CN107616981A - A kind of pectin solution for being thickened for Elental and promoting postoperative reparation - Google Patents
A kind of pectin solution for being thickened for Elental and promoting postoperative reparation Download PDFInfo
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Abstract
Present invention is disclosed a kind of aqueous pectin solution, the aqueous pectin solution includes ginseng pectin, pachymaran, glutamine, arginine, nucleotides, selenium（Salt）, zinc（Salt）, vitamin C, vitamin E and carotenoid.The aqueous pectin solution is used for Elental（Liquid）Thickening, can alleviate Elental（Liquid）User（Wound, patient with operation）The adverse reactions such as the Nausea and vomiting that occurs in clinical practice, abdominal distension, stomachache, diarrhoea, and promote postoperative reparation.
Description
Technical field
The present invention relates to a kind of pectin solution.It is used for Elental thickening more specifically to one kind and promotes art
The pectin solution repaired afterwards.
Background technology
Enteral nutrition（Enteral Nutrition）Refer to tube feed pipe through side nasal cavity, oral cavity or Gastroenteritic mouth etc.
Stomach or enteral are inserted, essential food or liquid diet are instilled out of pipe, to ensure that patient takes in controlling for enough protein and heat
Treatment method.Elental refers to the general name of the various products for clinical EN support, and rational nutritional support can increase
The resistance of strong body, sb.'s illness took a favorable turn for promotion, it might even be possible to extends patient vitals.
Wound, patient with operation need to often apply Elental.Under wound, Fundamental Operations situation, body is in high de-agglomeration
Metabolism state, histocyte intracellular metabolite get muddled.In this situation, the food of human body intake can not only consider that supplement is normal
The nutrient of demand, more importantly to adapt to and adjust the dysbolism in histocyte, with maintain the eubolism of cell and
The normal configuration and function of histoorgan.Wound, postoperative human body are yet often accompanied by immune dysfunction, intestinal mucosal permeability increases
The features such as, this causes immunity of organisms to reduce, so as to influence postoperative rehabilitation.
Further, since wound, Fundamental Operations can also by neuroendocrine system and immune system activation neutrophil leucocyte,
Discharge the inflammatory mediators such as IL-6, IL-1 β, TNF-α.Appropriate inflammation stress be favourable to body, and extrinsic damage, mistake are resisted beneficial to body
Degree inflammation stress can then cause a certain degree of infringement to body, weaken physiological reserve, be further development of various complicated by postoperative
Disease even MODS.
Wound, Fundamental Operations can cause vivo immunization competent cell largely to activate, and respiratory burst occurs for intracellular mitochondrial
And a large amount of free radicals are discharged, causing in-vivo tissue plus anoxic, ischemia reperfusion injury, a large amount of free radicals accumulate into the cell, often
Surgical tissue cellular oxidation ability is set to substantially exceed oxidation resistance and oxidative stress occurs.
Using some special compositions, immune and metabolic function, the wound for effectively facilitating postoperative patient that can improve patient are cured
Close, reduce peroxide injury, enhancing body immunity, mitigate harmful or excessive inflammatory response, and then promote post-operative recovery
Effect, such as ginseng pectin, glutamine, pachymaran, selenium, zinc, vitamin C, vitamin E and carotenoid.
Ginseng since ancient times just with physical fitness, promote longevity and famous, it has antifatigue, anti-oxidant, Auto-regulator
Metabolism, regulation central nervous system and other effects.Active component of the ginseng pectin as ginseng, have anti-oxidation stress (Luo,
D.H.,&Fang,B.S.(2008)
.Structuralidentificationofginsengpolysaccharidesandtestingoftheirantioxidant
Activities.CarbohydratePolymers, 72,376-381.) etc. biological function.
Glutamine can remarkably promote intestinal mucosa reparation, reduce Intestinal permeabiligy, prevent intestines source property bacterial translocation, reduce infection
Property complication, can also adjust gut flora, promote probiotics field planting and growth, suppress the breeding field planting of exogenous strain.
By glutamine and antioxidant interworking, strengthen enteral nutrition, reducing postoperative height stress inflammatory reaction, enhancing enteron aisle
Barrier function, and then effectively control inflammation reaction, the generation of reduction inflammation stress disease, while reduce inflammation stress be to
The effect for the harm that body is brought.
Pachymaran has the multiple biological activities such as immunological regulation, anti-oxidant, prevention infection.
