CN107646839A - A kind of composition grain for antibacterial and preparation method thereof - Google Patents

A kind of composition grain for antibacterial and preparation method thereof Download PDF

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Publication number
CN107646839A
CN107646839A CN201710936460.9A CN201710936460A CN107646839A CN 107646839 A CN107646839 A CN 107646839A CN 201710936460 A CN201710936460 A CN 201710936460A CN 107646839 A CN107646839 A CN 107646839A
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ginger
composition
antibacterial
weight
preparation
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胡江宇
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/40—Liliopsida [monocotyledons]
    • A01N65/48—Zingiberaceae [Ginger family], e.g. ginger or galangal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants

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Abstract

The present invention relates to a kind of composition grain for antibacterial and preparation method thereof, the composition grain of the present invention is combined by dextrin with ginger to be formed, ginger composition therein is made up of ginger, triethanolamine, propylene carbonate acid, polyacrylic resin, and its preparation characteristic is：Ginger juice is extracted using triethanolamine solution, propylene carbonate acid is added simultaneously, after open loop is combined with triethanolamine under alkaline environment, form macromolecular, not only preferably combine effective components of ginger, also act as certain protecting effect, the present invention is also included using polyacrylic resin to ginger composition, make the antibacterial effect of ginger composition more preferably notable, especially continuation antibiosis, the beneficial effects of the present invention are provide a kind of steady quality, preparation technology is simply to composition grain of antibacterial and preparation method thereof, composition grain obtained by this method is not only in antibiosis significant effect, also there is remarkable effect in terms of continuation.

Description

A kind of composition grain for antibacterial and preparation method thereof
Technical field
The present invention relates to a kind of composition grain for antibacterial and preparation method thereof, belong to field of daily chemicals.
Background technology
Ginger is generally called ginger, is the fresh and tender stem of zingiber, belongs to herbaceos perennial.Asia, Africa, Latin America etc. There is plantation on ground.China is one of ginger exported country maximum in the world, and ginger is more general in south China Guangdong, Zhejiang cultivation Time, next to that Jiangxi, Anhui, Sichuan, Yunnan, Hunan, Hubei etc.；In the north then using Shandong as the main place of production, also Henan, Shan West etc..
Ginger extensively should as a kind of flavouring, preservative and food additives and dyestuff in the country such as India, China With.In the rhizome of ginger mainly containing volatile oil, pigment, fat, bitter principle, resin, protein, cellulose, pentosan, starch, Mineral element etc..In addition, also containing olive oil resin, Arabic gum, fructose, glucose, fat oil, trace element etc..
In the active component of ginger, perillaldehyde, neral and fragrance aldehyde have very strong antifungal activity, and gingerol is to AIDS Patient susceptible bacterium Mycobacteriumavium and Mycobacterium tuberculosis has extremely significant inhibitory action, suppression Rate processed is reached for 85%~95% (100ug/m1) and 90%~95% (100 p g/m1)；Gingerol has stronger suppression to fungi Effect processed, while the Aqueous extracts of ginger have certain antibacterial action to staphylococcus aureus, Escherichia coli and Hansenula anomala.
Antibacterial particle tool has been widely used, available for cosmetics, health products, biomedicine field, fresh-keeping etc..At present The domestic research for antibacterial particle is a lot, but the research for pure natural antibacterial particle is less, present invention generally provides A kind of pure natural antibacterial preparation method of granules containing ginger composition.
The content of the invention
The invention provides a kind of composition grain for antibacterial and preparation method thereof, this method preparation technology is simple, Process control, is easy to industrialization, scale, and the antibacterial combination composition granule obtained by this method is a kind of pure natural additive-free resists Bacterium particle, available for multiple fields, there is remarkable result in terms of antibacterial effect, while also have very well in terms of sustained anti-microbial Continuation.
To achieve these goals, embodiment of the present invention is as follows：
A kind of composition grain for antibacterial is made up of dextrin, ginger composition, and the mass ratio of dextrin and ginger composition is about For 1:3-5.Preferable mass ratio is 1:4.
