CN107692219A - A kind of hypoglycemic fruit zymotic fluid and preparation method thereof - Google Patents
A kind of hypoglycemic fruit zymotic fluid and preparation method thereof Download PDFInfo
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- CN107692219A CN107692219A CN201710927690.9A CN201710927690A CN107692219A CN 107692219 A CN107692219 A CN 107692219A CN 201710927690 A CN201710927690 A CN 201710927690A CN 107692219 A CN107692219 A CN 107692219A
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- zymotic fluid
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- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 208000009928 nephrosis Diseases 0.000 description 1
- 231100001027 nephrosis Toxicity 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- YQUVCSBJEUQKSH-UHFFFAOYSA-N protochatechuic acid Natural products OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 235000020095 red wine Nutrition 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- YIBXWXOYFGZLRU-UHFFFAOYSA-N syringic aldehyde Natural products CC12CCC(C3(CCC(=O)C(C)(C)C3CC=3)C)C=3C1(C)CCC2C1COC(C)(C)C(O)C(O)C1 YIBXWXOYFGZLRU-UHFFFAOYSA-N 0.000 description 1
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- 230000009466 transformation Effects 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
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Abstract
The present invention discloses a kind of hypoglycemic fruit zymotic fluid, counts in parts by weight, and it is made by the following raw material fermentation：1~5 part of probiotics fermention liquid, 1~2 part of Banana Leaf, 1~3 part of Fructus psidii guajavae immaturus, 1~2 part of Guava Leaf, 1~5 part of Cordyceps militaris, 1~3 part of grape pip, 1~2 part of Grape Skin, 5~10 parts of D-sorbite, 3~7 parts of dietary fiber；Probiotics fermention liquid and natural plant extraction thing have synergy to reducing blood glucose.The present invention prepares fruit zymotic fluid and uses low-temperature extraction and Freeze Drying Technique combination probiotics fermention technology, improves disengaging for fruit zymotic fluid active ingredient, promotes absorption of the enteron aisle to active ingredient, so as to reach the concentration for reducing blood glucose.
Description
Technical field
The invention belongs to biological technical field.More particularly, to a kind of hypoglycemic fruit zymotic fluid and its preparation side
Method.
Background technology
In recent years, due to growth in the living standard, the change of dietary structure, the rhythm of life being becoming tight day and dynamic more less
The factors such as the life style of seat, global diabetes morbidity rapid development, diabetes have become after tumour, cardiovascular disease
The chronic disease of the third-largest serious threat human health afterwards.IDF (IDF) announces：The whole world 20~79 in 2013
Year maturity-onset diabetes illness rate 8.3%, number 3.82 hundred million, 80% is distributed in medium and low income country.It is expected that the whole world in 2035
Diabetic will be up to 5.92 hundred million, and China accounts for 25%, positioned at first place.The related people of people 5,100,000 of diabetes is died from the whole world in 2013,
Account for the 8.39% of all death tolls.Diabetes will turn into the serious public health problem in China in future 50 years.
Diabetes are a kind of chronic, lifelong diseases, are a kind of common diseases for seriously endangering health, due to insulin
It is relative or definitely insufficient, make the nutrient metabolics such as internal carbohydrate, fat, protein abnormal.Diabetic has typical case
Three-many-one-little clinical manifestation, i.e., more drinks, more food, diuresis, become thin, these contents are just on the books among the traditional Chinese medical science, i.e., in
The diabete of doctor.Research has shown that clinically have up to 6 to 8 proportional diabetics to merge and hypertension and high blood occur
Fat；High fat of blood, hypertension caused by hyperglycaemia cause common people's pathobolism and caused in sub-health state
Chronic disease is grown thickly.Diabetes are not only brought outside above-mentioned malaise symptoms to patient, can also trigger a variety of chronic complicating diseases, common
Diabetic complication have following a few classes：Diabetic oculopathy, diabetic neuropathy, vasculopathy of lower extremity in diabetes become, sugar
Urinate disease nephrosis, diabetic cardiomyopathy, daily life, the health and lives of serious threat diabetic.Patient needs long-term
Ground is controlled to blood glucose.It is often also complex in treatment.Therefore most important factor is to drop blood glucose in treating diabetes
Low to one normal scope.
The content of the invention
It is an object of the present invention to provide a kind of hypoglycemic fruit zymotic fluid.
It is a further object to provide a kind of preparation method of hypoglycemic fruit zymotic fluid.
To reach above-mentioned purpose, the present invention uses following technical proposals：
Natural plant extraction thing is fermented using probiotics fermention liquid, then adds D-sorbite and dietary fiber,
Obtain fruit zymotic fluid；On the one hand, it is direct containing the active ingredient for reducing blood glucose, the active ingredient in fruit zymotic fluid of the invention
Activation islet cells is absorbed by alimentary canal and improves its effect；On the other hand, also containing fermentation production in fruit zymotic fluid of the invention
Raw Amino acid, organic acid, the metabolite of vitamin and various ferment, can improve gastrointestinal disturbances absorption function, take the photograph simultaneously
The various nutrients needed for human metabolism are got, reach the function of regulation blood glucose.Therefore the fruit zymotic fluid of the present invention is not
Disengaging for active ingredient is improve only, and promotes absorption of the enteron aisle to active ingredient, so as to reach the concentration for reducing blood glucose.
