CN107711865A - Composition pesticide containing folpet and zoxamide - Google Patents
Composition pesticide containing folpet and zoxamide Download PDFInfo
- Publication number
- CN107711865A CN107711865A CN201711210843.4A CN201711210843A CN107711865A CN 107711865 A CN107711865 A CN 107711865A CN 201711210843 A CN201711210843 A CN 201711210843A CN 107711865 A CN107711865 A CN 107711865A
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- China
- Prior art keywords
- composition pesticide
- zoxamide
- folpet
- composition
- present
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
- A01N47/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing >N—S—C≡(Hal)3 groups
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
- A01N37/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof containing the group, wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of composition pesticide containing folpet and zoxamide, the weight of folpet and zoxamide ratio is 1 in the composition pesticide:40‑40:1, preferably 1:20‑20:1, most preferably 8：5.The composition pesticide active component of the present invention shows certain synergistic function in the range of aforementioned proportion between each other, it is possible to reduce pesticide activity component usage amount, improves prevention effect.The composition pesticide of the present invention can be prepared into any one type of dosage form for being adapted to agriculturally use by customary preparation methods, and the formulation can be one kind in missible oil, suspending agent, water dispersible granules, wettable powder, dry suspending agent, granule.The composition pesticide of the present invention is worthy of popularization to crop safety.
Description
Technical field
The invention belongs to composition pesticide technical field, and in particular to be a kind of agriculture containing folpet and zoxamide
Drug composition and its purposes for preventing and treating corps diseases.
Background technology
Oomycetes disease such as downy mildew, epidemic disease are diseases common in proportion of crop planting, yield and quality band to crops
Carry out very big damage.In the last few years, as the increase of China's cultivated area, causing harm for the vegetables production of oomycetes disease are also increasingly tight
Weight, the various diseases as caused by oomycetes are all the very strong species of harmfulness, although species is few, morbidity is rapid, propagates fast, danger
Evil weight.According to the literature, due to single drug and other irrational medications, already lead to some oomycetes disease such as downy mildew,
The diseases such as epidemic disease generate the resistance to the action of a drug to Multiple Pesticides, cause the prevention effect of these agricultural chemicals to decline, and for effectively preventing
Disease has in turn resulted in the pollution of environment, it is necessary to further increased to the usage amount of agricultural chemicals, is unfavorable for the sustainable development of agricultural
Exhibition.Therefore, find efficient, low toxicity, drug-fast novel agrochemical kind can be delayed to be one of important channel for solving the problem.
Folpet is organosulfureous fungicide, is mainly used in preventing and treating cereal crops, vegetables, the multiple diseases on fruit tree, and right
Plant growth has certain stimulation, and folpet can be widely used for preventing and treating rice blast, banded sclerotial blight, wheat rust, red mould
The multiple diseases such as disease, the late blight of potato, early blight of tomato, apple anthracnose.
Zoxamide is a kind of efficient protectiveness acid amide fungicides, has lasting period length and good resistance of rainwater washing against
Property, its mechanism of action is unique, suppresses nuclear division by combining tubulin β-subunit and destroying microtubule cytoskeleton, benzene
Acyl bacterium amine does not influence the travelling of zoospore, sporangiocyst is formed or sprouts, and along with first circulation of sclerotium division, germ tube is stretched
Length be suppressed, so as to organize germ to penetrate host plant, its be mainly used in prevent and treat downy mildew, epidemic disease, to solanaceous vegetables powdery mildew,
Gray mold is also effective.
The pesticide activity component of the different mechanisms of action is compounded, is one of major measure for solving resistance problem, no
The interaction that may be shown after being compounded with pesticide species mainly includes antagonism, addition, synergy, and synergy is especially
The obvious agriculture chemical compounding kind that acts synergistically is often less, it is necessary to largely be sieved for pesticide species, controlling object, proportioning
Choosing, and between composition whether with synergistic function often with not predictability.Present inventor is in a large amount of rooms
On the basis of interior determination of activity and field test, it is found surprisingly that after compounding folpet and zoxamide in certain scope
Preventing and treating to corps diseases can show synergistic function, complete the present invention after further research, not yet send out at present
The existing relevant report compounded on folpet and zoxamide.
The content of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of collaboration containing folpet and zoxamide
Synergistic bactericidal composition.
Another object of the present invention is to provide the application of the synergistic sterilizing composition, the synergistic sterilizing
Composition is used to prepare the application in the medicine of preventing and treating corps diseases, and the corps diseases especially can be epidemic disease, downy mildew
Disease, banded sclerotial blight, ring spot etc..
The present invention also aims to provide a kind of method of Synergistic biocidal composition preventing and treating corps diseases, including divide
Open, sequentially or simultaneously administration of sterile is red and zoxamide.
In order to achieve the above object, the present invention adopts the following technical scheme that：
A kind of composition pesticide, its active component comprise at least folpet and zoxamide, wherein, folpet and benzoyl
The weight ratio of bacterium amine is 1:40-40:1, preferably 1:20-20：1.