Preferable described ginger composition is made up of ginger, triethanolamine, polyacrylic resin, and its preparation method is such as Under：
1. taking fresh ginger, water of 0.3-0.7 times equivalent to ginger weight is added, is ground, crossed 100 mesh sieves, obtain ginger juice.
2. adding the triethanolamine solution containing 4%-8% in ginger juice, addition is 1-3 times of ginger juice weight, is adjusted with alkali PH value is heated to 60-80 DEG C, constant temperature adds propylene carbonate acid, and propylene carbonate acid addition is triethanolamine weight to 8-10 0.5-0.7 times, 2-4 hours are incubated, are cooled to room temperature, it is 1.1-1.2 to be concentrated into relative density（55-60 DEG C of detection）, add second Alcohol to solution ethanol concentration reaches 40%-60%, stands 6-12 hours, filtering, obtains filtrate.
Described alkali is the one or several kinds in sodium hydroxide, disodium hydrogen phosphate, dipotassium hydrogen phosphate, preferably hydrogen-oxygen Change sodium.
Described was filtered into 200 mesh sieves；Described triethanolamine is food-grade or pharmaceutical grade triethanolamine；Described Propylene carbonate acid is food-grade or pharmaceutical grade propylene carbonate acid.
3. filtrate is concentrated into no ethanol flavor, composition is obtained, adds equivalent to 0.8-1.2 times of the composition weight water measured, Stirring, with acid for adjusting pH to 5-6, adds equivalent to 0.1-0.3 times of polyacrylic resin measured of composition weight, is stirred, 40-60 DEG C is heated to, constant temperature stirs 2 hours, is cooled to room temperature, it is 1.1-1.2 to be concentrated into relative density（55-60 DEG C of detection）.
Described acid regulation refers to pH value is adjusted using the one or several kinds in hydrochloric acid, acetic acid, phosphoric acid, preferably adopted Use hydrochloric acid.
Described no ethanol flavor that is concentrated into refers to that by filtrate under the conditions of vacuum decompression vacuum is less than -0.06Mpa, dense Retract and receive ethanol, filtrate relative density reaches 1.1-1.2（55-60 DEG C of detection）When.
A kind of described composition grain for antibacterial, its preparation method are as follows：
Dextrin and water are added in ginger composition, softwood processed, 24 mesh sieves is crossed, 60 DEG C of dryings, 24 mesh sieve whole grains, produces.
The method have the characteristics that developing a kind of composition grain for antibacterial, said composition particle is by dextrin and ginger Composition forms, and the preparation of ginger composition is used as solvent using triethanolamine, and antimicrobial component is mainly to contain phenol hydroxyl in ginger Base, hydroxyl, carbonyl, carboxyl equimolecular compound, triethanolamine polarity is big, can dissolve very well antibacterial in ginger effectively into Point, under alkaline environment, the open loop of propylene carbonate acid is combined into macromolecular with triethanolamine, while side chain contains in the macromolecular formed There is the antibiotic effective ingredient in the groups, with ginger such as hydroxyl, carbonyl that condensation reaction easily occurs, make the antibiotic effective ingredient in ginger Combined closely with macromolecular, be both easy to the dissolution of active ingredient in ginger, and can enough forms a kind of new compound, has notable Antibacterial effect, while in alcohol precipitation separation process, due to newly into macromolecular also there is the characteristic of triethanolamine, be soluble in second Alcohol, therefore will not be fallen by alcohol precipitation.
Another feature of the present invention be using acrylic resin under mildly acidic conditions to composition carry out film forming inclusion, Protecting effect is played, while acrylic resin has in acid condition with the hydroxyl bonding in triethanolamine with reference to rear formation The molecular formula of certain two-dimensional structure, certain steric hindrance effect is played to active ingredient in ginger, forms sustained release releasing effect, The antibacterial time and stability of the composition of enhancing.