The hypoglycemic active ingredient is Polyphenols, natural plants antioxidant content, cordycepin and anthocyanidin etc..
Further, the natural plant extraction thing refers to Banana Leaf, Fructus psidii guajavae immaturus, Guava Leaf, Cordyceps militaris, grape pip
Freezing extraction is utilized respectively with Grape Skin to be extracted, then obtained from ground and mixed.
Grape：Contain substantial amounts of grape procyanidinses in grape, it is rare more can to produce many fresh grapes in air drying process for grape
Aldehydes matter grape procyanidinses, it can adjust blood fat, reduce low-density lipoprotein, suppress vascular endothelial cell proliferation, protect blood vessel
Smooth muscle cell, suppress platelet aggregation, promote fibrinolysis, vascular sclerosis, thrombosis effect are prevented so as to play,
Therefore it is the splendid food for preventing coronary heart disease.Grape procyanidinses are also anti-oxidant, anti-aging, hypotensive, anti-cancer efficacy.Grape procyanidinses are most
Exist in Grape Skin, grape procyanidinses are also contained in the red wine through brew, can effectively adjust blood glucose and blood fat.Grape pip has anti-
Oxidation, hypotensive, slow down brain degeneration, reduce the effect of harmful free radicals generation, prevention of cardiovascular disease, prevention diabetes.
Banana Leaf：Contain substantial amounts of plant polyphenol in Banana Leaf, there is preferable effect to improving diabetic symptom.Plant
Polyphenol is the polyphenoils that content is most abundant in diet, and having improves the effect such as angiocardiopathy, reducing blood lipid, hypoglycemic.
The absorption of exogenous cholesterol in enteron aisle can be suppressed, HDL~C levels are improved, accelerate the metabolism of cholesterol, promote the row of cholesterol
Let out, suppress the accumulation of lipomicron in adipocyte, so as to safeguard the health of cardiovascular and cerebrovascular.Lipid matter can be reduced in the blood vessels
The accumulation of film, increase radicals scavenging and antioxidant ability of organism, be metabolized by forward direction regulation body fat, it is raw to reduce fat
Into, increase lipolysis, and then the formation and development of prevention of arterial atherosis, reach reducing blood lipid purpose.
Guava Leaf：Paid close attention to strong anti-oxidation ability by scientists.Guava Leaf can soften blood vessel, drop blood
Fat and blood glucose, reduce cholesterol；There is the effect of resist oxygen lack, rapid relieving fatigue simultaneously；Contribute to the peroxide of postponement organism
Change process, can the chronic disease such as pre- anti-cancer, heart disease.In Guava Leaf, discovery contains a variety of important aromatics two levels
Metabolite such as polyphenolic substance.Exactly these phenolic compounds assign Guava Leaf multiple efficacies.
Fructus psidii guajavae immaturus：Guava averagely contains 125~180 milligrams of vitamin C, about the three of citrus times per hectogram pulp.Cause
This, the useful guava juice of foreign medical science man makees baby's beverage.Fructus psidii guajavae immaturus color is delicate and charming, fine and tender taste, smell delicate fragrance.Except being available for
Outside eating raw, jam, jelly and fruit juice etc. are may also be fabricated which, can also be made medicinal.The traditional Chinese medical science thinks the warm-natured sweet acid of guava, there is convergence
Antidiarrheal, hemostasis, antipruritic work(, cure mainly the diseases such as diarrhea, protracted dysentery, eczema, traumatic bleeding.It is early as the hypoglycemic effect of guava
Think Japanese Scientists demonstrated in animal experiment.
Cordyceps militaris：It is that cordyceps (Cordyceps militaris) are hosted by Lepidoptera noctuid larva and pupa
On.Cordycepic acid (mannitol) can significantly decrease cranium pressure, promote body metabolism, thus make cerebral hemorrhage and cerebral thrombosis disease
It is eased.Rich in having substantial amounts of cordycepin and Cordyceps sinensis polysaccharide in Cordyceps militaris, to reducing blood pressure, blood glucose and blood fat have significant treatment
Effect.Cordycepin is the core class material for having antibacterial activity, has very strong inhibitory action to the acid polymerization of core poly gland；Transcribed in DNA
Make mRNA dysmaturities during mRNA, suppress the growth of cancer cell, and have hypoglycemic effect.Cordyceps sinensis polysaccharide is highly branched
Galactomannans, can promote lymphocyte transformation, improve the immunologic function of serum lgG antibody contents and body, have anti-
The pharmacological actions such as tumour, radioresistance, hypoglycemic and lipoprotein, cough-relieving, resolving sputum, moistening lung and anti-aging, in addition, Cordyceps sinensis polysaccharide is also
Energy anti-arrhythmia, resists myocardial ischemia, and expands peripheral vascular, decompression, reducing blood lipid, suppresses the effect such as platelet aggregation.
