CN107693805A - A kind of sterilization process of insect-expelling saligna injection liquid - Google Patents
A kind of sterilization process of insect-expelling saligna injection liquid Download PDFInfo
- Publication number
- CN107693805A CN107693805A CN201710767604.2A CN201710767604A CN107693805A CN 107693805 A CN107693805 A CN 107693805A CN 201710767604 A CN201710767604 A CN 201710767604A CN 107693805 A CN107693805 A CN 107693805A
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- CN
- China
- Prior art keywords
- infusion bottle
- insect
- injection liquid
- sterilization
- sterilization process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/18—Aseptic storing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The present invention provides a kind of sterilization process of insect-expelling saligna injection liquid, the processing step of the secondary cleaning of accurate disinfected refrigeration sterilizing is quickly cooled down by the sterilizing of filling pressurized high-temperature, sterilizing works are carried out to insect-expelling saligna injection liquid, improve the effect of sterilizing, and the environment to placing infusion bottle is tightly controlled, prevent secondary pollution, improve the clean-up performance of infusion bottle, it is covert to shorten process time, operating efficiency is lifted, insect-expelling saligna injection liquid sterilizing works is solved and easily sterilizes incomplete problem.
Description
Technical field
The present invention relates to traditional Chinese medicine preparation field, more particularly to a kind of sterilization process of insect-expelling saligna injection liquid.
Background technology
At present when manufacturing insect-expelling saligna injection liquid, it is necessary to be sterilized to the infusion bottle equipped with parenteral solution, to ensure
The cleaning of parenteral solution, it is generally only that infusion bottle is heated when being sterilized at present for infusion bottle, to ensure infusion bottle
Cleaning, but simple heating is unable to reach absolutely to the sterilization effect of infusion bottle, it is necessary to transfusion after work is completed
Bottle carries out two-stage sterilization, increases procedure of processing, covert extension process time, causes to manufacture operating efficiency reduction, lifting processing
Cost.Therefore, solve the insect-expelling saligna injection liquid sterilizing works incomplete problem that easily sterilizes just to be particularly important.
The content of the invention
A kind of in view of the above-mentioned problems of the prior art, going out it is an object of the invention to provide insect-expelling saligna injection liquid
Bacterium technique is right by the processing step of filling pressurization-high-temperature sterilization-quick cooling-accurate sterilization-refrigeration sterilizing-secondary cleaning
Insect-expelling saligna injection liquid carries out sterilizing works, improves the effect of sterilizing, solves insect-expelling saligna injection liquid sterilizing works appearance
Easily sterilize incomplete problem.
The present invention provides a kind of sterilization process of insect-expelling saligna injection liquid, and the sterilization process step is as follows：
Step 1：Parenteral solution is filling into infusion bottle by bottle placer, and nitrogen charging in infusion bottle is pressurizeed；
Step 2：Infusion bottle is placed in sterilization tank and carries out high-temperature sterilization, and is placed in cooler bin and is rapidly cooled to room temperature；
Step 3：Carry out disinfection processing to infusion bottle mouth position, and carries out sealing detection to infusion bottle；
Step 4：Infusion bottle is placed in freezer, it is refrigerated, cold preservation time is 5 ~ 7 days；
Step 5：Clean appearance is carried out to infusion bottle after infusion bottle is taken out, and collected stand-by.
Further improvement is that：Infusion bottle is carried out in the step 2 to be kept for 120 ~ 150 DEG C during high-temperature sterilization, to defeated
Keeping temperature is declined with 5 DEG C per minute of speed when liquid bottle is cooled down.
Further improvement is that：Temperature in the step 4 in freezer is kept for -5 ~ 0 DEG C.
Further improvement is that：Needed when being collected in the step 5 to infusion bottle by infusion bottle be placed on sterilizing every
From in case.
The beneficial effects of the invention are as follows：Sterilized by filling pressurization-high-temperature sterilization-quick cooling-accurate sterilization-refrigeration-
The processing step of secondary cleaning, sterilizing works are carried out to insect-expelling saligna injection liquid, improve the effect of sterilizing, and it is defeated to placing
The environment of liquid bottle is tightly controlled, and prevents secondary pollution, is improved the clean-up performance of infusion bottle, is in a disguised form shortened process time, carries
Rise operating efficiency.