Selenium, vitamin C, vitamin E and carotenoid can dramatically increase the level of internal polyphenoils, make histocyte
Oxidative and anti-oxidative system maintains dynamic equilibrium, and then effectively prevents or reverse the destruction of free radical.
At present, in the market existing " peace element ", " Nutrison Fibre ", " auspicious element ", " Ensure Powder ", " power weighing apparatus is complete ", " good dimension body " etc. are
Row enteral nutrition preparation.However, be used to promote the nutraceutical of postoperative reparation few in the prior art, and effect is single, effect
It is bad, cause patient's convalescence longer, therefore need the nutraceutical that a kind of effect is good, recovery time is short badly.
In addition, Elental in process of clinical application there is also many deficiencies being difficult to avoid that, mainly have intestines and stomach
Reaction, Nausea and vomiting or abdominal distension, stomachache, diarrhoea etc..In order to overcome above mentioned problem, someone has used the pectin thickened in the intestine
Solution.As patent CN201380004157.5 disclose one kind can make enteric nutrient thicken and do not produced in preservation
The aqueous pectin solution of precipitation, aqueous pectin solution described in patent contain esterification degree for 5~15%,（It is viscous equal）Molecular weight is 10000
~35000 pectin, the calcium concentration of aqueous pectin solution is below 9ppm, pectin viscosity (25 DEG C) is 1~30mPas.And point out
The aqueous pectin solution 100mL and calcium/sodium water solution that calcium chloride is 0.019mol/L, sodium citrate is 0.020mol/L
The viscosity (25 DEG C) of 200mL mixed liquor is 700~10000mPas.The aqueous pectin solution of the invention, it is not only conventional sodium
Content is below 150mg/100mL enteric nutrient, even the more enteric nutrients of sodium content, especially sodium content are
More than 180mg/100mL enteric nutrient can also make its thickening, and the enteric nutrient that can prevent from giving into stomach falls
Stream, diarrhoea, dumping syndrome.For another example, patent US6187334 is disclosed containing LM（Esterification degree is less than 50%）, marine alga
Sour sodium, alginic acid, kappa carrageenans, iota carrageenans, lambda carrageenans, gellan gum（gellan gum）Only
The edible thing told.Such technology simply solely prevents the refluence of the enteric nutrient given into stomach, diarrhoea, dumping syndrome
Or antiemetic, to promoting patient's body recovery, shortening rehabilitation duration without Essential Action.
Therefore, reality needs a kind of pectin solution for meeting a variety of demands of wound, patient with operation, you can effectively avoids enteral
The appearance gastrointestinal reaction of nutritional preparation, the deficiency of the adverse reaction such as Nausea and vomiting or abdominal distension, stomachache, diarrhoea, it can promote to suffer from again
Person's body recovery, shorten rehabilitation duration.
The content of the invention
It is an object of the invention to provide a kind of pectin solution for meeting a variety of demands of wound, patient with operation, you can effectively
Avoid the appearance gastrointestinal reaction of enteral nutrition preparation, the deficiency of the adverse reaction such as Nausea and vomiting or abdominal distension, stomachache, diarrhoea, again
Patient's body recovery can be promoted, shorten rehabilitation duration.
Based on above-mentioned purpose, for the demand of wound, patient with operation nutrition, metabolic demand and the fast quick-recovery of body, by people
Ginseng pectin, pachymaran, glutamine, selenium, zinc, vitamin C, vitamin E and carotenoid etc. are compounded, and they can phase
Mutually collaboration, collective effect, you can avoid the deficiency of enteral nutrition preparation, wound, postoperative wound healing can be promoted again, reduce peroxide
Change damage, raising body immunity, reduction inflammatory reaction etc. to set about, be finally reached the effect for promoting postoperative reparation.
The present invention relates to a kind of aqueous pectin solution for being thickened for Elental and promoting postoperative reparation, the pectin are water-soluble
Liquid includes ginseng pectin's (pectin derives from ginseng), pachymaran, glutamine, selenium（Salt）, zinc（Salt）, vitamin C, dimension life
Plain E and carotenoid (and water).The aqueous pectin solution is used for Elental（Liquid）Thickening, for alleviating Elental
（Liquid）User（Wound, patient with operation）The Nausea and vomiting that occurs in clinical practice, abdominal distension, stomachache, diarrhoea etc. are bad
Reaction, and for promoting postoperative reparation.