Inonotus obliquus:Chemical composition has polysaccharide, inonotus obliquus, Inonotus obliquus alcohol, a variety of oxidation triterpene compounds, bolt
Bacterium is sour, a variety of lanosterol type triterpene compound, folic acid derivatives, aromatic vanillic acid, syringic acid and γ hydroxy benzenes first
Acid.Inonotus obliquus contains substantial amounts of anticancer, string class polysaccharide body that is hypoglycemic, bringing back to life immunization, can improve immune
The vigor of cell, suppress cancer cell diffusion and recurrence, the absorption of the harmful substances such as carcinogen is prevented in stomach and intestine, and promote to arrange
Let out.
Chinese photinia fruit：Kidney-invigorating and tendon-reinforcing, and have analgesia, anti-inflammatory and antitumaous effect.
Beneficial effects of the present invention are as follows：
1st, directly absorbed in the fruit zymotic fluid of invention containing the active ingredient for reducing blood glucose, the active ingredient by alimentary canal
Activation islet cells improves its effect；Compared with taking insulin, fruit zymotic fluid of the invention will not produce dependence, and can
So that human body recovers eubolism.
2nd, due to containing Amino acid caused by fermentation process, organic acid, vitamin and each in the fruit zymotic fluid of the present invention
The metabolite of kind ferment, therefore gastrointestinal disturbances absorption function can be improved, while absorb to each needed for human metabolism
Kind nutrient, reach the function of regulation blood glucose.
3rd, the present invention prepares fruit zymotic fluid and uses low-temperature extraction and Freeze Drying Technique combination probiotics fermention technology, carries
High disengaging for fruit zymotic fluid active ingredient, promotes absorption of the enteron aisle to active ingredient, the dense of blood glucose is reduced so as to reach
Degree.
Embodiment
In order to illustrate more clearly of the present invention, with reference to preferred embodiment, the present invention is described further.Ability
Field technique personnel should be appreciated that following specifically described content is illustrative and be not restrictive, and this should not be limited with this
The protection domain of invention.
A kind of hypoglycemic fruit zymotic fluid, is counted in parts by weight, and it includes the following raw material component：
1~5 part of probiotics fermention liquid,
1~2 part of Banana Leaf,
1~3 part of Fructus psidii guajavae immaturus,
1~2 part of Guava Leaf,
1~5 part of Cordyceps militaris,
1~3 part of grape pip,
1~2 part of Grape Skin,
5~10 parts of D-sorbite,
3~7 parts of dietary fiber.
A kind of preparation method of hypoglycemic fruit zymotic fluid, comprises the following steps：
1) Banana Leaf, Fructus psidii guajavae immaturus, Guava Leaf, Cordyceps militaris, grape pip and Grape Skin are crushed respectively, then by above-mentioned original
Material carries out oscillation extraction (speed of vibration is 150rpm/min) 3~5h respectively at 5~10 DEG C, then in temperature -50~-30
DEG C, vacuum is freeze-dried 40~50h under conditions of being 2mmHg, then is ground, and raw material powder is obtained after mixing, is natural plant
Thing extract.
2) the raw material powder and probiotics fermention liquid are mixed, and fermented 7~10 days under the conditions of 30~35 DEG C, work as pH value
For 3~4 when, terminate fermentation；Then D-sorbite and dietary fiber are added, obtains fruit zymotic fluid.
In some embodiments, the hypoglycemic fruit zymotic fluid of the present invention, is counted in parts by weight, and it also includes following former
Expect component：1~5 part of Inonotus obliquus, 1~4 part of Chinese photinia fruit.
In some preferred embodiments, a kind of hypoglycemic fruit zymotic fluid, it includes the following raw material component：It is prebiotic
1.2 parts of fermented liquid, 1.5 parts of Banana Leaf, 1.5 parts of Fructus psidii guajavae immaturus, 1.5 parts of Guava Leaf, 1.5 parts of Cordyceps militaris, grape pip 1.5
Part, 1.5 parts of Grape Skin, 2 parts of Inonotus obliquus, 3 parts of Chinese photinia fruit, 5.8 parts of D-sorbite, 4.6 parts of dietary fiber.
A kind of preparation method of hypoglycemic fruit zymotic fluid, can also be achieved by the steps of：
1) Banana Leaf, Fructus psidii guajavae immaturus, Guava Leaf, Cordyceps militaris, grape pip, Grape Skin and folium photiniae are crushed respectively, then
By above-mentioned raw materials respectively at 5~10 DEG C carry out oscillation extraction (speed of vibration is 150rpm/min) 3~5h, then in temperature-
50~-30 DEG C, vacuum is freeze-dried 40~50h under conditions of being 2mmHg, then is ground, and raw material powder is obtained after mixing, is
Natural plant extraction thing.
2) the raw material powder, Inonotus obliquus and probiotics fermention liquid are mixed, and the fermentation 7~10 under the conditions of 30~35 DEG C
My god, when pH value is 3~4, terminate fermentation；Then D-sorbite, dietary fiber are added, obtains fruit zymotic fluid.
