CN107669765A - A kind of banlangen granules, banlangen keli and preparation method thereof - Google Patents
A kind of banlangen granules, banlangen keli and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of banlangen granules, banlangen keli and preparation method thereof, the banlangen granules, banlangen keli, includes according to the raw material of parts by weight：23 31 parts of Radix Isatidis, 11 19 parts of catechu, 15 25 parts of clover, 37 parts of Herba Moslae Chinensis, 7 15 parts of roxburgh rose root.By catechu, Herba Moslae Chinensis crushing, add 40% ethanol, microwave abstracting, the obtained extraction concentrate of concentration；Roxburgh rose root is ground, with 60% ethanol Hybrid Heating, ultrasound, obtain mixed liquor A；By Radix Isatidis, clover crushing, add into mixed liquor A, heating, ultrasound, centrifugation take supernatant to obtain mixed liquid B；Mixed liquid B is produced with extracting concentrate Hybrid Heating, drying, being granulated.The present invention has good therapeutic effect not only for symptoms such as anemopyretic cold and caused heating, cough and abscesss of throat, it is also curative for effect to Behcet's disease, stably, it is quick, cure rate is high, has no toxic side effect, non-relapse after healing, drug safety, dosage is few.
Description
Technical field
The present invention relates to pharmaceutical technology field, specifically a kind of banlangen granules, banlangen keli and preparation method thereof.
Background technology
Radix Isatidis (conventional alias：Indigo-blue, indigo root, manyflower glorybower root) it is a kind of Chinese medicine.For cruciferae isatis
Dry root, generally excavated, can be used as medicine after processing in the fall.Produced all over China.Radix Isatidis be divided into northern Radix Isatidis and
Rhizoma et Radix Baphicacanthis Cusiae, northern Radix Isatidis source are the root of cruciferae isatis (Isatis tinctoria L.)；Rhizoma et Radix Baphicacanthis Cusiae is the rank of nobility
The rhizome and root of bed section's plant acanthaceous indigo (Baphicacanthus cusia (Nees) Brem.).Its is cold in nature, and taste is first bitter after micro- sweet tea
It is puckery, there is the effect of clearing heat and detoxicating, preventing cold, relieving sore-throat.It is mainly used in treating dark reddish purple dark, scarlet fever of febrile virulent maculae, tongue etc.
Disease.The curative effect of curing the disease of Radix Isatidis is more and more to be found, and is generally used for treatment flu, present invention discover that using Radix Isatidis and its
His Chinese medicine also has the effect for the treatment of Behcet's disease, and significant effect, and this is not directed in the prior art.
The content of the invention
It is an object of the invention to provide a kind of banlangen granules, banlangen keli and preparation method thereof, to solve to carry in above-mentioned background technology
The problem of going out.
To achieve the above object, the present invention provides following technical scheme：
A kind of banlangen granules, banlangen keli, include according to the raw material of parts by weight：Radix Isatidis 23-31 parts, catechu 11-19 parts, clover
15-25 parts, Herba Moslae Chinensis 3-7 parts, roxburgh rose root 7-15 parts.
As the further scheme of the present invention：The banlangen granules, banlangen keli, include according to the raw material of parts by weight：Radix Isatidis 25-
29 parts, catechu 13-17 parts, clover 18-22 parts, Herba Moslae Chinensis 4-6 parts, roxburgh rose root 9-13 parts.
As the further scheme of the present invention：The banlangen granules, banlangen keli, include according to the raw material of parts by weight：Radix Isatidis 27
Part, 15 parts of catechu, 20 parts of clover, 5 parts of Herba Moslae Chinensis, 11 parts of roxburgh rose root.
