CN108096403A - 一种可有效治疗鼻炎的胶囊剂药物及制备方法 - Google Patents
一种可有效治疗鼻炎的胶囊剂药物及制备方法 Download PDFInfo
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- CN108096403A CN108096403A CN201810046073.2A CN201810046073A CN108096403A CN 108096403 A CN108096403 A CN 108096403A CN 201810046073 A CN201810046073 A CN 201810046073A CN 108096403 A CN108096403 A CN 108096403A
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Abstract
本发明属于中药制剂领域,目的是根据中医治疗鼻炎的认识机理而提供一种可有效治疗鼻炎的胶囊剂药物,所述药物的各个组分及其质量份比如下:黄芩10~100g、大乌爪金龙150~300g、海芋30~100g、白芷30~120g、菊花脑150~350g、扁蒲扇25~50g、荆芥30~120g、细辛10~50g、决明子80~160g、伤寒草150~350g、石菖蒲30~100g、玉兰花100~160g、露蜂房30~70g、黄芪150~300g、桂枝15~80g;本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种可有效治疗鼻炎的胶囊剂药物,特别是供鼻炎患者使用的胶囊剂药物及制备方法的领域。
背景技术
祖国医学认为:鼻炎即鼻腔炎性疾病,是病毒、细菌、变应原、各种理化因子以及某些全身性疾病引起的鼻腔黏膜的炎症。鼻炎的主要病理改变是鼻腔黏膜充血、肿胀、渗出、增生、萎缩或坏死等证。
临床表现:
1.症状
(1)鼻塞 鼻塞特点为间歇性。在白天、天热、劳动或运动时鼻塞减轻,而夜间,静坐或寒冷时鼻塞加重。鼻塞的另一特点为交替性。如侧卧时,居下侧之鼻腔阻塞,上侧鼻腔通气良好。由于鼻塞,间或有嗅觉减退、头痛、头昏、说话呈闭塞性鼻音等症状。
(2)多涕 常为黏液性或黏脓性,偶成脓性。脓性多于继发性感染后出现。
(3)嗅觉下降 多为两种原因所致,一为鼻黏膜肿胀、鼻塞,气流不能进入嗅觉区域;二为嗅区黏膜受慢性炎症长期刺激,嗅觉功能减退或消失。
(4)头痛、头昏 慢性鼻窦炎多表现为头沉重感。
(5)全身表现 多数人还有头痛、食欲不振、易疲倦、记忆力减退及失眠等。
2.鼻炎的种类
鼻炎症状有很多种,依据鼻炎的种类不同,鼻炎症状也有所不同:
(1)慢性鼻炎 长期间歇性或交替性鼻塞,导致头晕脑胀,严重影响睡眠、工作和学习。黏脓性鼻涕常倒流入咽腔,出现咳嗽、多痰。
(2)急性鼻炎 ①初期 1~2天。病人常有全身不适、畏寒、发热、食欲不振、头痛等。鼻腔及鼻咽部干燥、灼热感,鼻内发痒,频发喷嚏。②急性期 2~5天。原有症状加重。成人体温38度左右,小儿高达39度以上,常因高热出现呕吐、腹泻、昏迷甚至抽搐。
(3)药物性鼻炎 长期使用各种伤害鼻黏膜的鼻炎药物或激光、手术,导致鼻腔持续性鼻塞,时常流鼻血。
(4)萎缩性鼻炎 呼吸恶臭、鼻腔分泌物呈块状、管筒状脓痂,不易擤出,用力抠出干痂时,有少量鼻出血。常误以为是感冒的初期鼻炎。
天气转凉后,有些病人早上起床后连续打喷嚏、流鼻水,温差大时鼻塞,误以为是感冒而随便吃点感冒药,导致病情日益加重。
那么,就如何找到一种可有效治疗鼻炎的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗鼻炎上,人们逐渐意识到了中医治疗鼻炎的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗鼻炎的现状,本发明的目的是在于提供一种可有效治疗鼻炎的胶囊剂药物,以解决鼻炎患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述鼻炎一证。