In some embodiments, the probiotics fermention liquid is by probiotics fermention pineapple, pawpaw, apple, mulberries, benefit
Prepared by raw bacterium and sucrose.
In some preferred embodiments, the probiotics be lactobacillus acidophilus, bifidobacterium longum, bifidobacterium lactis,
Lactobacillus fermenti, Lactobacillus casei, streptococcus thermophilus, Lactobacillus helveticus, Lactobacillus paracasei, Lactobacillus plantarum and rhamnose breast
One or more in bacillus.Strain source is general in China typical culture collection center (CCTCC) (China, Wuhan) or China
Logical Microbiological Culture Collection administrative center (CGMCC) (China, Beijing) is divided from the excrement or intestinal submucosa tissue of normal person
From obtaining these bacterium bacterial strains.
In some embodiments, the dietary fiber is FOS, oligoisomaltose or glucose oligosaccharide；It is preferred that
Ground, the dietary fiber are FOS.
In some preferred embodiments, in order to improve the keeping quality of fruit zymotic fluid and stability, the fruit hair
Pol >=60 ° the Brix of zymotic fluid.
In some embodiments, the probiotics fermention liquid is prepared via a method which to obtain：By pineapple, pawpaw, apple
Fruit and mulberries are cleaned respectively, and in pH=12 Ca (OH)22min sterilizations are soaked in solution, then are drained, are then mixed simultaneously
It is ground into pulp；The probiotics is seeded in the mixture of pulp and sucrose when temperature is 30~35 DEG C, in 20~35
DEG C fermentation 20~30 days, when pH value be 3.5 when, terminate fermentation；Then prebiotic fermented liquid is filtered to obtain.
In some preferred embodiments, the sucrose is brown sugar.
The present invention improves the concentration and peace of hypoglycemic active ingredient as a result of low-temperature extraction and Freeze Drying Technique
It is qualitative；The metabolism of Amino acid, organic acid, vitamin and various ferment with reference to caused by probiotics fermention technology causes fermentation process
Product, gastrointestinal disturbances absorption function can be improved, so as to reach reduction blood sugar concentration.
Embodiment 1
Probiotics fermention liquid, is counted in parts by weight, and it includes the following raw material component：6 parts of pineapple, 1 part of pawpaw, 1 part of apple,
2 parts of mulberries.
The preparation method of probiotics fermention liquid is as follows：
Pineapple, pawpaw, apple and mulberries are cleaned respectively, and in pH=12 Ca (OH)22min is soaked in solution
Sterilization, then drain, then mix and be ground into pulp；By the pulp and brown sugar according to 4:1 ratio mixing, when temperature is 30
1% probiotics of preculture is inoculated with~35 DEG C, is fermented 20~30 days in 20~35 DEG C, when pH is 3.5, terminates fermentation；
Then prebiotic fermented liquid is filtered to obtain.
Embodiment 2
Hypoglycemic fruit zymotic fluid, is counted in parts by weight, and it includes the following raw material component：1.2 parts of probiotics fermention liquid,
2 parts of Banana Leaf, 2 parts of Fructus psidii guajavae immaturus, 2 parts of Guava Leaf, 2 parts of Cordyceps militaris, 2 parts of grape pip, 2 parts of Grape Skin, 5 parts of D-sorbite,
4 parts of dietary fiber.
The preparation method of hypoglycemic fruit zymotic fluid is as follows：
Fresh Banana Leaf, Fructus psidii guajavae immaturus, Guava Leaf, Cordyceps militaris, grape pip and Grape Skin are crushed respectively, then will be upper
State raw material and carry out oscillation extraction (oscillation rate 150rpm/min) 4h respectively at 5~10 DEG C, then in -40 DEG C of temperature, vacuum
Spend to be freeze-dried 48h under conditions of 2mmHg, then be ground；Raw material after grinding is mixed, obtains natural plant extraction thing；
The natural plant extraction thing and probiotics fermention liquid are mixed, and fermented 7~10 days under the conditions of 30~35 DEG C, when pH value is
When 3, terminate fermentation；Then D-sorbite and FOS are added, obtains fruit zymotic fluid.The pol of the fruit zymotic fluid is
68°Brix。
Embodiment 3
Hypoglycemic fruit zymotic fluid, is counted in parts by weight, and it includes the following raw material component：2 parts of probiotics fermention liquid is fragrant
1 part of any of several broadleaf plants leaf, 2 parts of Fructus psidii guajavae immaturus, 2 parts of Guava Leaf, 2 parts of Cordyceps militaris, 3 parts of grape pip, 2 parts of Grape Skin, 5 parts of D-sorbite, meals
Eat 4 parts of fiber.
