CN107669334A - Ultrasound RF ablation temperature imaging method based on ultrasonic wave backscattered energy - Google Patents
Ultrasound RF ablation temperature imaging method based on ultrasonic wave backscattered energy Download PDFInfo
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- 238000002604 ultrasonography Methods 0.000 title claims abstract description 9
- 238000003384 imaging method Methods 0.000 title claims abstract description 8
- 238000007674 radiofrequency ablation Methods 0.000 title claims description 11
- 239000011159 matrix material Substances 0.000 claims abstract description 8
- 239000000523 sample Substances 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 5
- 238000002679 ablation Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 description 15
- 238000002592 echocardiography Methods 0.000 description 8
- 238000012544 monitoring process Methods 0.000 description 7
- 238000001354 calcination Methods 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000007340 echolocation Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
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- 208000014674 injury Diseases 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10132—Ultrasound image
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Abstract
The present invention relates to a kind of ultrasound RF based on ultrasonic wave backscattered energy to melt temperature imaging method, including：Obtain detecting ultrasonic wave backscatter signals, i.e. primary data using ultrasonic probe；Bandpass filtering is carried out to primary data to reduce noise；Try to achieve the envelope of primary data；By sliding window, when being calculated in each window, try to achieve envelope square with step 3) and obtain the moment energy, divided by square of reference temperature lower envelope, now only retain positive backscattered energy, remove negative backscattered energy, that is, obtain the matrix of positive excess sound wave backscattered energy；It is interpolated to original image size；Image at different moments is combined and removes part noise.
Description
Technical field
The invention belongs to medical image research field, is related to a kind of ultrasound RF ablation temperature imaging method.
Background technology
Today's society, tumour are to seize one of major reason of human life.Because its can not also specify pathogenesis so as to
Prevented, the treatment hence for tumour turns into the emphasis of medical field concern.Traditional therapeutic modality it is more using surgery excision as
It is main, it is very big to the physical trauma of patient.For the tumour of small volume, the mode of ablation can be used to carry out at present, there is high energy
The methods of focusing ultrasonic wave calcination and RF ablation, its biggest advantage is that it is minimally invasive, thus audient's scope can be very wide.To burning
Temperature conditions can be observed by nuclear magnetic resonance, ultrasonic wave, thermocouple etc. during burning, but ultrasonic wave have it is harmless,
The features such as cost is relatively low, easy to operate, therefore there is very big researching value.
Carrying out the existing method of temperature monitoring using ultrasonic wave includes echo location shifts, backscattered energy (Ultrasonic
Backscattering energy, abbreviation CBE) etc..The method of echo location shifts is by caused by the rise of burn area tissue temperature
Tissue bulking and velocity of sound situation of change are estimated temperature, but need to determine the parameters such as tissue bulking coefficient in advance, and temperature rise
It is up to 40 DEG C.Backscattered energy relies on the variation monitoring temperature of backscattered energy in heating process, and algorithm is easy, is adapted to
In real-time monitoring.
The Straube and Arthur of University of Washington have found that scattering has positive and negative point, are just scattering sub- backscattered energy
Value is raised and increased with temperature, is shown as in ablation procedure on the occasion of the backscattered energy value of negative scattering raises with temperature
And reduce, negative value is shown as in ablation procedure.It extrapolates the single scattering back of the body on the basis of Sigelment and Reid
To the normalization creep function [1-5] of scattering energy variation and temperature change relation, such as (1-1) formula：
Wherein, α (T) is attenuation coefficient, and η (T) is backscattering coefficient.If the size of scattering is less than ultrasonic wavelength,
Then model can be reduced to formula (1-2)：
CBE=η (T)/η (37) (1-2)
Tsui P H et al. researchs are found, cancel and backscattered energy and temperature are also can obtain to the bit shift compensation of initial data
Degree relation, and sensitivity is higher, more saves the time [6].
Summer proposes combined echocardiography ripple backscattered energy (Integrated in above theoretical foundation silently et al.