Embodiment
In order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be further described, the embodiment
It is only used for explaining the present invention, is not intended to limit the scope of the present invention..
Embodiment one
A kind of sterilization process of insect-expelling saligna injection liquid is present embodiments provided, the sterilization process step is as follows：
Step 1：Parenteral solution is filling into infusion bottle by bottle placer, and nitrogen charging in infusion bottle is pressurizeed；
Step 2：Infusion bottle is placed in sterilization tank and carries out high-temperature sterilization, and is placed in cooler bin and is rapidly cooled to room temperature；
Step 3：Carry out disinfection processing to infusion bottle mouth position, and carries out sealing detection to infusion bottle；
Step 4：Infusion bottle is placed in freezer, it is refrigerated, cold preservation time is 6 days；
Step 5：Clean appearance is carried out to infusion bottle after infusion bottle is taken out, and collected stand-by.
Infusion bottle is carried out in the step 2 to be kept for 140 DEG C during high-temperature sterilization, kept when being cooled down to infusion bottle
Temperature is declined with 5 DEG C per minute of speed.Temperature in the step 4 in freezer is kept for -2 DEG C.To transfusion in the step 5
Bottle needs infusion bottle being placed in sterilizing shielded box when being collected.
Embodiment two
A kind of sterilization process of insect-expelling saligna injection liquid is present embodiments provided, the sterilization process step is as follows：
Step 1：Parenteral solution is filling into infusion bottle by bottle placer, and nitrogen charging in infusion bottle is pressurizeed；
Step 2：Infusion bottle is placed in sterilization tank and carries out high-temperature sterilization, and is placed in cooler bin and is rapidly cooled to room temperature；
Step 3：Carry out disinfection processing to infusion bottle mouth position, and carries out sealing detection to infusion bottle；
Step 4：Infusion bottle is placed in freezer, it is refrigerated, cold preservation time is 5 days；
Step 5：Clean appearance is carried out to infusion bottle after infusion bottle is taken out, and collected stand-by.
Infusion bottle is carried out in the step 2 to be kept for 120 DEG C during high-temperature sterilization, kept when being cooled down to infusion bottle
Temperature is declined with 5 DEG C per minute of speed.Temperature in the step 4 in freezer is kept for -5 DEG C.To transfusion in the step 5
Bottle needs infusion bottle being placed in sterilizing shielded box when being collected.
Embodiment three
A kind of sterilization process of insect-expelling saligna injection liquid is present embodiments provided, the sterilization process step is as follows：
Step 1：Parenteral solution is filling into infusion bottle by bottle placer, and nitrogen charging in infusion bottle is pressurizeed；
Step 2：Infusion bottle is placed in sterilization tank and carries out high-temperature sterilization, and is placed in cooler bin and is rapidly cooled to room temperature；
Step 3：Carry out disinfection processing to infusion bottle mouth position, and carries out sealing detection to infusion bottle；
Step 4：Infusion bottle is placed in freezer, it is refrigerated, cold preservation time is 7 days；
Step 5：Clean appearance is carried out to infusion bottle after infusion bottle is taken out, and collected stand-by.
Infusion bottle is carried out in the step 2 to be kept for 150 DEG C during high-temperature sterilization, kept when being cooled down to infusion bottle
Temperature is declined with 5 DEG C per minute of speed.Temperature in the step 4 in freezer is kept for -0 DEG C.To transfusion in the step 5
Bottle needs infusion bottle being placed in sterilizing shielded box when being collected.
Sterilized by filling pressurization-high-temperature sterilization-quick cooling-accurate sterilization-refrigeration-the processing step of secondary cleaning,
Sterilizing works are carried out to insect-expelling saligna injection liquid, improve the effect of sterilizing, and the environment to placing infusion bottle is carried out tightly
Control, prevents secondary pollution, improves the clean-up performance of infusion bottle, in a disguised form shorten process time, lifts operating efficiency.