The preparation method of hypoglycemic fruit zymotic fluid is as follows：
Fresh Banana Leaf, Fructus psidii guajavae immaturus, Guava Leaf, Cordyceps militaris, grape pip and Grape Skin are crushed respectively, then will be upper
State raw material and carry out oscillation extraction (oscillation rate 150rpm/min) 4h respectively at 5~10 DEG C, then in -40 DEG C of temperature, vacuum
Spend to be freeze-dried 48h under conditions of 2mmHg, then be ground；Raw material after grinding is mixed, obtains natural plant extraction thing；
The natural plant extraction thing and probiotics fermention liquid are mixed, and fermented 7~10 days under the conditions of 30~35 DEG C, when pH value is
When 3, terminate fermentation；Then D-sorbite and FOS are added, obtains fruit zymotic fluid.The pol of the fruit zymotic fluid is
65°Brix。
Embodiment 4
Hypoglycemic fruit zymotic fluid, is counted in parts by weight, and it includes the following raw material component：1.2 parts of probiotics fermention liquid,
1.5 parts of Banana Leaf, 1.5 parts of Fructus psidii guajavae immaturus, 1.5 parts of Guava Leaf, 1.5 parts of Cordyceps militaris, 1.5 parts of grape pip, 1.5 parts of Grape Skin,
2 parts of Inonotus obliquus, 3 parts of Chinese photinia fruit, 5.8 parts of D-sorbite, 4.6 parts of dietary fiber.
The preparation method of hypoglycemic fruit zymotic fluid is as follows：
Fresh Banana Leaf, Fructus psidii guajavae immaturus, Guava Leaf, Cordyceps militaris, grape pip, Grape Skin and Chinese photinia fruit are broken respectively
It is broken, then by above-mentioned raw materials respectively at 5~10 DEG C carry out oscillation extraction (oscillation rate 150rpm/min) 4h, then in temperature-
40 DEG C, vacuum is freeze-dried 48h under conditions of being 2mmHg, then is ground；Raw material after grinding is mixed, obtains and naturally plants
Thing extract；The natural plant extraction thing, Inonotus obliquus and probiotics fermention liquid are mixed, and issued in 30~35 DEG C of conditions
Ferment 7~10 days, when pH value is 4, terminate fermentation；Then D-sorbite and FOS are added, obtains fruit zymotic fluid.The water
The pol of fruit zymotic fluid is 61 ° of Brix.
Embodiment 5
Hypoglycemic fruit zymotic fluid, is counted in parts by weight, and it includes the following raw material component：1 part of probiotics fermention liquid is fragrant
1 part of any of several broadleaf plants leaf, 1 part of Fructus psidii guajavae immaturus, 1 part of Guava Leaf, 1 part of Cordyceps militaris, 1 part of grape pip, 2 parts of Grape Skin, 2 parts of Inonotus obliquus, stone
3 parts of nanmu fruit, 5 parts of D-sorbite, 4 parts of dietary fiber.
The preparation method of hypoglycemic fruit zymotic fluid is as follows：
Fresh Banana Leaf, Fructus psidii guajavae immaturus, Guava Leaf, Cordyceps militaris, grape pip, Grape Skin and Chinese photinia fruit are broken respectively
It is broken, then by above-mentioned raw materials respectively at 5~10 DEG C carry out oscillation extraction (oscillation rate 150rpm/min) 4h, then in temperature-
40 DEG C, vacuum is freeze-dried 48h under conditions of being 2mmHg, then is ground；Raw material after grinding is mixed, obtains and naturally plants
Thing extract；The natural plant extraction thing, Inonotus obliquus and probiotics fermention liquid are mixed, and issued in 30~35 DEG C of conditions
Ferment 7~10 days, when pH value is 4, terminate fermentation；Then D-sorbite and FOS are added, obtains fruit zymotic fluid.The water
The pol of fruit zymotic fluid is 60 ° of Brix.
Embodiment 6
Hypoglycemic fruit zymotic fluid, is counted in parts by weight, and it includes the following raw material component：1.6 parts of probiotics fermention liquid,
2 parts of Banana Leaf, 2 parts of Fructus psidii guajavae immaturus, 2 parts of Guava Leaf, 2 parts of Cordyceps militaris, 2 parts of grape pip, 2 parts of Grape Skin, 4 parts of Inonotus obliquus,
4 parts of Chinese photinia fruit, 8.2 parts of D-sorbite, 6.5 parts of dietary fiber.
The preparation method of hypoglycemic fruit zymotic fluid is as follows：
Fresh Banana Leaf, Fructus psidii guajavae immaturus, Guava Leaf, Cordyceps militaris, grape pip, Grape Skin and Chinese photinia fruit are broken respectively
It is broken, then by above-mentioned raw materials respectively at 5~10 DEG C carry out oscillation extraction (oscillation rate 150rpm/min) 4h, then in temperature-
40 DEG C, vacuum is freeze-dried 48h under conditions of being 2mmHg, then is ground；Raw material after grinding is mixed, obtains and naturally plants
Thing extract；The natural plant extraction thing, Inonotus obliquus and probiotics fermention liquid are mixed, and issued in 30~35 DEG C of conditions
Ferment 7~10 days, when pH value is 4, terminate fermentation；Then D-sorbite and FOS are added, obtains fruit zymotic fluid.The water
The pol of fruit zymotic fluid is 65 ° of Brix.