Above-mentioned ginseng pectin is that extraction separation and purification obtains pectin polysaccharide RSP in ginseng, and its molecular weight is 26.6 kD, RSP
HG (50%) and RG-I regions (50%) mainly are included, RG-I regions have substantial amounts of branched structure, branch master in Rha O-4 positions
To be made up of Ara and Gal, including p- (1 → 4) galactan, β-(1 → 6) gala using β-(1 → 3,6)-Gal as branch point
Glycan, α-(1 → 5) araban using α-(1 → 3,5)-Ara as branch point.
Content of the above-mentioned ginseng pectin in above-mentioned aqueous pectin solution is 0.1~10%（W/w）, preferably 0.3~
5%（W/w）, more preferably 0.5~3%（W/w）.
The above-mentioned preferred carboxymethylpachymaran of pachymaran, above-mentioned pachymaran are preferably that molecular weight is 80000-300000
Dalton, more preferably 100000-200000 dalton.
Content of the above-mentioned pachymaran in above-mentioned aqueous pectin solution is 0.1~5%（W/w）, preferably 0.3~
3%（W/w）, more preferably 0.5~2%（W/w）.
Content of the above-mentioned glutamine in above-mentioned aqueous pectin solution is 0.1~30%（W/w）, preferably 0.3~
20%（W/w）, more preferably 0.5~10%（W/w）.
The content in above-mentioned aqueous pectin solution is 0.001~2% respectively for said vitamin C, vitamin E and carotenoid
（W/w）, preferably 0.005~1%（W/w）, more preferably 0.005~0.5%（W/w）.
Above-mentioned selenium（Salt）Source for Se-enriched yeast, sodium selenate.
Above-mentioned zinc（Salt）Source for Zinc-rich saccharomyces cerevisiae, zinc sulfate, zinc gluconate, zinc oxide, zinc lactate, zinc citrate,
Zinc chloride or zinc acetate.
Above-mentioned selenium（Salt）, zinc（Salt）The content in above-mentioned aqueous pectin solution is 0.00001~0.05% respectively（Weight/weight
Amount）, preferably 0.00001~0.005%（W/w）, more preferably 0.0001~0.0005%（W/w）.
But in the aqueous pectin solution of the present invention, the content of pectin can be according to pectin（It is viscous equal）Molecular weight etc. suitably adjusts
So that the viscosity of aqueous pectin solution reaches above-mentioned scope, for example, in pectin（It is viscous equal）Molecular weight is 10000~35000
In the case of, it is set to 1~5 mass %.When the content of pectin is very few, enteral nutrition composition can not be made fully to thicken, phase
When anti-excessive, firm gel is generated due to the reaction with enteral nutrition composition, therefore from the point of view of in terms of digesting and assimilating
It is undesirable.
The nutritional ingredient of the addible needed by human body of aqueous pectin solution of the present invention and suitable additive.
The nutritional ingredient that can include of aqueous pectin solution of the present invention includes amino acid, peptide, protein, monosaccharide and disaccharide, 3 to
20 sugar and their sugar alcohol, the polysaccharide in addition to pectin, vitamin, trace element（Not comprising calcium ion, preferably not comprising other
Divalent cation or more high-valence cationic）, and their any combination etc..
Above-mentioned addible nutritional ingredient, can include monose as shown below, disaccharides, 3~20 sugar sugar or they
Sugar alcohol.
As monosaccharide, such as the aldotetroses such as erythrose, threose can be included；Ribose, lyxose, xylose, arabinose
Deng aldopentose；The aldohexoses such as allose, talose, gulose, glucose, altrose, mannose, galactolipin, idose；Red moss
The ketotetroses such as ketose；The pentuloses such as xylulose, ribulose；Ketohexoses such as psicose, fructose, sorbose, Tagatose etc..As
Disaccharides, such as the α-diglucoside such as trehalose, kojibiose, nigerose, maltose, isomaltose can be included；Different marine alga
β-the diglucoside such as sugar, sophorose, laminaribiose, cellobiose, gentiobiose；The α such as neotrehalose, β-diglucoside；And breast
Sugar, sucrose, isomaltoketose (palatinose) etc..As three carbohydrates, such as gossypose etc. can be included.It is sugared as trisaccharide~six
Oligosaccharide, such as can to include FOS, galacto-oligosaccharide, xylo-oligosaccharide, oligoisomaltose, chitin oligo saccharide, shell few
Cyclic oligosaccharides such as sugar, oligo-glucosamine, dextrin, cyclodextrin etc..
