CN107669901A - 一种用于治疗小儿口腔溃疡的外用油剂及制备方法 - Google Patents
一种用于治疗小儿口腔溃疡的外用油剂及制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂领域，目的是根据中医治疗小儿口腔溃疡的认识机理而提供一种用于治疗小儿口腔溃疡的外用油剂，所述外用油剂的各个组分及其质量份比如下：冰片0.3～0.6g、蓖麻子1～6g、白芨5～16g、白芷3～10g、五倍子3～10g、寒水石10～30g、黄连2～5g、牡丹皮6～15g、龙骨15～45g、蒲公英9～16g、海螵蛸5～10g、紫草5～10g、儿茶1～5g、赤芍4～10g，本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域，具体涉及一种用于治疗小儿口腔溃疡的外用油剂，特别是供小儿口腔溃疡患者使用的外用油剂及制备方法
的领域。
背景技术
医者认为：小儿口腔溃疡小儿口腔溃疡（口疮）是一种最常见的口腔粘膜疾病，在小儿群中患病率一般认为超过10%，小儿口腔溃疡是一种以周期性反复发作为特点的口腔粘膜局限性溃疡损害，可以自愈，可发生于口腔粘膜的任何部位，以唇、颊、舌部多见，严重者可以波及咽部粘膜。不少患儿随着病程的延长，溃疡面积增大，数日增多，疼痛加重，愈合期延长，间隔期缩短等，影响纳食和说话。
那么，就如何找到一种可效治疗小儿口腔溃疡的中药组合物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗小儿口腔溃疡上，人们逐渐意识到了中医治疗小儿口腔溃疡的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗小儿口腔溃疡的现状，本发明的目的是在于提供一种用于治疗小儿口腔溃疡的外用油剂，以解决小儿口腔溃疡患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及质量份比，可有效治疗上述小儿口腔溃疡。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种用于治疗小儿口腔溃疡的外用油剂及制备方法，其特征在于，所述外用油剂的各个组分及其质量份比如下所示：
冰片0.3～0.6g、蓖麻子1～6g、白芨5～16g、白芷3～10g、五倍子3～10g、寒水石10～30g、黄连2～5g、牡丹皮6～15g、龙骨15～45g、蒲公英9～16g、海螵蛸5～10g、紫草5～10g、儿茶1～5g、赤芍4～10g。
一种用于治疗小儿口腔溃疡的外用油剂及制备方法，其特征在于，所述外用油剂的各个组分及其质量份比如下所示：
冰片0.35～0.55g、蓖麻子2～5g、白芨8～14g、白芷5～9g、五倍子5～9g、寒水石11～26g、黄连3～4.5g、牡丹皮8～13g、龙骨18～40g、蒲公英10～14g、海螵蛸6～9g、紫草6～9g、儿茶2～4g、赤芍5～9g。
一种用于治疗小儿口腔溃疡的外用油剂及制备方法，其特征在于，所述外用油剂的各个组分及其质量份比如下所示：
冰片0.50g、蓖麻子4g、白芨13g、白芷8g、五倍子8g、寒水石23g、黄连4g、牡丹皮12g、龙骨35g、蒲公英13g、海螵蛸8g、紫草8g、儿茶3g、赤芍8g。
一种用于治疗小儿口腔溃疡的外用油剂及制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、除冰片、儿茶、白芷（放在胡麻香油中浸泡360小时，进而将油、渣分离，并将油脂过120目的筛，即得胡麻香油药物）外，将上述其它原料中药拣去杂质、粉尘及干燥后，按照质量份比共研为极细末待用；
B、将上述过滤后的胡麻香油药物与极细末药物混合均匀，调成稀糊状，分装封口后，进行消毒灭菌处理，即得外用油剂。
一种用于治疗小儿口腔溃疡的外用油剂及制备方法，其特征在于，所述使用方法为：将制备好的外用油剂以每日三次涂搽患处，早中晚各搽药一次， 7天为一个疗程，治疗1～2个疗程，症状消失，病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
冰片，性味：辛、苦、微寒，具有开窍醒神、清热止痛之功效，用于治疗热病神昏、痉厥、中风痰厥、气郁暴厥、中恶昏迷、目赤、口疮、咽喉肿痛、耳道流脓等症；
蓖麻子，性味：甘、辛、平，有毒，具有消肿拨毒、泻下通滞之功效，用于治疗痈疽肿毒、喉痹、瘰疬、大便燥结；
白芨，性味：苦甘，凉，具有补肺、止血、消肿、生肌、敛疮之功效，用于治疗肺伤咳血、衄血、金疮出血、痈疽肿毒、溃疡疼痛、汤火灼伤、手足皲裂；
白芷，性味：辛、温，具有散风除湿、通窍止痛、消肿排脓之功效，用于治疗感冒头痛、眉棱骨痛、鼻塞、鼻渊、牙痛、白带、疮疡肿痛；