The beneficial effects of the present invention are：
1. a kind of steady quality of present invention offer, preparation technology are simply controllable, it is easy to the combination for antibacterial of industrialization production Composition granule
2. there is very strong effect in antibiosis as the particle obtained by the present invention, while there is significant continuation antibacterial to imitate Fruit.
Embodiment
In order to preferably explain the present invention, the present invention is described in further detail using following embodiments, but not to the present invention Protection domain play restriction effect.
Comparative example 1：
Appropriate dextrin is taken, water is added, softwood processed, crosses 24 mesh sieves, 60 DEG C of dryings, 24 mesh sieve whole grains, produce.
Comparative example 2：
A kind of composition grain proportion of composing for antibacterial is as follows：
Dextrin 20%
Ginger composition 80%
Described ginger preparation method of composition is as follows：
1. taking fresh ginger, water of 0.5 times equivalent to ginger weight is added, is ground, crossed 100 mesh sieves, obtain ginger juice.
2. adding water in ginger juice, addition is 2 times of ginger juice weight, adjusts pH value to 9 with alkali, is heated to 60-80 DEG C, perseverance Temperature, 3 hours are incubated, is cooled to room temperature, be concentrated into relative density as 1.15（58 DEG C of detections）, ethanol is added to solution ethanol concentration Reach 50%, stand 10 hours, filtering, obtain filtrate, be concentrated into relative density as 1.15（58 DEG C of detections）.
Comparative example 3
A kind of composition grain proportion of composing for antibacterial is as follows：
Dextrin 1kg
Ginger composition 4kg
Described ginger preparation method of composition is as follows：
1. taking fresh ginger, water of 0.5 times equivalent to ginger weight is added, is ground, crossed 100 mesh sieves, obtain ginger juice.
2. being added in ginger juice containing 6% triethanolamine solution, addition is 2 times of ginger juice weight, with alkali adjust pH value to 9,60-80 DEG C is heated to, constant temperature, 3 hours is incubated, is cooled to room temperature, is concentrated into relative density as 1.15（58 DEG C of detections）, add second Alcohol to solution ethanol concentration reaches 50%, stands 10 hours, filtering, obtains filtrate, is concentrated into relative density as 1.15（58 DEG C of detections）.
Comparative example 4
A kind of composition grain proportion of composing for antibacterial is as follows：
Dextrin 1kg
Ginger composition 4kg
Described ginger preparation method of composition is as follows：
1. taking fresh ginger, water of 0.5 times equivalent to ginger weight is added, is ground, crossed 100 mesh sieves, obtain ginger juice.
2. adding 2 times of water of ginger juice weight in ginger juice, pH value is adjusted to 9 with alkali, 70 DEG C is heated to, constant temperature, adds carbon Acid acrylic acid, propylene carbonate acid addition are 0.6 times of triethanolamine weight, are incubated 3 hours, are cooled to room temperature, are concentrated into phase It is 1.15 to density（58 DEG C of detections）, add ethanol to solution ethanol concentration and reach 50%, stand 10 hours, filtering, obtain filtrate, Relative density is concentrated into as 1.15（58 DEG C of detections）.
Comparative example 5
A kind of composition grain proportion of composing for antibacterial is as follows：
Dextrin 1kg
Ginger composition 4kg
Described ginger preparation method of composition is as follows：
1. taking fresh ginger, water of 0.5 times equivalent to ginger weight is added, is ground, crossed 100 mesh sieves, obtain ginger juice.
2. adding 2 times of water of ginger juice weight in ginger juice, pH value is adjusted to 9 with alkali, is heated to 70 DEG C, constant temperature, 3 hours, Room temperature is cooled to, is concentrated into relative density as 1.15（58 DEG C of detections）, add ethanol to solution ethanol concentration and reach 50%, stand 10 hours, filtering, obtain filtrate.
