CN107714783A - A kind of first and positive stomach piece - Google Patents
A kind of first and positive stomach piece Download PDFInfo
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- CN107714783A CN107714783A CN201711082574.8A CN201711082574A CN107714783A CN 107714783 A CN107714783 A CN 107714783A CN 201711082574 A CN201711082574 A CN 201711082574A CN 107714783 A CN107714783 A CN 107714783A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
It is specific that a kind of first and positive stomach piece is provided the invention belongs to field of traditional Chinese, it is prepared by the bulk drug extraction of following parts by weight：Rheum officinale 3000g, rough gentian 300g, banksia rose 3000g, corydalis tuber 200g, peppermint 25g, radix glycyrrhizae 200g, cloves 20g, sodium acid carbonate 600g are made as bulk drug, have the function that to significantly improve helicobacter pylori negative conversion rate.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to a kind of member and the preparation method and application of positive stomach piece.
Background technology
First and positive stomach piece is recorded in national drug food Surveillance Authority standard, and prescription is rheum officinale 300g, rough gentian 300g, wood
Fragrant 300g, corydalis tuber 200g, peppermint 25g, radix glycyrrhizae 200g, cloves 20g, sodium acid carbonate 600g, the taste of the above eight, take the banksia rose, cloves,
Peppermint extraction by steam distillation volatile oil 6 hours, distills rear solution and volatile oil is standby, and the dregs of a decoction add water to cook 2 hours,
Filtration, filtrate are standby；Rheum officinale, rough gentian, corydalis tuber, radix glycyrrhizae add water to cook it is secondary, 2 hours every time, by several times filter, merging filtrate,
Merge with the aqueous solution after above-mentioned distillation and decocting liquid, it is the thick of 1.30-1.35 (60~70 DEG C) to be concentrated under reduced pressure into relative density
Cream, fine powder is dry, pulverize into, add sodium bicarbonate powder, mixed, above-mentioned volatile oil is dissolved with a small amount of ethanol, is uniformly sprayed into, and is mixed
It is even, tabletting, 1000 are made, is produced.Energy normalizing the stomach by guiding QI downward, relieving haperacidity analgesic.For having a stomachache, abdominal fullness and distention, eating accumulation, appetite is not
Shake, gasteremphraxis sour regurgitation, peptic ulcer.Find that its treatment hyperhydrochloria effect is preferable during Clinical practice, but to pylorus spiral
Bacillus effect of turning out cloudy is not fine.
The content of the invention
Goal of the invention：In order to solve the above problems, inventor in a clinical line, has been surprisingly found that increase rheum officinale and the banksia rose for a long time
Dosage, helicobacter pylori negative conversion rate can be improved very well, it is an object of the invention to provide the preparation of a kind of member and positive stomach piece
Method.
Technical scheme：The purpose of the present invention is realized by following scheme：
A kind of first and positive stomach piece, it is prepared by the bulk drug extraction of following parts by weight：Rheum officinale 3000g, rough gentian 300g, wood
Fragrant 3000g, corydalis tuber 200g, peppermint 25g, radix glycyrrhizae 200g, cloves 20g, sodium acid carbonate 600g.
The member and positive stomach piece, preparation method are made up of the following steps：The taste of the above eight, takes the banksia rose, cloves, peppermint to be steamed with water
Steam distillation method extraction volatile oil 6 hours, distills rear solution and volatile oil is standby, and the dregs of a decoction add water to cook 2 hours, filtration, filtrate
It is standby；Rheum officinale, rough gentian, corydalis tuber, radix glycyrrhizae add water to cook it is secondary, 2 hours every time, by several times filter, merging filtrate, with above-mentioned distillation
The aqueous solution and decocting liquid afterwards merges, and is concentrated under reduced pressure into the thick paste that 60~70 DEG C of relative densities are 1.30-1.35, dry, pulverize
Into fine powder, sodium bicarbonate powder is added, is mixed, above-mentioned volatile oil is dissolved with a small amount of ethanol, is uniformly sprayed into, and is mixed, tabletting, system
Into.
