CN107648502A - A kind of pharmaceutical composition for nursing one's health yin-deficiency constitution and its production and use - Google Patents
A kind of pharmaceutical composition for nursing one's health yin-deficiency constitution and its production and use Download PDFInfo
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- CN107648502A CN107648502A CN201711129304.8A CN201711129304A CN107648502A CN 107648502 A CN107648502 A CN 107648502A CN 201711129304 A CN201711129304 A CN 201711129304A CN 107648502 A CN107648502 A CN 107648502A
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- pharmaceutical composition
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- deficiency
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention discloses a kind of pharmaceutical composition, and it is the preparation being prepared by the bulk drug of following weight proportioning：2 10 parts of sealwort, 15 parts of donkey-hide gelatin, 16 parts of radix polygonati officinalis, 15 parts of lily, 3 12 parts of rhizoma imperatae, 2 10 parts of reed rhizome.Present invention also offers the preparation method of the pharmaceutical composition and purposes.Pharmaceutical composition of the present invention, compatibility is precise and appropriate, and each taste medicine complements each other, and can significantly alleviate and treat as the insomnia caused by yin-deficiency constitution, abnormal heat is dry and the symptoms such as fire of deficiency type dysphoria is not peaceful, can effectively nurse one's health yin-deficiency constitution, new selection is provided for clinical application.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for nursing one's health yin-deficiency constitution and its production and use.
Background technology
Phenomenon of constitution is a kind of important behaviour form of human life activity, and its health and disease with human body ceases manner of breathing
Close.Yin-deficiency constitution is one of nine kinds of biased constitutions in traditional Chinese medicine constitution typing, and yin-deficiency constitution morbidity is invaded because scorching heresy is outer more, mistake
Eat after the product of temperate-dryness, over-anxiety, intemperance in sexual life, prolonged illness etc. and to cause visceral dysfunction, yin-fluid secretly consumption lost into yin-fluid it is few,
Deficiency of Yin Sheng Neire, performance body lose the nourishing that makes moist, the syndrome that abnormal heat is dry, fire of deficiency type dysphoria is not peaceful.The common table of yin-deficiency constitution
It is existing：Body is become thin, dryness of the mouth and throat, hectically flushed cheeks, feverishness in palms and soles, hectic fever night sweat, dysphoria, dry, tongue extra dry red wine, few tongue, very
To smooth no tongue.Morbidity tendency：Be susceptible to suffer from consumptive disease, lose essence, be insomnia, the resistance to winter intolerant to the summer, intolerant to suffer from heatstroke, heat, dryness evil.
Yin-deficiency constitution is the constitution status based on yin asthenia generating intrinsic heat, is constitution basis, physical factors caused by many diseases
It can determine that body to the neurological susceptibility of certain pathogenic factor and the tendentiousness of lesion type, therefore, it is necessary to improve yin-deficiency constitution, entangles again
The biased constitution status of the positive deficiency of Yin, effectively prevents the generation of relevant disease.
Traditional Chinese medicine conditioning yin-deficiency constitution has unique advantage, can obviously improve yin-deficiency constitution.Hao Lixia, " anemarrhena
Tonga subtracts 63 clinical observations for the treatment of yin-deficiency constitution periodontosis ", the Hebei traditional Chinese medical science the 10th phase in 2013 discloses wind-weed 20g, Chinese yam
20g, moutan bark 10g, Poria cocos 7g, golden cypress 10g, rhizoma imperatae 15g, rhizoma alismatis 7g, Fructus Corni 10g, honeysuckle 15g, radix rehmanniae recen 20g energy
Treat yin-deficiency constitution periodontosis.Number of patent application：201510910273.4 title：A kind of medicine for yin-deficiency constitution eats formula
A kind of formula for improving yin-deficiency constitution is disclosed, it is formed using the following raw material：Sealwort 15g, Chinese yam 9g, radix polygonati officinalis 9g, lily
9g, fruit of Chinese wolfberry 9g, spina date seed (stir-fry) 6g, raspberry 6g, reed rhizome 6g, radix glycyrrhizae (process) 3g.
Now have no the report of sealwort, donkey-hide gelatin, radix polygonati officinalis, lily, rhizoma imperatae and reed rhizome for nursing one's health yin-deficiency constitution.
The content of the invention
The invention provides it is a kind of effectively conditioning blood stasis constitution pharmaceutical composition, and its production and use.
Present invention also offers a kind of pharmaceutical composition, and it is the system being prepared by the bulk drug of following weight proportioning
Agent：Sealwort 2-10 parts, donkey-hide gelatin 1-5 parts, radix polygonati officinalis 1-6 parts, lily 1-5 parts, rhizoma imperatae 3-12 parts, reed rhizome 2-10 parts.