3. filtrate is concentrated into no ethanol flavor, composition is obtained, the water of 1 times of amount equivalent to composition weight is added, stirs, use Acid for adjusting pH adds the polyacrylic resin equivalent to 0.2 times of amount of composition weight, is stirred, be heated to 50 DEG C, perseverance to 5 Temperature stirring 2 hours, is cooled to room temperature, is concentrated into relative density as 1.15（58 DEG C of detections）.
Embodiment 1
A kind of composition grain proportion of composing for antibacterial is as follows：
Dextrin 1kg
Ginger composition 4kg
Described ginger preparation method of composition is as follows：
1. taking fresh ginger, water of 0.5 times equivalent to ginger weight is added, is ground, crossed 100 mesh sieves, obtain ginger juice.
2. being added in ginger juice containing 6% triethanolamine solution, addition is 2 times of ginger juice weight, with alkali adjust pH value to 9,70 DEG C are heated to, constant temperature, adds propylene carbonate acid, propylene carbonate acid addition is 0.6 times of triethanolamine weight, is incubated 3 Hour, room temperature is cooled to, is concentrated into relative density as 1.15（58 DEG C of detections）, add ethanol to solution ethanol concentration and reach 50%, 10 hours are stood, filtering, obtains filtrate.
3. filtrate is concentrated into no ethanol flavor, composition is obtained, the water of 1.0 times of amounts equivalent to composition weight is added, stirs, With acid for adjusting pH to 6, the polyacrylic resin equivalent to 0.2 times of amount of composition weight is added, is stirred, is heated to 50 DEG C, Constant temperature stirs 2 hours, is cooled to room temperature, is concentrated into relative density as 1.15（58 DEG C of detections）.
Embodiment 2
A kind of composition grain proportion of composing for antibacterial is as follows：
Dextrin 1kg
Ginger composition 3kg
Described ginger preparation method of composition is as follows：
1. taking fresh ginger, water of 0.3 times equivalent to ginger weight is added, is ground, crossed 100 mesh sieves, obtain ginger juice.
2. being added in ginger juice containing 4% triethanolamine solution, addition is 1 times of ginger juice weight, with alkali adjust pH value to 8,60 DEG C are heated to, constant temperature, adds propylene carbonate acid, propylene carbonate acid addition is 0.5 times of triethanolamine weight, is incubated 2 Hour, room temperature is cooled to, is concentrated into relative density as 1.10（55 DEG C of detections）, add ethanol to solution ethanol concentration and reach 40%, 6 hours are stood, filtering, obtains filtrate.
3. filtrate is concentrated into no ethanol flavor, composition is obtained, adds 0.8 times of water equivalent to composition weight, is stirred, with acid PH to 5 is adjusted, the polyacrylic resin equivalent to 0.1 times of amount of composition weight is added, is stirred, is heated to 40 DEG C, constant temperature Stirring 2 hours, is cooled to room temperature, is concentrated into relative density as 1.10（55 DEG C of detections）.
Embodiment 3
A kind of composition grain proportion of composing for antibacterial is as follows：
Dextrin 1kg
Ginger composition 6kg
Described ginger preparation method of composition is as follows：
1. taking fresh ginger, water of 0.7 times equivalent to ginger weight is added, is ground, crossed 100 mesh sieves, obtain ginger juice.
2. being added in ginger juice containing 8% triethanolamine solution, addition is 3 times of ginger juice weight, with alkali adjust pH value to 10,80 DEG C are heated to, constant temperature, adds propylene carbonate acid, propylene carbonate acid addition is 0.7 times of triethanolamine weight, is incubated 4 Hour, room temperature is cooled to, is concentrated into relative density as 1.2（60 DEG C of detections）, add ethanol to solution ethanol concentration and reach 60%, 12 hours are stood, filtering, obtains filtrate.
3. filtrate is concentrated into no ethanol flavor, composition is obtained, adds 1.2 times of water equivalent to composition weight, is stirred, with acid PH to 6 is adjusted, the polyacrylic resin equivalent to 0.3 times of amount of composition weight is added, is stirred, is heated to 60 DEG C, constant temperature Stirring 2 hours, is cooled to room temperature, is concentrated into relative density as 1.2（60 DEG C of detections）.