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种可有效治疗鼻炎的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芩10~100g、大乌爪金龙150~300g、海芋30~100g、白芷30~120g、菊花脑150~350g、扁蒲扇25~50g、荆芥30~120g、细辛10~50g、决明子80~160g、伤寒草150~350g、石菖蒲30~100g、玉兰花100~160g、露蜂房30~70g、黄芪150~300g、桂枝15~80g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种可有效治疗鼻炎的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芩12~90g、大乌爪金龙180~260g、海芋36~90g、白芷38~105g、菊花脑180~310g、扁蒲扇28~42g、荆芥36~105g、细辛12~42g、决明子90~140g、伤寒草180~310g、石菖蒲35~90g、玉兰花115~140g、露蜂房36~60g、黄芪180~260g、桂枝18~70g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种可有效治疗鼻炎的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芩80g、大乌爪金龙230g、海芋80g、白芷95g、菊花脑280g、扁蒲扇36g、荆芥95g、细辛36g、决明子120g、伤寒草280g、石菖蒲80g、玉兰花120g、露蜂房52g、黄芪230g、桂枝60g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种可有效治疗鼻炎的胶囊剂药物及制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比共粉碎成(30~50目)颗粒状包煎;
B、①将包好的原料中药放入冷开水中浸泡50min,然后再将浸泡好的药物放入砂锅内,加入原料中药重量7~8倍的冷开水进行第一次武火煎煮,待煎煮到18min时,转文火熬制120min,滤取药液;②药渣中再次加入原料中药重量6~7倍的冷开水进行第二次武火煎煮,待煎煮到15min时,转文火熬制110min,滤取药液;③将二次药液混合浓缩成相对密度为1.08 的清膏,然后干燥、研末和消毒后备用;
C、①按照传统制备中药胶囊剂的方法,将B中研磨好的细末过筛后,加入适量的微粉硅胶、微晶纤维素和淀粉混合均匀,然后制备成胶囊剂(其胶囊锁合后总长度为23.3mm,药粉容量0.4~0.5g/粒),②继而抛光、消毒,分装密封即可。
一种可有效治疗鼻炎的胶囊剂药物及制备方法,其特征在于,所述服用方法为:将制备好的胶囊剂药物以每日三次服用,早中晚各服一次,给药量2.5g(5粒)/次,温开水送服。30天为一个疗程,治疗1~2个疗程,鼻炎消失,病告痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
黄芩,性味:味苦、性寒,具有清热泻火、燥湿解毒、止血、安胎之功效,用于治疗肺热咳嗽、热病高热神昏、肝火头痛、目赤肿痛、湿热黄疸、泻痢、热淋、吐衄血、崩漏、胎热不安、痈肿疔疮;
大乌爪金龙,性味:辛、温,具有祛风、活血、消肿之功效,用于治疗风湿关节疼痛、口腔炎、鼻炎,外用治跌打损伤、骨折等症;
海芋,性味:味辛、性寒,具有清热解毒、行气止痛、散结消肿之功效,用于治疗流感、感冒、腹痛、肺结核、风湿骨痛、疔疮、痈疽肿毒、瘰疬、附骨疽、斑秃、疥癣、虫蛇咬伤;
白芷,性味:味辛、性温,具有祛风除湿、通窃止痛、消肿排脓之功效,用于治疗感冒头痛、眉棱骨痛、牙痛、鼻塞、鼻渊、湿胜久泻、妇女白带、痈疽疮疡、毒蛇咬伤;
菊花脑,性味:味苦、辛、性凉,具有清热解毒之功效,用于治疗风火赤眼、鼻炎、咽喉肿痛、支气管炎、疮疖肿痛;
扁蒲扇,性味:苦、寒,有小毒,具有清热解毒,活血消肿之功效,用于治疗咽喉肿痛、扁桃体炎、肝炎、肝肿大、胃痛、乳腺炎等病症;
荆芥,性味:味辛、微苦、性微湿,具有祛风、解表、透疹、止血之功效,用于治疗感冒发热、头痛、目痒、咳嗽、咽喉肿痛、麻疹、痈肿、疮疥、衄血、吐血、便血、崩漏、产后血晕;
细辛,性味:辛、温,具有祛风散寒、通窍止痛、温肺化饮之功效,用于治疗风寒感冒、头痛、牙痛、鼻塞鼻渊、风湿痹痛、痰饮喘咳;
决明子,性味:咸苦、平凉,无毒,具有祛风清热、解毒利湿之功效,用于治疗风热感冒、流感、急性结膜炎、湿热黄疸、急慢性肾炎、带下、瘰疬、疮痈疖肿、乳腺炎等症;
伤寒草,性味:味苦、辛、性凉,具有疏风清热、除湿、解毒之功效,用于治疗外感发热、咳嗽、急性黄疸型肝炎、湿热腹泻、白带、疔疮肿毒、乳腺炎、鼻炎、毒蛇咬伤;
石菖蒲,性味:辛、苦、温,具有化湿开胃、开窍豁痰、醒神益智之功效,用于治疗脘痞不饥、噤口下痢、神昏癫痫、健忘耳聋;
玉兰花,性味:辛、苦、温,具有止咳、行气、化浊之功效,用于治疗慢性气管炎、前列腺炎、白浊、白带等症;
露蜂房,性味:甘、平,具有祛风、攻毒、杀虫、止痛、抗过敏之功效,用于治疗祛风镇痛、功毒散结、杀虫止痒;