Comparative example 1
Hypoglycemic fruit zymotic fluid, is counted in parts by weight, including the following raw material component：1.8 parts of probiotics fermention liquid, banana
2 parts of leaf, 2 parts of Fructus psidii guajavae immaturus, 2 parts of Guava Leaf, 2 parts of Cordyceps militaris, 2 parts of grape pip, 2 parts of Grape Skin, 2 parts of dragon fruit, Kiwi berry 2
Part, 2 parts of the wild cherry certain kind of berries, 7.5 parts of D-sorbite, 6 parts of dietary fiber；
The preparation method of hypoglycemic zymotic fluid is as follows：
By fresh Banana Leaf, Fructus psidii guajavae immaturus, Guava Leaf, Cordyceps militaris, grape pip, Grape Skin, dragon fruit, Kiwi berry,
The wild cherry certain kind of berries is crushed respectively, then above-mentioned raw materials are carried out into oscillation extraction (oscillation rate 150rpm/min) 4h respectively at 5~10 DEG C,
Then in -40 DEG C of temperature, vacuum is freeze-dried 48h under conditions of being 2mmHg, then is ground；Raw material after grinding is mixed
Close, obtain natural plant extraction thing；According to mass ratio it is 10 by the natural plant extraction thing and probiotics fermention liquid:1 ratio
Mixing, and fermented 7~10 days under the conditions of 30~35 DEG C, when pH value is 3, terminate fermentation；Then D-sorbite and low is added
Fructooligosaccharides, obtain fruit zymotic fluid.The pol of the fruit zymotic fluid is 70 ° of Brix.
Comparative example 2
Hypoglycemic fruit zymotic fluid, is counted in parts by weight, including the following raw material component：Hypoglycemic fruit zymotic fluid, is pressed
Parts by weight meter, it includes the following raw material component：0.9 part of probiotics fermention liquid, 1.5 parts of Banana Leaf, 1.5 parts of Fructus psidii guajavae immaturus, kind
1.5 parts of pomegranate leaf, 1.5 parts of Cordyceps militaris, 1.5 parts of grape pip, 1.5 parts of Grape Skin, 2 parts of Inonotus obliquus, 4.5 parts of D-sorbite, meals
Eat 3.6 parts of fiber.
The preparation method of hypoglycemic fruit zymotic fluid is as follows：
Fresh Banana Leaf, Fructus psidii guajavae immaturus, Guava Leaf, Cordyceps militaris, grape pip and Grape Skin are crushed respectively, then will be upper
State raw material and carry out oscillation extraction (oscillation rate 150rpm/min) 4h respectively at 5~10 DEG C, then in -40 DEG C of temperature, vacuum
Spend to be freeze-dried 48h under conditions of 2mmHg, then be ground；Raw material after grinding is mixed, obtains natural plant extraction thing；
By the natural plant extraction thing, Inonotus obliquus and probiotics fermention liquid according to mass ratio be 9:2:1 ratio mixing, and in 30
Fermented 7~10 days under the conditions of~35 DEG C, when pH value is 4, terminate fermentation；Then D-sorbite and FOS are added, obtains water
Fruit zymotic fluid.The pol of the fruit zymotic fluid is 63 ° of Brix.
The hypoglycemic experiment of the fruit zymotic fluid of the present invention of embodiment 7
The present embodiment is intended to the hyperglycemia model using big white mouse, the fruit fermentation that citing description is prepared by the inventive method
The blood sugar decreasing effect of liquid.
Hypoglycemic experiment：Example 2 and embodiment 3, embodiment 4, embodiment 5, embodiment 6, comparative example 1 and contrast
Probiotics fermention liquid prepared by fruit zymotic fluid and embodiment 1 prepared by example 2, as test sample.Using FORA Fu Er blood
Sugar determination instrument determines blood glucose value.Average ferment intake is calculated using the average magnitude of discharge reduction.
The individual instances of big white mouse are illustrated, take male white rat 90 more than body weight 170g, adaptability raising 3
My god, then it is randomly divided into 9 groups；Respectively blank group, experimental group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5, control
Group 1, control group 2 and control group 3；The fruit zymotic fluid of embodiment 2 to 6, comparative example 1 and comparative example 2 is distinguished using drinking water
50 times of dilution, obtain the fruit zymotic fluid that concentration is 2%；The probiotics fermention liquid of embodiment 1 is diluted 50 using drinking water
Times, obtain the probiotics fermention liquid that concentration is 2%；The fruit that the concentration of the big white mouse feeding embodiment 2 of experimental group 1 is 2% ferments
Liquid, the concentration of the big white mouse feeding embodiment 3 of experimental group 2 are 2% fruit zymotic fluid, and the big white mouse feeding of experimental group 3 is implemented
The concentration of example 4 is 2% fruit zymotic fluid, and the concentration of the big white mouse feeding embodiment 5 of experimental group 4 is 2% fruit zymotic fluid,
The concentration of the big white mouse feeding embodiment 6 of experimental group 5 be 2% fruit zymotic fluid, the big white mouse feeding comparative example 1 of control group 1
Concentration be 2% fruit zymotic fluid, the concentration of the big white mouse feeding comparative example 2 of control group 2 is 2% fruit zymotic fluid, right
The probiotics fermention liquid that concentration according to the big white mouse feeding embodiment 1 of group 3 is 2%；Blank big white mouse feeding normal drinking water.It is real
Test the continuous feeding of group, blank group, the big white mouse of control group 28 days, and results of regular determination its blood glucose value, compare each group animal blood glucose value.