Claims (4)
- A kind of 1. sterilization process of insect-expelling saligna injection liquid, it is characterised in that：The sterilization process step is as follows：Step 1：Parenteral solution is filling into infusion bottle by bottle placer, and nitrogen charging in infusion bottle is pressurizeed；Step 2：Infusion bottle is placed in sterilization tank and carries out high-temperature sterilization, and is placed in cooler bin and is rapidly cooled to room temperature；Step 3：Carry out disinfection processing to infusion bottle mouth position, and carries out sealing detection to infusion bottle；Step 4：Infusion bottle is placed in freezer, it is refrigerated, cold preservation time is 5 ~ 7 days；Step 5：Clean appearance is carried out to infusion bottle after infusion bottle is taken out, and collected stand-by.
- A kind of 2. sterilization process of insect-expelling saligna injection liquid as claimed in claim 1, it is characterised in that：In the step 2 Infusion bottle is carried out to be kept for 120 ~ 150 DEG C during high-temperature sterilization, when cooling down infusion bottle, keeping temperature is with 5 DEG C per minute Speed declines.
- A kind of 3. sterilization process of insect-expelling saligna injection liquid as claimed in claim 1, it is characterised in that：In the step 4 Temperature in freezer is kept for -5 ~ 0 DEG C.
- A kind of 4. sterilization process of insect-expelling saligna injection liquid as claimed in claim 1, it is characterised in that：In the step 5 Need infusion bottle being placed in sterilizing shielded box when collecting infusion bottle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710767604.2A CN107693805A (en) | 2017-08-31 | 2017-08-31 | A kind of sterilization process of insect-expelling saligna injection liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710767604.2A CN107693805A (en) | 2017-08-31 | 2017-08-31 | A kind of sterilization process of insect-expelling saligna injection liquid |
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| Publication Number | Publication Date |
|---|---|
| CN107693805A true CN107693805A (en) | 2018-02-16 |
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| CN201710767604.2A Pending CN107693805A (en) | 2017-08-31 | 2017-08-31 | A kind of sterilization process of insect-expelling saligna injection liquid |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813778A (en) * | 2005-11-18 | 2006-08-09 | 广东大光药业有限公司 | Method for preparing baicalin injection |
| CN102302489A (en) * | 2011-07-14 | 2012-01-04 | 青岛华仁药业股份有限公司 | Preparation method of compound amino acid injection |
| CN103340853A (en) * | 2013-06-21 | 2013-10-09 | 广东利泰制药股份有限公司 | Compound 18-amino acid injection containing little amount of antioxidant and preparation method thereof |
| CN104069101A (en) * | 2014-06-09 | 2014-10-01 | 广东利泰制药股份有限公司 | Amino acid injection for non-PVC (polyvinyl chloride) three-layer co-extruded transfusion bag and preparation process of amino acid injection |
| CN106418485A (en) * | 2015-08-04 | 2017-02-22 | 安徽华明制药有限公司 | Enteral nutritionemulsion containing lipoic acid |
-
2017
- 2017-08-31 CN CN201710767604.2A patent/CN107693805A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813778A (en) * | 2005-11-18 | 2006-08-09 | 广东大光药业有限公司 | Method for preparing baicalin injection |
| CN102302489A (en) * | 2011-07-14 | 2012-01-04 | 青岛华仁药业股份有限公司 | Preparation method of compound amino acid injection |
| CN103340853A (en) * | 2013-06-21 | 2013-10-09 | 广东利泰制药股份有限公司 | Compound 18-amino acid injection containing little amount of antioxidant and preparation method thereof |
| CN104069101A (en) * | 2014-06-09 | 2014-10-01 | 广东利泰制药股份有限公司 | Amino acid injection for non-PVC (polyvinyl chloride) three-layer co-extruded transfusion bag and preparation process of amino acid injection |
| CN106418485A (en) * | 2015-08-04 | 2017-02-22 | 安徽华明制药有限公司 | Enteral nutritionemulsion containing lipoic acid |
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Application publication date: 20180216 |
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