In addition, the alcohol as monose, such as the tetritol such as erythrite, D- threitols, L- threitols can be included；D- I
The pentitols such as primary sugar alcohol, xylitol；D- iditols, galactitol (dulcitol), D- glucitols (sorbierite), mannitol etc. oneself
Sugar alcohol；Cyclitols such as inositol etc..In addition, as dialditol, such as maltitol, lactitol, isomalt can be included
(isomalt) etc., as the alcohol of oligosaccharide, pentaerythrite, reduction maltose syrups etc. can be included.
As needed, suitable additive includes any conditions such as pH adjusting agent, thickening polysaccharide, stabilizer.
The present invention aqueous pectin solution be further characterized in that, calcium concentration as little as below 9ppm, preferably below 4.5ppm, from
And aqueous pectin solution is inhibited to produce precipitation in preservation.
In addition, the pH of the aqueous pectin solution of the present invention is preferably 3~8, more preferably 4~6.5.
(25 DEG C) of the viscosity of the aqueous pectin solution of the present invention is below 30mPas, is preferably below 10mPas.From making
Enteral nutrition composition is moderately from the viewpoint of thickening, (25 DEG C) of viscosity for making the aqueous pectin solution of the present invention be 1mPas with
On.
Because the nutritional ingredient of needed by human body also includes calcium ion（And other divalent cations or more high-valence cationic）, and
Calcium ion（And other divalent cations or more high-valence cationic）Be not suitable for adding aqueous pectin solution simultaneously with pectin, if thus people
Body needs calcium ion（And other divalent cations or more high-valence cationic）, then pectin water is being applied to people after being made into solution
Enteral is applied to before or after solution.
As the manufacture method of the aqueous pectin solution of the present invention, for example, using commercially available above-mentioned pectin as raw material pectin, make
It is dissolved in pure water, so as to prepare（Concentration of pectin is 1~5 mass %'s）Aqueous pectin solution（And determine its calcium concentration）, afterwards
Nutritional ingredient and possible additive are added, is eventually adding probiotics.In the present invention, in the fruit that concentration of pectin is 1~5 mass %
In the case that the calcium concentration of glue solution is more than 9ppm, by carrying out drop Calcium treatment to raw material pectin, so as to will equally be prepared into
Concentration of pectin is that the calcium concentration in 1~5 mass % aqueous pectin solution is reduced to below 9ppm.On the other hand, it is in calcium concentration
In the case of below 9ppm, select the raw material pectin as workable pectin in the present invention without carrying out drop Calcium treatment.
It is diluted with water using the pectin for implementing drop Calcium treatment or as the pectin that need not be dropped Calcium treatment and select, according to need
Implement heating or ferment treatment, so as to carry out degraded to pectin and incite somebody to action（It is viscous equal）Molecular weight adjusted to 10000~
35000th, it is preferably 12000~27000, the viscosity that can obtain aqueous pectin solution reaches 1~30mPas fruit of the invention
Glue solution.Or carry out dropping at calcium after pectin can also be diluted with water in a manner of aqueous pectin solution reaches above-mentioned viscosity
Reason.It should be noted that as water used herein, preferably pure water or ion exchange water.
Embodiment
Embodiment 1
Formula：Ginseng pectin 1.2g, glutamine 10g, carotenoid 0.0016g, vitamin E 0.083g, vitamin
C0.25g, zinc 0.0034g, selenium 0.00005g, carboxymethylpachymaran (molecular weight is 100000-200000 dalton) 0.36g,
Pure water adds to 100ml.
Reference examples 1
Reference examples 1-1
Formula：Dietary fiber 1.2g, glutamine 10g, carotenoid 0.0016g, vitamin E 0.083g, vitamin
C0.25g, zinc 0.0034g, selenium 0.00005g, carboxymethylpachymaran (molecular weight is 100000-200000 dalton) 0.36g,
Pure water adds to 100ml.
Reference examples 1-2
Formula：Commonly（Citrus）Pectin 1.2g, glutamine 10g, carotenoid 0.0016g, vitamin E 0.083g, vitamin
C0.25g, zinc 0.0034g, selenium 0.00005g, carboxymethylpachymaran (molecular weight is 100000-200000 dalton) 0.36g,
Pure water adds to 100ml.