Beneficial effect：Inventor in a clinical line, has been surprisingly found that the dosage of increase rheum officinale and the banksia rose, can improved very well for a long time
Helicobacter pylori negative conversion rate.
Embodiment
Form by the following examples, the above of the present invention is described in further detail again, but should not be by this
The scope for being interpreted as the above-mentioned theme of the present invention is only limitted to following example, and all technologies for being realized based on the above of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1：Take rheum officinale 3000g, rough gentian 300g, banksia rose 3000g, corydalis tuber 200g, peppermint 25g, radix glycyrrhizae 200g, fourth
Fragrant 20g, sodium acid carbonate 600g, preparation method are made up of the following steps：The taste of the above eight, takes the banksia rose, cloves, peppermint to be steamed with vapor
Evaporate method extraction volatile oil 6 hours, distill rear solution and volatile oil is standby, the dregs of a decoction add water to cook 2 hours, filtration, and filtrate is standby；
Rheum officinale, rough gentian, corydalis tuber, radix glycyrrhizae add water to cook secondary, 2 hours every time, filter by several times, after merging filtrate, with above-mentioned distillation
The aqueous solution and decocting liquid merge, and are concentrated under reduced pressure into the thick paste that 60 DEG C of relative densities are 1.35, dry, pulverize into fine powder, add carbon
Sour hydrogen sodium powder end, is mixed, and above-mentioned volatile oil is dissolved with a small amount of ethanol, is uniformly sprayed into, and is mixed, tabletting, is made.
Embodiment 2：Take rheum officinale 3000g, rough gentian 300g, banksia rose 3000g, corydalis tuber 200g, peppermint 25g, radix glycyrrhizae 200g, fourth
Fragrant 20g, sodium acid carbonate 600g, preparation method are made up of the following steps：The taste of the above eight, takes the banksia rose, cloves, peppermint to be steamed with vapor
Evaporate method extraction volatile oil 6 hours, distill rear solution and volatile oil is standby, the dregs of a decoction add water to cook 2 hours, filtration, and filtrate is standby；
Rheum officinale, rough gentian, corydalis tuber, radix glycyrrhizae add water to cook secondary, 2 hours every time, filter by several times, after merging filtrate, with above-mentioned distillation
The aqueous solution and decocting liquid merge, and are concentrated under reduced pressure into the thick paste that 70 DEG C of relative densities are 1.30, dry, pulverize into fine powder, add carbon
Sour hydrogen sodium powder end, is mixed, and above-mentioned volatile oil is dissolved with a small amount of ethanol, is uniformly sprayed into, and is mixed, tabletting, is made.
Embodiment 3：Take rheum officinale 3000g, rough gentian 300g, banksia rose 3000g, corydalis tuber 200g, peppermint 25g, radix glycyrrhizae 200g, fourth
Fragrant 20g, sodium acid carbonate 600g, preparation method are made up of the following steps：The taste of the above eight, takes the banksia rose, cloves, peppermint to be steamed with vapor
Evaporate method extraction volatile oil 6 hours, distill rear solution and volatile oil is standby, the dregs of a decoction add water to cook 2 hours, filtration, and filtrate is standby；
Rheum officinale, rough gentian, corydalis tuber, radix glycyrrhizae add water to cook secondary, 2 hours every time, filter by several times, after merging filtrate, with above-mentioned distillation
The aqueous solution and decocting liquid merge, and are concentrated under reduced pressure into the thick paste that 605 DEG C of relative densities are 1.32, dry, pulverize into fine powder, add carbon
Sour hydrogen sodium powder end, is mixed, and above-mentioned volatile oil is dissolved with a small amount of ethanol, is uniformly sprayed into, and is mixed, tabletting, is made.