It is yet another object of the invention to provide a kind of preparation method of banlangen granules, banlangen keli, comprise the following steps：
1) by catechu, excessively Herba Moslae Chinensis crushing, 100-150 mesh sieves, 40% ethanol of the two 5-6 times of quality of addition, in 68-70
Stir process 50-60min at DEG C, then microwave abstracting 5-6min is carried out, microwave abstracting power 500W, microwave abstracting 2 times, merge
Extract, the 22-25% of original volume is concentrated into, extraction concentrate is made；
2) roxburgh rose root is pulverized, crosses 120-200 mesh sieves, then mixed with 60% ethanol of 8-9 times of its quality, is heated to
75-78 DEG C, and 25-30min is stirred at this temperature, supersound process 48-55min is then carried out, obtains mixed liquor A；
3) by Radix Isatidis, clover crush, cross 120-200 mesh sieves, by above-mentioned powder and the deionization of 3-4 times of its weight
Water is added into mixed liquor A, is heated to 88-90 DEG C, and stirs 45-50min at this temperature, is then cooled to 60-65 DEG C simultaneously
65-70min is ultrasonically treated at such a temperature, and centrifugation takes supernatant to obtain mixed liquid B；
4) mixed liquid B is mixed with extraction concentrate, is heated to 70-72 DEG C and stirs 35-40min at this temperature, so
By drying, it is granulated and produces banlangen granules, banlangen keli.
As the further scheme of the present invention：In step 2), ultrasonic power 400W.
As the further scheme of the present invention：In step 2), mixing speed 200-250r/min.
As the further scheme of the present invention：In step 3), ultrasonic power 800W.
As the further scheme of the present invention：In step 3), mixing speed 180-200r/min.
It is yet another object of the invention to provide the banlangen granules, banlangen keli to prepare the application in treating anemopyretic cold medicine.
It is yet another object of the invention to provide the banlangen granules, banlangen keli to prepare the application in treating Behcet's disease medicine.
Radix Isatidis has the effect of clearing heat and detoxicating, cool blood relieving sore-throat.It is usually used in poison during warm epidemic disease, pharyngalgia of generating heat, febrile virulent maculae, Zha
The cheek, scarlet fever, major part pestilence, erysipelas, carbuncle swells.Catechu has a promoting blood circulation and stopping pain, hemostasia and promoting granulation, hygroscopic sore, clearing lung and eliminating phlegm
Effect.Do not held back for the pain of injury caused by falling and tumbling, traumatism and bleeding, hematemesis and epistaxis, sore, eczema, wet sore, cough with lung heat.Clover heat-clearing solution
Poison, invigorating spleen to remove dampness.Cured cold heating, and summer-heat and damp is vomited and diarrhoea, malaria, dysentery, catarrhal jaundice, heat gonorrhea, gonorrhoea.Herba Moslae Chinensis driving away summer heat, it is living
Blood, qi-regulating, dampness elimination.Control Xia Yue flu, heatstroke evil of vomitting, diarrhea of suffering from abdominal pain, bruise stasis caused pain, eczema, furuncle.Roxburgh rose root stomach invigorating, helps digestion,
Antidiarrheal, puckery essence.Stomachache is cured mainly, diarrhea, dysentery, is passed out semen, uterine bleeding, with, chronic cough.
Compared with prior art, the beneficial effects of the invention are as follows：
The present invention is using banlangen granules, banlangen keli made from above-mentioned raw materials and preparation technology, for anemopyretic cold and caused hair
The symptoms such as heat, cough and abscess of throat have good therapeutic effect, and treatment anemopyretic cold is rapid-action, and curative effect is high, treatment time
It is short, securely and reliably, there is preferable clinical efficacy, anemopyretic cold total effective rate is up to 100%.The present invention is also to Behcet's disease curative effect
Definitely, stably, it is quick, cure rate is high, has no toxic side effect, non-relapse after healing, drug safety, dosage is few, to the heart, liver,
Kidney is harmless.Preparation technology of the present invention is simple, is promoted suitable for large-scale production.
Embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of banlangen granules, banlangen keli, including following raw material：Radix Isatidis 23kg, catechu 11kg, clover
15kg, Herba Moslae Chinensis 3kg, roxburgh rose root 7kg.