Embodiment 2
Formula：Ginseng pectin 0.5g, glutamine 5g, carotenoid 0.001g, vitamin E 0.07g, vitamin C 0.15g, zinc
0.002g, selenium 0.00003g, carboxymethylpachymaran (molecular weight is 80000-100000 dalton) 0.2g pure water add to
100ml。
Reference examples 2
Reference examples 2-1
Formula：Dietary fiber 0.5g, glutamine 5g, carotenoid 0.001g, vitamin E 0.07g, vitamin C 0.15g, zinc
0.002g, selenium 0.00003g, carboxymethylpachymaran (molecular weight is 80000-100000 dalton) 0.2g, pure water add to
100ml。
Reference examples 2-2
Formula：Commonly（Lemon）Pectin 0.5g, glutamine 5g, carotenoid 0.001g, vitamin E 0.07g, vitamin
C0.15g, zinc 0.002g, selenium 0.00003g, carboxymethylpachymaran (molecular weight is 80000-100000 dalton) 0.2g are pure
Water purification adds to 100ml.
Embodiment 3
Formula：Ginseng pectin 7g, glutamine 25g, carotenoid 0.02g, vitamin E 0.9g, the 5g of vitamin C 2., zinc
0.004g, selenium 0.00007g, pachymaran (molecular weight is 100000-300000 dalton) 0.5g, pure water add to 100ml.
Reference examples 3
Reference examples 3-1
Formula：Commonly（Grape）Pectin 7g, glutamine 25g, carotenoid 0.02g, vitamin E 0.9g, vitamin C
2.0g, zinc 0.04g, selenium 0.0007g, pachymaran (molecular weight is 100000-300000 dalton) 2.5g, pure water add to
100ml。
Reference examples 3-2
Formula：Commonly（Lemon）Pectin 7g, glutamine 25g, carotenoid 0.02g, vitamin E 0.9g, vitamin C 2.
5g, zinc 0.004g, selenium 0.00007g, pachymaran (molecular weight is 100000-300000 dalton) 0.5g, pure water add to
100ml。
Embodiment 4
Formula：Ginseng pectin 3g, glutamine 15g, carotenoid 0.005g, vitamin E 0.06g, the 5g of vitamin C 0.,
Zinc 0.0004g, selenium 0.000005g, pachymaran (molecular weight is 100000-300000 dalton) 0.5g, pure water add to
100ml。
Reference examples 4
Reference examples 4-1
Formula：Commonly（Grape）Pectin 3g, glutamine 15g, carotenoid 0.005g, vitamin E 0.06g, vitamin C
0. 5g, zinc 0.0004g, selenium 0.000005g, pachymaran (molecular weight is 100000-300000 dalton) 0.5g, pure water
Add to 100ml.
Reference examples 4-2
Formula：Commonly（Lemon）Pectin 3g, glutamine 15g, carotenoid 0.005g, vitamin E 0.06g, vitamin C
0. 5g, zinc 0.0004g, selenium 0.000005g, pachymaran (molecular weight is 100000-300000 dalton) 0.5g, pure water
Add to 100ml.
Embodiment 5
Formula：Ginseng pectin 2.5g, glutamine 15g, carotenoid 0.003g, vitamin E 0.04g, vitamin C 0.
3g, zinc 0.0002g, selenium 0.000005g, carboxymethylpachymaran (molecular weight is 100000-300000 dalton) 1.5g are pure
Water adds to 100ml.
Embodiment 6
Formula：Ginseng pectin 1.5g, glutamine 10g, carotenoid 0.003g, vitamin E 0.04g, vitamin C 0.
3g, zinc 0.0002g, selenium 0.000005g, carboxymethylpachymaran (molecular weight is 100000-300000 dalton) 1.5g are pure
Water adds to 100ml.
Embodiment 7
Formula：Ginseng pectin 1.5g, glutamine 25g, carotenoid 0.003g, vitamin E 0.04g, vitamin C 0.
3g, zinc 0.0002g, selenium 0.000005g, carboxymethylpachymaran (molecular weight is 100000-300000 dalton) 1.5g are pure
Water adds to 100ml.