Comparative example 1：Take rheum officinale 300g, rough gentian 300g, banksia rose 300g, corydalis tuber 200g, peppermint 25g, radix glycyrrhizae 200g,
Cloves 20g, sodium acid carbonate 600g, preparation method are made up of the following steps：The taste of the above eight, take the banksia rose, cloves, peppermint vapor
Way of distillation extraction volatile oil 6 hours, distills rear solution and volatile oil is standby, and the dregs of a decoction add water to cook 2 hours, filtration, and filtrate is standby
With；Rheum officinale, rough gentian, corydalis tuber, radix glycyrrhizae add water to cook secondary, 2 hours every time, filter by several times, after merging filtrate, with above-mentioned distillation
The aqueous solution and decocting liquid merge, be concentrated under reduced pressure into 605 DEG C of relative densities be 1.32 thick paste, dry, pulverize into fine powder, add
Sodium bicarbonate powder, mix, above-mentioned volatile oil is dissolved with a small amount of ethanol, is uniformly sprayed into, and is mixed, tabletting, is made.
Embodiment 4：Pharmacodynamic study of the present invention to helicobacter pylori infections gastritis model
Experiment material：Medicine and reagent：Embodiment 3 and the method for comparative example 1 prepare sample, positive drug bismuth potassium citrate
(production of Zhuhai Li Zhu pharmaceutical factories), urokinase, oxidizing ferment, catalase (being purchased from Sigma), 0.9% chloride injection
Liquid, 5%Na2HCO3 solution, PBS solution (autogamy).Animal Wister rats, at 4 monthly ages, body weight 112-158g, are moved by our company
Thing center provides.
Method：Be for experiment drug sample preparation by table middle dosage, it is suitable to be configured to 0.9% sodium chloride injection
Concentration is for experiment.
The preparation of helicobacter pylori (HP) infection model：HP strain culturings take the chronic active gastritis of gastro-endoscopic room inspection to suffer from
Person's mucosa tissue pincers take thing, are inoculated on campylobacter jejuni selective medium, put micro- oxygen environment, and 37 DEG C are cultivated 72 hours,
Bacterium colony is checked, Gram's staining is cloudy J dangers bacillus, and urokinase, oxidizing ferment, catalase test are positive, after being defined as HP bacterium,
Secondary Culture is as test strain.
Infection method：Take Wlister rats 64, male and female half and half are randomly divided into 4 groups, every group 16, wherein 1 group is sky
White group, infected without HP, sub-cage rearing.Used after fasting 12 hours after 5%Na2HCO3 solution 2m1/ ig, 15min to mixing
HP bacterial strains (1012Cfu/L bacterium solutions) feed after 2m1/ ig, 30min.Infect 1 time, totally 4 times weekly.
Anti- HP infection gastritis experiment：After experiment packet and medication HP lasts infect one week, press respectively column split to
Medicine：3 groups of embodiment, 1 group of comparative example, physiological saline (NS) control group, positive drug (bismuth potassium citrate) control group, daily ig give
Medicine 1 time, the course for the treatment of 10 days.Dosage is shown in Table 1.Administration by above-mentioned 4 groups every group is randomly divided into 2 groups after terminating, each 8, respectively at
Next day and 1 month acute execution animal after end, sterile working take stomach, cut off along greater curvature after treatment end, and PBS liquid washes away stomach
Content, position is relatively fixed at pylorus end and takes 5 pieces of tissues, for direct smear, urease test, HP cultivate, remaining be put into by
It is fixed in 10% formalin that PBS liquid is prepared, for pathological examination.
Pathological examination method：Gastric tissue is cut into slices and dyed with HE, with the disease of each animal subject gastric mucosa of micro- sem observation
Change situation.
As a result：Judge tri- inspections of HP：Smear for microscopic examination does not check HP, urease test reaction negative, HP and cultivates and have no
HP person calculates every group of negative conversion rate to turn out cloudy, with number of animals of turning out cloudy, and the negative conversion rate after treatment is HP clearance rates, treatment end one month
HP negative conversion rates afterwards are eradication rate.