Specific experiment the results are shown in Table 1.
Influence of the fruit zymotic fluid of table 1 to big white mouse blood glucose
Before feeding：There was no significant difference between blank group, experimental group and control group, illustrates modeling success；Great Bai during feeding
Mouse changes of weight also indifference, feeding after 28 days the big white mouse body weight of experimental group, blank group and control group be kept at 300-
310g.Compared with blank group, the big white mouse blood glucose value of experimental group and control group reduces, and illustrates probiotics fermention liquid and fruit
Zymotic fluid has the effect for reducing blood glucose.Compared with control group 3, the big white mouse blood glucose value of experimental group 1 and experimental group 2 during feeding
It is obvious to reduce, and maintain normal value (<In the range of 100mg/L), illustrate probiotics fermention liquid and natural plant extraction thing to drop
Hypoglycemia has synergy.Compare control group 1 and experimental group 1, it is known that the big white mouse blood glucose value of experimental group 1 is obvious during feeding
Less than control group 1, illustrate to increase hypoglycemic component in the fruit fermentation liquor formulation of embodiment 2 to differ and surely effectively realize drop
The effect of hypoglycemia.The hypoglycemic effect of experimental group 1 is better than experimental group 2 during feeding, illustrates that the fruit of the embodiment of the present invention 2 ferments
Formula of the formula of liquid better than embodiment 3.The big white mouse blood glucose value of experimental group 3, experimental group 4 and experimental group 5 is bright during feeding
It is aobvious to reduce, and maintain normal value (<In the range of 100mg/L), illustrate probiotics fermention liquid, Inonotus obliquus and natural plant extraction
Thing has synergy to reducing blood glucose；The hypoglycemic effect of experimental group 3 is better than experimental group 4 and experimental group 5 during feeding, illustrates real
Apply formula of the formula better than embodiment 4 and embodiment 5 of the fruit zymotic fluid of example 4；Comparative experiments group 3 and control group 2 are understood, real
The big white mouse blood glucose value for testing group 3 is less than control group 2, illustrates that the Chinese photinia fruit composition in the fruit zymotic fluid of embodiment 4 can promote greatly
Absorption of the white mouse enteron aisle to hypoglycemic material, and then be advantageous to the reduction of big white mouse blood glucose value.
Influence of the fruit zymotic fluid of the present invention of embodiment 8 to hyperglycemia model big white mouse gut flora
Intestinal flora determines：Big white mouse excrement 0.1g is taken with aseptic procedure, is placed in the sterile vials with bead, by 1：
10 add appropriate dilution, and then bottle is placed on oscillator and fully vibrated, and after making it well mixed, then carry out 10 times successively
It is serially diluted to 10-7.Suitable dilution factor is selected by Selective agar medium, and kind is dripped with liquid getting device (25 μ L), is then carried out respectively
Aerobic and Anaerobic culturel.Bifidobacterium is with MRS culture mediums, 37 DEG C, 48~72 hours, Anaerobic culturel；Lactobacillus is cultivated with LBS
Base, 37 DEG C, % cultures in 48 hours；Enterobacteria 37 DEG C, is cultivated for 24 hours with EMB culture mediums；Enterococcus is with EC culture mediums, 37 DEG C,
Cultivate within 24 hours, finally count each group bacterium clump count.Calculate the bacteria colony count in every gram of excrement.
The big white mouse of the blank group of embodiment 7, control group and experimental group is chosen, and using method similarly to Example 7
Feeding 28 days, detects the quantity of feeding big white mouse gut flora after 28 days, and specific test result is shown in Table 2.
Influence of the fruit zymotic fluid of table 2 to hyperglycemia model big white mouse gut flora
The beneficial bacterium of big white mouse enteron aisle is above blank group in experimental group of the present invention and control group；This is due to the present invention's
Absorption of the fruit zymotic fluid to the enteron aisle of big white mouse has facilitation.The big white mouse feeding fruit zymotic fluid of experimental group 1 28 days
Afterwards, the number of enterobacteria, enterococcus, lactobacillus and Bifidobacterium is apparently higher than control group 3；Illustrate probiotics fermention liquid and natural
Plant extract has synergy, and probiotics fermention liquid can promote absorption of the enteron aisle to hypoglycemic active ingredient；Experiment
The group enterobacteria of 3 big white mouse, enterococcus, the number of lactobacillus and Bifidobacterium are apparently higher than control group 1；Illustrate the water of the present invention
Chinese photinia fruit active ingredient in fruit zymotic fluid directly absorbs activation islet cells by alimentary canal and improves its effect；Reduced so as to realize
The purpose of blood glucose.