Wherein, it is the preparation being prepared by the bulk drug of following weight proportioning：Sealwort 4-8 parts, donkey-hide gelatin 2-4 parts, jade
Bamboo 2-5 parts, lily 2-4 parts, rhizoma imperatae 4-10 parts, reed rhizome 3-8 parts.
Wherein, it is the preparation being prepared by the bulk drug of following weight proportioning：6 parts of sealwort, 3 parts of donkey-hide gelatin, radix polygonati officinalis 3
Part, 3 parts of lily, 6 parts of rhizoma imperatae, 6 parts of reed rhizome.
Wherein, the composition is with the medicinal powder of sealwort, donkey-hide gelatin, radix polygonati officinalis, lily, rhizoma imperatae and reed rhizome, or water or is had
Solvent extract is active ingredient, and pharmaceutically conventional preparation is prepared into plus pharmaceutically acceptable auxiliary material.
Wherein, the preparation is oral formulations.
Wherein, the oral formulations are powder, decoction, granule, tablet, capsule, oral liquid, pill.
Present invention also offers the preparation method of foregoing pharmaceutical composition, and it is comprised the following steps：
(1) bulk drug of each weight proportion is weighed；
(2) bulk drug directly beats powder, or bulk drug is added water to cook or organic solvent extracts, and extract solution concentration, adds
Pharmaceutically acceptable auxiliary material or complementary composition are prepared into pharmaceutically conventional preparation.
Present invention also offers purposes of the foregoing pharmaceutical composition in the medicine for preparing conditioning yin-deficiency constitution.
Present invention also offers foregoing pharmaceutical composition in the medicine for preparing the insomnia caused by treatment yin-deficiency constitution
Purposes.
The present invention finally provide foregoing pharmaceutical composition prepare the abnormal heat caused by treatment yin-deficiency constitution it is dry or
Purposes in the not peaceful medicine of fire of deficiency type dysphoria.
In side of the present invention：
Sealwort：It is sweet, put down；Boosting qi and nourishing yin, invigorating the spleen, moistening lung, the effect of kidney-nourishing.
Donkey-hide gelatin：It is sweet, put down；Enrich blood enriching yin, moisturize, stop blooding.
Radix polygonati officinalis：It is sweet, it is slightly cold；With nourishing yin to moisten dryness, the effect of promoting the production of body fluid to quench thirst.
Lily：It is sweet, tremble with fear；Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing.
Rhizoma imperatae：It is sweet, tremble with fear；Cooling blood and hemostasis, reducing fever and causing diuresis.
Reed rhizome：It is sweet, tremble with fear；With clearing heat-fire, promote the production of body fluid to quench thirst, relieving restlessness, preventing or arresting vomiting, diuresis effect.
Rhizoma imperatae, reed rhizome clearing deficient heat, remove heat from the blood and induce diuresis in drug regimen object space of the present invention；Donkey-hide gelatin, sealwort nourishing yin and supplementing blood benefit
Gas；Help with radix polygonati officinalis, lily nourishing yin to moisten dryness, calm the nerves, so as to adjust internal organs body fluid essence and blood loss caused by yin-deficiency constitution etc..
Pharmaceutical composition of the present invention, compatibility is precise and appropriate, and each taste medicine complements each other, and can significantly alleviate and treat by yin-deficiency constitution institute
Caused insomnia, abnormal heat be dry and the symptoms such as fire of deficiency type dysphoria is not peaceful, can effectively nurse one's health yin-deficiency constitution, be provided newly for clinical application
Selection.
Obviously, according to the above of the present invention, according to the ordinary technical knowledge and customary means of this area, do not departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The embodiment of form by the following examples, the above of the present invention is remake further specifically
It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Embodiment
The preparation of the medicine decoction of the present invention of embodiment 1
Take sealwort 6g, donkey-hide gelatin 3g, radix polygonati officinalis 3g, lily 3g, rhizoma imperatae 6g, reed rhizome 6g；Decoction is soaked, keeps micro-boiling 20
~30 minutes, decoct 2 times, merging filtrate, filtering, produce decoction.
The preparation of 2 medicinal tablet of the present invention of embodiment
Take sealwort 2g, donkey-hide gelatin 1g, radix polygonati officinalis 1g, lily 1g, rhizoma imperatae 3g, reed rhizome 2g；Add water to cook extraction, be condensed into leaching
Cream, starch granulation, whole grain, tabletting are added, produces tablet.
The preparation of 3 medicine capsule of the present invention of embodiment
Take sealwort 10g, donkey-hide gelatin 5g, radix polygonati officinalis 6g, lily 5g, rhizoma imperatae 12g, reed rhizome 10g；Extracted with ethanol, obtain ethanol
Extract solution, medicinal extract is condensed into, adds auxiliary material, mixed, packing, produce capsule.
