CN1076355A

CN1076355A - Ginseng and astragalus trichogen

Info

Publication number: CN1076355A
Application number: CN 93101119
Authority: CN
Inventors: 贺运道; 贺艳佩; 贺开颜; 李秀桃
Original assignee: Individual
Current assignee: Individual
Priority date: 1993-01-19
Filing date: 1993-01-19
Publication date: 1993-09-22
Anticipated expiration: 2013-01-19
Also published as: CN1048156C

Abstract

The invention provides a kind of treatment alopecia, promote that the All Pure Nature Chinese medicine ginseng stilbene growth of New Development growth is smart, mainly contain 1-10 parts of (parts by weight) Radix Ginsengs, 1-10 parts of Fructus Zanthoxylis, 1-10 parts on Flos Carthami, 1-10 parts of the Radixs Astragali, 1-10 parts of Rhizoma Zingiberiss.The present invention is to controlling the alopecia patient curative effect height of fullying recover from an illness, and is especially better, faster to the alopecia areata effect.

Description

Ginseng and astragalus trichogen

The invention belongs to a kind of health care medicine, especially belong to a kind of inhibition alopecia, grow the ginseng and astragalus trichogen of the effect of New Development.

At present, the medicine that is used for the treatment of alopecia has YANGXUE SHENGFA JIAONANG, the Radix Ginseng hair growth liquor, and the 101 HAIR REGENERATING MEDICINE series of products, and have the greatest impact the then first-elected preferably 101 HAIR REGENERATING MEDICINE of reflection.But, because 101 HAIR REGENERATING MEDICINE contains speckle Eriocheir sinensis tincture and so on poisonous substance.Willian.C.W.Wu company assay: " 101 " be a kind of material that causes cancer and scalp produced allergic phenomena such as the redness of very itching, thus many people dare not with or avoid and use this type of medicine.

Purpose of the present invention again in provide a kind of have the treatment alopecia effective, have no side effect, and human body had the ginseng and astragalus trichogen of health-care effect.

The solution of the present invention is that the parts by weight of realizing like this are

Fructus Zanthoxyli 1-10 part, Flos Carthami 1-10 part, Radix Ginseng 1-10 part, Fructus Schisandrae Chinensis 1-10 part, Radix Angelicae Sinensis 1-10 part, Rhizoma Zingiberis 1-10 part, Radix Astragali 1-10 part, Radix Polygoni Multiflori 1-10 part.

The present invention can also be realized by following scheme: parts by weight are

Fructus Zanthoxyli 1-10 part, Flos Carthami 1-10 part, Radix Ginseng 1-10 part, Fructus Schisandrae Chinensis 1-10 part, Radix Angelicae Sinensis 1-10 part, Rhizoma Zingiberis 1-10 part, Radix Astragali 1-10 part, Fructus Lycii 1-10 part, Rhizoma Chuanxiong 1-10 part, Cortex Dictamni 1-10 part.

The solution of the present invention can also be realized by following scheme: Fructus Zanthoxyli 1-10 part, Flos Carthami 1-10 part, Radix Ginseng 1-10 part, Fructus Schisandrae Chinensis 1-10 part, Radix Angelicae Sinensis 1-10 part, Rhizoma Zingiberis 1-10 part, Radix Astragali 1-10 part, Fructus Lycii 1-10 part.Parts by weight

Preparation method of the present invention is: pack into after above-mentioned Chinese medicine section is mixed in the acid and alkali-resistance container, add ethanol (content 30-75%) then, addition is as the criterion with the submergence medicine, and is airtight under the room temperature.Stir every day once, after-filtration on the 15th, filtrate is sub-packed in the bottle.

Good effect of the present invention is: can suppress alopecia rapidly, promote that the New Development growth is especially better to alopecia areata patient effect, can make the affected part bear New Development in general medication 9-20 days.And the hair of promotion chap blackening is arranged, suppress scalp pomade, dandruff, the curative effect of hypermnesis.