By catechu, Herba Moslae Chinensis crushing, 100 mesh sieves are crossed, 40% ethanol of the two 5 times of quality are added, at 68 DEG C at stirring
50min is managed, then carries out microwave abstracting 5min, microwave abstracting power 500W, microwave abstracting 2 times, combining extraction liquid, is concentrated into original
The 22% of volume, extraction concentrate is made.Roxburgh rose root is pulverized, crosses 120 mesh sieves, then 60% ethanol with 8 times of its quality
Mixing, is heated to 75 DEG C, and stirs 25min at this temperature, then carries out supersound process 48min, obtains mixed liquor A；Stirring
Speed is 200r/min, ultrasonic power 400W.By Radix Isatidis, clover crush, cross 120 mesh sieves, by above-mentioned powder and its
The deionized water that 3 times of weight is added into mixed liquor A, is heated to 88 DEG C, and stirs 45min at this temperature, is then cooled to
And 65min is ultrasonically treated at such a temperature, centrifugation takes supernatant to obtain mixed liquid B by 60 DEG C；Ultrasonic power is 800W, stirring
Speed is 180-200r/min.Mixed liquid B is mixed with extraction concentrate, 70 DEG C is heated to and stirs 35min at this temperature,
Then through drying, be granulated and produce banlangen granules, banlangen keli.
Embodiment 2
In the embodiment of the present invention, a kind of banlangen granules, banlangen keli, including following raw material：Radix Isatidis 31kg, catechu 19kg, clover
25kg, Herba Moslae Chinensis 7kg, roxburgh rose root 15kg.
By catechu, Herba Moslae Chinensis crushing, 150 mesh sieves are crossed, 40% ethanol of the two 6 times of quality are added, at 70 DEG C at stirring
60min is managed, then carries out microwave abstracting 6min, microwave abstracting power 500W, microwave abstracting 2 times, combining extraction liquid, is concentrated into original
The 25% of volume, extraction concentrate is made.Roxburgh rose root is pulverized, crosses 200 mesh sieves, then 60% ethanol with 9 times of its quality
Mixing, is heated to 78 DEG C, and stirs 30min at this temperature, then carries out supersound process 55min, obtains mixed liquor A；Stirring
Speed is 250r/min, ultrasonic power 400W.By Radix Isatidis, clover crush, cross 200 mesh sieves, by above-mentioned powder and its
The deionized water that 4 times of weight is added into mixed liquor A, is heated to 90 DEG C, and stirs 50min at this temperature, is then cooled to
And 70min is ultrasonically treated at such a temperature, centrifugation takes supernatant to obtain mixed liquid B by 65 DEG C；Ultrasonic power is 800W, stirring
Speed is 200r/min.Mixed liquid B is mixed with extraction concentrate, 72 DEG C is heated to and stirs 40min at this temperature, then
Through drying, it is granulated and produces banlangen granules, banlangen keli.
Embodiment 3
In the embodiment of the present invention, a kind of banlangen granules, banlangen keli, including following raw material：Radix Isatidis 25kg, catechu 13kg, clover
18kg, Herba Moslae Chinensis 4kg, roxburgh rose root 9kg.
By catechu, Herba Moslae Chinensis crushing, 120 mesh sieves are crossed, 40% ethanol of the two 6 times of quality are added, at 69 DEG C at stirring
60min is managed, then carries out microwave abstracting 6min, microwave abstracting power 500W, microwave abstracting 2 times, combining extraction liquid, is concentrated into original
The 25% of volume, extraction concentrate is made.Roxburgh rose root is pulverized, crosses 150 mesh sieves, then 60% ethanol with 9 times of its quality
Mixing, is heated to 76 DEG C, and stirs 30min at this temperature, then carries out supersound process 50min, obtains mixed liquor A；Stirring
Speed is 250r/min, ultrasonic power 400W.By Radix Isatidis, clover crush, cross 15 mesh sieves, by above-mentioned powder and its is heavy
The deionized water of 4 times of amount is added into mixed liquor A, is heated to 89 DEG C, and stirs 50min at this temperature, is then cooled to 62
DEG C and be ultrasonically treated 70min at such a temperature, centrifugation takes supernatant to obtain mixed liquid B；Ultrasonic power is 800W, stirring speed
Spend for 200r/min.Mixed liquid B is mixed with extraction concentrate, 71 DEG C is heated to and stirs 40min, Ran Houjing at this temperature
Dry, be granulated and produce banlangen granules, banlangen keli.