Ultrasonic backscatter energy, abbreviation ICBE) and the method for sliding window obtain heating region temperature profile
The backscattered energy born in ablation procedure is negated, entered together with positive backscattered energy by picture, comprehensive backscattered energy
Trip temperature distribution display.Comprehensive backscattered energy value in each window of sliding window：
Combined echocardiography ripple backscattered energy method is used to find can exist below calcination pin during live tissue RF ablation
Artifact, combined echocardiography ripple backscattered energy value and the correlation of temperature value are influenceed, has also had a strong impact on tissue temperature distribution map
Picture.
Bibliography：
[1]Straube W L and Arthur R M,Theoretical Estimation of the
Temperature Dependence of Backscattered Ultrasonic Power for Noninvasive
Thermometry,Ultrasound in Medicine&Biology,1994,20(9):915~922.
[2]Arthur R M,Trobaugh J W,Straube W L,et al.,Temperature Dependence
of Ultrasonic Backscattered Energy in Images Compensated for Tissue Motion,
2003IEEE Symposium on Ultrasonics,2003,1:990~993.
[3]Arthur R M,Trobaugh J W,Straube W L,et al.,Temperature Dependence
of Ultrasonic Backscattered Energy in Motion Compensated Images,Ultrasonics,
Ferroelectrics,and Frequency Control,2005,52(10):1644~1652.
[4]Arthur R M,Straube W L,Starman J D,et al.,Noninvasive Temperature
Estimation Based on the Energy of Backscattered Ultrasound,Medical physics,
2003,30(6):1021~1029.
[5]Arthur R M,Straube W L,Trobaugh J W,et al.,Non-Invasive Estimation
of Hyperthermia Temperatures with Ultrasound,International journal of
hyperthermia,2005,21(6):589~600.
[6]Po-Hsiang Tsui,Yu-Ting Chien,et al,Using Ultrasound CBE Imaging
Without Echo Shift Compensation for Temperature Estimation,Ultrasonics,2012,
52:925–935.
The content of the invention
It is an object of the invention to provide one kind can effectively remove artifact, make that temperature distribution image is more accurate, also can more accord with
The ultrasound RF ablation temperature imaging method of temperature value change curve is closed, technical scheme is as follows：
A kind of ultrasound RF ablation temperature imaging method based on ultrasonic wave backscattered energy, comprises the following steps：
1) obtain detecting ultrasonic wave backscatter signals, i.e. primary data using ultrasonic probe；
2) bandpass filtering is carried out to primary data to reduce noise；
3) envelope of primary data is tried to achieve；
4) by sliding window, when being calculated in each window, try to achieve envelope square with step 3) and obtain the moment energy, divided by
Square of reference temperature lower envelope, now only retain positive backscattered energy, remove negative backscattered energy, that is, obtain just
The matrix of ultrasonic wave backscattered energy；
5) it is interpolated to original image size；
6) image at different moments is combined and removes part noise, and shown；
7) circle selects area-of-interest, and part of the matrix that step 4) is obtained in area-of-interest is averaged, and is tried to achieve
Positive backscattered energy value in area-of-interest, it can also carry out the calculating of follow-up ablation area.
Beneficial effects of the present invention are as follows：
1. combined echocardiography ripple backscattered energy is used for RF ablation, serious artifact can be produced below calcination pin.Fortune
Artifact can be effectively removed with positive ultrasonic wave backscattered energy, makes temperature distribution image more accurate, can preferably apply to
It is clinical.
2. the fitting effect of positive ultrasonic wave backscattered energy value and temperature is also superior to combined echocardiography ripple backscattered energy,
Therefore, the change of temperature value in ablation procedure can be best understood from positive backscattered energy.
Brief description of the drawings
Accompanying drawing 1 is the inventive method flow chart.
Accompanying drawing 2 be positive ultrasonic wave backscattered energy method, combined echocardiography ripple backscattered energy method respectively with temperature
The comparison diagram of curve.
Embodiment
The ablation temperature imaging method of the ultrasound RF based on ultrasonic wave backscattered energy of the present invention, utilizes positive ultrasound
The method of ripple backscattered energy (Positive ultrasonic backscattering energy, abbreviation PCBE) is to penetrating
The artifact problem of the temperature distribution image presented in real time in frequency ablation procedure is improved, and positive ultrasonic wave backscattered energy
Value more meets the curve of temperature value.