五倍子，性味：酸、涩、寒，具有敛肺、止汗、涩肠、固精、止血、解毒之功效，用于治疗肺虚久咳、自汗盗汗、久痢久泻、脱肛、遗精、白浊、各种出血、痈肿疮疖等症；
寒水石，性味：辛、咸、寒，具有清热泻火，除烦止渴之功效，用于治疗发热烦渴、咽喉肿痛、口舌生疮、牙痛，外用治烧烫伤；
黄连，性味：苦、寒，具有清热泻火、燥湿、解毒之功效，用于治疗病邪入心经之高热、烦躁、谵妄或热盛迫血妄行之吐衄、湿热胸痞、泄泻、痢疾、心火亢盛之心烦失眠、胃热呕吐或消谷善饥、肝火目赤肿痛以及热毒疮疡、疔毒走黄、牙龈肿痛、口舌生疮、聤耳、阴肿、痔血、湿疹、烫伤等症；
牡丹皮，性味：苦、辛、微寒，具有清热凉血、活血化瘀之功效，用于治疗温毒发斑、吐血衄血、夜热早凉、无汗骨蒸、经闭痛经、痈肿疮毒、跌扑伤痛；
龙骨，性味：甘、涩、平，具有镇静、敛汗涩精、生肌敛疮之功效，用于治疗神经衰弱、心悸、失眠、多梦、自汗、盗汗、遗精、遗尿、崩漏、带下，外用治疮疡久溃不敛；
蒲公英，性味：苦、甘、寒，具有清热解毒、消肿散结、利尿通淋之功效，用于治疗疔疮肿毒、乳痈、瘰疠、目赤、咽痛、肺痈、肠痈、湿热黄疸、热淋涩痛；
海螵蛸，性味：咸、涩、温，具有收敛止血、涩精止带、制酸、敛疮之功效，用于治疗胃痛吞酸、吐血衄血、崩漏便血、遗精滑精、赤白带下、溃疡病，外治损伤出血、疮多脓汁；
紫草，性味：甘、咸、寒，具有凉血、活血、解毒透疹之功效，用于治疗血热毒盛、斑疹紫黑、麻疹不透、疮疡、湿疹、水火烫伤等症；
儿茶，性味：苦、涩、微寒，具有收湿生肌敛疮之功效，用于治疗溃疡不敛、湿疹、口疮、跌扑伤痛、外伤出血；
赤芍，性味：苦、微寒，具有清热凉血、活血祛瘀之功效，用于治疗温毒发斑、吐血衄血、肠风下血、目赤肿痛、痈肿疮疡、闭经、痛经、崩带淋浊、瘀滞胁痛、疝瘕积聚、跌扑损伤等症。
本发明药物是基于中医治疗小儿口腔溃疡的原则，从依据小儿口腔溃疡的病理机制及药理作用认为：就小儿口腔溃疡，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的效果。
具体实施方式
本发明就是针对上述小儿口腔溃疡的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个很好的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种用于治疗小儿口腔溃疡的外用油剂，其特征在于，所述外用油剂的各个组分及其质量份比如下所示：
冰片0.50g、蓖麻子4g、白芨13g、白芷8g、五倍子8g、寒水石23g、黄连4g、牡丹皮12g、龙骨35g、蒲公英13g、海螵蛸8g、紫草8g、儿茶3g、赤芍8g。
实施例2：
一种用于治疗小儿口腔溃疡的外用油剂，其特征在于，所述外用油剂的各个组分及其质量份比如下所示：
冰片0.55g、蓖麻子5g、白芨14g、白芷9g、五倍子9g、寒水石26g、黄连4.5g、牡丹皮13g、龙骨40g、蒲公英14g、海螵蛸9g、紫草9g、儿茶4g、赤芍9g。
实施例3：
一种用于治疗小儿口腔溃疡的外用油剂，其特征在于，所述外用油剂的各个组分及其质量份比如下所示：
冰片0.6g、蓖麻子6g、白芨16g、白芷10g、五倍子10g、寒水石30g、黄连5g、牡丹皮15g、龙骨45g、蒲公英16g、海螵蛸10g、紫草10g、儿茶5g、赤芍10g。
典型病例
经临床诊断治疗小儿口腔溃疡患者共1570例，年龄为5岁以上的895例，只有675例为5岁以下。1570例患者中痊愈的935例，有效的588例，无效的47例。总有效率达97%。
Claims (3)
1.一种用于治疗小儿口腔溃疡的外用油剂，其特征在于，所述外用油剂的各个组分及其质量份比如下所示：
冰片0.3～0.6g、蓖麻子1～6g、白芨5～16g、白芷3～10g、五倍子3～10g、寒水石10～30g、黄连2～5g、牡丹皮6～15g、龙骨15～45g、蒲公英9～16g、海螵蛸5～10g、紫草5～10g、儿茶1～5g、赤芍4～10g。
2.根据权利要求1所述的用于治疗小儿口腔溃疡的外用油剂，其特征在于，所述外用油剂的各个组分及其质量份比如下所示：
冰片0.35～0.55g、蓖麻子2～5g、白芨8～14g、白芷5～9g、五倍子5～9g、寒水石11～26g、黄连3～4.5g、牡丹皮8～13g、龙骨18～40g、蒲公英10～14g、海螵蛸6～9g、紫草6～9g、儿茶2～4g、赤芍5～9g。
3.根据权利要求1至2所述的用于治疗小儿口腔溃疡的外用油剂，其特征在于，所述外用油剂的各个组分及其质量份比如下所示：
冰片0.50g、蓖麻子4g、白芨13g、白芷8g、五倍子8g、寒水石23g、黄连4g、牡丹皮12g、龙骨35g、蒲公英13g、海螵蛸8g、紫草8g、儿茶3g、赤芍8g。
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