluid is taken, is mixed with sorbitan monostearate, is stirred, ethanol is distilled off, obtains the drop Blood glucose emulsion.
A kind of preparation method of traditional Chinese medicinal composition with effect of reducing blood sugar, comprises the following steps：
(1) the above-mentioned bighead atractylodes rhizome, Radix Codonopsis mixing are taken, is added in the acetone of 40 times of compound weight, stirs, raise temperature For 60 DEG C, insulated and stirred 1 hour, filtering, filtrate is obtained；
(2) linoleic acid is taken, is added in above-mentioned filtrate, stirs, acetone is distilled off, obtains oleic acid extract solution；
(3) selenium-rich pumpkin is taken, is cooked, mashing, mixes, stirs with above-mentioned oleic acid extract solution, adds compound weight 3% protease, regulation temperature are 30 DEG C, insulated and stirred 2 hours, filtering, obtain selenium-rich extract solution；
(4) oyster meat, blue or green money willow mixing are taken, is added in above-mentioned selenium-rich extract solution, is ultrasonically treated 10 minutes, treatment temperature For 55 DEG C, power 500w, filtering, selenium-rich slurries are obtained；
(5) above-mentioned selenium-rich slurries are taken, mixes, stirs with hypoglycemic emulsion, the acetum that concentration is 1% is added dropwise, It is 1 to adjust pH, stands 2 hours, centrifugation, takes supernatant, obtains selenium-rich taurine；
(6) above-mentioned olive oil, sodium chloride mixing are taken, is added in above-mentioned selenium-rich taurine, stirs, be spray-dried, Produce the traditional Chinese medicinal composition with effect of reducing blood sugar.

Claims (4)

1. a kind of traditional Chinese medicinal composition with effect of reducing blood sugar, it is characterised in that it is made up of the raw material of following weight parts：
Oyster meat 30-40, blue or green money willow 4-7, olive oil 0.1-0.3, bighead atractylodes rhizome 2-3, Radix Codonopsis 3-4, linoleic acid 0.8-1, selenium-rich pumpkin 46-50, hypoglycemic emulsion 10-23, sodium chloride 190-200.
2. a kind of traditional Chinese medicinal composition with effect of reducing blood sugar according to claim 1, it is characterised in that described hypoglycemic emulsion is It is made up of the raw material of following weight parts：
Onion 3-5, tuber of dwarf lilyturf 4-6, polished rice 10-15, sorbitan monostearate 0.07-0.1, vinasse 0.2-1, lemon 2-3.
A kind of 3. traditional Chinese medicinal composition with effect of reducing blood sugar according to claim 1-2, it is characterised in that described hypoglycemic emulsion Preparation method comprise the following steps：
(1) onion, the tuber of dwarf lilyturf are taken, is added in compound weight (15-20) ethanol solution, stirs, is protected at 70-75 DEG C Temperature stirring 1-2 hours, filtering, obtain filtrate；
(2) polished rice is taken, adds boiling ripe, mixed mashing after lemon is removed the peel, mixes, stirs with above-mentioned filtrate, is added Above-mentioned vinasse, are sent in wooden barrel, the sealing thermal insulation 4-5 hours at 30-35 DEG C, discharging, obtain zymotic fluid；
(3) above-mentioned zymotic fluid is taken, is mixed with sorbitan monostearate, is stirred, ethanol is distilled off, is obtained described hypoglycemic Emulsion.
4. the preparation method of a kind of traditional Chinese medicinal composition with effect of reducing blood sugar as described in claim 1-3, it is characterised in that including following Step：
(1) the above-mentioned bighead atractylodes rhizome, Radix Codonopsis mixing are taken, is added in the acetone of 40-50 times of compound weight, stirs, raise temperature For 60-70 DEG C, insulated and stirred 1-2 hours, filtering, filtrate is obtained；
(2) linoleic acid is taken, is added in above-mentioned filtrate, stirs, acetone is distilled off, obtains oleic acid extract solution；
(3) selenium-rich pumpkin is taken, is cooked, mashing, mixes, stirs with above-mentioned oleic acid extract solution, adds compound weight 3-4% Protease, regulation temperature be 30-40 DEG C, insulated and stirred 2-3 hours, filtering, obtain selenium-rich extract solution；
(4) oyster meat, blue or green money willow mixing are taken, is added in above-mentioned selenium-rich extract solution, is ultrasonically treated 10-20 minutes, treatment temperature For 55-65 DEG C, power 500-600w, filtering, selenium-rich slurries are obtained；
(5) above-mentioned selenium-rich slurries are taken, mixes, stirs with hypoglycemic emulsion, the acetum that concentration is 1-2% is added dropwise, adjusts Section pH is 1-2, stands 2-3 hours, centrifugation, takes supernatant, obtains selenium-rich taurine；
(6) above-mentioned olive oil, sodium chloride mixing are taken, is added in above-mentioned selenium-rich taurine, stirs, be spray-dried, produce The traditional Chinese medicinal composition with effect of reducing blood sugar.
CN201710944999.9A 2017-10-12 2017-10-12 A kind of traditional Chinese medicinal composition with effect of reducing blood sugar containing blue or green money willow and preparation method thereof Pending CN107714967A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
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