The preparation of the medicine paste of the present invention of embodiment 4
Take sealwort 4g, donkey-hide gelatin 2g, radix polygonati officinalis 2g, lily 2g, rhizoma imperatae 4g, reed rhizome 3g；Add water to cook extraction, be condensed into leaching
Cream, auxiliary material is added, mix, produce paste.
The preparation of the medicine decoction of the present invention of embodiment 5
Take sealwort 8g, donkey-hide gelatin 4g, radix polygonati officinalis 5g, lily 4g, rhizoma imperatae 10g, reed rhizome 8g；Soak decoction, merging filtrate,
Filtering, produces decoction.
Beneficial effects of the present invention are proved below by way of specific clinical test：
1 pharmaceutical composition of the present invention of test example nurses one's health the clinical efficacy of yin-deficiency constitution
1 experiment material
1.1 Experimental agents sealwort 6g, donkey-hide gelatin 3g, radix polygonati officinalis 3g, lily 3g, rhizoma imperatae 6g, reed rhizome 6g.
1.2 patient data patients 47, women 24, male 23.
2 experimental methods
2.1 diagnostic criteria：
With reference to China Association of Traditional Chinese Medicine's issue《Traditional Chinese Medicine Constitution Classification is with judging》Standard screening, clinical diagnosis mainly show
For, be unaccommodated to the hot weather in summer, dry skin, often feel like the trick heart heating, cheek flush or partially red, eyes are dry and astringent, dry mouth and throat, volatile
Sleep, dry and hard excrement etc..
2.2 treatment standards
It is clearly better (clinical symptoms, sign disappear substantially)；
Take a turn for the better (clinical symptoms, sign improve)；
Invalid (clinical symptoms, sign change without obvious).
2.3 treatment method
Each bulk drug is weighed according to prescription ratio, adds water, is put into pot and decocts, keeps micro-boiling 20~30 minutes.Decoct 2
It is secondary, collecting decoction, mix after donkey-hide gelatin molten and take, it is daily 1 dose, early, middle and late respectively to take 1 time, continuously take 1 month.
3 experimental results
Efficacy determination：As a result such as table 1
Comparison of therapeutic after table 1 is taken medicine
As shown in Table 1, the total effective rate for taking pharmaceutical composition of the present invention is 97.8%, effectively can alleviate and control
Treat the illness caused by the deficiency of Yin.
2 pharmaceutical composition of the present invention of test example nurses one's health the model case of yin-deficiency constitution
Case 1：Zhao, female, 51 years old, climacteric, flushed face, hectic fever night sweat, often feel like palpitaition, headache, mood
Emotional, irritated, insomnia and dreamful sleep, dry skin is lackluster.Through Chinese medical discrimination caused by the deficiency of Yin, the present composition 2 is taken
Take a turn for the better within individual month, continued to take 2 months, symptom is alleviated substantially.
Case 2：Liao, man, 75 years old, has tuberculosis medical history, hypertension, often feels that eyes are dry and astringent, dry and hard excrement, dry pharynx
It is dry, less, dry skin of sleeping, through caused by the Chinese medical discrimination category deficiency of Yin.Take the present composition 3 months, symptom has been alleviated,
Continue to take 6 months, life returns to normal.
Case 3：Zhang, man, 25 years old, long campaigns computer operation, often stays up late, and eats maror, oral cavity occurs
Ulcer and halitosis, are hard and dry, and scanty drak urine, thirst with desire to drink, xerophtalmia, the bodily form is tall and thin, and sleep quality is poor.Through Chinese medical discrimination
Caused by the deficiency of Yin, to take the present composition 1 week, remission, continue after taking two weeks, body returns to normal.
Case 4：Mr. Wang, female, 28 years old, menstruation often shifted to an earlier date, and menstrual period shorten, and often heating is sweated for trick, dry skin, mouth
Dry tongue is dry, dry and hard excrement, is unaccommodated to the hot weather in summer.Through Chinese medical discrimination caused by the deficiency of Yin, the present composition is taken 1 month, symptom obtains
Alleviate, continue to take 2 months, clinical symptoms return to normal.
To sum up, pharmaceutical composition of the present invention, compatibility is precise and appropriate, and each taste medicine complements each other, and significantly can alleviate and treat by the deficiency of Yin
Insomnia caused by constitution, abnormal heat be dry and the symptoms such as fire of deficiency type dysphoria is not peaceful, can effectively nurse one's health yin-deficiency constitution, be carried for clinical application
New selection is supplied.