Test case
The stomach and intestine adverse reaction such as 1 pre- anti-diarrhea of test case or reduction diarrhoea sends rate clinical test
Data：Accept tube-fed patients 157 for medical treatment, without diarrhoea when being admitted to hospital, hepatic and renal function is without exception, patient source ICU, division of respiratory disease, god
Through internal medicine, neurosurgery.Wherein man 82, female 75, average age 45.5.Patient is randomly divided into two groups, wherein control group
7O examples, man 38, female 32, average age 45.3, seminar 87, man 44, female 43, average age 45.7 years old, patient
Sex, age, state of an illness seminar and control group indifference.
Method：Seminar uses embodiment sample, and control group is only with reference examples sample.The equal conventional therapy of patient clinical,
Two groups are continuously pumped into using nose supply bobbin, and nutrient solution is maintained at 38 DEG C or so by thermostat.According to the height of patient, body weight, year
Age, active level give nutritional support, 20 days time.Testing index：Two groups of people digest roads during nutritional support：Diarrhoea, abdomen
The number of the infected of the complication such as swollen, vomiting, which is given, to be recorded.Statistical procedures：Measurement data is represented using (X ± S), is contrasted between group
Examined using t and the contrast of two groups of rates is using examining, P≤0.05 is that difference has conspicuousness statistical significance.
It the results are shown in Table 1.
The embodiment of table 1 and reference examples stomach and intestine adverse reaction send rate clinical test results
The nutraceutical of test case 2 is to patient's post-operative recovery measure of merit
First, experimental method
A, research object
Surgical operation inpatient 150, man 76, female 74；It is age 18-80 year, average 45.8 ± 5.7 years old.
B, nutritional support method
Nutritional supplementation is carried out to surgical operation inpatient.Patient is evenly distributed to test group and two pairs using table of random number
According to group, the nutritional preparation that test group uses is the nutraceutical of embodiment, and two control groups use the nutrition of reference examples 1 and 2 respectively
Food.
Test group：In operation adjust nose nutrient canal of intestine to Treitz ligaments under about at 20cm (away from stomach intestinal anastomosis mouth about
At 40cm), postoperative nasointestinal tube is temporarily closed, and postoperative 8~12h starts to be transfused 250~500ml of physiological saline, Post operation the 2nd
It starts the post-operative recovery food of the input present invention through nasointestinal tube, controls drop speed with infusion pump, 50ml/h rises, as Intestinal Mucosal Injury in Patients Undergoing obtains
To adapt to, after the symptom of digestive tract such as no diarrhoea, abdominal distension, Nausea and vomiting, speed gradually increases to 100~120ml/h, during to 3~5d
Enteral nutrition is transitted to completely.
Control group：Same procedure gives the food of the energy such as the albumen such as patient.
C, index evaluation of each stage
Subjective assessment：Side effect is observed.
Objective indicator：Albumin (ALB), prealbumin (PA) and t lymphocyte subset group CD3+, CD4+, CD4/CD8；It is living
Property oxygen (ROS) concentration, MDA (MDA) concentration, superoxide dismutase (SOD) activity, GPX3
(GSH-Px) it is active；IL 6 (IL-6), interleukin_1 0 (IL-10), IL-6/IL-10；Wound is cured
Close curative effect etc..As a result paired t-test statistics is carried out using SPSS19.0 softwares, contrasts two groups of patient's nutrition in postoperative situations and be immunized
Index, p value are significant difference less than 0.05, and it 0.01 is pole significant difference that p value, which is,.
2nd, experimental result
A, immune change result before and after nutritional support treatment
As a result referring to table 2, as known from Table 2：Test group and control group indices are all remarkably decreased art one day after, and postoperative eight days
Test group (the post-operative recovery food group obtained by embodiment 1) ALB, PA and t lymphocyte subset group's CD3+, CD4+, CD4/CD8 number
Amount increase is more notable, and recovery extent is higher, has significant difference with control group.Show the post-operative recovery food obtained by the present invention
Product can significantly improve the immunity of patient.
Immunity evaluation index before and after the nutritional support treatment of table 2
B, oxidative stress result of variations before and after nutritional support treatment
As a result referring to table 3, as known from Table 3：Postoperative 8th day, test group ROS, MDA activity was substantially less than control group, test group
SOD, GSH-Px activity are all remarkably higher than control group.As a result show：Post-operative recovery food group obtained by the present invention can be more preferable
Ground suppresses ROS and the MDA activity of body after wound, preferably enhancement of SOD, GSH-Px activity, has stronger anti-oxidation stress
Effect.