Embodiment 4
The composition grain preparation method for antibacterial described in embodiment 1 to embodiment 3 is as follows：Paste is added in ginger composition Essence and water, softwood processed, 24 mesh sieves are crossed, 60 DEG C of dryings, 24 mesh sieve whole grains, are produced.
The antibacterial effect of comparative example 1 to 3 and embodiment 1 to 3, reference are detected using cylinder-plate method《Chinese Pharmacopoeia》Middle pipe The related operating method of dish method, investigate comparative example 1-3 and embodiment 1-3 antibacterial effect.
Solvent is prepared：20% ethanol.
Culture medium：Beef peptone culture medium, potato dextrose agar.
Main agents：Absolute ethyl alcohol.
Strain：Escherichia coli, staphylococcus aureus, saccharomyces cerevisiae, Penicillium citrinum, aspergillus niger, Sharpe typhoid bacillus.
Actication of culture：By the test tube slant of all strain access responses for test, every kind of to connect 2,37 DEG C of constant temperature of bacterium Culture 24 hours in incubator, saccharomyces cerevisiae, Penicillium citrinum, aspergillus niger culture 48 hours.
The composition of the various embodiments described above is taken respectively, is diluted with 20% ethanol, ultrasonic dissolution, is diluted to 50mg/ml.Respectively By beef peptone culture medium（Bacterium is used）, potato dextrose agar（Mould and fungi are used）After hot melt, fill respectively In 20*200mm test tube, every 15ml, sterilizing is cooled to 40 DEG C, is separately added into above-mentioned experiment bacteria suspension 0.2ml, mixing is fallen Flat board, every group of bacterium is repeated 2 times, in each flat board, 4 stainless steel Oxford rings of equidistant placement, and interior warp（6.0+0.1）Mm, It is high（5.0+0.1mm）, drop dress need testing solution, is covered with ceramic dome, using 20% ethanol as blank solvent, in 0-4 in sequence DEG C diffusion 2 hours after, bacterium is cultivated 24 hours under the conditions of 37 DEG C, and saccharomycete and mould are cultivated 48 hours under the conditions of 28 DEG C, Detect each inhibition zone.
Result of the test is as follows：
Table 1, the anti-bacterial result table of each example composition（mm）
Strain Escherichia coli Staphylococcus aureus Saccharomyces cerevisiae Penicillium citrinum Aspergillus niger Sharpe typhoid bacillus
20% ethanol 3.91 3.28 2.44 1.22 1.66 2.31
Comparative examples 1 3.94 3.34 2.49 1.24 1.62 2.28
Comparative examples 2 5.32 5.68 4.56 3.32 2.97 5.59
Comparative examples 3 5.27 5.59 4.55 3.41 3.05 5.64
Comparative examples 4 5.26 5.57 4.67 3.36 3.14 5.54
Comparative examples 5 5.33 5.61 4.49 3.34 3.09 5.61
Embodiment 1 10.24 11.14 8.84 6.98 7.78 11.40
Embodiment 2 10.25 11.55 8.89 7.08 7.84 11.34
Embodiment 3 10.64 11.42 8.92 7.02 7.81 11.39
Above-mentioned sample is continued to cultivate in 37 DEG C of insulating boxs, detects each inhibition zone 5 days, 10 days respectively, it is as a result as follows：
Table each example composition the anti-bacterial result table after 2,5 days（mm）
Strain Escherichia coli Staphylococcus aureus Saccharomyces cerevisiae Penicillium citrinum Aspergillus niger Sharpe typhoid bacillus
20% ethanol 3.86 3.24 2.53 1.23 1.67 2.34