Alopecia person is the speckle size no matter, alopecia what, its reason is different, but therefrom says that all belonging to meridians is obstructed on the medical angle, qi depression to blood stasis.The present invention adopts tincture to smear the affected part, makes the efficacy of a drug lesion that goes directly, and with its acrid in the mouth rapid blood circulation promoting and blood stasis dispelling warm in nature, promoting the flow of QI-blood by warming the meridian quickens cutaneous circulation, and medicinal liquid infiltration skin, can nourish hair follicle immediately first, second can absorb and enter internal organs and send out battalion thoroughly and defend and QI and blood regulating by subcutaneous blood capillary.Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong have the effect of blood circulation promoting and blood stasis dispelling.Rhizoma Zingiberis, Fructus Zanthoxyli, Cortex Dictamni, but promoting the flow of QI in the collateral by warming the meridian, the happiness of dispeling the wind is itched; Radix Ginseng, the Radix Astragali, Radix Polygoni Multiflori.Fructus Schisandrae Chinensis, Fructus Lycii, the nutrition hair follicle, becomes the agent of blood nourishing and hair altogether at nourishing the liver and kidney.Flos Carthami in addition, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Zingiberis, the Radix Astragali, Fructus Schisandrae Chinensis, can promote cutaneous circulation, the Radix Astragali can make non-viable non-apoptotic cell rejuvenate, Radix Polygoni Multiflori can be treated psychosis, alopecia, cerebral trauma, amyotrophy, Flos Carthami, Rhizoma Chuanxiong can be treated ischemic cerebrovascular, Fructus Lycii can strengthen hemopoietic function and immunologic function, its contained betanin can stimulate body growth, it is (too high as temperature to various destructive stimuluses that the ginsenoside can improve body, cross low, various harmful substances, antibacterial etc.) resistance, Fructus Schisandrae Chinensis has nervous system regulation and improves metabolic function, vasodilator is arranged, the effect of blood pressure regulation, and can improve not normal blood circulation; Cortex Dictamni, Fructus Zanthoxyli, Rhizoma Chuanxiong, ethanol have sterilization, and the various skin fungus is had inhibitory action.Thereby decapacitation of the present invention cures outside the alopecia, and the thin Huang of hair, dizziness, headache, scalp pomade, dandruff, the bad chronic disease of memory are also had significant curative effect.

Below in conjunction with embodiment the present invention is described in further detail:

Embodiment 1: each 10 parts of each 1 part of Radix Ginseng, the Radix Astragali, Radix Polygoni Multiflori, Fructus Zanthoxyli, Flos Carthami, Fructus Lycii, Rhizoma Chuanxiong, Cortex Dictamni, each 5 parts of Rhizoma Zingiberiss, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, (parts by weight).

Above-mentioned Chinese medicine section is mixed, in the container of the acid and alkali-resistance of packing into, add ethanol (content is 30-75%) addition then and be as the criterion with the submergence medicine.Airtight under the room temperature.Stir once every day, filtered later in 15th, in the dried bottle of filtrate packing.

Embodiment 2: respectively 4 parts on Radix Ginseng, Radix Angelicae Sinensis, Flos Carthami; Respectively 10 parts of Fructus Zanthoxyli, Rhizoma Chuanxiong, the Radix Astragali, Radix Polygoni Multiflori; Respectively 1 part of Rhizoma Zingiberis, Fructus Schisandrae Chinensis, Fructus Lycii, Cortex Dictamni.(parts by weight) preparation method is with embodiment 1.

Embodiment 3: each 1 part of Radix Angelicae Sinensis, Rhizoma Chuanxiong; Respectively 6 parts of the Radix Astragali, Radix Polygoni Multiflori, Fructus Zanthoxyli, Fructus Schisandrae Chinensis; Respectively 10 parts of Radix Ginseng, Flos Carthami, Fructus Lycii, Cortex Dictamni, Rhizoma Zingiberiss.Parts by weight

Embodiment 4: respectively 6 parts on Radix Ginseng, Radix Angelicae Sinensis, Flos Carthami; Respectively 7 parts of Fructus Zanthoxyli, the Radix Astragali, Radix Polygoni Multiflori; Respectively 3 parts of Rhizoma Zingiberis, Fructus Schisandrae Chinensis, Cortex Dictamnis.Preparation method is with embodiment 1.