Embodiment 4
In the embodiment of the present invention, a kind of banlangen granules, banlangen keli, including following raw material：Radix Isatidis 29kg, catechu 17kg, clover
22kg, Herba Moslae Chinensis 6kg, roxburgh rose root 13kg.
By catechu, Herba Moslae Chinensis crushing, 120 mesh sieves are crossed, 40% ethanol of the two 6 times of quality are added, at 69 DEG C at stirring
60min is managed, then carries out microwave abstracting 6min, microwave abstracting power 500W, microwave abstracting 2 times, combining extraction liquid, is concentrated into original
The 25% of volume, extraction concentrate is made.Roxburgh rose root is pulverized, crosses 150 mesh sieves, then 60% ethanol with 9 times of its quality
Mixing, is heated to 76 DEG C, and stirs 30min at this temperature, then carries out supersound process 50min, obtains mixed liquor A；Stirring
Speed is 250r/min, ultrasonic power 400W.By Radix Isatidis, clover crush, cross 15 mesh sieves, by above-mentioned powder and its is heavy
The deionized water of 4 times of amount is added into mixed liquor A, is heated to 89 DEG C, and stirs 50min at this temperature, is then cooled to 62
DEG C and be ultrasonically treated 70min at such a temperature, centrifugation takes supernatant to obtain mixed liquid B；Ultrasonic power is 800W, stirring speed
Spend for 200r/min.Mixed liquid B is mixed with extraction concentrate, 71 DEG C is heated to and stirs 40min, Ran Houjing at this temperature
Dry, be granulated and produce banlangen granules, banlangen keli.
Embodiment 5
In the embodiment of the present invention, a kind of banlangen granules, banlangen keli, including following raw material：Radix Isatidis 27kg, catechu 15kg, clover
20kg, Herba Moslae Chinensis 5kg, roxburgh rose root 11kg.
By catechu, Herba Moslae Chinensis crushing, 120 mesh sieves are crossed, 40% ethanol of the two 6 times of quality are added, at 69 DEG C at stirring
60min is managed, then carries out microwave abstracting 6min, microwave abstracting power 500W, microwave abstracting 2 times, combining extraction liquid, is concentrated into original
The 25% of volume, extraction concentrate is made.Roxburgh rose root is pulverized, crosses 150 mesh sieves, then 60% ethanol with 9 times of its quality
Mixing, is heated to 76 DEG C, and stirs 30min at this temperature, then carries out supersound process 50min, obtains mixed liquor A；Stirring
Speed is 250r/min, ultrasonic power 400W.By Radix Isatidis, clover crush, cross 15 mesh sieves, by above-mentioned powder and its is heavy
The deionized water of 4 times of amount is added into mixed liquor A, is heated to 89 DEG C, and stirs 50min at this temperature, is then cooled to 62
DEG C and be ultrasonically treated 70min at such a temperature, centrifugation takes supernatant to obtain mixed liquid B；Ultrasonic power is 800W, stirring speed
Spend for 200r/min.Mixed liquid B is mixed with extraction concentrate, 71 DEG C is heated to and stirs 40min, Ran Houjing at this temperature
Dry, be granulated and produce banlangen granules, banlangen keli.
Comparative example 1
In addition to Radix Isatidis is not contained, it is formulated and preparation process is consistent with embodiment 5.