Comparative examples 1 3.84 3.19 2.54 1.99 1.66 2.61
Comparative examples 2 4.81 4.96 3.99 3.08 2.69 4.99
Comparative examples 3 4.84 4.99 3.91 3.42 2.68 4.95
Comparative examples 4 4.88 4.99 3.98 3.24 2.65 4.81
Comparative examples 5 5.54 4.97 3.97 3.19 2.61 4.94
Embodiment 1 10.42 11.07 8.92 7.11 7.89 11.42
Embodiment 2 10.86 10.99 8.99 7.09 7.84 11.49
Embodiment 3 3.86 3.24 2.53 1.23 1.67 2.34
Table each example composition the anti-bacterial result table after 3,10 days（mm）
Strain Escherichia coli Staphylococcus aureus Saccharomyces cerevisiae Penicillium citrinum Aspergillus niger Sharpe typhoid bacillus
20% ethanol 3.79 3.24 2.48 1.22 1.49 2.21
Comparative examples 1 3.77 3.26 2.51 1.24 1.51 2.23
Comparative examples 2 4.25 4.49 3.49 2.09 2.11 4.43
Comparative examples 3 4.19 4.61 3.57 2.21 2.01 4.48
Comparative examples 4 4.26 4.57 3.53 2.14 2.02 4.41
Comparative examples 5 4.22 4.52 3.46 2.18 2.07 4.56
Embodiment 1 10.17 10.99 8.59 7.08 7.69 11.32
Embodiment 2 10.16 10.79 8.72 7.06 7.87 11.25
Embodiment 3 10.21 10.68 8.81 7.09 7.91 11.14
Above-mentioned comparative example 1-3 and embodiment 1-3 composition is placed 6 months under 40 DEG C, 75% damp condition, detected Its March and the antibacterial activity in June, it is as a result as follows：
Table 4, place antibacterial activity result table after March（mm）
Strain Escherichia coli Staphylococcus aureus Saccharomyces cerevisiae Penicillium citrinum Aspergillus niger Sharpe typhoid bacillus
20% ethanol 3.84 3.32 2.49 1.24 1.58 2.24
Comparative examples 1 3.85 3.34 2.53 1.23 1.56 2.47
Comparative examples 2 4.65 4.99 4.14 2.56 2.47 4.15
Comparative examples 3 5.67 4.89 4.17 2.57 2.51 4.36
Comparative examples 4 4.69 4.96 4.12 2.61 2.49 4.25
Comparative examples 5 4.58 4.97 4.08 2.55 2.43 4.34
Embodiment 1 9.98 10.01 7.96 6.79 6.69 10.66
Embodiment 2 9.91 10.05 7.94 6.84 6.67 10.56
Embodiment 3 9.93 10.04 7.92 6.95 6.81 10.61
Table 5, place antibacterial activity result table after June（mm）
Strain Escherichia coli Staphylococcus aureus Saccharomyces cerevisiae Penicillium citrinum Aspergillus niger Sharpe typhoid bacillus
20% ethanol 3.95 3.34 2.44 1.29 1.55 2.41
Comparative examples 1 3.94 3.36 2.45 1.28 1.57 2.45
Comparative examples 2 4.21 4.22 3.12 1.88 1.85 3.12
Comparative examples 3 4.18 4.19 3.24 1.79 1.76 3.24
Comparative examples 4 4.16 4.3 3.15 1.68 1.84 3.28
Comparative examples 5 4.16 4.16 3.31 1.74 1.79 3.19
Embodiment 1 9.9 9.97 7.45 6.69 6.59 10.14
Embodiment 2 9.87 9.94 7.58 6.68 6.64 10.04
Embodiment 3 9.68 9.96 7.51 6.72 6.62 10.02
From upper interpretation of result, resulting composition of the present invention is as notable in antibiosis effect, and 6 are deposited under acceleration environment Month, still there is very strong antibacterial effect, while composition had preferable antibacterial continuation within 10 day time.

Claims (6)

1. a kind of composition grain for antibacterial, it is characterised in that be made up of dextrin and ginger composition, dextrin and ginger group The mass ratio of compound is about 1:3-5.
2. one kind according to claim 1 is used for antibacterial combination composition granule, it is characterised in that described dextrin and ginger group Compound mass ratio is 1:4.