During temperature monitoring is carried out, only retain positive backscattered energy part, and remove negative backscattering energy
Part is measured, i.e., the display of temperature distribution image and the calculating of backscattered energy value are carried out merely with positive backscattered energy,
Artifact below calcination pin, and positive ultrasonic wave backscattered energy can be effectively improved in the real time temperature monitoring of RF ablation
Value more meets temperature curve than combined echocardiography ripple backscattered energy value.
Comprise the following steps that：
1) obtain detecting ultrasonic wave backscatter signals, i.e. primary data using ultrasonic probe；
2) bandpass filtering is carried out to primary data and reduces noise
3) envelope of primary data is tried to achieve
4) by sliding window, when being calculated in each window, try to achieve envelope square with step 3) and obtain the moment energy, divided by
Square of reference temperature lower envelope, now only retain positive backscattered energy, remove negative backscattered energy, that is, obtain just
The matrix of ultrasonic wave backscattered energy
5) it is interpolated to original image size
6) image at different moments is combined and removes part noise and show
7) circle selects area-of-interest, and part of the matrix that step 4) is obtained in area-of-interest is averaged, and is tried to achieve
Positive backscattered energy value in area-of-interest.Also the calculating of follow-up ablation area etc. can be carried out
Embodiment is as follows：
Appropriately sized pig tenterloin is placed in acrylic box, radio frequency calcination pin is inserted in tenterloin by the duck eye on box
Portion, calcination pin band water circulation, temperature thermocouple monitoring.The section of needle point is found with ultrasonic probe, 50W patterns are burnt
Burn.One primary data of every two seconds records, continuous heating 12min.
Obtained data are handled：It is defined by experiment with ultrasonic probe centre frequency, each data is carried out
Filtering, remove noise beyond bandwidth；The data for removing noise are subjected to Hilbert transform and obtain signal envelope；Image is divided into
Many size identical windows, obtain the positive ultrasonic wave backscattered energy value in each window；Row interpolation is entered to obtained matrix, into
For original image size；Data at different moments are carried out with compound, elimination part noise；Align ultrasonic wave backscattered energy temperature
Distributed image is shown, and obtains the average value of positive ultrasonic wave backscattered energy and heat in area-of-interest on this basis
The temperature value of galvanic couple record is compared.
Obtained result and combined echocardiography ripple backscattered energy (ICBE) method can be contrasted, verify positive ultrasonic wave
Advantage of the backscattered energy (PCBE) in RF ablation temperature monitoring.
Claims (1)
1. a kind of ultrasound RF ablation temperature imaging method based on ultrasonic wave backscattered energy, comprises the following steps：
1) obtain detecting ultrasonic wave backscatter signals, i.e. primary data using ultrasonic probe；
2) bandpass filtering is carried out to primary data to reduce noise；
3) envelope of primary data is tried to achieve；
4) by sliding window, when being calculated in each window, try to achieve envelope square with step 3) and obtain the moment energy, divided by reference
Square of temperature lower envelope, now only retain positive backscattered energy, remove negative backscattered energy, that is, obtain positive excess sound
The matrix of ripple backscattered energy；
5) it is interpolated to original image size；
6) image at different moments is combined and removes part noise, and shown；
7) circle selects area-of-interest, and part of the matrix that step 4) is obtained in area-of-interest is averaged, and it is emerging to try to achieve sense
Positive backscattered energy value in interesting region, it can also carry out the calculating of follow-up ablation area.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109394263A (en) * | 2018-09-25 | 2019-03-01 | 北京工业大学 | A kind of sub- multiple dimensioned imaging method of diameter of ultrasonic scattering based on backscattering coefficient |
| CN110681077A (en) * | 2019-09-25 | 2020-01-14 | 天津大学 | HIFU hotspot imaging method based on phantom and frequency domain single-phase CBE |
| CN112966212A (en) * | 2021-02-07 | 2021-06-15 | 西安交通大学 | Multi-parameter real-time monitoring imaging system based on ultrasonic echo backscattering energy change |
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| CN110681077A (en) * | 2019-09-25 | 2020-01-14 | 天津大学 | HIFU hotspot imaging method based on phantom and frequency domain single-phase CBE |
| CN112966212A (en) * | 2021-02-07 | 2021-06-15 | 西安交通大学 | Multi-parameter real-time monitoring imaging system based on ultrasonic echo backscattering energy change |
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