Comparative example 2
Only contain Radix Isatidis, its preparation process is consistent with embodiment 5.
Comparative example 3
Each raw material is directly mixed, Radix Isatidis, the deionized water of 4 times of clover weight is added, is heated to 89 DEG C, and herein
At a temperature of stir 50min, be then cooled to 62 DEG C and be ultrasonically treated 70min at such a temperature, centrifugation take supernatant；Ultrasound
Power is 800W, mixing speed 200r/min.By supernatant, it is heated to 71 DEG C and stirs 40min, Ran Houjing at this temperature
Dry, be granulated and produce banlangen granules, banlangen keli.Each raw material dosage is consistent with embodiment 5.
The toxicity test of embodiment 6
Acute toxicity test in mice：Mouse is tested using 1-5 of embodiment of the present invention banlangen granules, banlangen keli, it is continuous to see
Examine 14 days, have no dead and undue toxicity reaction during experiment, off-test, Dissection test mouse, observation liver,kidney,spleen, stomach,
The heart, lung and intestines, are showed no abnormal change.According to acute toxicity criteria, the sample belongs to nontoxic level.
Chronic toxicity test：Mouse is tested using 1-5 of embodiment of the present invention banlangen granules, banlangen keli, continuous 90 days,
As a result show：Mouse fur using 1-5 of embodiment of the present invention banlangen granules, banlangen keli is smooth, and behavioral activity is normal, drinking-water of ingesting
Normally, Normal-weight increase, blood parameters and hematology fluctuate in normal range (NR), and routine urinalysis and marrow index exist
Fluctuated in normal range (NR), organize internal organs no abnormality seen, generally speaking have no that toxicity reacts.
Tested more than, banlangen granules, banlangen keli of the invention is safe and nontoxic.
The clinical test of embodiment 7
1. Behcet's disease patient 450, wherein man 250, female 200,25~55 years old age, the course of disease 2~5 years.It is
Acute attack stage, there are oral cavity and external genital organs ulcer.9 groups are randomly divided into, every group 50, wherein totally five groups for the treatment of group, is distinguished
For treatment 1 group, treatment 2 groups, treatment 3 groups, treatment 4 groups, treatment 5 groups, totally 4 groups of control group, respectively compare 1 group, control 2 groups,
3 groups, 4 groups of control are compareed, age, sex, the course of disease and the severity extent aspect comparing difference of each group patient is without conspicuousness (P>
0.05), there is comparativity.
2. treatment method
Treat 1 group：The banlangen granules, banlangen keli of the preparation of the embodiment of the present invention 1 is given, 1 time a day, each 0.5g, 5 days are 1 treatment
Journey, totally 2 courses for the treatment of.
Treat 2 groups：The banlangen granules, banlangen keli of the preparation of the embodiment of the present invention 2 is given, 1 time a day, each 0.5g, 5 days are 1 treatment
Journey, totally 2 courses for the treatment of.
Treat 3 groups：The banlangen granules, banlangen keli of the preparation of the embodiment of the present invention 3 is given, 1 time a day, each 0.5g, 5 days are 1 treatment
Journey, totally 2 courses for the treatment of.
Treat 4 groups：The banlangen granules, banlangen keli of the preparation of the embodiment of the present invention 4 is given, 1 time a day, each 0.5g, 5 days are 1 treatment
Journey, totally 2 courses for the treatment of.
Treat 5 groups：The banlangen granules, banlangen keli of the preparation of the embodiment of the present invention 5 is given, 1 time a day, each 0.5g, 5 days are 1 treatment
Journey, totally 2 courses for the treatment of.
Compare 1 group：Alone glucocorticoid treatment.According to state of an illness needs, prednisone consumption per day is between 10-50mg, 5 days
For 1 course for the treatment of, hormone is reduced gradually after stable disease.
Compare 2 groups：The particle of the preparation of comparative example 1 is given, 1 time a day, each 0.5g, 5 days are 1 course for the treatment of, totally 2 treatments
Journey.