Further, the weight percentage of composition shared by folpet and zoxamide is 5- in the composition pesticide
90%, preferably 20-70%, remaining is the auxiliary element commonly used in Pesticide formulation.
Further, the agricultural chemicals auxiliary element is preferably various surfactant and carrier.
Further, the surfactant can be the surfactant commonly used in Pesticide formulation, such as can be with
It is the one or more in emulsifying agent, dispersant and wetting agent.
Further, composition pesticide of the invention can be prepared into by customary preparation methods is adapted to what is agriculturally used
Any one type of dosage form, the formulation can be missible oil, suspending agent, water dispersible granules, wettable powder, dry suspending agent,
One kind in granula.
Further, composition pesticide of the invention can be provided in the form of finished product preparation, i.e., each material in composition
Be adequately mixed and be prepared into the dosage form for being adapted to use, can also be used alone with unit dose preparation, using it is preceding in bucket or
Voluntarily mixed in tank, and optionally mixed and be diluted with water according to the concentration of required active material.
Further, the processing of composition pesticide of the invention to plant or plant part, directly entered by conventional method
Row is carried out by acting on its environment, living environment or storage space, and the conventional method includes but is not limited to spray, spread
Broadcast, dress seed, smearing, atomizing, irrigation, and for seed treatment, can also be applied by way of seed pelleting.
Compared with prior art, composition pesticide of the invention has the beneficial effect that：
(1) prevention effect is not simple after active component folpet and zoxamide compound in composition pesticide of the invention
Superposition, but both compounding after can show synergistic function, it is possible to reduce pesticide activity component usage amount, carry
High prevention effect.
(2) the house type composition mechanism of action is different in composition pesticide of the invention, and both compoundings can be with increasing action
Site, so as to delay the drug-fast generation of pathogen.
(3) composition pesticide preparation technology of the invention is simple, and prevention effect is good, to crop safety.
Embodiment
In order that the purpose of the present invention, technical scheme are definitely, present disclosure is made with reference to embodiment into
One step is described in detail, and the content mentioned in embodiment is not construed as limitation of the invention, and the selection of material prescription can basis
Actual conditions are replaced by other equivalent or with similar purpose alternative features.That is, such as it is not particularly limited, each feature is only
It is a series of equivalent or similar characteristics a example, the protection domain of technical scheme is defined to claim
It is accurate.
First, toxicity determines
1st, controlling object：Cucumber downy mildew；
2nd, test method：Experiment uses pot-culture method, chooses and grows consistent two panels leaf period cucumber seedling, and each processing is selected
10 basins are standby for examination melon seedling, numbering.Sprayed with Potter spray towers under 50PSI pressure, per basin 5mL.Each medicament sets 6
Concentration gradient, to spray the processing of equivalent clear water as blank control.The downy mildew leaf for picking up from field is taken, 10 DEG C of left sides are dipped with writing brush
The sporangium in right distillation washing lower back face, is made into concentration as 3 × 105Individual/mL sporangia suspension.In chemicals treatment 24h
Spray inoculation spore cyst fluid afterwards, cucumber seedling is placed in growth cabinet (relative humidity 100%, 15~20 DEG C of temperature) after inoculation
Cultivate, 15~24 DEG C of keeping temperature, the moisturizing of relative humidity 90% or so induction after 24h, investigation record incidence after 10d, meter
Calculate disease index and prevention effect.Concentration EC in suppressing is calculated with least square method50, then according to the abundant method calculating co-toxicity coefficients of Sun Yun
(CTC).As CTC ＜ 80, then composition shows as antagonism, and as 80 ＜ CTC ＜ 120, then composition shows as summation action,
As CTC ＞ 120, then composition shows as synergistic effect.
Survey toxicity index (ATI)=(standard agent EC50/ reagent agent EC50)×100
A percentage composition+B medicament toxicity index in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed
B percentage composition in agent
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] × 100
Toxicity test the results are shown in Table 1.
The folpet of table 1 and zoxamide compound the prevention effect to cucumber downy mildew
As shown in Table 1, folpet and zoxamide are 1:30-40:Compounding is total to cucumber downy mildew preventing and treating in the range of 1
Malicious coefficient shows certain synergistic function more than 120.Both compound proportions are 1:20-20:When 1, co-toxicity coefficient
More than 150, synergistic function is relative to be become apparent from.
2nd, example of formulations
1st, embodiment 1:34% folpet zoxamide wettable powder (1：1)
The preparation method of the wettable powder is：Active component, wetting agent, dispersant and filler are mixed by above-mentioned formula
Close uniformly, after air-flow crushing, stir about 30 minutes, you can wettable powder of the present invention is made.
2nd, embodiment 2：44% folpet zoxamide water dispersible granule (10:1)
The preparation method of the water dispersible granules is：By above-mentioned formula by folpet, zoxamide, wetting agent, dispersant,
Disintegrant, binding agent and filler are well mixed, and after air-flow crushing, stir about 30 minutes is mediated and added in fluid bed and is granulated,
Then dry, sieve in drying machine, you can water dispersible granules of the present invention are made.