Embodiment 5: respectively 10 parts on Radix Ginseng, Radix Angelicae Sinensis, Flos Carthami; Each 8 parts of Fructus Zanthoxyli, the Radixs Astragali; Each 5 parts of Rhizoma Zingiberis, Fructus Schisandrae Chinensis.Preparation method is with embodiment 1.

Effluent of the present invention south pharmacology teaching and research room of preclinical medicine portion of medical university makes to irritate stomach to white mice acute toxicity LD ₅₀Experiment.Test method is to raise 50 of three days healthy mices in this chamber, male and female half and half, and body weight 18-22 gram is divided into five groups, and 10 every group, fasting 12 hours is freely drunk water.With 200mg/kg; 160mg/kg, 128mg/kg, 103mg/kg; 82mg/kg; Ratio 0.8 between group, once irritates stomach with 50mg/ml crude drug solution, observes seven days.According to each group death condition, data are imported computer.With the one weighted linear regression method statistical disposition of median effective dose probit method, its acute toxicity LD ₅₀Be 128.19mg/kg, LD ₅95% credibility interval be 116.33-141.26mg/kg.

Two, be coated with skin to the rat acute toxicity testing

Be selected in this chamber and raise 18 of three days healthy white rats, male female being regardless of.Body weight 160-250 gram.Be divided into 6 groups two batches, a collection of is the intact skin group, and a collection of is the damaged skin group, three groups every batch, and 3 every group, respectively with 1 group of 50mg/kg; 2 groups of 20mg/kg; The medication of three dosage groups of 3 groups of 8mg/kg.After animal skin of abdomen unhairing, the damaged skin group is done behind the well shape cut with 54mg/ml crude drug solution coat, spreading area 15-40cm with pin ², stopping 6 hours, flush away does not see that medicine is absorbed and the whole body poisoning symptom of appearance by dry skin then, does not also see that skin has redness, erythra phenomenon to take place.

The toxicity test conclusion is:

1, hair growth tonic is irritated stomach to white mice acute experiment, LD ₅₀Bigger 1500 times than the outer consumption 0.08mg/kg of clinical people, clinical amount is safe.

2, hair growth tonic is coated with skin and all shows nontoxic to rat acute toxicity testing and pathological examination.

Hair growth tonic is treated alopecia areata 42 examples in clinical experiment, 9-20 days hair growth promoting person 40 examples, and age reckling 1 years old 8 months, maximum 52 years old, cure rate was 95.2%, invalid 2 examples, inefficiency 4.8%.Treatment seborrheic alopecia 11 examples, 9-20 days hair growth promoting person 7 examples, cure rate 63.6%, invalid 4 examples, effective percentage 36.4%.

Claims

1, a kind of ginseng and astragalus trichogen of suppressing alopecia, growing New Development of being used to, comprising: parts by weight are: Radix Polygoni Multiflori 1-10 part, Fructus Zanthoxyli 1-10 part, Flos Carthami 1-10 part, Radix Ginseng 1-10 part, Fructus Schisandrae Chinensis 1-10 part, Radix Angelicae Sinensis 1-10 part, Rhizoma Zingiberis 1-10 part, Radix Astragali 1-10 part.

2, a kind of ginseng and astragalus trichogen as claimed in claim 1 comprises also that wherein parts by weight are: Fructus Lycii 1-10 part, Rhizoma Chuanxiong 1-10 part.

3, a kind of ginseng and astragalus trichogen as claimed in claim 2 comprises also that wherein parts by weight are Cortex Dictamni 1-10 part.