Compare 3 groups：Give comparative example 2 preparation banlangen granules, banlangen keli, 2g/ times, 2 times/day, 1 time a day, each 0.5g, 5 days
For 1 course for the treatment of, totally 2 courses for the treatment of.
Compare 4 groups：Give comparative example 3 preparation banlangen granules, banlangen keli, 2g/ times, 2 times/day, 1 time a day, each 0.5g, 5 days
For 1 course for the treatment of, totally 2 courses for the treatment of.
3. the standard for the treatment of
Cure：1st, canker sore, genital ulcer, eyes ulcer, arthralgia, erythema nodosum are wholly absent；2nd, exempt from
Epidemic disease functional rehabilitation is normally uneasy to recur；3rd, not capable other any treatments.
It is effective：The symptom such as oral cavity, genitals, eyes ulcer surface is healed, joint is not ached, erythema disappearance substantially mitigates.
Effectively：The symptoms such as canker sore, genital ulcer, eyes ulcer, joint, erythema nodosum subtract before relatively treating
Gently.
It is invalid：Improve without any sign and show.
4. statistical disposition result is as shown in table 1.
Table 1
As can be known from Table 1,1-5 of embodiment of the present invention therapeutic effect is better than control 1-4 groups.The cure rate of the present invention exists
More than 70%, total effective rate more than 96%, and non-relapse after healing, preferably it is embodiment 3-5, optimal is embodiment 5；It is right
Although high according to 1 group of total effective rate, its cure rate is not high, is 52%, controls recurrence rate after healing as 57.7%.In therapeutic process
In, banlangen granules, banlangen keli of the present invention does not find any toxicity, side effect.5 groups are treated compared with control 2-4 groups, it can be seen that this hair
Bright is to play effect under the synergy of each component and the above-mentioned technique of use.
5. model case：
Korea Spro, man, 48 years old, suffers from Behcet's disease for many years, genital ulcer area is larger；Blood routine examination, leucocyte increase；
Routine urinalysis is examined, and has slight albumen to change with red blood cell；Analysis of cases, it is slough, uses the plate of the embodiment of the present invention 5
After 5 days, symptom is wholly absent blue root particle, and is not recurred in the follow-up of 2 years, is cured completely.
The clinical pharrnacokinetics of embodiment 8 are tested
1. anemopyretic cold patient cases' selection standard：Disease is shown in the micro- foul wind of heating, and sweat lets out not smooth, distending pain in the head, cough, phlegm it is viscous or
Huang, dry, abscess of throat is swallowed, nasal obstruction, flows turbid nasal discharge, thirst with desire to drink, tongue side point is red, thin lingual fur or micro- Huang, superficial and rapid pulse person.
2. treatment method：
Embodiment 1-5 for oral administration, 3 times a day, 0.5g/ times, 3 are a course for the treatment of, and treatment is optionally added after a course for the treatment of.
Required during observation without this sick medicine of other treatment.
3. imitate criterion：
1) cure：Anemopyretic cold related symptoms disappear, and sign and laboratory examination are without exception.
2) take a turn for the better：Anemopyretic cold related symptoms, sign and laboratory examination have improvement.
3) it is invalid：Anemopyretic cold related symptoms, sign and laboratory examination are without improvement.
4. result：
Total people of case load 100 is treated altogether, wherein：Cure 95 people, take a turn for the better 5 people, invalid 0 people, total effective rate 100%.Wherein
Embodiment 3-5 banlangen granules, banlangen keli, cure rate is up to 100%, and 1-2 days can cure, and particularly embodiment is cured in 5 one days.
Medicine of the present invention has preferable clinical efficacy to anemopyretic cold.