As a result：HP infection gastritis model prepare one group of HP infected group of arbitrary extracting, take mucosa tissue carry out smear for microscopic examination,
Urokinase is tested, and 8 mouse can detect HP in infected group, and 8 gastric mucosa of rat tissues of blank control group are not detected by HP.
The anti-HP effects of given the test agent：Each reagent group of clearance rate and eradication rate and positive control drug group to HP have one to HP
Fixed clearance rate and eradication rate, 3 groups of embodiment is preferable with positive control drug group effect, non-with 1 group of comparing difference of comparative example
Chang Xianzhu (P<0.01), 1 group of comparative example also has certain anti-HP effects, is respectively provided with significantly with control group comparing difference
Property.Wherein, embodiment 3 is suitable with positive control drug group effect, mutual no significant difference (P>0.05).
Clearance rate and eradication rate of each group to HP
Pathological change saline control group：Gastric mucosa body of gland destroys, and interstitial edema is with inflammatory cell infiltration.Physiological saline
Group：Gastric mucosa focal inflammation cell effect.1 group of comparative example：Gastric mucosa body of gland is normal, and shallow-layer has a small amount of inflammatory cell.It is real
Apply 3 groups of example and bismuth potassium citrate group:Gastric gland is normal, has no inflammatory cell.
Result of study shows that the present invention has preferably anti-HP effects, and suitable with the anti-HP effects of positive control drug, effect is good
In 1 group of the comparative example of original prescription.
Claims (2)
1. a kind of first and positive stomach piece, it is characterised in that be prepared by the bulk drug extraction of following parts by weight：Rheum officinale 3000g, dragon
Courage 300g, banksia rose 3000g, corydalis tuber 200g, peppermint 25g, radix glycyrrhizae 200g, cloves 20g, sodium acid carbonate 600g.
2. first and positive stomach piece according to claim 1, it is characterised in that preparation method is made up of the following steps：The taste of the above eight,
The banksia rose, cloves, peppermint extraction by steam distillation volatile oil 6 hours are taken, rear solution is distilled and volatile oil is standby, the dregs of a decoction add
Decocting is boiled 2 hours, filtration, and filtrate is standby；Rheum officinale, rough gentian, corydalis tuber, radix glycyrrhizae add water to cook it is secondary, 2 hours every time, by several times filter
Cross, merging filtrate, merge with the aqueous solution after above-mentioned distillation and decocting liquid, being concentrated under reduced pressure into 60~70 DEG C of relative densities is
1.30-1.35 thick paste, fine powder is dry, pulverize into, add sodium bicarbonate powder, mixed, above-mentioned volatile oil is molten with a small amount of ethanol
Solution, uniformly spray into, mix, tabletting, be made.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711082574.8A CN107714783A (en) | 2017-11-07 | 2017-11-07 | A kind of first and positive stomach piece |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711082574.8A CN107714783A (en) | 2017-11-07 | 2017-11-07 | A kind of first and positive stomach piece |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108771704A (en) * | 2018-07-24 | 2018-11-09 | 广东名辰堂健康产业股份有限公司 | A kind of powder and preparation method thereof of strong stomach body-building |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101104018A (en) * | 2007-02-13 | 2008-01-16 | 通化正和药业有限公司 | Medicinal composition for treating stomach disease and preparation process thereof |
| CN104922227A (en) * | 2015-05-28 | 2015-09-23 | 吉林省正和药业集团股份有限公司 | Preparation method of Yuanhe stomach tablet and application |
-
2017
- 2017-11-07 CN CN201711082574.8A patent/CN107714783A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101104018A (en) * | 2007-02-13 | 2008-01-16 | 通化正和药业有限公司 | Medicinal composition for treating stomach disease and preparation process thereof |
| CN104922227A (en) * | 2015-05-28 | 2015-09-23 | 吉林省正和药业集团股份有限公司 | Preparation method of Yuanhe stomach tablet and application |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108771704A (en) * | 2018-07-24 | 2018-11-09 | 广东名辰堂健康产业股份有限公司 | A kind of powder and preparation method thereof of strong stomach body-building |
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Application publication date: 20180223 |