黄芪,性味:甘、微温,具有补齐固表、托疮生肌之功效,用于治疗体虚自汗、久泻、脱肛、子宫脱垂、慢性肾炎、体虚浮肿、慢性溃疡、疮口久不愈合;
桂枝,性味:辛、甘、性温,具有散寒解表、温通经脉、通阳化气之功效,用于治疗风寒表证、寒湿痹痛、四肢厥冷、经闭痛经、癥瘕结块、胸痹、心悸、痰饮、小便不利等症。
本发明药物是基于中医治疗鼻炎的原则,从依据鼻炎的病理机制及药理作用认为:就鼻炎,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述鼻炎的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个很好的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种可有效治疗鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芩80g、大乌爪金龙230g、海芋80g、白芷95g、菊花脑280g、扁蒲扇36g、荆芥95g、细辛36g、决明子120g、伤寒草280g、石菖蒲80g、玉兰花120g、露蜂房52g、黄芪230g、桂枝60g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
实施例2:
一种可有效治疗鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芩90g、大乌爪金龙260g、海芋90g、白芷105g、菊花脑310g、扁蒲扇42g、荆芥105g、细辛42g、决明子140g、伤寒草310g、石菖蒲90g、玉兰花140g、露蜂房60g、黄芪260g、桂枝70g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
实施例3:
一种可有效治疗鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芩100g、大乌爪金龙300g、海芋100g、白芷120g、菊花脑350g、扁蒲扇50g、荆芥120g、细辛50g、决明子160g、伤寒草350g、石菖蒲100g、玉兰花160g、露蜂房70g、黄芪300g、桂枝80g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
典型病例:
经临床诊断治疗鼻炎患者共1465例,年龄为32岁以上的750例,只有715例为32岁以下。1465例患者中痊愈的有989例,有效的417例,无效的59例。总有效率达96%。
Claims (3)
1.一种可有效治疗鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
黄芩10~100g、大乌爪金龙150~300g、海芋30~100g、白芷30~120g、菊花脑150~350g、扁蒲扇25~50g、荆芥30~120g、细辛10~50g、决明子80~160g、伤寒草150~350g、石菖蒲30~100g、玉兰花100~160g、露蜂房30~70g、黄芪150~300g、桂枝15~80g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
2.根据权利要求1所述的可有效治疗鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
黄芩12~90g、大乌爪金龙180~260g、海芋36~90g、白芷38~105g、菊花脑180~310g、扁蒲扇28~42g、荆芥36~105g、细辛12~42g、决明子90~140g、伤寒草180~310g、石菖蒲35~90g、玉兰花115~140g、露蜂房36~60g、黄芪180~260g、桂枝18~70g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
3.根据权利要求1至2所述的可有效治疗鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
黄芩80g、大乌爪金龙230g、海芋80g、白芷95g、菊花脑280g、扁蒲扇36g、荆芥95g、细辛36g、决明子120g、伤寒草280g、石菖蒲80g、玉兰花120g、露蜂房52g、黄芪230g、桂枝60g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
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