Obviously, the above embodiment of the present invention is only intended to clearly illustrate example of the present invention, and is not pair
The restriction of embodiments of the present invention, for those of ordinary skill in the field, may be used also on the basis of the above description
To make other changes in different forms, all embodiments can not be exhaustive here, it is every to belong to this hair
Row of the obvious changes or variations that bright technical scheme is extended out still in protection scope of the present invention.
Claims (10)
1. a kind of hypoglycemic fruit zymotic fluid, it is characterised in that count in parts by weight, it includes the following raw material component：
1~5 part of probiotics fermention liquid,
1~2 part of Banana Leaf,
1~3 part of Fructus psidii guajavae immaturus,
1~2 part of Guava Leaf,
1~5 part of Cordyceps militaris,
1~3 part of grape pip,
1~2 part of Grape Skin,
5~10 parts of D-sorbite,
3~7 parts of dietary fiber.
2. fruit zymotic fluid according to claim 1, it is characterised in that count in parts by weight, it also includes the following raw material
Component：1~5 part of Inonotus obliquus, 1~4 part of Chinese photinia fruit.
3. fruit zymotic fluid according to claim 2, it is characterised in that count in parts by weight, it includes the following raw material group
Point：1.2 parts of probiotics fermention liquid, 1.5 parts of Banana Leaf, 1.5 parts of Fructus psidii guajavae immaturus, 1.5 parts of Guava Leaf, 1.5 parts of Cordyceps militaris, grape
1.5 parts of seed, 1.5 parts of Grape Skin, 2 parts of Inonotus obliquus, 3 parts of Chinese photinia fruit, 5.8 parts of D-sorbite, 4.6 parts of dietary fiber.
4. fruit zymotic fluid according to claim 1, it is characterised in that the probiotics fermention liquid is by probiotics fermention
Prepared by pineapple, pawpaw, apple, mulberries, probiotics and sucrose.
5. fruit zymotic fluid according to claim 4, it is characterised in that the probiotics is lactobacillus acidophilus, long bifid
Bacillus, bifidobacterium lactis, lactobacillus fermenti, Lactobacillus casei, streptococcus thermophilus, Lactobacillus helveticus, Lactobacillus paracasei, plant
One or more in lactobacillus and Lactobacillus rhamnosus.
6. fruit zymotic fluid according to claim 1, it is characterised in that the dietary fiber is FOS, oligomeric different
Maltose or glucose oligosaccharide.
7. a kind of preparation method of fruit zymotic fluid as described in claim 1-6 is any, comprises the following steps：
1) Banana Leaf, Fructus psidii guajavae immaturus, Guava Leaf, Cordyceps militaris, grape pip, Grape Skin and Chinese photinia fruit are crushed respectively, then will be upper
State raw material and carry out low-temperature extraction respectively, be then freeze-dried and grind；Raw material powder, as natural plant extraction thing are obtained after mixing；
2) the raw material powder, Inonotus obliquus and probiotics fermention liquid are mixed, and fermented 7~10 days under the conditions of 30~35 DEG C,
When pH value is 3~4, terminate fermentation；Then D-sorbite and dietary fiber are added, obtains fruit zymotic fluid.
8. preparation method according to claim 7, it is characterised in that the ゜ Brix of the pol of the fruit zymotic fluid >=60.
9. preparation method according to claim 7, it is characterised in that the temperature of the extraction be 5~10 DEG C, extraction when
Between be 3~5h.
10. preparation method according to claim 7, it is characterised in that the temperature of the freeze-drying is -50~-30 DEG C,
40~50h of time of freeze-drying, vacuum 2mmHg.
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| CN109055278A (en) * | 2018-09-17 | 2018-12-21 | 山东中科嘉亿生物工程有限公司 | A kind of Lactobacillus rhamnosus JYLR-005 and its hypoglycemic product and application |
| CN109601619A (en) * | 2018-10-31 | 2019-04-12 | 广州明为生物科技有限公司 | A kind of auxiliary hyperglycemic type lactic bacteria composition and the method for preparing sour milk beverage with it |
| TWI730719B (en) * | 2020-04-13 | 2021-06-11 | 陳俊宏 | Plant fermented product, method of manufacturing the same, composition of plant fermented product and use thereof |
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| CN107873894A (en) * | 2017-11-23 | 2018-04-06 | 丹寨县黔丹硒业有限责任公司 | The processing method of selenium-rich black tea |
| CN107712127A (en) * | 2017-11-24 | 2018-02-23 | 丹寨县黔丹硒业有限责任公司 | The processing method of selenium-rich black tea |
| CN109645459A (en) * | 2018-12-17 | 2019-04-19 | 青岛国海生物制药有限公司 | A kind of preparation method and production equipment of hypoglycemic fruit fermentation liquid |
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| CN109055278A (en) * | 2018-09-17 | 2018-12-21 | 山东中科嘉亿生物工程有限公司 | A kind of Lactobacillus rhamnosus JYLR-005 and its hypoglycemic product and application |
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Application publication date: 20180216 |