Claims (10)
- A kind of 1. pharmaceutical composition, it is characterised in that：It is the preparation being prepared by the bulk drug of following weight proportioning：Sealwort 2-10 parts, donkey-hide gelatin 1-5 parts, radix polygonati officinalis 1-6 parts, lily 1-5 parts, rhizoma imperatae 3-12 parts, reed rhizome 2-10 parts.
- 2. pharmaceutical composition according to claim 1, it is characterised in that：It is prepared by the bulk drug of following weight proportioning The preparation formed：Sealwort 4-8 parts, donkey-hide gelatin 2-4 parts, radix polygonati officinalis 2-5 parts, lily 2-4 parts, rhizoma imperatae 4-10 parts, reed rhizome 3-8 parts.
- 3. pharmaceutical composition according to claim 2, it is characterised in that：It is prepared by the bulk drug of following weight proportioning The preparation formed：6 parts of sealwort, 3 parts of donkey-hide gelatin, 3 parts of radix polygonati officinalis, 3 parts of lily, 6 parts of rhizoma imperatae, 6 parts of reed rhizome.
- 4. according to the pharmaceutical composition described in claim 1-3 any one, it is characterised in that：The composition be with sealwort, Donkey-hide gelatin, radix polygonati officinalis, lily, the medicinal powder of rhizoma imperatae and reed rhizome, or water or extractive with organic solvent are active ingredient, plus pharmaceutically Acceptable auxiliary material is prepared into pharmaceutically conventional preparation.
- 5. pharmaceutical composition according to claim 4, it is characterised in that：The preparation is oral formulations.
- 6. pharmaceutical composition according to claim 5, it is characterised in that：The oral formulations are powder, decoction, particle Agent, tablet, capsule, oral liquid, pill.
- 7. the preparation method of the pharmaceutical composition described in claim 1-6 any one, it is characterised in that：It includes following step Suddenly：(1) bulk drug of each weight proportion is weighed；(2) bulk drug directly beats powder, or bulk drug is added water to cook or organic solvent extracts, and extract solution concentration, adds pharmacy Upper acceptable auxiliary material or complementary composition are prepared into pharmaceutically conventional preparation.
- 8. purposes of the pharmaceutical composition in the medicine for preparing conditioning yin-deficiency constitution described in claim 1-6 any one.
- 9. the pharmaceutical composition described in claim 1-6 any one is in the medicine for preparing the insomnia caused by treatment yin-deficiency constitution In purposes.
- 10. the pharmaceutical composition described in claim 1-6 any one is preparing the abnormal heat drying caused by treatment yin-deficiency constitution Or the purposes in the not peaceful medicine of fire of deficiency type dysphoria.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711129304.8A CN107648502A (en) | 2017-11-15 | 2017-11-15 | A kind of pharmaceutical composition for nursing one's health yin-deficiency constitution and its production and use |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711129304.8A CN107648502A (en) | 2017-11-15 | 2017-11-15 | A kind of pharmaceutical composition for nursing one's health yin-deficiency constitution and its production and use |
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| CN107648502A true CN107648502A (en) | 2018-02-02 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178840A (en) * | 2011-04-21 | 2011-09-14 | 北京身心康国际中医研究院 | Chinese medicinal preparation for relieving body fluid deficiency for people with yin-deficiency physique, preparation method thereof and application thereof |
| CN103041209A (en) * | 2012-12-27 | 2013-04-17 | 青岛华仁信息技术开发有限公司 | Chinese herbal preparation for curing deficiency of kidney-yin and preparation method thereof |
| CN104839707A (en) * | 2015-04-23 | 2015-08-19 | 劲膳美生物科技股份有限公司 | Yin deficiency physique non-total nutrient formula food |
| CN105288324A (en) * | 2015-12-10 | 2016-02-03 | 辽宁中医药大学 | Medicine-food formula for constitutions with Yin-deficiency |
-
2017
- 2017-11-15 CN CN201711129304.8A patent/CN107648502A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178840A (en) * | 2011-04-21 | 2011-09-14 | 北京身心康国际中医研究院 | Chinese medicinal preparation for relieving body fluid deficiency for people with yin-deficiency physique, preparation method thereof and application thereof |
| CN103041209A (en) * | 2012-12-27 | 2013-04-17 | 青岛华仁信息技术开发有限公司 | Chinese herbal preparation for curing deficiency of kidney-yin and preparation method thereof |
| CN104839707A (en) * | 2015-04-23 | 2015-08-19 | 劲膳美生物科技股份有限公司 | Yin deficiency physique non-total nutrient formula food |
| CN105288324A (en) * | 2015-12-10 | 2016-02-03 | 辽宁中医药大学 | Medicine-food formula for constitutions with Yin-deficiency |
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Application publication date: 20180202 |