5. model case：
Cai, female, 42 years old, anemopyretic cold 5 days, distending pain in the head, turbid nasal discharge is flowed, abscess of throat, takes other cold drugs not
Get better and turn.5 medicine of the embodiment of the present invention is taken after 1 day, above-mentioned symptom disappears, and throws off a cold.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that those skilled in the art should for clarity
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (10)
1. a kind of banlangen granules, banlangen keli, it is characterised in that include according to the raw material of parts by weight：Radix Isatidis 23-31 parts, catechu 11-19
Part, clover 15-25 parts, Herba Moslae Chinensis 3-7 parts, roxburgh rose root 7-15 parts.
2. banlangen granules, banlangen keli according to claim 1, it is characterised in that include according to the raw material of parts by weight：Radix Isatidis 25-
29 parts, catechu 13-17 parts, clover 18-22 parts, Herba Moslae Chinensis 4-6 parts, roxburgh rose root 9-13 parts.
3. banlangen granules, banlangen keli according to claim 1, it is characterised in that include according to the raw material of parts by weight：Radix Isatidis 27
Part, 15 parts of catechu, 20 parts of clover, 5 parts of Herba Moslae Chinensis, 11 parts of roxburgh rose root.
4. the preparation method of a kind of banlangen granules, banlangen keli as described in claim 1-3 is any, it is characterised in that including following step
Suddenly：
1) by catechu, excessively Herba Moslae Chinensis crushing, 100-150 mesh sieves, 40% ethanol of the two 5-6 times of quality of addition, at 68-70 DEG C
Stir process 50-60min, then microwave abstracting 5-6min is carried out, microwave abstracting power 500W, microwave abstracting 2 times, merge extraction
Liquid, the 22-25% of original volume is concentrated into, extraction concentrate is made；
2) roxburgh rose root is pulverized, crosses 120-200 mesh sieves, then mixed with 60% ethanol of 8-9 times of its quality, be heated to 75-
78 DEG C, and 25-30min is stirred at this temperature, supersound process 48-55min is then carried out, obtains mixed liquor A；
3) by Radix Isatidis, excessively clover crushing, 120-200 mesh sieves, the deionized water of 3-4 times of above-mentioned powder and its weight is added
Enter into mixed liquor A, be heated to 88-90 DEG C, and stir 45-50min at this temperature, be then cooled to 60-65 DEG C and at this
At a temperature of be ultrasonically treated 65-70min, centrifugation takes supernatant to obtain mixed liquid B；
4) mixed liquid B is mixed with extraction concentrate, is heated to 70-72 DEG C and stirs 35-40min, Ran Houjing at this temperature
Dry, be granulated and produce banlangen granules, banlangen keli.
5. the preparation method of banlangen granules, banlangen keli according to claim 4, it is characterised in that in step 2), ultrasonic power is
400W。
6. the preparation method of banlangen granules, banlangen keli according to claim 4, it is characterised in that in step 2), mixing speed is
200-250r/min。
7. the preparation method of banlangen granules, banlangen keli according to claim 4, it is characterised in that in step 3), ultrasonic power is
800W。
8. the preparation method of banlangen granules, banlangen keli according to claim 4, it is characterised in that in step 3), mixing speed is
180-200r/min。
9. the banlangen granules, banlangen keli as described in claim 1-3 is any is preparing the application in treating anemopyretic cold medicine.
10. the banlangen granules, banlangen keli as described in claim 1-3 is any is preparing the application in treating Behcet's disease medicine.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727667A (en) * | 2011-04-08 | 2012-10-17 | 四川旭阳药业有限责任公司 | Compound isatis root puffed granules and preparation method of same |
-
2017
- 2017-11-11 CN CN201711109042.9A patent/CN107669765A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727667A (en) * | 2011-04-08 | 2012-10-17 | 四川旭阳药业有限责任公司 | Compound isatis root puffed granules and preparation method of same |
Non-Patent Citations (2)
| Title |
|---|
| ZIFENG YANG: "Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A and B viruses in vitro", 《INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE》 * |
| 张燚等: "《田素琴皮肤病临证经验集》", 30 June 2016, 沈阳：辽宁科学技术出版社 * |
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