The comparison of 3 two groups of patient's blood oxidative stress index changes of table
C, before and after nutritional support treatment serum cytokines result of variations
As a result referring to table 4.As known from Table 4：The postoperative 1d of blood serum IL-6 rises to top, and more preoperative difference has very significant meaning
Justice.Test group postoperative 8th day IL-6, IL-10 are horizontal and IL-6/IL-10 ratios are substantially less than control group.As a result the present invention is shown
Obtained post-operative recovery food can preferably mitigate patient's Postoperative inflammatory reaction.
The change of 4 two groups of serum cytokines of table
D, before and after nutritional support treatment wound healing curative effect result of variations
As a result referring to table 5.As known from Table 5：Test group Wound healing total effective rate, particularly cure rate are higher than control group, and control
Compole is substantially less than control group when more.As a result show：Post-operative recovery food obtained by the present invention contributes to patient with operation wound
Healing.
The comparison of 5 two groups of patient wounds' healing curative effects of table
Claims (12)
1. a kind of thicken for Elental and promote the aqueous pectin solution of postoperative reparation, the aqueous pectin solution include pectin,
Glutamine, selenium salt, zinc salt, pachymaran, vitamin C, vitamin E and carotenoid, above-mentioned pectin derive from ginseng.
2. aqueous pectin solution according to claim 1, the aqueous pectin solution should in clinic for alleviating Elental user
With the Nausea and vomiting of middle appearance, the adverse reaction of abdominal distension, stomachache, class of suffering from diarrhoea.
3. aqueous pectin solution according to claim 1, wherein content of the pectin in the aqueous pectin solution is 0.1~10%
（W/w）.
4. aqueous pectin solution according to claim 1, wherein the pachymaran is selected from carboxymethylpachymaran.
5. aqueous pectin solution according to claim 1, wherein the molecular weight of the pachymaran is 80000-300000 dalton.
6. aqueous pectin solution according to claim 1, wherein the molecular weight of the pachymaran is 100000-200000 dongles
.
7. aqueous pectin solution according to claim 1, wherein content of the pachymaran in the aqueous pectin solution be 0.1~
5%（W/w）.
8. aqueous pectin solution according to claim 1, wherein content of the glutamine in the aqueous pectin solution be 0.1~
30%（W/w）.
9. aqueous pectin solution according to claim 1, wherein the vitamin C, vitamin E and carotenoid are respectively in the fruit
Content in glue solution is 0.001~2%（W/w）.
10. aqueous pectin solution according to claim 1, wherein the source of the selenium salt is Se-enriched yeast, sodium selenate.
11. aqueous pectin solution according to claim 1, wherein the source of the zinc salt is Zinc-rich saccharomyces cerevisiae, zinc sulfate, gluconic acid
Zinc, zinc oxide, zinc lactate, zinc citrate, zinc chloride or zinc acetate.
12. aqueous pectin solution according to claim 1, wherein the selenium salt, the zinc salt content in the aqueous pectin solution respectively
For 0.00001~0.05%（W/w）.
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| CN201710022217.6A Pending CN107616981A (en) | 2017-01-13 | 2017-01-13 | A kind of pectin solution for being thickened for Elental and promoting postoperative reparation |
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| CN (1) | CN107616981A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109567167A (en) * | 2018-12-25 | 2019-04-05 | 梁力中 | A kind of alimentation composition and its preparation method and application containing Pseudobulbus Bletillae (Rhizoma Bletillae) extract suitable for pre-operative patients |
| CN111493326A (en) * | 2020-04-28 | 2020-08-07 | 成都尚医信息科技有限公司 | Enteral nutrition food and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104432107A (en) * | 2014-12-18 | 2015-03-25 | 广州纽健生物科技有限公司 | Nutritious food for promoting postoperative recovery and application thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104432107A (en) * | 2014-12-18 | 2015-03-25 | 广州纽健生物科技有限公司 | Nutritious food for promoting postoperative recovery and application thereof |
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| 许凤芹: "《人参果胶的研究概况》", 《佳木斯教育学院学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109567167A (en) * | 2018-12-25 | 2019-04-05 | 梁力中 | A kind of alimentation composition and its preparation method and application containing Pseudobulbus Bletillae (Rhizoma Bletillae) extract suitable for pre-operative patients |
| CN111493326A (en) * | 2020-04-28 | 2020-08-07 | 成都尚医信息科技有限公司 | Enteral nutrition food and preparation method and application thereof |
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