CN107669920A - 中药治疗胃粘膜脱垂症及制备 - Google Patents

中药治疗胃粘膜脱垂症及制备 Download PDF

Info

Publication number
CN107669920A
CN107669920A CN201710885420.6A CN201710885420A CN107669920A CN 107669920 A CN107669920 A CN 107669920A CN 201710885420 A CN201710885420 A CN 201710885420A CN 107669920 A CN107669920 A CN 107669920A
Authority
CN
China
Prior art keywords
treatment
gastric mucosa
chinese medicine
prolapse
chinese
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201710885420.6A
Other languages
English (en)
Inventor
胡静
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201710885420.6A priority Critical patent/CN107669920A/zh
Publication of CN107669920A publication Critical patent/CN107669920A/zh
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016Disaccharides, e.g. lactose, lactulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/342Adenophora
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/64Orobanchaceae (Broom-rape family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/79Schisandraceae (Schisandra family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明公开了一种中药治疗胃粘膜脱垂症,按重量份数是包括以下中药成分:半夏24g,麦冬16g,人参7g,甘草6g,粳米7g,大枣12枚,沙参7g,冰糖4g,生地黄16g,玉竹6g。本发明中药组合物的制备和使用方法:将药材(除冰糖外)用清水浸泡1小时,浸泡的水量以淹没药面5cm为宜,将药放在火上,用武火熬开,沸腾后改用文火煎煮50分钟,将药液倒出,用冰糖冲服,每天1剂,分3次温服,6剂为1个疗程,需用药2~5个疗程。

Description

中药治疗胃粘膜脱垂症及制备
技术领域
本发明属于中药组合物,具体地说,是涉及一种用于胃粘膜脱垂症治疗的中药配方及其制备方法。
背景技术
胃黏膜脱垂是由于异常松弛的胃黏膜逆行突入食管或向前通过幽门管脱入十二指肠球部,临床上以后者多见。临床症状表现有腹痛,上消化道出血,恶心、呕吐,消瘦、轻度贫血,上腹部可有轻压痛,无反跳痛。本病可分为原发和继发两种,前者与高度活动的胃黏膜皱襞和先天性胃皱襞肥大有关;后者多继发于胃炎、消化性溃疡以及心力衰竭、低蛋白血症引起的黏膜下水肿。本病常见于30~60岁的成年人,患者以30—60岁为多见。
目前,胃粘膜脱垂症尚无特效疗法。以内科治疗为主,注意饮食,少吃多餐,戒烟酒,避免刺激性食物;注意体位,采用左侧卧位,尽量避免右侧卧位;可给予镇静药和抗胆碱能类药物,以抑制过强的胃蠕动,以减少脱垂机会,应尽量避免使用促胃动力药,以免加重黏膜脱垂。有幽门梗阻者应禁食、胃肠减压,并补液、纠正水电解质紊乱;对伴有胃炎、溃疡或上消化道出血者应给予相应的治疗。而内科保守治疗失败时,需考虑行外科手术治疗。但长期或短时间进行治疗,原发病变反跳加重与继发的副作用,可使患者产生很大的痛苦,治疗过程反反复复,效果不明显,费用高等,给患者的造成较大的心里压力和病痛压力。
发明内容
本发明的目的在于提供一种用于胃粘膜脱垂症的中药制剂及其制备方法,该中药制剂对于治疗胃粘膜脱垂症具有治疗效果显著,治愈时间短,价格低廉,无不良反应和副毒作用的特点。
为了实现上述发明目的,本发明制成该药物有效成分的原料组成及其重量配比为:半夏24g,麦冬16g,人参7g,甘草6g,粳米7g,大枣12枚,沙参7g,冰糖4g,生地黄16g,玉竹6g。
本发明中药组合物的制备和使用方法:将药材(除冰糖外)用清水浸泡1小时,浸泡的水量以淹没药面5cm为宜,将药放在火上,用武火熬开,沸腾后改用文火煎煮50分钟,将药液倒出,用冰糖冲服,每天1剂,分3次温服,6剂为1个疗程,需用药2~5个疗程。
发明用于治疗胃粘膜脱垂症的中药汤剂,选择天然药物,针对胃粘膜脱垂症病因病机,各味药材各具其效,互相协调,麦冬、生地黄生津养阴,滋液除燥;人参益气生津,调营和阴;粳米益脾胃,化生阴津;半夏开胃行津,调畅气机,降肺胃逆气;沙参、玉竹滋养脾胃之阴,清热润燥;冰糖滋阴生津,兼以益气;大枣、甘草益胃气,养脾阴。
具体实施方式
实施例1:一种治疗胃粘膜脱垂症的中药汤剂,按重量份数包括以下中药成分:半夏24g,麦冬16g,人参7g,甘草6g,粳米7g,大枣12枚,沙参7g,冰糖4g,生地黄16g,玉竹6g。
实施例2:如果患者饥不欲食,在上述组分中加山楂7g,鸡内金7g,神曲7g。
实施例3:如果患者大便干,在上述组分中加肉苁蓉6g,火麻仁6g。
实施例4:如果患者盗汗,在上述组分中加五味子7g,牡蛎7g。
将药材(除冰糖外)用清水浸泡1小时,浸泡的水量以淹没药面5cm为宜,将药放在火上,用武火熬开,沸腾后改用文火煎煮50分钟,将药液倒出,用冰糖冲服,每天1剂,分3次温服,6剂为1个疗程,需用药2~5个疗程。
以下通过实用例来阐明本发明所述用于胃粘膜脱垂症护理的中药配方的临床治疗效果。
1、临床资料
患者60例,诊断标准:上腹部疼痛:多发于饭后,常呈阵发性,缺乏周期性及节律性,用碱性药物不易缓解,右侧卧位易引起疼痛或使其加重,左侧卧位常可使疼痛减轻,常伴有上腹饱胀、嗳气、恶心、呕吐等症状,亦可出现幽门梗阻和上消化道出血的症状,有些患者可无明显症状。
2、疗效标准
治愈:症状消失,多次上消化道钡餐造影无异常发现;
好转:症状减轻,多次上消化道钡餐造影仍有反复;
无效:临床症状无明显好转或加重。
3、治疗结果
治疗效果:该临床观察病例中,服药2-5个疗程,痊愈45例,随访未见复发;显效 8例,有效5例,无效2例,总有效率88.3%,中药品不良反应(ADR)评价,未发生不良反应和毒副作用。
典型案例:
患者王某,女,36岁,青岛市人,主诉:饭后上腹部疼痛,呈阵发性,缺乏周期性及节律性,用碱性药物不易缓解,患者上腹部有压痛,X线检查十二指肠球底部出现蕈状充盈缺损影,幽门管常增宽,确诊为胃粘膜脱垂症,服用本发明配方1个疗程后症状减退,用药6天后,疼痛消失,继续用药6天,彻底治愈,电话随访半年未复发。