3. one kind according to claim 2 is used for antibacterial combination composition granule, it is characterised in that described ginger composition by Ginger, triethanolamine, propylene carbonate acid, polyacrylic resin composition.
4. one kind according to claim 3 is used for antibacterial combination composition granule, it is characterised in that described ginger composition Preparation method is as follows：
（1）Fresh ginger is taken, water of 0.3-0.7 times equivalent to ginger weight is added, grinds, 100 mesh sieves is crossed, obtains ginger juice；
（2）The triethanolamine solution containing 4%-8% is added in ginger juice, addition is 1-3 times of ginger juice weight, and pH value is adjusted with alkali To 8-10,60-80 DEG C is heated to, constant temperature adds propylene carbonate acid, and propylene carbonate acid addition is the 0.5- of triethanolamine weight 0.7 times, 2-4 hours are incubated, are cooled to room temperature, it is 1.1-1.2 to be concentrated into relative density（55-60 DEG C of detection）, add ethanol extremely Solution ethanol concentration reaches 40%-60%, stands 6-12 hours, filtering, obtains filtrate；
（3）Filtrate is concentrated into no ethanol flavor, obtains composition, adds equivalent to 0.8-1.2 times of the composition weight water measured, stirs Mix, with acid for adjusting pH to 5-6, add equivalent to 0.1-0.3 times of polyacrylic resin measured of composition weight, be stirred, add To 40-60 DEG C, constant temperature stirs 2 hours heat, is cooled to room temperature, it is 1.1-1.2 to be concentrated into relative density（55-60 DEG C of detection）.
5. one kind according to claim 4 is used for antibacterial combination composition granule, it is characterised in that described alkali be sodium hydroxide, One or several kinds in disodium hydrogen phosphate, dipotassium hydrogen phosphate.
6. one kind according to claim 1 is used for antibacterial combination composition granule, it is characterised in that described one kind is used for antibacterial Composition grain, its preparation method is as follows：Dextrin and water are added in ginger composition, softwood processed, crosses 24 mesh sieves, 60 DEG C dry It is dry, 24 mesh sieve whole grains, produce.
CN201710936460.9A 2017-10-10 2017-10-10 A kind of composition grain for antibacterial and preparation method thereof Pending CN107646839A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104337719A (en) * 2013-07-31 2015-02-11 徐州金牌药业有限公司 Natural sterilization liquid soap
CN104825356A (en) * 2015-04-30 2015-08-12 威莱(广州)日用品有限公司 Anti-bacterial hand-washing solution and preparation method thereof
CN105997699A (en) * 2016-06-30 2016-10-12 江苏敖广日化集团股份有限公司 Fishy smell removal liquid soap
CN106236629A (en) * 2016-08-15 2016-12-21 袁海忠 A kind of special handwashing liquid of Hotel attendants
CN106265228A (en) * 2016-08-15 2017-01-04 袁海忠 A kind of Flos Magnoliae bacteriostatic hand sanitizer
CN106580724A (en) * 2017-02-27 2017-04-26 宁波圆明工业设计有限公司 Hand sanitizer containing Arborisidine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104337719A (en) * 2013-07-31 2015-02-11 徐州金牌药业有限公司 Natural sterilization liquid soap
CN104825356A (en) * 2015-04-30 2015-08-12 威莱(广州)日用品有限公司 Anti-bacterial hand-washing solution and preparation method thereof
CN105997699A (en) * 2016-06-30 2016-10-12 江苏敖广日化集团股份有限公司 Fishy smell removal liquid soap
CN106236629A (en) * 2016-08-15 2016-12-21 袁海忠 A kind of special handwashing liquid of Hotel attendants
CN106265228A (en) * 2016-08-15 2017-01-04 袁海忠 A kind of Flos Magnoliae bacteriostatic hand sanitizer
CN106580724A (en) * 2017-02-27 2017-04-26 宁波圆明工业设计有限公司 Hand sanitizer containing Arborisidine

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