3rd, embodiment 3:39% folpet zoxamide wettable powder (8：5)
The preparation method of the wettable powder is：Active component, wetting agent, dispersant and filler are mixed by above-mentioned formula
Close uniformly, after air-flow crushing, stir about 30 minutes, you can wettable powder of the present invention is made.
4th, embodiment 4：33% folpet zoxamide water dispersible granule (1：10)
The preparation method of the water dispersible granules is：By above-mentioned formula by folpet, zoxamide, wetting agent, dispersant,
Disintegrant, binding agent and filler are well mixed, and after air-flow crushing, stir about 30 minutes is mediated and added in fluid bed and is granulated,
Then dry, sieve in drying machine, you can water dispersible granules of the present invention are made.
3rd, field control effectiveness test
1st, controlling object：Cucumber downy mildew；
2nd, test method：Test site is arranged in Shouguang City of Shandong Province somewhere green house of vegetables, screens full cucumber kind
Son, during vernalization is broadcast to the paper that a diameter of 10cm is seeded in when showing money or valuables one carries unintentionally, cultivate into transplanting rice greenhouse during 2 needles, normal cultivation
Management, when cucumber is grown to 10 needles by embodiment 1-4 and contrast single dose (comparative example 1:50% folpet wettable powder；
Comparative example 2：50% zoxamide water dispersible granule) preparation be watered and be uniformly sprayed at afterwards on the positive and negative of cucumber leaves；Often locate
20 cucumber are managed, are repeated 4 times, random alignment.After sprinkling 1 day, spray inoculation bacterium of downy mildew of cucumber, greenhouse temperature is controlled after inoculation
Between 20-24 DEG C, humidity 80-90%；Incidence is investigated when clear water blank control is fully fallen ill and after falling ill 7 days, and
Calculate disease index and preventive effect.Result of the test is as shown in table 2.
As shown in Table 2, example of formulations 1-4 folpet and zoxamide composition pesticide preparation are to cucumber downy mildew
Prevention effect is good.Prevention effect is better than single active agent preparation after both compoundings, shows that both can show to assist after compounding
Same synergistic effect.In addition, it was observed that the composition pesticide of the present invention and the test medicine of control group are to Huang in scope of medication
Melon crop has poisoning generation, to also being had no adverse effects beneficial to natural enemy.
Field control effectiveness test of the different agents of table 2 processing to cucumber downy mildew
Claims (8)
1. a kind of composition pesticide, it is characterised in that active component comprises at least folpet and zoxamide.
2. composition pesticide according to claim 1, it is characterised in that the weight ratio of the folpet and zoxamide is
1:40-40：1.
3. composition pesticide according to claim 2, it is characterised in that the weight ratio of the folpet and zoxamide is excellent
Elect 1 as:20-20:1.
4. composition pesticide according to claim 3, it is characterised in that the weight ratio of the folpet and zoxamide is excellent
Elect 8 as:5.
5. according to the composition pesticide described in any one of claim 1-4 claim, it is characterised in that the pesticide combination
Thing can be prepared into any one formulation for being adapted to agriculturally use.
6. composition pesticide according to claim 5, it is characterised in that the formulation of the composition pesticide is preferably breast
It is any in oil, suspending agent, water dispersible granules, wettable powder, dry suspending agent, granule.
7. the composition pesticide according to any one of claim 1-6 claim is used for the use for preventing and treating corps diseases
On the way.
8. purposes according to claim 7, it is characterised in that the corps diseases are preferably downy mildew.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711210843.4A CN107711865A (en) | 2017-11-27 | 2017-11-27 | Composition pesticide containing folpet and zoxamide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711210843.4A CN107711865A (en) | 2017-11-27 | 2017-11-27 | Composition pesticide containing folpet and zoxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107711865A true CN107711865A (en) | 2018-02-23 |
Family
ID=61219753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711210843.4A Pending CN107711865A (en) | 2017-11-27 | 2017-11-27 | Composition pesticide containing folpet and zoxamide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107711865A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1229580A (en) * | 1998-01-27 | 1999-09-29 | 罗姆和哈斯公司 | Fungicidal compositions containing N-acetonylbenzamides |
| CN107279161A (en) * | 2017-08-02 | 2017-10-24 | 广东广康生化科技股份有限公司 | A kind of bactericidal composition containing folpet and fluopyram |
-
2017
- 2017-11-27 CN CN201711210843.4A patent/CN107711865A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1229580A (en) * | 1998-01-27 | 1999-09-29 | 罗姆和哈斯公司 | Fungicidal compositions containing N-acetonylbenzamides |
| CN107279161A (en) * | 2017-08-02 | 2017-10-24 | 广东广康生化科技股份有限公司 | A kind of bactericidal composition containing folpet and fluopyram |
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Application publication date: 20180223 |
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