Claims (5)

1.一种中药治疗胃粘膜脱垂症,其特征在于:该中药配方按重量份数包括以下中药成分:半夏24g,麦冬16g,人参7g,甘草6g,粳米7g,大枣12枚,沙参7g,冰糖4g,生地黄16g,玉竹6g。
2.如权利要求1所述的中药治疗胃粘膜脱垂症,其特征在于:该中药配方还包括山楂7g,鸡内金7g,神曲7g。
3.如权利要求1所述的中药治疗胃粘膜脱垂症,其特征在于:该中药配方还包括肉苁蓉6g,火麻仁6g。
4.如权利要求1所述的中药治疗胃粘膜脱垂症,其特征在于:该中药配方还包括五味子7g,牡蛎7g。
5.如权利要求1所述的中药治疗胃粘膜脱垂症的制备方法,其特征在于:将药材(除冰糖外)用清水浸泡1小时,浸泡的水量以淹没药面5cm为宜,将药放在火上,用武火熬开,沸腾后改用文火煎煮50分钟,将药液倒出,用冰糖冲服,每天1剂,分3次温服,6剂为1个疗程,需用药2~5个疗程。
CN201710885420.6A 2017-09-27 2017-09-27 中药治疗胃粘膜脱垂症及制备 Withdrawn CN107669920A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710885420.6A CN107669920A (zh) 2017-09-27 2017-09-27 中药治疗胃粘膜脱垂症及制备

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710885420.6A CN107669920A (zh) 2017-09-27 2017-09-27 中药治疗胃粘膜脱垂症及制备

Publications (1)

Publication Number Publication Date
CN107669920A true CN107669920A (zh) 2018-02-09

Family

ID=61136258

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710885420.6A Withdrawn CN107669920A (zh) 2017-09-27 2017-09-27 中药治疗胃粘膜脱垂症及制备

Country Status (1)

Country Link
CN (1) CN107669920A (zh)

Similar Documents

Publication Publication Date Title
CN102764403B (zh) 一种治疗慢性胃炎、胃十二指肠溃疡的中药
CN102935199A (zh) 一种治疗慢性胃炎的中药组合物
CN104352920A (zh) 一种消食和胃的中药组合物
CN107095995B (zh) 一种治疗胃炎和胃溃疡的药物组合物及制备方法
CN103431260B (zh) 供胃肠道吸收障碍、胰腺炎患者食用的五谷杂粮全营养配方食品
CN103989955A (zh) 一种治疗胃、十二指肠溃疡、浅表性多发性胃溃疡、糜烂性胃溃疡的药物组合物
CN103212013B (zh) 一种治疗胃脘痛的中药组合物
CN107669920A (zh) 中药治疗胃粘膜脱垂症及制备
CN107854662A (zh) 一种治疗肝硬化腹水的中药制剂及其制备方法
CN103877390A (zh) 一种治疗风湿热的中药制剂及制备方法
CN107596327A (zh) 一种治疗寒热错杂型功能性消化不良的药物
CN102302764B (zh) 治疗胃病的中药组合物
CN107583023A (zh) 治疗肠梗阻的中药配方及制备
CN106729543A (zh) 一种治疗肠易激综合征的中药
CN105902766A (zh) 治疗消化性溃疡的药物及制备方法
CN105770821A (zh) 一种含艾叶的治疗功能性消化不良的药物组合物
CN102652827B (zh) 一种治疗癌症的药物和制备方法
CN104621475A (zh) 一种具有滋补肝肾功效的粳米粥
CN104013895A (zh) 一种治疗十二指肠溃疡引发胃脘痛的中药组合物
CN105125688B (zh) 一种含牛奶碱性蛋白的制酸止痛药物组合物及其制备方法
CN104398977A (zh) 一种用于治疗功能性消化不良的中药
CN107812124A (zh) 一种治疗慢性胃炎的中药组合物及其制备方法
CN103566302A (zh) 一种治疗萎缩性胃炎的中药药物
CN107375603A (zh) 一种治疗慢性胃炎的胶囊剂药物及其制备方法
CN107115512A (zh) 一种治疗胃脘疼痛的中药

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20180209

WW01 Invention patent application withdrawn after publication